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3. The burden of cardiovascular disease in Asia from 2025 to 2050: a forecast analysis for East Asia, South Asia, South-East Asia, Central Asia, and high-income Asia Pacific regions

Author

Goh, Rachel Sze Jen, Chong, Bryan, Jayabaskaran, Jayanth, Jauhari, Silingga Metta, Chan, Siew Pang, Kueh, Martin Tze Wah, Shankar, Kannan, Li, Henry, Chin, Yip Han, Kong, Gwyneth, Anand, Vickram Vijay, Chan, Keith Andrew, Sukmawati, Indah, Toh, Sue Anne, Muthiah, Mark, Wang, Jiong-Wei, Tse, Gary, Mehta, Anurag, Fong, Alan, Baskaran, Lohendran, Zhong, Liang, Yap, Jonathan, Yeo, Khung Keong, Hausenloy, Derek J., Tan, Jack Wei Chieh, Chao, Tze-Fan, Li, Yi-Heng, Lim, Shir Lynn, Chan, Koo Hui, Loh, Poay Huan, Chai, Ping, Yeo, Tiong Cheng, Low, Adrian F., Lee, Chi Hang, Foo, Roger, Tan, Huay Cheem, Yip, James, Rao, Sarita, Honda, Satoshi, Yasuda, Satoshi, Kajiya, Takashi, Goto, Shinya, Yan, Bryan P., Zhou, Xin, Figtree, Gemma A., Mamas, Mamas A., Kim, Yongcheol, Jeong, Young-Hoon, Kim, Moo Hyun, Park, Duk-Woo, Park, Seung-Jung, Richards, A Mark, Chan, Mark Y., Lip, Gregory Y.H., and Chew, Nicholas W.S.

Published
2024
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5. A Systematic Approach to the Evaluation of the Coronary Microcirculation Using Bolus Thermodilution: CATH CMD

Author

Collet, Carlos, Yong, Andy, Munhoz, Daniel, Akasaka, Takashi, Berry, Colin, Blair, John E.A., Collison, Damien, Engstrøm, Thomas, Escaned, Javier, Fearon, William F., Ford, Tom, Gori, Tommaso, Koo, Bon-Kwon, Low, Adrian F, Miner, Steve, Ng, Martin K.C., Mizukami, Takuya, Shimokawa, Hiroki, Smilowitz, Nathaniel R., Sutton, Nadia R., Svanerud, Johan, Tremmel, Jennifer A., Warisawa, Takayuki, West, Nick E.J., and Ali, Ziad A.

Published
2024
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10. Practical Application of Coronary Physiologic Assessment: Asia-Pacific Expert Consensus Document: Part 2

Author

Koo, Bon-Kwon, Hwang, Doyeon, Park, Sungjoon, Kuramitsu, Shoichi, Yonetsu, Taishi, Kim, Chee Hae, Zhang, Jinlong, Yang, Seokhun, Doh, Joon-Hyung, Jeong, Young-Hoon, Choi, Ki Hong, Lee, Joo Myung, Ahn, Jung-Min, Matsuo, Hitoshi, Shin, Eun-Seok, Hu, Xinyang, Low, Adrian F., Kubo, Takashi, Nam, Chang-Wook, Yong, Andy S.C., Harding, Scott A., Xu, Bo, Hur, Seung-Ho, Choo, Gim Hooi, Tan, Huay Cheem, Mullasari, Ajit, Hsieh, I-Chang, Kakuta, Tsunekazu, Akasaka, Takashi, Wang, Jian'an, Tahk, Seung-Jea, Fearon, William F., Escaned, Javier, and Park, Seung-Jung

Published
2023
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11. Practical Application of Coronary Physiologic Assessment: Asia-Pacific Expert Consensus Document: Part 1

Author

Koo, Bon-Kwon, Lee, Joo Myung, Hwang, Doyeon, Park, Sungjoon, Shiono, Yasutsugu, Yonetsu, Taishi, Lee, Seung Hun, Kawase, Yoshiaki, Ahn, Jung-Min, Matsuo, Hitoshi, Shin, Eun-Seok, Hu, Xinyang, Ding, Daixin, Fezzi, Simone, Tu, Shengxian, Low, Adrian F., Kubo, Takashi, Nam, Chang-Wook, Yong, Andy S.C., Harding, Scott A., Xu, Bo, Hur, Seung-Ho, Choo, Gim Hooi, Tan, Huay Cheem, Mullasari, Ajit, Hsieh, I-Chang, Kakuta, Tsunekazu, Akasaka, Takashi, Wang, Jian'an, Tahk, Seung-Jea, Fearon, William F., Escaned, Javier, and Park, Seung-Jung

Published
2023
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12. Trends and predictions of metabolic risk factors for acute myocardial infarction: findings from a multiethnic nationwide cohort

Author

Chew, Nicholas W.S., Chong, Bryan, Kuo, Si Min, Jayabaskaran, Jayanth, Cai, Mingshi, Zheng, Huili, Goh, Rachel, Kong, Gwyneth, Chin, Yip Han, Imran, Syed Saqib, Liang, Michael, Lim, Patrick, Yong, Thon Hon, Liew, Boon Wah, Chia, Pow Li, Ho, Hee Hwa, Foo, David, Khoo, Deanna, Huang, Zijuan, Chua, Terrance, Tan, Jack Wei Chieh, Yeo, Khung Keong, Hausenloy, Derek, Sim, Hui Wen, Kua, Jieli, Chan, Koo Hui, Loh, Poay Huan, Lim, Toon Wei, Low, Adrian F., Chai, Ping, Lee, Chi Hang, Yeo, Tiong Cheng, Yip, James, Tan, Huay Cheem, Mamas, Mamas A., Nicholls, Stephen J., and Chan, Mark Y.

Published
2023
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15. Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Author

Tay, Kai Yi, Wu, Kan Xing, Chioh, Florence Wen Jing, Autio, Matias Ilmari, Pek, Nicole Min Qian, Narmada, Balakrishnan Chakrapani, Tan, Sock-Hwee, Low, Adrian Fatt-Hoe, Lian, Michelle Mulan, Chew, Elaine Guo Yan, Lau, Hwee Hui, Kao, Shih Ling, Teo, Adrian Kee Keong, Foo, Jia Nee, Foo, Roger Sik Yin, Heng, Chew Kiat, Chan, Mark Yan Yee, and Cheung, Christine

Published
2022
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18. One-year outcomes of patients with ST-segment elevation myocardial infarction during the COVID-19 pandemic

Author

Phua, Kailun, Chew, Nicholas W. S., Sim, Vincent, Zhang, Audrey A., Rastogi, Saurabh, Kojodjojo, Pipin, Chor, Wei-Ping Daniel, Koh, Brandon Chi-Ping, Leong, Benjamin Sieu-Hon, Ng, Zhe-Yan, Tung, Benjamin Wei-Liang, Ambhore, Anand, Kong, William K. F., Poh, Kian-Keong, Chai, Ping, Ng, Gavin, Chan, Koo-Hui, Lee, Chi-Hang, Loh, Joshua Ping-Yun, Low, Adrian Fatt-Hoe, Chan, Mark Yan-Yee, Yeo, Tiong-Cheng, Tan, Huay-Cheem, and Loh, Poay-Huan

Published
2022
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21. The prognostic value of metabolic dysfunction‐associated steatotic liver disease in acute myocardial infarction: A propensity score‐matched analysis.

Author

Kong, Gwyneth, Cao, Grace, Koh, Jaycie, Chan, Siew Pang, Zhang, Audrey, Wong, Esther, Chong, Bryan, Jauhari, Silingga Metta, Wang, Jiong‐Wei, Mehta, Anurag, Figtree, Gemma A., Mamas, Mamas A., Ng, Gavin, Chan, Koo Hui, Chai, Ping, Low, Adrian F., Lee, Chi Hang, Yeo, Tiong Cheng, Yip, James, and Foo, Roger

Subjects
MYOCARDIAL infarction, PROPENSITY score matching, PROGNOSIS, LIVER diseases, CARDIOMYOPATHIES, ACUTE diseases
Abstract

Aim: Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) are at increased risk of incident cardiovascular disease. However, the clinical characteristics and prognostic importance of MASLD in patients presenting with acute myocardial infarction (AMI) have yet to be examined. Methods: This study compared the characteristics and outcomes of patients with and without MASLD presenting with AMI at a tertiary centre in Singapore. MASLD was defined as hepatic steatosis, with at least one of five metabolic criteria. Hepatic steatosis was determined using the Hepatic Steatosis Index. Propensity score matching was performed to adjust for age and sex. The Kaplan‐Meier curve was constructed for long‐term all‐cause mortality. Cox regression analysis was used to investigate independent predictors of long‐term all‐cause mortality. Results: In this study of 4446 patients with AMI, 2223 patients with MASLD were matched with patients without MASLD using propensity scores. The mean follow‐up duration was 3.4 ± 2.4 years. The MASLD group had higher rates of obesity, diabetes and chronic kidney disease than their counterparts. Patients with MASLD had early excess all‐cause mortality (6.8% vs. 3.6%, p <.001) at 30 days, with unfavourable mortality rates sustained in the long‐term (18.3% vs. 14.5%, p =.001) compared with those without MASLD. After adjustment, MASLD remained independently associated with higher long‐term all‐cause mortality (hazard ratio 1.330, 95% confidence interval 1.106‐1.598, p =.002). Conclusion: MASLD embodies a higher burden of metabolic dysfunction and is an independent predictor of long‐term mortality in the AMI population. Its early identification may be beneficial for risk stratification and provide therapeutic targets for secondary preventive strategies in AMI. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Predictors of Mortality in Acute Myocardial Infarction Complicated by Cardiogenic Shock despite Intra-Aortic Balloon Pump: Opportunities for Advanced Mechanical Circulatory Support in Asia.

Author

Lin, Weiqin, Yip, Alfred Chung Lum, Cherian, Robin, Chan, Siew Pang, Evangelista, Lauren Kay Mance, Sari, Novi Yanti, Ling, Hwei Sung, Lim, Yoke Ching, Wong, Raymond Ching Chiew, Tung, Benjamin Wei Liang, Tan, Li-Ling, Low, Adrian F., Ambhore, Anand Adinath, and Lim, Shir Lynn

Subjects
INTRA-aortic balloon counterpulsation, ARTIFICIAL blood circulation, MYOCARDIAL infarction, CARDIOGENIC shock, HEART assist devices
Abstract

Introduction: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) mortality remains high despite revascularization and the use of the intra-aortic balloon pump (IABP). Advanced mechanical circulatory support (MCS) devices, such as catheter-based ventricular assist devices (cVAD), may impact mortality. We aim to identify predictors of mortality in AMI-CS implanted with IABP and the proportion eligible for advanced MCS in an Asian population. Methods: We retrospectively analyzed a cohort of Society for Cardiovascular Angiography and Intervention (SCAI) stage C and above AMI-CS patients with IABP implanted from 2017–2019. We excluded patients who had IABP implanted for indications other than AMI-CS. Primary outcome was 30-day mortality. Binary logistic regression was used to calculate adjusted odds ratios (aOR) for patient characteristics. Results: Over the 3-year period, 242 patients (mean age 64.1 ± 12.4 years, 88% males) with AMI-CS had IABP implanted. 30-day mortality was 55%. On univariate analysis, cardiac arrest (p < 0.001), inotrope/vasopressor use prior to IABP (p = 0.004) was more common in non-survivors. Non-survivors were less likely to be smokers (p = 0.001), had lower ejection fraction, higher creatinine/ lactate and lower pH (all p < 0.001). On multi-variate analysis, predictors of mortality were cardiac arrest prior to IABP (aOR 4.00, CI 2.28–7.03), inotrope/vasopressor prior to IABP (aOR 2.41, CI 1.18–4.96), lower arterial pH (aOR 0.02, CI 0.00–0.31), higher lactate (aOR 2.42, CI 1.00–1.19), and lower hemoglobin (aOR 0.83, CI 0.71–0.98). Using institutional MCS criteria, 106 patients (44%) would have qualified for advanced MCS. Conclusions: Early mortality in AMI-CS remains high despite IABP. Many patients would have qualified for higher degrees of MCS. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Sex Differences in 1-Year Rehospitalization for Heart Failure and Myocardial Infarction After Primary Percutaneous Coronary Intervention

Author

Zheng, Huili, Foo, Ling Li, Tan, Huay Cheem, Richards, Authur Mark, Chan, Siew Pang, Lee, Chi-Hang, Low, Adrian F.H., Hausenloy, Derek J., Tan, Jack W.C., Sahlen, Anders O., Ho, Hee Hwa, Chai, Siang Chew, Tong, Khim Leng, Tan, Doreen S.Y., Yeo, Khung Keong, Chua, Terrance S.J., Lam, Carolyn S.P., and Chan, Mark Y.

Published
2019
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30. Combining Circulating MicroRNA and NT-proBNP to Detect and Categorize Heart Failure Subtypes

Author

Wong, Lee Lee, Zou, Ruiyang, Zhou, Lihan, Lim, Jia Yuen, Phua, Dominic C.Y., Liu, Chengcheng, Chong, Jenny P.C., Ng, Jessica Y.X., Liew, Oi Wah, Chan, Siew Pang, Chen, Yei-Tsung, Chan, Michelle M.Y., Yeo, Poh Shuan D., Ng, Tze Pin, Ling, Lieng H., Sim, David, Leong, Kui Toh G., Ong, Hean Y., Jaufeerally, Fazlur, Wong, Raymond, Chai, Ping, Low, Adrian F., Lund, Mayanna, Devlin, Gerry, Troughton, Richard, Cameron, Vicky A., Doughty, Robert N., Lam, Carolyn S.P., Too, Heng Phon, and Richards, Arthur Mark

Published
2019
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36. Current practices of Asia-Pacific cardiologists in the utilization of bioresorbable scaffolds

Author

Chanana, B.B., Chandra, Praveen, Cheng, Jack Jun, Dick, Ron, Gwon, Hyeon-Cheol, Hiremath, M.S., Huan, Do Quang, Jeamanukoolkit, Anuruck, Jiang, Tiemin, Kwok, On-Hing, Lim, Michael C.L., Low, Adrian F., Mathew, Rony, Mathew, Samuel K., McClean, Dougal, Nakamura, Sunao, Nguyen, Michael, Qiao, Shubin, Santoso, Teguh, Saxena, Sudheer, Schultz, Carl, Sengottuvelu, G., Seth, Ashok, Simonton, Charles A., Soo, Chee Siong, Sudhir, Krishnankutty, Tsai, Cheng-Ting, Wasan, Udayachalerm, Whelan, Alan, Wong, Chris, and Yap, Yee Guan

Published
2016
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39. Absorb Bioresorbable Vascular Scaffold Versus Everolimus-Eluting Metallic Stent in ST-Segment Elevation Myocardial Infarction: 1-Year Results of a Propensity Score Matching Comparison: The BVS-EXAMINATION Study (Bioresorbable Vascular Scaffold-A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction)

Author

Brugaletta, Salvatore, Gori, Tommaso, Low, Adrian F., Tousek, Petr, Pinar, Eduardo, Gomez-Lara, Josep, Scalone, Giancarla, Schulz, Eberhard, Chan, Mark Y., Kocka, Viktor, Hurtado, Jose, Gomez-Hospital, Juan Antoni, Münzel, Thomas, Lee, Chi-Hang, Cequier, Angel, Valdés, Mariano, Widimsky, Petr, Serruys, Patrick W., and Sabaté, Manel

Published
2015
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42. Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction.

Author

Chin, YipHan, Lim, Jieyu, Kong, Gwyneth, Ng, Cheng Han, Goh, Rachel, Muthiah, Mark, Mehta, Anurag, Chong, Bryan, Lin, Chaoxing, Chan, Kai En, Kong, William, Poh, Kian Keong, Foo, Roger, Chai, Ping, Yeo, Tiong‐Cheng, Low, Adrian F., Lee, Chi Hang, Tan, Huay Cheem, Chan, Mark Yan‐Yee, and Richards, A Mark

Subjects
FATTY liver, MYOCARDIAL infarction, HEPATIC fibrosis, BODY mass index, MORTALITY
Abstract

Aim: To examine the prevalence and prognosis of hepatic steatosis and fibrosis in post‐acute myocardial infarction (AMI) patients. Methods: Patients presenting with AMI to a tertiary hospital were examined from 2014 to 2021. Hepatic steatosis and advanced hepatic fibrosis were determined using the Hepatic Steatosis Index and fibrosis‐4 index, respectively. The primary outcome was all‐cause mortality. Cox regression models identified determinants of mortality after adjustments and Kaplan–Meier curves were constructed for all‐cause mortality, stratified by hepatic steatosis and advanced fibrosis. Results: Of 5765 patients included, 24.8% had hepatic steatosis, of whom 41.7% were diagnosed with advanced fibrosis. The median follow‐up duration was 2.7 years. Patients with hepatic steatosis tended to be younger, female, with elevated body mass index and an increased metabolic burden of diabetes, hypertension and hyperlipidaemia. Patients with hepatic steatosis (24.6% vs. 20.9% mortality, P <.001) and advanced fibrosis (45.6% vs. 32.9% mortality, P <.001) had higher all‐cause mortality rates compared with their respective counterparts. Hepatic steatosis (adjusted hazard ratio 1.364, 95% CI 1.145‐1.625, P =.001) was associated with all‐cause mortality after adjustment for confounders. Survival curves showed excess mortality in patients with hepatic steatosis compared with those without (P =.002). Conclusions: Hepatic steatosis and advanced fibrosis have a substantial prevalence among patients with AMI. Both are associated with mortality, with an incrementally higher risk when advanced fibrosis ensues. Hepatic steatosis and fibrosis could help risk stratification of AMI patients beyond conventional risk factors. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Myocardial Segmentation of Late Gadolinium Enhanced MR Images by Propagation of Contours from Cine MR Images

Author

Wei, Dong, Sun, Ying, Chai, Ping, Low, Adrian, and Ong, Sim Heng

Subjects
FOS: Computer and information sciences, Computer Vision and Pattern Recognition (cs.CV), Image and Video Processing (eess.IV), embryonic structures, FOS: Electrical engineering, electronic engineering, information engineering, cardiovascular system, Computer Science - Computer Vision and Pattern Recognition, cardiovascular diseases, Electrical Engineering and Systems Science - Image and Video Processing, circulatory and respiratory physiology
Abstract

Automatic segmentation of myocardium in Late Gadolinium Enhanced (LGE) Cardiac MR (CMR) images is often difficult due to the intensity heterogeneity resulting from accumulation of contrast agent in infarcted areas. In this paper, we propose an automatic segmentation framework that fully utilizes shared information between corresponding cine and LGE images of a same patient. Given myocardial contours in cine CMR images, the proposed framework achieves accurate segmentation of LGE CMR images in a coarse-to-fine manner. Affine registration is first performed between the corresponding cine and LGE image pair, followed by nonrigid registration, and finally local deformation of myocardial contours driven by forces derived from local features of the LGE image. Experimental results on real patient data with expert outlined ground truth show that the proposed framework can generate accurate and reliable results for myocardial segmentation of LGE CMR images., MICCAI 2011

Published
2022

46. The Singapore Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design

Author

Santhanakrishnan, Rajalakshmi, Ng, Tze P., Cameron, Vicky A., Gamble, Greg D., Ling, Lieng H., Sim, David, Leong, Gerard Kui Toh, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Wong, Raymond Ching-Chiew, Chai, Ping, Low, Adrian F., Lund, Mayanna, Devlin, Gerry, Troughton, Richard, Richards, A. Mark, Doughty, Robert N., and Lam, Carolyn S.P.

Published
2013
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