26 results on '"Lopes, Fernando Brito"'
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2. Multi trait genetic evaluation of growth traits in Nellore sheep raised on pasture in semi-arid regions of India using Bayesian approach
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Illa, Satish Kumar, Gollamoori, Gangaraju, Lopes, Fernando Brito, Nath, Sapna, and A.K., Thiruvenkadan
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- 2020
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3. Autozygosity islands and ROH patterns in Nellore lineages: evidence of selection for functionally important traits
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Peripolli, Elisa, Metzger, Julia, de Lemos, Marcos Vinícius Antunes, Stafuzza, Nedenia Bonvino, Kluska, Sabrina, Olivieri, Bianca Ferreira, Feitosa, Fabieli Louise Braga, Berton, Mariana Piatto, Lopes, Fernando Brito, Munari, Danísio Prado, Lôbo, Raysildo Barbosa, Magnabosco, Cláudio de Ulhoa, Di Croce, Fernando, Osterstock, Jason, Denise, Sue, Pereira, Angélica Simone Cravo, and Baldi, Fernando
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- 2018
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4. Multivariate analysis to evaluate genetic groups and production traits of crossbred Holstein × Zebu cows
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Fraga, Angelina Bossi, de Lima Silva, Fabiane, Hongyu, Kuang, Da Silva Santos, Darlim, Murphy, Thomas Wayne, and Lopes, Fernando Brito
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- 2016
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5. Genomic prediction for meat and carcass traits in Nellore cattle using a Markov blanket algorithm.
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Lopes, Fernando Brito, Baldi, Fernando, Brunes, Ludmilla Costa, Oliveira e Costa, Marcos Fernando, da Costa Eifert, Eduardo, Rosa, Guilherme Jordão Magalhães, Lobo, Raysildo Barbosa, and Magnabosco, Cláudio Ulhoa
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CATTLE , *RACTOPAMINE , *MEAT quality , *SHEARING force , *SIMMENTAL cattle , *REGRESSION analysis - Abstract
This study was carried out to evaluate the advantage of preselecting SNP markers using Markov blanket algorithm regarding the accuracy of genomic prediction for carcass and meat quality traits in Nellore cattle. This study considered 3675, 3680, 3660 and 524 records of rib eye area (REA), back fat thickness (BF), rump fat (RF), and Warner–Bratzler shear force (WBSF), respectively, from the Nellore Brazil Breeding Program. The animals have been genotyped using low‐density SNP panel (30 k), and subsequently imputed for arrays with 777 k SNPs. Four Bayesian specifications of genomic regression models, namely Bayes A, Bayes B, Bayes Cπ and Bayesian Ridge Regression methods were compared in terms of prediction accuracy using a five folds cross‐validation. Prediction accuracy for REA, BF and RF was all similar using the Bayesian Alphabet models, ranging from 0.75 to 0.95. For WBSF, the predictive ability was higher using Bayes B (0.47) than other methods (0.39 to 0.42). Although the prediction accuracies using Markov blanket of SNP markers were lower than those using all SNPs, for WBSF the relative gain was lower than 13%. With a subset of informative SNPs markers, identified using Markov blanket, probably, is possible to capture a large proportion of the genetic variance for WBSF. The development of low‐density and customized arrays using Markov blanket might be cost‐effective to perform a genomic selection for this trait, increasing the number of evaluated animals, improving the management decisions based on genomic information and applying genomic selection on a large scale. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Multivariate approach for young bull selection from a performance test using multiple traits of economic importance
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Lopes, Fernando Brito, Magnabosco, Cláudio Ulhôa, Mamede, Mariana Márcia, da Silva, Marcelo Corrêa, Myiage, Eliane Sayuri, Paulini, Fernanda, and Lôbo, Raysildo Barbosa
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- 2013
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7. Analysis of longitudinal data of Nellore cattle from performance test at pasture using random regression model
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Lopes, Fernando Brito, Magnabosco, Cláudio Ulhôa, Paulini, Fernanda, da Silva, Marcelo Corrêa, Miyagi, Eliane Sayuri, and Lôbo, Raysildo Barbosa
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- 2012
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8. Bayesian and Machine Learning Models for Genomic Prediction of Anterior Cruciate Ligament Rupture in the Canine Model
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Baker, Lauren A., Momen, Mehdi, Chan, Kore, Bollig, Nathan, Lopes, Fernando Brito, Rosa, Guilherme J. M., Todhunter, Rory J., Binversie, Emily E., Sample, Susannah J., and Muir, Peter
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0106 biological sciences ,Anterior cruciate ligament ,Bayesian probability ,Dog model ,Genome-wide association study ,QH426-470 ,Biology ,Machine learning ,computer.software_genre ,01 natural sciences ,Canine ,Machine Learning ,03 medical and health sciences ,Dogs ,Genetics ,medicine ,Animals ,Shared data resources ,Clinical significance ,Anterior Cruciate Ligament ,Anterior cruciate ligament rupture ,Molecular Biology ,Genetics (clinical) ,030304 developmental biology ,Genetic association ,0303 health sciences ,business.industry ,Anterior Cruciate Ligament Injuries ,ACL rupture ,Bayes Theorem ,Genomics ,musculoskeletal system ,Acl rupture ,GenPred ,medicine.anatomical_structure ,Genomic Prediction ,Artificial intelligence ,business ,Canine model ,computer ,Genome-Wide Association Study ,010606 plant biology & botany - Abstract
Anterior cruciate ligament (ACL) rupture is a common, debilitating condition that leads to early-onset osteoarthritis and reduced quality of human life. ACL rupture is a complex disease with both genetic and environmental risk factors. Characterizing the genetic basis of ACL rupture would provide the ability to identify individuals that have high genetic risk and allow the opportunity for preventative management. Spontaneous ACL rupture is also common in dogs and shows a similar clinical presentation and progression. Thus, the dog has emerged as an excellent genomic model for human ACL rupture. Genome-wide association studies (GWAS) in the dog have identified a number of candidate genetic variants, but research in genomic prediction has been limited. In this analysis, we explore several Bayesian and machine learning models for genomic prediction of ACL rupture in the Labrador Retriever dog. Our work demonstrates the feasibility of predicting ACL rupture from SNPs in the Labrador Retriever model with and without consideration of non-genetic risk factors. Genomic prediction including non-genetic risk factors approached clinical relevance using multiple linear Bayesian and non-linear models. This analysis represents the first steps toward development of a predictive algorithm for ACL rupture in the Labrador Retriever model. Future work may extend this algorithm to other high-risk breeds of dog. The ability to accurately predict individual dogs at high risk for ACL rupture would identify candidates for clinical trials that would benefit both veterinary and human medicine.
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- 2020
9. Autozygosity islands and ROH patterns in Nellore lineages: Evidence of selection for functionally important traits 06 Biological Sciences 0604 Genetics
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Peripolli, Elisa [UNESP], Metzger, Julia, De Lemos, Marcos Vinícius Antunes [UNESP], Stafuzza, Nedenia Bonvino [UNESP], Kluska, Sabrina [UNESP], Olivieri, Bianca Ferreira [UNESP], Feitosa, Fabieli Louise Braga [UNESP], Berton, Mariana Piatto [UNESP], Lopes, Fernando Brito [UNESP], Munari, Danísio Prado [UNESP], Lôbo, Raysildo Barbosa, Magnabosco, Cláudio De Ulhoa, Di Croce, Fernando, Osterstock, Jason, Denise, Sue, Pereira, Angélica Simone Cravo, Baldi, Fernando [UNESP], Universidade Estadual Paulista (Unesp), University of Veterinary Medicine Hannover, Associação Nacional de Criadores e Pesquisadores (ANCP), Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Zoetis, and Universidade de São Paulo (USP)
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Genomic inbreeding ,Bos indicus ,Gene ontology ,Indicine - Abstract
Made available in DSpace on 2018-12-11T17:22:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-09-17 Background: The aim of this study was to assess genome-wide autozygosity in a Nellore cattle population and to characterize ROH patterns and autozygosity islands that may have occurred due to selection within its lineages. It attempts also to compare estimates of inbreeding calculated from ROH (FROH), genomic relationship matrix (FGRM), and pedigree-based coefficient (FPED). Results: The average number of ROH per animal was 55.15 ± 13.01 with an average size of 3.24 Mb. The Nellore genome is composed mostly by a high number of shorter segments accounting for 78% of all ROH, although the proportion of the genome covered by them was relatively small. The genome autozygosity proportion indicates moderate to high inbreeding levels for classical standards, with an average value of 7.15% (178.70 Mb). The average of FPED and FROH, and their correlations (- 0.05 to 0.26) were low. Estimates of correlation between FGRM-FPED was zero, while the correlation (- 0.01 to - 0.07) between FGRM-FROH decreased as a function of ROH length, except for FROH > 8Mb (- 0.03). Overall, inbreeding coefficients were not high for the genotyped animals. Autozygosity islands were evident across the genome (n = 62) and their genomic location did not largely differ within lineages. Enriched terms (p < 0.01) associated with defense response to bacteria (GO:0042742), immune complex reaction (GO:0045647), pregnancy-associated glycoproteins genes (GO:0030163), and organism growth (GO:0040014) were described within the autozygotic islands. Conclusions: Low FPED-FROH correlation estimates indicate that FPED is not the most suitable method for capturing ancient inbreeding when the pedigree does not extend back many generations and FROH should be used instead. Enriched terms (p < 0.01) suggest a strong selection for immune response. Non-overlapping islands within the lineages greatly explain the mechanism underlying selection for functionally important traits in Nellore cattle. Departamento de Zootecnia Faculdade de Ciências Agrárias e Veterinárias UNESP Univ Estadual Paulista Júlio de Mesquita Filho Institute for Animal Breeding and Genetics University of Veterinary Medicine Hannover Departamento de Ciências Exatas Faculdade de Ciências Agrárias e Veterinárias UNESP Univ Estadual Paulista Júlio de Mesquita Filho Associação Nacional de Criadores e Pesquisadores (ANCP) Embrapa Cerrados Zoetis Universidade de São Paulo Departamento de Nutrição e Produção Animal Departamento de Zootecnia Faculdade de Ciências Agrárias e Veterinárias UNESP Univ Estadual Paulista Júlio de Mesquita Filho Departamento de Ciências Exatas Faculdade de Ciências Agrárias e Veterinárias UNESP Univ Estadual Paulista Júlio de Mesquita Filho
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- 2018
10. ANÁLISE ECONÔMICA SOBRE O MANEJO NUTRICIONAL E SANITÁRIO EM CRIAÇÕES DE OVINOS NAS PROPRIEDADES DO SUL DE TOCANTINS
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Lopes, Fernando Brito, Cavalcante, Tânia Vasconcelos, Rosanova, Clauber, Dias, Francisca Elda Ferreira, and da Silva, Rubens Fausto
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lcsh:Agriculture ,lcsh:Biology (General) ,lcsh:S ,lcsh:QH301-705.5 - Abstract
With the objective of analyzing the impact of the nutritional and sanitary manages bioeconomically in properties of the South of the State of Tocantins, through productivity indices, it accomplished a survey, through questionnaire, in 12 properties, of the which, it was selected intentionally six, that it were divided in two groups: group "A", containing three properties that accomplish appropriate nutritional and sanitarium manages; and group "B", also with three properties whose nutritional and sanitarium manages are deficient. After completion of the questionnaire, for gauging of the productivity indices of each group, it can be glimpsed the magnitude of the impact of the nutritional and sanitary manages on the systems of creation of animals sheep, demonstrating that the properties of the group "A", in spite of the expenses with feeding and medicines, it possess more competitive and lucrative profile in relation to the group "B". Of ownership of the data of the indexes productivity, it took place an evolution of a flock, containing 100 ewes and three reproductive, where the group "A" presented a larger number of animals to be sloughtered, proving the profitability of the systems that use an appropriate nutritional and sanitarium manages rationally.
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- 2008
11. Genotype-environment interaction of maternal influence characteristics in Nellore cattle bred in the Brazilian humid tropical regions by reaction norm
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Ferreira, Jorge Luís, Lopes, Fernando Brito, Lira, Thaymisson Santos de, Garcia, José Américo Soares, Lôbo, Raysildo Barbosa, and Sainz, Roberto Daniel
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Heritability ,Animal genetic improvement ,Zebu ,5.04.02.00-5 Genética e Melhoramento dos Animais Domésticos ,Herdabilidade ,Zebu cattle ,Melhoramento genético animal - Abstract
Norma de reação (NR) é um estudo de interação genótipo ambiente (IGA) que observa as vias alternativas dos genótipos em diferentes ambientes. Objetivou-se com este trabalho verificar a IGA via modelo de norma de reação dos pesos calculados aos 120 (P120) e 210 (P210) dias de idade em bovinos da raça Nelore criados na região do Trópico Úmido do Brasil. As gradientes ambientais foram obtidas por meio das soluções dos grupos de contemporâneos, que serviram de covariáveis no modelo de regressão aleatória via NR. A média para peso aos 120 dias de idade P120 foi de 127,97 Kg, as gradientes ambientais variaram de -27 a +26 kg. Para peso aos 210 dias de idade a média foi de 185,60 Kg, e as gradientes variaram de -54 a +55 kg. Houve alterações de escala dos valores genéticos e das estimativas de herdabilidades entre as gradientes para ambos os pesos, as correlações genéticas entre os valores genéticos foram similares para os dois pesos, as quais apresentaram-se elevadas entre os gradientes próximos e baixas e até negativas entre ambientes extremos. As inclinações que representam a sensibilidade ambiental foram altas, havendo alterações de escala e de classificação dos dez touros com maior número de filhos para ambas as características. Ao avaliar as inclinações das regressões dos dez touros com maiores valores genéticos, observou-se que para P120, estas diferiram das inclinações dos P210, o que pode ser justificado pela maior influência do efeito maternal sobre P120. Os resultados permitiram caracterizar influência da IGA sobre os pesos pré-desmame de animais no trópico úmido do Brasil, assim como permitiu a obtenção de maior precisão sobre as predições dos valores genéticos dos animais, o que resultou em seleção menos viesada e com maior progresso genético. Reaction Norm (RN) is the study of genotype-environment interaction (GxE) that complies with alternative ways of genotypes within different environments. This study was carried out to verify GxE by a reaction norm model of weights at 120 (W120) and 210 (W210) days of age in Nellore cattle raised in the Humid Tropical Regions of Brazil. Environmental gradients were obtained by solutions of contemporary groups which were fitted as co-variables in the random regression model via reaction norms. Mean weight at 120 days of age was 127.97 kg, and environmental gradients ranged between -27 and +26 kg. Average was 185.60 kg at 210 days of age and gradients ranged from -54 to +55 kg. Scale changes in the breeding values and heritability estimates occurred along the gradients for the two weights; the genetic correlations between breeding value breeding values were also similar for both weights. These correlations were high between the close gradients, and low to even negative between extreme environments. Slopes representing the environmental sensitivity were high, with changes of scale and changes in classification of ten bulls with a great numbers of calves for the two traits. When regression slopes of the ten bulls with the highest breeding value breeding values were evaluated, these values were different in W120 from those in W210, perhaps due to the greater influence of maternal effect on W120. These results characterize the influence of GxE on the pre-weaning weights of animals in the humid tropical regions of Brazil. Due to this, it is possible to get greater precision on the predictions of the animals breeding values breeding value. A less biased selection and a greater genetic progress occurred.
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- 2015
12. Quantitative genetic analysis for meat tenderness trait in Polled Nellore cattle
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Castro, Letícia Mendes de, Magnabosco, Cláudio Ulhôa, Sainz, Roberto Daniel, Faria, Carina Ubirajara de, and Lopes, Fernando Brito
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Shear force ,Carcass ,Força de cisalhamento ,Carcaça ,Pedigree - Abstract
The aim of the present study was to analyze the interrelationships among the variables and also estimate the genetic correlations between tenderness (WBSF), growth (ILW, FLW and ADG) and carcass (BF, RF and LMA) features. Other purpose was to identify individuals who were more likely to be carriers of favorable genes for tenderness. Growth, carcass and tenderness data from 415 Polled Nellore animals was analyzed. Factor analysis and canonical correlations were used to analyze the phenotypic relationships. The covariance components and genetic parameters were estimated using Gibbs Sampling method. Lack of phenotypical correlations between the WBSF and the other traits were observed. The genetic correlations between WBSF and the other evaluated traits were of a low magnitude, with values of -0.15; -0.18; -0.13; 0.10; -0.12 and 0.18, between WBSF and ILW, FLW, ADG, BF, RF and LMA, respectively. The results support the conclusion that tenderness selection will not affect the selection of other economic traits and vice-versa, but for a better knowledge of the genetic relationships between meat tenderness and other traits for Polled Nellore more studies are required. The heritability estimated for WBSF was of a low magnitude (0.11 ± 0.022). Based on the principle of probability of identical genes by ancestry individuals who were more likely to be carriers of favorable genes for tenderness were identified. Further work will include creation of a segregating population that will serve as experimental material for future gene prospecting and identification research. Objetivou-se analisar os inter-relacionamentos entre as variáveis, além de estimar as correlações genéticas entre os grupos de características de maciez (FC), crescimento (PI, PF e GPD) e carcaça (EG, P8 e AOL). Foi proposto também, identificar indivíduos que apresentem alta probabilidade de serem portadores de genes favoráveis à maciez. Analisou-se dados de 415 animais Nelore Mocho, filhos de touros representativos das principais linhagens Nelore, avaliados para características de crescimento, carcaça e maciez. Para análises de relacionamentos fenotípicos foram utilizadas análises de fatores e correlações canônicas. Os componentes de variância necessários à obtenção dos parâmetros genéticos foram estimados pelo método da Amostragem de Gibbs. Observou-se ausência de correlações fenotípicas entre FC e as outras características produtivas. As correlações genéticas entre FC e PI, PF, GPD, EG, P8 e AOL foram de baixa magnitude (-0,15; -0,18; -0,13; 0,10; -0,12 e 0,18). A seleção para a maciez não influenciará na seleção de outras características de interesse econômico e vice-versa, porém serão necessários mais estudos para melhor conhecimento sobre as relações genéticas da maciez e outras características produtivas em bovinos Nelore Mocho. A estimativa de herdabilidade para a característica FC foi de baixa magnitude (0,11 ± 0,022). Baseando-se no princípio da probabilidade de genes idênticos por descendência, identificou-se indivíduos com alta probabilidade de possuírem genes favoráveis à maciez. Posterior trabalho irá incluir a criação de uma população segregante a partir desses animais identificados, que irá servir como população experimental para posterior pesquisa de prospecção e identificação de genes para maciez da carne em bovinos Nelore Mocho.
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- 2014
13. Multivariate approach of inter-relationships among growth, consumption and carcass traits in Nellore cattle
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Magnabosco, Cláudio Ulhôa, Lopes, Fernando Brito, Miyagi, Eliane Sayuri, Lôbo, Raysildo Barbosa, and Sainz, Roberto Daniel
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Residual feed intake ,Cluster ,Multivariate statistic ,Estatística multivariada ,Ganho em peso ,Zebu ,Weight gain ,Consumo alimentar residual - Abstract
The objective of the present study was to analyze the phenotypic inter-relationships between growth, feed intake and carcass traits in polled Nellore cattle, as well as to determine which bulls produced the most efficient progeny. The experiment was conducted in the feedlot of the Guaporé Pecuária (Livestock) Company, OB Brand. The following traits were analyzed: initial live weight (ILW); final live weight (FLW); average daily gain (ADG); dry matter intake (DMI); gain:feed (G:F); residual feed intake (RFI); rib-eye area (REA); rump fat thickness (RF); backfat thickness at the 12th-13th rib (BF); weighted fat score (WF); and intramuscular fat percentage (IMF). Both univariate and multivariate analyses were performed to analyze the inter-relationships between the studied traits. No significant phenotypic associations were observed between growth, carcass traits and residual feed intake, while the correlation between RFI and G:F was negative. Therefore, RFI may be used to select more nutritionally efficient animals without compromising growth or adult size. The selection of bulls with progeny showing low residual feed intake is recommended, as selection for low RFI tends to improve feed efficiency without compromising growth and development. Objetivou-se analisar os inter-relacionamentos fenotípicos existentes entre características de crescimento, consumo alimentar e de carcaça de bovinos Nelore Mocho, assim como determinar quais touros apresentaram progênies mais eficientes. O experimento foi conduzido no confinamento da Empresa Guaporé Pecuária, Marca OB. As características analisadas foram: peso vivo inicial (PVI); peso vivo final (PVF); ganho em peso diário (GDP); consumo de matéria seca (CMS); eficiência alimentar (EA); consumo alimentar residual (CAR); área de olho de lombo (AOL); espessura de gordura na garupa (EGP8); espessura de gordura na 12ª-13ª costela (EG); acabamento (ACAB); e porcentagem de gordura intramuscular (PGIM). Foram realizadas análises uni e multivariadas, a fim de se entenderem os inter-relacionamentos entre as características estudadas. Não foi evidenciada associação fenotípica entre características de crescimento, carcaça e consumo alimentar residual. A correlação entre CAR e EA foi negativa. Assim, ao se utilizar CAR, é possível selecionar animais nutricionalmente mais eficientes sem comprometimento do crescimento e tamanho adulto. Dessa fora, sugere-se a seleção dos touros que apresentaram progênies com baixa estimativa de consumo alimentar residual, pois a seleção de animais de baixo CAR tende a não comprometer o crescimento e desenvolvimento animal, mas sim melhorar a eficiência alimentar dos animais selecionados para essa característica.
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- 2014
14. Comparação de índices de seleção de caprinos leiteiros em regiões tropicais
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Lopes, Fernando Brito, Silva, Marcelo Corrêa da, Miyagi, Eliane Sayuri, Fioravanti, Maria Clorinda Soares, Facó, Olivardo, and McManus, Concepta
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milk ,sólidos totais ,first calving ,primeiro parto ,objetivo de seleção ,breeding goals ,leite ,critério de seleção ,selection criteria ,total solids - Abstract
The selection process in dairy goat was evaluated by selection indexes. Basal population of 1,000 does, randomly mated by 50 unselected and unrelated bucks, was simulated. Eight selection indexes in two production systems (intensive - indexes I-IV and semi-intensive - indexes V-XIII) were compared. Three groups of dairy goats (A, B and C) were simulated with a respective intensity of 10, 25 and 50%. Each group was composed of five generations and each generation was replicated 20 times. All traits were simulated using matrices of direct additive genetic and the residual (co)variance and the effect of Mendelian segregation. Statistical analyses were performed by repeated measurements in time. Selection using the suggested indexes improved all traits. Selection indexes III and VII are suggested due to simultaneous production and reproduction trait improvement. Indexes IV and VIII are recommended when higher rates of total solids and somatic cell count occur and would correspond to differentiated payment for the milk. Objetivou-se avaliar o processo de seleção de caprinos leiteiros utilizando-se índices de seleção. Foi simulada população a base composta por 1.000 fêmeas, acasaladas aleatoriamente com 50 reprodutores, não selecionados e não aparentados. Foram comparados oito índices de seleção em cada sistema de criação: intensivo (índices I-IV) e semi-intensivo (índices V-VIII). Foram simulados três grupos de caprinos leiteiros (A, B e C), utilizando-se intensidade de seleção de 10, 25 e 50%, respectivamente. Cada grupo foi composto por cinco gerações e cada geração foi replicada 20 vezes. Todas as características foram simuladas utilizando-se as matrizes de (co) variância genética aditiva direta, residual e o efeito da segregação Mendeliana. As análises estatísticas foram realizadas por meio de medidas repetidas no tempo. A seleção realizada por meio dos índices propostos promoveu melhorias em todas as características. Sugere-se a utilização dos índices III e VII, por promoverem melhorias simultâneas nas características produtivas e reprodutivas. Da mesma forma, sugere-se a utilização dos índices IV e VIII havendo pagamento diferenciado por maiores teores de sólidos totais e à contagem de células somáticas.
- Published
- 2013
15. Estimativas de parâmetros genéticos de características de crescimento, carcaça e perímetro escrotal de animais da raça nelore avaliados em provas de ganho em peso em confinamento
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Marques, Ednira Gleida, Magnabosco, Cláudio Ulhôa, Lopes, Fernando Brito, and Silva, Marcelo Corrêia
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Avaliação de tipo. Características de carcaça. Correlação genética. Herdabilidade ,Agricultural Sciences ,QH301-705.5 ,Agriculture ,Biology (General) - Abstract
O objetivo deste estudo foi estimar os parâmetros genéticos das características avaliadas nas provas de ganho em peso, de bovinos da raça Nelore, realizadas pela Associação Brasileira dos Criadores de Zebu - ABCZ. Foram estudados peso final, ganho médio diário, perímetro escrotal, área de olho de lombo, espessura de gordura subcutânea e as características morfológicas de musculosidade, estrutura física e precocidade. Os componentes de (co)variância e parâmetros genéticos foram estimados usando modelos animais comumente aplicados no método de Máxima Verossimilhança Restrita (REML). As estimativas de herdabilidade obtidas para todas as características apresentaram valores medianos a altos. As estimativas de correlações genéticas (gr) das características peso final e ganho médio diário, perímetro escrotal e características de carcaça foram de baixa magnitude. As estimativas de gr entre peso final e área de olho de lombo, e ganho médio diário e espessura de gordura foram consideradas medianas. Os resultados indicam que as características avaliadas nas provas de ganho em peso podem ser usadas como critérios de seleção no intuito de obter progresso genético para tais características.
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- 2013
16. Bayesian estimates of genetic parameters for reproductive traits in Nellore cows raised on pasture in tropical regions.
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Magnabosco, Cláudio Ulhôa, Lopes, Fernando Brito, de Magalhaes Rosa, Guilherme Jordão, and Sainz, Roberto Daniel
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COWS , *PARTURITION grounds , *COVARIANCE matrices , *BAYESIAN analysis , *PREGNANCY in animals - Abstract
Background: Nellore cows are well adapted to tropical conditions, and they have good maternal ability as well as long and prolific reproductive life. Objective: to estimate (co)variances and genetic parameters for calving interval (CI), age at first calving (AFC), gestation length (GL), and days open (DO) in Nellore cows. Methods: covariance components and genetic parameters were estimated using multi-trait Bayesian procedures. Results: three traits had low but statistically significant heritabilities, averaging 0.05, 0.10, and 0.04 for CI, GL, and DO, respectively, whereas age at first calving had a higher heritability (0.36). The permanent environmental effects for CI, GL, and DO were also low, averaging 0.08, 0.07, and 0.15, respectively. The genetic correlations between AFC and CI, AFC and GL, AFC and DO, GL and CI, CI and DO, GL and DO were 0.20, 0.12, 0.11, 0.02, 0.92, and -0.21, respectively. Selection for shorter CI would contribute towards decreasing DO. However, selection for decreased GL could result in a greater number of DO. Despite the favorable genetic correlations, the direct selection responses for these traits would be low. Conclusion: reproductive traits are strongly influenced by environmental effects. Changes in management and environmental factors could rapidly improve reproductive performance of Polled Nellore herds. Genetic selection for these traits should produce a much slower but permanent response. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
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17. Quantitative genetic analysis for meat tenderness trait in Polled Nellore cattle.
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de Castro, Letícia Mendes, Magnabosco, Cláudio Ulhôa, Sainz, Roberto Daniel, de Faria, Carina Ubirajara, and Lopes, Fernando Brito
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- 2014
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18. Multivariate approach of inter-relationships among growth, consumption and carcass traits in Nellore cattle.
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Magnaboscoz, Cláudio Ulhôa, Lopes, Fernando Brito, Miyagi, Eliane Sayuri, Lôbo, Raysildo Barbosa, and Sainz, Roberto Daniel
- Abstract
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- Published
- 2014
19. Genetic Analysis of Growth Traits in Polled Nellore Cattle Raised on Pasture in Tropical Region Using Bayesian Approaches.
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Lopes, Fernando Brito, Magnabosco, Cláudio Ulhôa, Paulini, Fernanda, da Silva, Marcelo Corrêa, Miyagi, Eliane Sayuri, and Lôbo, Raysildo Barbosa
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CATTLE growth , *CATTLE genetics , *ANIMAL models in research , *PASTURES , *ANALYSIS of covariance , *BIOLOGICAL variation , *BAYESIAN analysis - Abstract
Components of (co)variance and genetic parameters were estimated for adjusted weights at ages 120 (W120), 240 (W240), 365 (W365) and 450 (W450) days of Polled Nellore cattle raised on pasture and born between 1987 and 2010. Analyses were performed using an animal model, considering fixed effects: herd-year-season of birth and calf sex as contemporary groups and the age of cow as a covariate. Gibbs Samplers were used to estimate (co)variance components, genetic parameters and additive genetic effects, which accounted for great proportion of total variation in these traits. High direct heritability estimates for the growth traits were revealed and presented mean 0.43, 0.61, 0.72 and 0.67 for W120, W240, W365 and W450, respectively. Maternal heritabilities were 0.07 and 0.08 for W120 and W240, respectively. Direct additive genetic correlations between the weight at 120, 240, 365 and 450 days old were strong and positive. These estimates ranged from 0.68 to 0.98. Direct-maternal genetic correlations were negative for W120 and W240. The estimates ranged from −0.31 to −0.54. Estimates of maternal heritability ranged from 0.056 to 0.092 for W120 and from 0.064 to 0.096 for W240. This study showed that genetic progress is possible for the growth traits we studied, which is a novel and favorable indicator for an upcoming and promising Polled Zebu breed in Tropical regions. Maternal effects influenced the performance of weight at 120 and 240 days old. These effects should be taken into account in genetic analyses of growth traits by fitting them as a genetic or a permanent environmental effect, or even both. In general, due to a medium-high estimate of environmental (co)variance components, management and feeding conditions for Polled Nellore raised at pasture in tropical regions of Brazil needs improvement and growth performance can be enhanced. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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20. Breeding goals and selection criteria for intensive and semi-intensive dairy goat system in Brazil
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Lopes, Fernando Brito, Borjas, Arcadio de los Reyes, da Silva, Marcelo Correia, Facó, Olivardo, Lôbo, Raimundo Nonato, Fiorvanti, Maria Clorinda Soares, and McManus, Concepta
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ANIMAL breeding , *GOATS , *SOCIOECONOMICS , *GOAT milk yield , *LACTATION , *SOMATIC cells - Abstract
Abstract: The aim of this study was to identify traits of socio-economic relevance for intensive and semi-intensive dairy goat production system, to derive economic weights for the breeding goals and to propose selection indices whose criteria are easily collected by dairy goat breeders. The economic value of each trait was calculated as the difference between the average profit before and after the improvement of criteria, after increasing each trait by 1%, keeping the average of other traits unchanged. Eight selection indices were proposed. Four indices (I–IV) were determined for the intensive system and four (V–VIII) for the semi-intensive system. The traits included in each index were: milk production (MP) and lactation length (LL) (I and V); MP, LL, and age at first kidding (AFC) (II and VI); MP, LL, AFC and kidding interval (CI) (III and VII); and MP, LL, AFC, CI, somatic cell count (SCC) and total solids (TS) (IV and VIII). The average profit of the semi-intensive system was higher than the intensive system, R$ 0.18 and R$ 0.14, respectively. The use of indices III and VI promoted simultaneous improvement in both productive and reproductive traits. With differential payment for better quality milk, TS and SCC levels, use of indices IV and VIII are indicated. The choice and use of these indices depend on the definition of objectives and of the measurement ease of selection criteria. [Copyright &y& Elsevier]
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- 2012
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21. Inferring phenotypic causal networks for tick infestation, Babesia bovis infection, and weight gain in Hereford and Braford cattle using structural equation models.
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Cavani, Ligia, Lopes, Fernando Brito, Giglioti, Rodrigo, Bresolin, Tiago, Campos, Gabriel Soares, Okino, Cintia Hiromi, Gulias-Gomes, Claudia Cristina, Caetano, Alexandre Rodrigues, Oliveira, Márcia Cristina de Sena, Cardoso, Fernando Flores, Rosa, Guilherme Jordão de Magalhães, and de Oliveira, Henrique Nunes
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HEREFORD cattle , *STRUCTURAL equation modeling , *WEIGHT gain , *TICK infestations , *BABESIA , *BIRTH weight , *RHIPICEPHALUS - Abstract
• Four different networks among tick infestation, B. bovis infection level, weight gain from birth to weaning, and weight gain from weaning to yearling were compared. • There is a potential causal relationship between tick count and weight gain from birth to weaning. • There is a negative causal effect of pre-weaning gain on post-weaning gain. Tick infestation and associated diseases (i.e., babesiosis) constitute major drawbacks for improvement of beef cattle productivity in the tropics, mainly when purebred and crossbred taurine animals are used. Host-parasite-pathogen interactions form complex biological systems that are poorly understood and which significantly affect production and quality traits in ways yet to be dissected and described. This research was carried out to investigate potential causal relationships, through the use of structural equation modeling (SEM), among tick counts (TC), Babesia bovis infection level (IB) and the gains in weight: from birth to adjusted weaning age (WG), and from weaning to yearling (YG). Statistical analyses were conducted in three steps: 1) Partition of (co)variances into genetic and residual components using Bayesian multiple-trait modeling (MTM); of 2) Search for plausible causal structures by applying the inductive causation (IC) algorithm to the residual (co)variances obtained in the first step; and 3) Final analysis using SEM, which was based on the causal network learned from the IC algorithm. The most plausible results comprised three direct links between traits: WG→YG, TC→WG, and WG→IB with structural coefficients posterior means equal to -0.3026, 6.3620, and 0.0004, respectively. The final inferred directed acyclic graph (DAG) suggests that interventions on TC would directly affect WG, which would then affected YG; moreover, WG could also present a small positive effect on IB. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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22. Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging.
- Author
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Roudbar, Mahmoud Amiri, Mousavi, Seyedeh Fatemeh, Ardestani, Siavash Salek, Lopes, Fernando Brito, Momen, Mehdi, Gianola, Daniel, and Khatib, Hasan
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STANDARD deviations , *AGE , *AGING , *DNA methylation , *HILBERT space , *SUBSET selection - Abstract
The use of DNA methylation signatures to predict chronological age and aging rate is of interest in many fields, including disease prevention and treatment, forensics, and anti-aging medicine. Although a large number of methylation markers are significantly associated with age, most age-prediction methods use a few markers selected based on either previously published studies or datasets containing methylation information. Here, we implemented reproducing kernel Hilbert spaces (RKHS) regression and a ridge regression model in a Bayesian framework that utilized phenotypic and methylation profiles simultaneously to predict chronological age. We used over 450,000 CpG sites from the whole blood of a large cohort of 4409 human individuals with a range of 10-101 years of age. Models were fitted using adjusted and un-adjusted methylation measurements for cell heterogeneity. Un-adjusted methylation scores delivered a significantly higher prediction accuracy than adjusted methylation data, with a correlation between age and predicted age of 0.98 and a root mean square error (RMSE) of 3.54 years in un-adjusted data, and 0.90 (correlation) and 7.16 (RMSE) years in adjusted data. Reducing the number of predictors (CpG sites) through subset selection improved predictive power with a correlation of 0.98 and an RMSE of 2.98 years in the RKHS model. We found distinct global methylation patterns, with a significant increase in the proportion of methylated cytosines in CpG islands and a decreased proportion in other CpG types, including CpG shore, shelf, and open sea (P<5e-06). Epigenetic drift seemed to be a widespread phenomenon as more than 97% of the age-associated methylation sites had heteroscedasticity. Apparent methylomic aging rate (AMAR) had a sex-specific pattern, with an increase in AMAR in females with age related to males. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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23. Estimates of genetic parameters for growth, reproductive, and carcass traits in Nelore cattle using the single step genomic BLUP procedure.
- Author
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Kluska, Sabrina, Olivieri, Bianca Ferreira, Bonamy, Martin, Chiaia, Hermenegildo Lucas Justino, Feitosa, Fabieli Loise Braga, Berton, Mariana Piatto, Peripolli, Elisa, Lemos, Marcos Vinicíus Antunes, Tonussi, Rafael Lara, Lôbo, Raysildo Barbosa, Magnabosco, Cláudio De Ulhoa, Di Croce, Fernando, Osterstock, Jason, Pereira, Angélica Simone Cravo, Munari, Danísio Prado, Bezerra, Luiz Antônio, Lopes, Fernando Brito, and Baldi, Fernando
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CATTLE growth , *CATTLE reproduction , *CATTLE carcasses , *GENETIC correlations , *HERITABILITY , *CATTLE - Abstract
Highlights • Reproductive traits showed a low correlation with carcass traits. • The results of this study are encouraging for using the probability of precocious calving as selection criteria in Nelore breed. • Selection to increase growth should increase carcass yield and scrotal circumference. • The inclusion of subcutaneous backfat or rump fat thickness in selection indexes would increase the carcass grade. Abstract This study was carried out to estimate the heritability and genetic correlations between adjusted weights at 210 (W210) and 450 (W450) days of age, scrotal circumference adjusted at 365 (SC365) and 450 (SC450) days of age, age at first calving (AFC), probability of precocious calving (PPC), stayability (STAY), ribeye area (REA), subcutaneous backfat thickness (BF), and rump fat (RF) traits. The covariance components and genetic parameters for all traits but PPC and STAY were estimated considering a linear animal model, for the remaining traits a threshold animal model was used. The single-step genomic BLUP (ssGBLUP) procedure was used for all traits, and the correlation estimates were obtained by two-traits analysis. The heritability estimated by single-trait analysis were 0.21 ± 0.01, 0.43 ± 0.01, 0.47 ± 0.02, 0.52 ± 0.02, 0.11 ± 0.01, 0.12 (0.07–0.16), 0.37 (0.26–0.38), 0.33 ± 0.02, 0.17 ± 0.01 and 0.33 ± 0.02 for W210, W450, SC365, SC450, AFC, PPC, STAY, REA, BF and RF, respectively. Growth traits (W210 and W450) showed high (0.95) genetic correlation with one another, moderate (0.30 to 0.66) with REA and scrotal circumferences, and low (−0.07 to 0.20) with female reproductive traits (AFC, PPC, and STAY) and fat carcass indicator traits (BF and RF). Female reproductive traits displayed moderate (−0.29 to 0.52) genetic correlations with male reproductive traits, and varied from low to moderate (−0.02 to 0.35) with carcass traits. Additionally, carcass traits exhibited low to moderate (−0.02 to 0.48) genetic correlations with all traits, except for the genetic correlation between BF and RF (0.73). Hence, higher genetic gains by direct selection would be obtained for W450, SC365, SC450, STAY, REA, and RF. Selection to increase growth traits might increase carcass yield and scrotal circumference, and it would not affect carcass fat content, precocity, and cow longevity indicator traits. The results of this study encourage the use of PPC in Nelore cattle since the selection for such trait would improve the productivity and longevity of the cows. The inclusion of carcass quality indicator traits such as BF or RF in selection indices would increase the genetic gain for carcass grade, but it will require further studies to estimate the economic value of these traits. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
24. (Quasi) multitask support vector regression with heuristic hyperparameter optimization for whole-genome prediction of complex traits: a case study with carcass traits in broilers.
- Author
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Alves AAC, Fernandes AFA, Lopes FB, Breen V, Hawken R, Gianola D, and Rosa GJM
- Subjects
- Animals, Bayes Theorem, Heuristics, Phenotype, Models, Genetic, Genotype, Multifactorial Inheritance, Chickens genetics
- Abstract
This study investigates nonlinear kernels for multitrait (MT) genomic prediction using support vector regression (SVR) models. We assessed the predictive ability delivered by single-trait (ST) and MT models for 2 carcass traits (CT1 and CT2) measured in purebred broiler chickens. The MT models also included information on indicator traits measured in vivo [Growth and feed efficiency trait (FE)]. We proposed an approach termed (quasi) multitask SVR (QMTSVR), with hyperparameter optimization performed via genetic algorithm. ST and MT Bayesian shrinkage and variable selection models [genomic best linear unbiased predictor (GBLUP), BayesC (BC), and reproducing kernel Hilbert space (RKHS) regression] were employed as benchmarks. MT models were trained using 2 validation designs (CV1 and CV2), which differ if the information on secondary traits is available in the testing set. Models' predictive ability was assessed with prediction accuracy (ACC; i.e. the correlation between predicted and observed values, divided by the square root of phenotype accuracy), standardized root-mean-squared error (RMSE*), and inflation factor (b). To account for potential bias in CV2-style predictions, we also computed a parametric estimate of accuracy (ACCpar). Predictive ability metrics varied according to trait, model, and validation design (CV1 or CV2), ranging from 0.71 to 0.84 for ACC, 0.78 to 0.92 for RMSE*, and between 0.82 and 1.34 for b. The highest ACC and smallest RMSE* were achieved with QMTSVR-CV2 in both traits. We observed that for CT1, model/validation design selection was sensitive to the choice of accuracy metric (ACC or ACCpar). Nonetheless, the higher predictive accuracy of QMTSVR over MTGBLUP and MTBC was replicated across accuracy metrics, besides the similar performance between the proposed method and the MTRKHS model. Results showed that the proposed approach is competitive with conventional MT Bayesian regression models using either Gaussian or spike-slab multivariate priors., Competing Interests: Conflicts of interest The author(s) declare no conflict of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Genetics Society of America.)
- Published
- 2023
- Full Text
- View/download PDF
25. Prediction of biological age and evaluation of genome-wide dynamic methylomic changes throughout human aging.
- Author
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Amiri Roudbar M, Mousavi SF, Salek Ardestani S, Lopes FB, Momen M, Gianola D, and Khatib H
- Subjects
- Male, Female, Humans, Child, Preschool, Bayes Theorem, CpG Islands, Epigenesis, Genetic, DNA Methylation genetics, Aging genetics
- Abstract
The use of DNA methylation signatures to predict chronological age and aging rate is of interest in many fields, including disease prevention and treatment, forensics, and anti-aging medicine. Although a large number of methylation markers are significantly associated with age, most age-prediction methods use a few markers selected based on either previously published studies or datasets containing methylation information. Here, we implemented reproducing kernel Hilbert spaces (RKHS) regression and a ridge regression model in a Bayesian framework that utilized phenotypic and methylation profiles simultaneously to predict chronological age. We used over 450,000 CpG sites from the whole blood of a large cohort of 4409 human individuals with a range of 10-101 years of age. Models were fitted using adjusted and un-adjusted methylation measurements for cell heterogeneity. Un-adjusted methylation scores delivered a significantly higher prediction accuracy than adjusted methylation data, with a correlation between age and predicted age of 0.98 and a root mean square error (RMSE) of 3.54 years in un-adjusted data, and 0.90 (correlation) and 7.16 (RMSE) years in adjusted data. Reducing the number of predictors (CpG sites) through subset selection improved predictive power with a correlation of 0.98 and an RMSE of 2.98 years in the RKHS model. We found distinct global methylation patterns, with a significant increase in the proportion of methylated cytosines in CpG islands and a decreased proportion in other CpG types, including CpG shore, shelf, and open sea (P < 5e-06). Epigenetic drift seemed to be a widespread phenomenon as more than 97% of the age-associated methylation sites had heteroscedasticity. Apparent methylomic aging rate (AMAR) had a sex-specific pattern, with an increase in AMAR in females with age related to males., (© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.)
- Published
- 2021
- Full Text
- View/download PDF
26. Bayesian and Machine Learning Models for Genomic Prediction of Anterior Cruciate Ligament Rupture in the Canine Model.
- Author
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Baker LA, Momen M, Chan K, Bollig N, Lopes FB, Rosa GJM, Todhunter RJ, Binversie EE, Sample SJ, and Muir P
- Subjects
- Animals, Bayes Theorem, Dogs, Genome-Wide Association Study, Genomics, Machine Learning, Anterior Cruciate Ligament, Anterior Cruciate Ligament Injuries genetics
- Abstract
Anterior cruciate ligament (ACL) rupture is a common, debilitating condition that leads to early-onset osteoarthritis and reduced quality of human life. ACL rupture is a complex disease with both genetic and environmental risk factors. Characterizing the genetic basis of ACL rupture would provide the ability to identify individuals that have high genetic risk and allow the opportunity for preventative management. Spontaneous ACL rupture is also common in dogs and shows a similar clinical presentation and progression. Thus, the dog has emerged as an excellent genomic model for human ACL rupture. Genome-wide association studies (GWAS) in the dog have identified a number of candidate genetic variants, but research in genomic prediction has been limited. In this analysis, we explore several Bayesian and machine learning models for genomic prediction of ACL rupture in the Labrador Retriever dog. Our work demonstrates the feasibility of predicting ACL rupture from SNPs in the Labrador Retriever model with and without consideration of non-genetic risk factors. Genomic prediction including non-genetic risk factors approached clinical relevance using multiple linear Bayesian and non-linear models. This analysis represents the first steps toward development of a predictive algorithm for ACL rupture in the Labrador Retriever model. Future work may extend this algorithm to other high-risk breeds of dog. The ability to accurately predict individual dogs at high risk for ACL rupture would identify candidates for clinical trials that would benefit both veterinary and human medicine., (Copyright © 2020 Baker et al.)
- Published
- 2020
- Full Text
- View/download PDF
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