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132 results on '"Lozier J"'

5. Measurement of neutrino-induced neutral-current coherent π⁰ production in the NOvA near detector

Author

Acero, M. A., Adamson, P., Aliaga, L., Alion, T., Allakhverdian, V., Anfimov, N., Antoshkin, A., Arrieta-Diaz, E., Aurisano, A., Back, A., Backhouse, C., Baird, M., Balashov, N., Baldi, P., Bambah, B. A., Basher, S., Bays, K., Behera, B., Bending, S., Bernstein, R., Bhatnagar, V., Bhuyan, B., Bian, J., Blair, J., Booth, A. C., Bolshakova, A., Bour, P., Bromberg, C., Buchanan, N., Butkevich, A., Campbell, M., Carroll, T. J., Catano-Mur, E., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Colo, M., Corwin, L., Cremonesi, L., Cronin-Hennessy, D., Davies, G. S., Derwent, P. F., Ding, P., Djurcic, Z., Doyle, D., Dukes, E. C., Dung, P., Duyang, H., Edayath, S., Ehrlich, R., Feldman, G. J., Flanagan, W., Frank, M. J., Gallagher, H. R., Gandrajula, R., Gao, F., Germani, S., Giri, A., Gomes, R. A., Goodman, M. C., Grichine, V., Groh, M., Group, R., Guo, B., Habig, A., Hakl, F., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Himmel, A., Holin, A., Howard, B., Huang, J., Hylen, J., Jediny, F., Johnson, C., Judah, M., Kakorin, I., Kalra, D., Kaplan, D. M., Keloth, R., Klimov, O., Koerner, L. W., Kolupaeva, L., Kotelnikov, S., Kreymer, A., Kullenberg, Ch., Kumar, A., Kuruppu, C. D., Kus, V., Lackey, T., Lang, K., Lin, S., Lokajicek, M., Lozier, J., Luchuk, S., Maan, K., Magill, S., Mann, W. A., Marshak, M. L., Matveev, V., Méndez, D. P., Messier, M. D., Meyer, H., Miao, T., Miller, W. H., Mishra, S. R., Mislivec, A., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mulder, K., Mufson, S., Murphy, R., Musser, J., Naples, D., Nayak, N., Nelson, J. K., Nichol, R., Niner, E., Norman, A., Nosek, T., Oksuzian, Y., Olshevskiy, A., Olson, T., Paley, J., Patterson, R. B., Pawloski, G., Pershey, D., Petrova, O., Petti, R., Plunkett, R. K., Potukuchi, B., Principato, C., Psihas, F., Raj, V., Radovic, A., Rameika, R. A., Rebel, B., Rojas, P., Ryabov, V., Sachdev, K., Samoylov, O., Sanchez, M. C., Seong, I. S., Shanahan, P., Sheshukov, A., Singh, P., Singh, V., Smith, E., Smolik, J., Snopok, P., Solomey, N., Song, E., Sousa, A., Soustruznik, K., Strait, M., Suter, L., Talaga, R. L., Tas, P., Thayyullathil, R. B., Thomas, J., Tiras, E., Torbunov, D., Tripathi, J., Tsaris, A., Torun, Y., Urheim, J., Vahle, P., Vasel, J., Vinton, L., Vokac, P., Vrba, T., Wang, B., Warburton, T. K., Wetstein, M., While, M., Whittington, D., Wojcicki, S. G., Wolcott, J., Yadav, N., Yallappa Dombara, A., Yang, S., Yonehara, K., Yu, S., Zalesak, J., Zamorano, B., and Zwaska, R.

Subjects
Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment
Abstract

The cross section of neutrino-induced neutral-current coherent π⁰ production on a carbon-dominated target is measured in the NOvA near detector. This measurement uses a narrow-band neutrino beam with an average neutrino energy of 2.7 GeV, which is of interest to ongoing and future long-baseline neutrino oscillation experiments. The measured, flux-averaged cross section is σ = 13.8±0.9(stat)±2.3(syst)×10⁻⁴⁰ cm²/nucleus, consistent with model prediction. This result is the most precise measurement of neutral-current coherent π⁰ production in the few-GeV neutrino energy region.

Published
2020

12. New constraints on oscillation parameters from <math><msub><mi>ν</mi><mi>e</mi></msub></math> appearance and <math><msub><mi>ν</mi><mi>μ</mi></msub></math> disappearance in the NOvA experiment

Author

Acero, M. A., Adamson, P., Aliaga, L., Alion, T., Allakhverdian, V., Anfimov, N., Antoshkin, A., Arrieta-Diaz, E., Aurisano, A., Back, A., Backhouse, C., Baird, M., Balashov, N., Bambah, B. A., Bays, K., Behera, B., Bending, S., Bernstein, R., Bhatnagar, V., Bhuyan, B., Bian, J., Blackburn, T., Blair, J., Bolshakova, A., Bour, P., Bromberg, C., Brown, J., Buchanan, N., Butkevich, A., Bychkov, V., Campbell, M., Carroll, T. J., Catano-Mur, E., Cedeno, A., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Colo, M., Cooper, J., Corwin, L., Cremonesi, L., Cronin-Hennessy, D., Davies, G. S., Davies, J. P., De Rijck, S., Derwent, P. F., Dharmapalan, R., Ding, P., Djurcic, Z., Dukes, E. C., Dung, P., Duyang, H., Edayath, S., Ehrlich, R., Feldman, G. J., Frank, M. J., Gallagher, H. R., Gandrajula, R., Gao, F., Germani, S., Giri, A., Gomes, R. A., Goodman, M. C., Grichine, V., Groh, M., Group, R., Grover, D., Guo, B., Habig, A., Hakl, F., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Himmel, A., Holin, A., Howard, B., Huang, J., Hylen, J., Jediny, F., Judah, M., Kakorin, I., Kalra, D., Kaplan, D. M., Keloth, R., Klimov, O., Koerner, L. W., Kolupaeva, L., Kotelnikov, S., Kourbanis, I., Kreymer, A., Kulenberg, C., Kumar, A., Kuruppu, C., Kus, V., Lackey, T., Lang, K., Lin, S., Lokajicek, M., Lozier, J., Luchuk, S., Maan, K., Magill, S., Mann, W. A., Marshak, M. L., Matveev, V., Mendez, D. P., Messier, M. D., Meyer, H., Miao, T., Miller, W. H., Mishra, S. R., Mislivec, A., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mufson, S., Murphy, R., Musser, J., Naples, D., Nayak, N., Nelson, J. K., Nichol, R., Niner, E., Norman, A., Nosek, T., Oksuzian, Y., Olshevskiy, A., Olson, T., Paley, J., Patterson, R. B., Pawloski, G., Pershey, D., Petrova, O., Petti, R., Phan-Budd, S., Plunkett, R. K., Potukuchi, B., Principato, C., Psihas, F., Radovic, A., Rameika, R. A., Rebel, B., Rojas, P., Ryabov, V., Sachdev, K., Samoylov, O., Sanchez, M. C., Sepulveda-Quiroz, J., Shanahan, P., Sheshukov, A., Singh, P., Singh, V., Smith, E., Smolik, J., Snopok, P., Solomey, N., Song, E., Sousa, A., Soustruznik, K., Strait, M., Suter, L., Talaga, R. L., Tas, P., Thayyullathil, R. B., Thomas, J., Tiras, E., Tognini, S. C., Torbunov, D., Tripathi, J., Tsaris, A., Torun, Y., Urheim, J., Vahle, P., Vasel, J., Vinton, L., Vokac, P., Vold, A., Vrba, T., Wang, B., Warburton, T. K., Wetstein, M., Whittington, D., Wojcicki, S. G., Wolcott, J., Yang, S., Yu, S., Zalesak, J., Zamorano, B., and Zwaska, R.

Abstract

We present updated results from the NOvA experiment for νμ→νμ and νμ→νe oscillations from an exposure of 8.85×1020 protons on target, which represents an increase of 46% compared to our previous publication. The results utilize significant improvements in both the simulations and analysis of the data. A joint fit to the data for νμ disappearance and νe appearance gives the best-fit point as normal mass hierarchy, Δm322=2.44×10−3 eV2/c4, sin2θ23=0.56, and δCP=1.21π. The 68.3% confidence intervals in the normal mass hierarchy are Δm322∈[2.37,2.52]×10−3 eV2/c4, sin2θ23∈[0.43,0.51]∪[0.52,0.60], and δCP∈[0,0.12π]∪[0.91π,2π]. The inverted mass hierarchy is disfavored at the 95% confidence level for all choices of the other oscillation parameters.

Published
2018

13. New constraints on oscillation parameters from ν_e appearance and ν_μ disappearance in the NOvA experiment

Author

Acero, M. A., Bays, K., Lozier, J., Mualem, L., Patterson, R. B., and Pershey, D.

Abstract

We present updated results from the NOvA experiment for ν_μ → ν_μ and ν_μ → ν_e oscillations from an exposure of 8.85×10^(20) protons on target, which represents an increase of 46% compared to our previous publication. The results utilize significant improvements in both the simulations and analysis of the data. A joint fit to the data for ν_μ disappearance and ν_e appearance gives the best-fit point as normal mass hierarchy, Δm^2_(32) = 2.44×10^(-3) eV^2/c^4, sin^2 θ_(23) = 0.56, and δ_(CP) = 1.21π. The 68.3% confidence intervals in the normal mass hierarchy are Δm^2_(32) ∈ [2.37,2.52] × 10^(-3) eV^2/c^4, sin^2 θ_(23) ∈ [0.43,0.51] ∪ [0.52,0.60], and δ_(CP) ∈ [0,0.12π] ∪ [0.91π,2π]. The inverted mass hierarchy is disfavored at the 95% confidence level for all choices of the other oscillation parameters.

Published
2018

14. New constraints on oscillation parameters from $\nu_e$ appearance and $\nu_\mu$ disappearance in the NOvA experiment

Author

Acero, M. A., Adamson, P., Alion, L. Aliaga T., Allakhverdian, V., Antoshkin, N. Anfimov A., Arrieta-Diaz, E., Back, A. Aurisano A., Backhouse, C., Balashov, M. Baird N., Bambah, B. A., Behera, K. Bays B., Bending, S., Bhatnagar, R. Bernstein V., Bhuyan, B., Blackburn, J. Bian T., Blair, J., Bour, A. Bolshakova P., Bromberg, C., Buchanan, J. Brown N., Butkevich, A., Campbell, V. Bychkov M., Carroll, T. J., Cedeno, E. Catano-Mur A., Childress, S., Chowdhury, B. C. Choudhary B., Coan, T. E., Cooper, M. Colo J., Corwin, L., Cronin-Hennessy, L. Cremonesi D., Davies, G. S., De Rijck, J. P. Davies S., Derwent, P. F., Ding, R. Dharmapalan P., Djurcic, Z., Dung, E. C. Dukes P., Duyang, H., Ehrlich, S. Edayath R., Feldman, G. J., Gallagher, M. J. Frank H. R., Gandrajula, R., Germani, F. Gao S., Giri, A., Goodman, R. A. Gomes M. C., Grichine, V., Group, M. Groh R., Grover, D., Habig, B. Guo A., Hakl, F., Hatcher, J. Hartnell R., Hatzikoutelis, A., Himmel, K. Heller A., Holin, A., Huang, B. Howard J., Hylen, J., Judah, F. Jediny M., Kakorin, I., Kaplan, D. Kalra D. M., Keloth, R., Koerner, O. Klimov L. W., Kolupaeva, L., Kourbanis, S. Kotelnikov I., Kreymer, A., Kumar, Ch. Kulenberg A., Kuruppu, C., Lackey, V. Kus T., Lang, K., Lokajicek, S. Lin M., Lozier, J., Maan, S. Luchuk K., Magill, S., Marshak, W. A. Mann M. L., Matveev, V., Messier, D. P. Méndez M. D., Meyer, H., Miller, T. Miao W. H., Mishra, S. R., Mohanta, A. Mislivec R., Moren, A., Muether, L. Mualem M., Mufson, S., Musser, R. Murphy J., Naples, D., Nelson, N. Nayak J. K., Nichol, R., Norman, E. Niner A., Nosek, T., Olshevskiy, Y. Oksuzian A., Olson, T., Patterson, J. Paley R. B., Pawloski, G., Petrova, D. Pershey O., Petti, R., Plunkett, S. Phan-Budd R. K., Potukuchi, B., Psihas, C. Principato F., Radovic, A., Rebel, R. A. Rameika B., Rojas, P., Sachdev, V. Ryabov K., Samoylov, O., Sepulveda-Quiroz, M. C. Sanchez J., Shanahan, P., Singh, A. Sheshukov P., Singh, V., Smolik, E. Smith J., Snopok, P., Song, N. Solomey E., Sousa, A., Strait, K. Soustruznik M., Suter, L., Tas, R. L. Talaga P., Thayyullathil, R. B., Tiras, J. Thomas E., Tognini, S. C., Tripathi, D. Torbunov J., Tsaris, A., Urheim, Y. Torun J., Vahle, P., Vinton, J. Vasel L., Vokac, P., Vrba, A. Vold T., Wang, B., Wetstein, T. K. Warburton M., Whittington, D., Wolcott, S. G. Wojcicki J., Yang, S., Zalesak, S. Yu J., Zamorano, B., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

We present updated results from the NOvA experiment for $\nu_\mu\rightarrow\nu_\mu$ and $\nu_\mu\rightarrow\nu_e$ oscillations from an exposure of $8.85\times10^{20}$ protons on target, which represents an increase of 46% compared to our previous publication. The results utilize significant improvements in both the simulations and analysis of the data. A joint fit to the data for $\nu_\mu$ disappearance and $\nu_e$ appearance gives the best fit point as normal mass hierarchy, $\Delta m^2_{32} = 2.44\times 10^{-3}{{\rm eV}^2}/c^4$, $\sin^2\theta_{23} = 0.56$, and $\delta_{CP} = 1.21\pi$. The 68.3% confidence intervals in the normal mass hierarchy are $\Delta m^2_{32} \in [2.37,2.52]\times 10^{-3}{{\rm eV}^2}/c^4$, $\sin^2\theta_{23} \in [0.43,0.51] \cup [0.52,0.60]$, and $\delta_{CP} \in [0,0.12\pi] \cup [0.91\pi,2\pi]$. The inverted mass hierarchy is disfavored at the 95% confidence level for all choices of the other oscillation parameters.

Published
2018

15. Constraints on Oscillation Parameters from ν_e Appearance and ν_μ Disappearance in NOvA

Author

Adamson, P., Backhouse, C., Bays, K., Lozier, J., Mualem, L., Patterson, R. B., and Pershey, D.

Abstract

Results are reported from an improved measurement of ν_μ→ν_e transitions by the NOvA experiment. Using an exposure equivalent to 6.05×10^(20) protons on target, 33 ν_e candidates are observed with a background of 8.2±0.8 (syst.). Combined with the latest NOvA ν_μ disappearance data and external constraints from reactor experiments on sin^2 2θ_(13), the hypothesis of inverted mass hierarchy with θ_(23) in the lower octant is disfavored at greater than 93% C.L. for all values of δ_(CP).

Published
2017

16. Measurement of the Neutrino Mixing Angle θ_(23) in NOvA

Author

Adamson, P., Backhouse, C., Bays, K., Lozier, J., Mualem, L., Patterson, R. B., and Pershey, D.

Abstract

This Letter reports new results on muon neutrino disappearance from NOvA, using a 14 kton detector equivalent exposure of 6.05×10^(20) protons on target from the NuMI beam at the Fermi National Accelerator Laboratory. The measurement probes the muon-tau symmetry hypothesis that requires maximal θ_(23) mixing (θ_(23)=π/4). Assuming the normal mass hierarchy, we find Δm^2_(32)=(2.67±0.11)×10^(−3) eV^2 and sin^2 θ_(23) at the two statistically degenerate values 0.404^(+0.030)_(−0.022) and 0.624^(+0.022)_(−0.030), both at the 68% confidence level. Our data disfavor the maximal mixing scenario with 2.6σ significance.

Published
2017

17. Constraints on Oscillation Parameters from $\nu_e$ Appearance and $\nu_\mu$ Disappearance in NOvA

Author

The NOvA Collaboration, Adamson, P., Aliaga, L., Ambrose, D., Anfimov, N., Antoshkin, A., Arrieta-Diaz, E., Augsten, K., Aurisano, A., Backhouse, C., Baird, M., Bambah, B. A., Bays, K., Behera, B., Bending, S., Bernstein, R., Bhatnagar, V., Bhuyan, B., Bian, J., Blackburn, T., Bolshakova, A., Bromberg, C., Brown, J., Brunetti, G., Buchanan, N., Butkevich, A., Bychkov, V., Campbell, M., Catano-Mur, E., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Coelho, J. A. B., Colo, M., Cooper, J., Corwin, L., Cremonesi, L., Cronin-Hennessy, D., Davies, G. S., Davies, J. P., Derwent, P. F., Dharmapalan, R., Ding, P., Djurcic, Z., Dukes, E. C., Duyang, H., Edayath, S., Ehrlich, R., Feldman, G. J., Frank, M. J., Gabrielyan, M., Gallagher, H. R., Germani, S., Ghosh, T., Giri, A., Gomes, R. A., Goodman, M. C., Grichine, V., Group, R., Grover, D., Guo, B., Habig, A., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Himmel, A., Holin, A., Hylen, J., Jediny, F., Judah, M., Kafka, G. K., Kalra, D., Kasahara, S. M. S., Kasetti, S., Keloth, R., Kolupaeva, L., Kotelnikov, S., Kourbanis, I., Kreymer, A., Kumar, A., Kurbanov, S., Lang, K., Lee, W. M., Lin, S., Liu, J., Lokajicek, M., Lozier, J., Luchuk, S., Maan, K., Magill, S., Mann, W. A., Marshak, M. L., Matera, K., Matveev, V., Méndez, D. P., Messier, M. D., Meyer, H., Miao, T., Miller, W. H., Mishra, S. R., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mufson, S., Murphy, R., Musser, J., Nelson, J. K., Nichol, R., Niner, E., Norman, A., Nosek, T., Oksuzian, Y., Olshevskiy, A., Olson, T., Paley, J., Pandey, P., Patterson, R. B., Pawloski, G., Pershey, D., Petrova, O., Petti, R., Phan-Budd, S., Plunkett, R. K., Poling, R., Potukuchi, B., Principato, C., Psihas, F., Radovic, A., Rameika, R. A., Rebel, B., Reed, B., Rocco, D., Rojas, P., Ryabov, V., Sachdev, K., Sail, P., Samoylov, O., Sanchez, M. C., Schroeter, R., Sepulveda-Quiroz, J., Shanahan, P., Sheshukov, A., Singh, J., Singh, P., Singh, V., Smolik, J., Solomey, N., Song, E., Sousa, A., Soustruznik, K., Strait, M., Suter, L., Talaga, R. L., Tamsett, M. C., Tas, P., Thayyullathil, R. B., Thomas, J., Tian, X., Tognini, S. C., Tripathi, J., Tsaris, A., Urheim, J., Vahle, P., Vasel, J., Vinton, L., Vold, A., Vrba, T., Wang, B., Wetstein, M., Whittington, D., Wojcicki, S. G., Wolcott, J., Yadav, N., Yang, S., Zalesak, J., Zamorano, B., and Zwaska, R.

Subjects
Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, High Energy Physics::Experiment, High Energy Physics - Experiment
Abstract

Results are reported from an improved measurement of $\nu_\mu \rightarrow \nu_e$ transitions by the NOvA experiment. Using an exposure equivalent to $6.05\times10^{20}$ protons-on-target 33 $\nu_e$ candidates were observed with a background of $8.2\pm0.8$ (syst.). Combined with the latest NOvA $\nu_\mu$ disappearance data and external constraints from reactor experiments on $\sin^22\theta_{13}$, the hypothesis of inverted mass hierarchy with $\theta_{23}$ in the lower octant is disfavored at greater than $93\%$ C.L. for all values of $\delta_{CP}$., Comment: 6 pages, 4 figures

Published
2017

19. First measurement of muon-neutrino disappearance in NOvA

Author

Adamson, P. Ader, C. Andrews, M. Anfimov, N. Anghel, I. and Arms, K. Arrieta-Diaz, E. Aurisano, A. Ayres, D. S. and Backhouse, C. Baird, M. Bambah, B. A. Bays, K. and Bernstein, R. Betancourt, M. Bhatnagar, V. Bhuyan, B. and Bian, J. Biery, K. Blackburn, T. Bocean, V. Bogert, D. and Bolshakova, A. Bowden, M. Bower, C. Broemmelsiek, D. and Bromberg, C. Brunetti, G. Bu, X. Butkevich, A. Capista, D. Catano-Mur, E. Chase, T. R. Childress, S. Choudhary, B. C. Chowdhury, B. Coan, T. E. Coelho, J. A. B. Colo, M. Cooper, J. Corwin, L. Cronin-Hennessy, D. Cunningham, A. Davies, G. S. Davies, J. P. Del Tutto, M. Derwent, P. F. Deepthi, K. N. Demuth, D. Desai, S. Deuerling, G. and Devan, A. Dey, J. Dharmapalan, R. Ding, P. Dixon, S. and Djurcic, Z. Dukes, E. C. Duyang, H. Ehrlich, R. Feldman, G. J. Felt, N. Fenyves, E. J. Flumerfelt, E. Foulkes, S. and Frank, M. J. Freeman, W. Gabrielyan, M. Gallagher, H. R. and Gebhard, M. Ghosh, T. Gilbert, W. Giri, A. and Goadhouse, S. Gomes, R. A. Goodenough, L. Goodman, M. C. and Grichine, V. Grossman, N. Group, R. Grudzinski, J. and Guarino, V. Guo, B. Habig, A. Handler, T. Hartnell, J. and Hatcher, R. Hatzikoutelis, A. Heller, K. Howcroft, C. and Huang, J. Huang, X. Hylen, J. Ishitsuka, M. Jediny, F. Jensen, C. Jensen, D. Johnson, C. Jostlein, H. and Kafka, G. K. Kamyshkov, Y. Kasahara, S. M. S. Kasetti, S. and Kephart, K. Koizumi, G. Kotelnikov, S. Kourbanis, I. and Krahn, Z. Kravtsov, V. Kreymer, A. Kulenberg, Ch. Kumar, A. Kutnink, T. Kwarciancy, R. Kwong, J. Lang, K. and Lee, A. Lee, W. M. Lee, K. Lein, S. Liu, J. and Lokajicek, M. Lozier, J. Lu, Q. Lucas, P. Luchuk, S. and Lukens, P. Lukhanin, G. Magill, S. Maan, K. Mann, W. A. and Marshak, M. L. Martens, M. Martincik, J. Mason, P. and Matera, K. Mathis, M. Matveev, V. Mayer, N. McCluskey, E. Mehdiyev, R. Merritt, H. Messier, M. D. Meyer, H. and Miao, T. Michael, D. Mikheyev, S. P. Miller, W. H. and Mishra, S. R. Mohanta, R. Moren, A. Mualem, L. Muether, M. Mufson, S. Musser, J. Newman, H. B. Nelson, J. K. and Niner, E. Norman, A. Nowak, J. Oksuzian, Y. Olshevskiy, A. Oliver, J. Olson, T. Paley, J. Pandey, P. Para, A. Patterson, R. B. Pawloski, G. Pearson, N. Perevalov, D. Pershey, D. Peterson, E. Petti, R. Phan-Budd, S. and Piccoli, L. Pla-Dalmau, A. Plunkett, R. K. Poling, R. and Potukuchi, B. Psihas, F. Pushka, D. Qiu, X. Raddatz, N. and Radovic, A. Rameika, R. A. Ray, R. Rebel, B. and Rechenmacher, R. Reed, B. Reilly, R. Rocco, D. Rodkin, D. Ruddick, K. Rusack, R. Ryabov, V. Sachdev, K. and Sahijpal, S. Sahoo, H. Samoylov, O. Sanchez, M. C. and Saoulidou, N. Schlabach, P. Schneps, J. Schroeter, R. and Sepulveda-Quiroz, J. Shanahan, P. Sherwood, B. Sheshukov, A. and Singh, J. Singh, V. Smith, A. Smith, D. Smolik, J. and Solomey, N. Sotnikov, A. Sousa, A. Soustruznik, K. and Stenkin, Y. Strait, M. Suter, L. Talaga, R. L. Tamsett, M. C. Tariq, S. Tas, P. Tesarek, R. J. Thayyullathil, R. B. Thomsen, K. Tian, X. Tognini, S. C. Toner, R. and Trevor, J. Tzanakos, G. Urheim, J. Vahle, P. Valerio, L. and Vinton, L. Vrba, T. Waldron, A. V. Wang, B. Wang, Z. and Weber, A. Wehmann, A. Whittington, D. Wilcer, N. and Wildberger, R. Wildman, D. Williams, K. Wojcicki, S. G. and Wood, K. Xiao, M. Xin, T. Yadav, N. Yang, S. and Zadorozhnyy, S. Zalesak, J. Zamorano, B. Zhao, A. and Zirnstein, J. Zwaska, R. NOvA Collaboration

Abstract

This paper reports the first measurement using the NOvA detectors of nu(mu) disappearance in a nu(mu) beam. The analysis uses a 14 kton-equivalent exposure of 2.74 x 10(20) protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure Delta m(32)(2) = (2.52(-0.18)(+0.20)) x 10(-3) eV(2) and sin(2) theta(23) in the range 0.38-0.65, both at the 68% confidence level, with two statistically degenerate best-fit points at sin(2) theta(23) = 0.43 and 0.60. Results for the inverted mass hierarchy are also presented.

Published
2016

20. First Measurement of Electron Neutrino Appearance in NOvA

Author

Adamson, P. Ader, C. Andrews, M. Anfimov, N. Anghel, I. and Arms, K. Arrieta-Diaz, E. Aurisano, A. Ayres, D. S. and Backhouse, C. Baird, M. Bambah, B. A. Bays, K. and Bernstein, R. Betancourt, M. Bhatnagar, V. Bhuyan, B. and Bian, J. Biery, K. Blackburn, T. Bocean, V. Bogert, D. and Bolshakova, A. Bowden, M. Bower, C. Broemmelsiek, D. and Bromberg, C. Brunetti, G. Bu, X. Butkevich, A. Capista, D. Catano-Mur, E. Chase, T. R. Childress, S. Choudhary, B. C. Chowdhury, B. Coan, T. E. Coelho, J. A. B. Colo, M. Cooper, J. Corwin, L. Cronin-Hennessy, D. Cunningham, A. Davies, G. S. Davies, J. P. Del Tutto, M. Derwent, P. F. Deepthi, K. N. Demuth, D. Desai, S. Deuerling, G. and Devan, A. Dey, J. Dharmapalan, R. Ding, P. Dixon, S. and Djurcic, Z. Dukes, E. C. Duyang, H. Ehrlich, R. Feldman, G. J. Felt, N. Fenyves, E. J. Flumerfelt, E. Foulkes, S. and Frank, M. J. Freeman, W. Gabrielyan, M. Gallagher, H. R. and Gebhard, M. Ghosh, T. Gilbert, W. Giri, A. and Goadhouse, S. Gomes, R. A. Goodenough, L. Goodman, M. C. and Grichine, V. Grossman, N. Group, R. Grudzinski, J. and Guarino, V. Guo, B. Habig, A. Handler, T. Hartnell, J. and Hatcher, R. Hatzikoutelis, A. Heller, K. Howcroft, C. and Huang, J. Huang, X. Hylen, J. Ishitsuka, M. Jediny, F. Jensen, C. Jensen, D. Johnson, C. Jostlein, H. and Kafka, G. K. Kamyshkov, Y. Kasahara, S. M. S. Kasetti, S. and Kephart, K. Koizumi, G. Kotelnikov, S. Kourbanis, I. and Krahn, Z. Kravtsov, V. Kreymer, A. Kulenberg, Ch. Kumar, A. Kutnink, T. Kwarciancy, R. Kwong, J. Lang, K. and Lee, A. Lee, W. M. Lee, K. Lein, S. Liu, J. and Lokajicek, M. Lozier, J. Lu, Q. Lucas, P. Luchuk, S. and Lukens, P. Lukhanin, G. Magill, S. Maan, K. Mann, W. A. and Marshak, M. L. Martens, M. Martincik, J. Mason, P. and Matera, K. Mathis, M. Matveev, V. Mayer, N. McCluskey, E. Mehdiyev, R. Merritt, H. Messier, M. D. Meyer, H. and Miao, T. Michael, D. Mikheyev, S. P. Miller, W. H. and Mishra, S. R. Mohanta, R. Moren, A. Mualem, L. Muether, M. Mufson, S. Musser, J. Newman, H. B. Nelson, J. K. and Niner, E. Norman, A. Nowak, J. Oksuzian, Y. Olshevskiy, A. Oliver, J. Olson, T. Paley, J. Pandey, P. Para, A. Patterson, R. B. Pawloski, G. Pearson, N. Perevalov, D. Pershey, D. Peterson, E. Petti, R. Phan-Budd, S. and Piccoli, L. Pla-Dalmau, A. Plunkett, R. K. Poling, R. and Potukuchi, B. Psihas, F. Pushka, D. Qiu, X. Raddatz, N. and Radovic, A. Rameika, R. A. Ray, R. Rebel, B. and Rechenmacher, R. Reed, B. Reilly, R. Rocco, D. Rodkin, D. Ruddick, K. Rusack, R. Ryabov, V. Sachdev, K. and Sahijpal, S. Sahoo, H. Samoylov, O. Sanchez, M. C. and Saoulidou, N. Schlabach, P. Schneps, J. Schroeter, R. and Sepulveda-Quiroz, J. Shanahan, P. Sherwood, B. Sheshukov, A. and Singh, J. Singh, V. Smith, A. Smith, D. Smolik, J. and Solomey, N. Sotnikov, A. Sousa, A. Soustruznik, K. and Stenkin, Y. Strait, M. Suter, L. Talaga, R. L. Tamsett, M. C. Tariq, S. Tas, P. Tesarek, R. J. Thayyullathil, R. B. Thomsen, K. Tian, X. Tognini, S. C. Toner, R. and Trevor, J. Tzanakos, G. Urheim, J. Vahle, P. Valerio, L. and Vinton, L. Vrba, T. Waldron, A. V. Wang, B. Wang, Z. and Weber, A. Wehmann, A. Whittington, D. Wilcer, N. and Wildberger, R. Wildman, D. Williams, K. Wojcicki, S. G. and Wood, K. Xiao, M. Xin, T. Yadav, N. Yang, S. and Zadorozhnyy, S. Zalesak, J. Zamorano, B. Zhao, A. and Zirnstein, J. Zwaska, R.

Abstract

We report results from the first search for nu(mu) -> nu(e) transitions by the NOvA experiment. In an exposure equivalent to 2.74 x 10(20) protons on target in the upgraded NuMI beam at Fermilab, we observe 6 events in the Far Detector, compared to a background expectation of 0.99 +/- 0.11 (syst) events based on the Near Detector measurement. A secondary analysis observes 11 events with a background of 1.07 +/- 0.14 (syst). The 3.3 sigma excess of events observed in the primary analysis disfavors 0.1 pi < delta(CP) < 0.5 pi in the inverted mass hierarchy at the 90% C.L.

Published
2016

21. Fundamental Physics at the Intensity Frontier

Author

Hewett, J.L., Weerts, H., Brock, R., Butler, J.N., Casey, B.C.K., Collar, J., de Gouvea, A., Essig, R., Grossman, Y., Haxton, W., Jaros, J.A., Jung, C.K., Lu, Z.T., Pitts, K., Ligeti, Z., Patterson, J.R., Ramsey-Musolf, M., Ritchie, J.L., Roodman, A., Scholberg, K., Wagner, C.E.M., Zeller, G.P., Aefsky, S., Afanasev, A., Agashe, K., Albright, C., Alonso, J., Ankenbrandt, C., Aoki, M., Arguelles, C.A., Arkani-Hamed, N., Armendariz, J.R., Armendariz-Picon, C., Arrieta Diaz, E., Asaadi, J., Asner, D.M., Babu, K.S., Bailey, K., Baker, O., Balantekin, B., Baller, B., Bass, M., Batell, B., Beacham, J., Behr, J., Berger, N., Bergevin, M., Berman, E., Bernstein, R., Bevan, A.J., Bishai, M., Blanke, M., Blessing, S., Blondel, A., Blum, T., Bock, G., Bodek, A., Bonvicini, G., Bossi, F., Boyce, J., Breedon, R., Breidenbach, M., Brice, S.J., Briere, R.A., Brodsky, S., Bromberg, C., Bross, A., Browder, T.E., Bryman, D.A., Buckley, M., Burnstein, R., Caden, E., Campana, P., Carlini, R., Carosi, G., Castromonte, C., Cenci, R., Chakaberia, I., Chen, Mu-Chun, Cheng, C.H., Choudhary, B., Christ, N.H., Christensen, E., Christy, M.E., Chupp, T.E., Church, E., Cline, D.B., Coan, T.E., Coloma, P., Comfort, J., Coney, L., Cooper, J., Cooper, R.J., Cowan, R., Cowen, D.F., Cronin-Hennessy, D., Datta, A., Davies, G.S., Demarteau, M., DeMille, D.P., Denig, A., Dermisek, R., Deshpande, A., Dewey, M.S., Dharmapalan, R., Dhooghe, J., Dietrich, M.R., Diwan, M., Djurcic, Z., Dobbs, S., Duraisamy, M., Dutta, Bhaskar, Duyang, H., Dwyer, D.A., Eads, M., Echenard, B., Elliott, S.R., Escobar, C., Fajans, J., Farooq, S., Faroughy, C., Fast, J.E., Feinberg, B., Felde, J., Feldman, G., Fierlinger, P., Fileviez Perez, P., Filippone, B., Fisher, P., Fleming, B.T., Flood, K.T., Forty, R., Frank, M.J., Freyberger, A., Friedland, A., Gandhi, R., Ganezer, K.S., Garcia, A., Garcia, F.G., Gardner, S., Garrison, L., Gasparian, A., Geer, S., Gehman, V.M., Gershon, T., Gilchriese, M., Ginsberg, C., Gogoladze, I., Gonderinger, M., Goodman, M., Gould, H., Graham, M., Graham, P.W., Gran, R., Grange, J., Gratta, G., Green, J.P., Greenlee, H., Group, R.C., Guardincerri, E., Gudkov, V., Guenette, R., Haas, A., Hahn, A., Han, T., Handler, T., Hardy, J.C., Harnik, R., Harris, D.A., Harris, F.A., Harris, P.G., Hartnett, J., He, B., Heckel, B.R., Heeger, K.M., Henderson, S., Hertzog, D., Hill, R., Hinds, E.A., Hitlin, D.G., Holt, R.J., Holtkamp, N., Horton-Smith, G., Huber, P., Huelsnitz, W., Imber, J., Irastorza, I., Jaeckel, J., Jaegle, I., James, C., Jawahery, A., Jensen, D., Jessop, C.P., Jones, B., Jostlein, H., Junk, T., Kagan, A.L., Kalita, M., Kamyshkov, Y., Kaplan, D.M., Karagiorgi, G., Karle, A., Katori, T., Kayser, B., Kephart, R., Kettell, S., Kim, Y.K., Kirby, M., Kirch, K., Klein, J., Kneller, J., Kobach, A., Kohl, M., Kopp, J., Kordosky, M., Korsch, W., Kourbanis, I., Krisch, A.D., Krizan, P., Kronfeld, A.S., Kulkarni, S., Kumar, K.S., Kuno, Y., Kutter, T., Lachenmaier, T., Lamm, M., Lancaster, J., Lancaster, M., Lane, C., Lang, K., Langacker, P., Lazarevic, S., Le, T., Lee, K., Lesko, K.T., Li, Y., Lindgren, M., Lindner, A., Link, J., Lissauer, D., Littenberg, L.S., Littlejohn, B., Liu, C.Y., Loinaz, W., Lorenzon, W., Louis, W.C., Lozier, J., Ludovici, L., Lueking, L., Lunardini, C., MacFarlane, D.B., Machado, P.A.N., Mackenzie, P.B., Maloney, J., Marciano, W.J., Marsh, W., Marshak, M., Martin, J.W., Mauger, C., McFarland, K.S., McGrew, C., McLaughlin, G., McKeen, D., McKeown, R., Meadows, B.T., Mehdiyev, R., Melconian, D., Merkel, H., Messier, M., Miller, J.P., Mills, G., Minamisono, U.K., Mishra, S.R., Mocioiu, I., Sher, S.Moed, Mohapatra, R.N., Monreal, B., Moore, C.D., Morfin, J.G., Mousseau, J., Moustakas, L.A., Mueller, G., Mueller, P., Muether, M., Mumm, H.P., Munger, C., Murayama, H., Nath, P., Naviliat-Cuncin, O., Nelson, J.K., Neuffer, D., Nico, J.S., Norman, A., Nygren, D., Obayashi, Y., O'Connor, T.P., Okada, Y., Olsen, J., Orozco, L., Orrell, J.L., Osta, J., Pahlka, B., Paley, J., Papadimitriou, V., Papucci, M., Parke, S., Parker, R.H., Parsa, Z., Partyka, K., Patch, A., Pati, J.C., Patterson, R.B., Pavlovic, Z., Paz, Gil, Perdue, G.N., Perevalov, D., Perez, G., Petti, R., Pettus, W., Piepke, A., Pivovaroff, M., Plunkett, R., Polly, C.C., Pospelov, M., Povey, R., Prakesh, A., Purohit, M.V., Raby, S., Raaf, J.L., Rajendran, R., Rajendran, S., Rameika, G., Ramsey, R., Rashed, A., Ratcliff, B.N., Rebel, B., Redondo, J., Reimer, P., Reitzner, D., Ringer, F., Ringwald, A., Riordan, S., Roberts, B.L., Roberts, D.A., Robertson, R., Robicheaux, F., Rominsky, M., Roser, R., Rosner, J.L., Rott, C., Rubin, P., Saito, N., Sanchez, M., Sarkar, S., Schellman, H., Schmidt, B., Schmitt, M., Schmitz, D.W., Schneps, J., Schopper, A., Schuster, P., Schwartz, A.J., Schwarz, M., Seeman, J., Semertzidis, Y.K., Seth, K.K., Shafi, Q., Shanahan, P., Sharma, R., Sharpe, S.R., Shiozawa, M., Shiltsev, V., Sigurdson, K., Sikivie, P., Singh, J., Sivers, D., Skwarnicki, T., Smith, N., Sobczyk, J., Sobel, H., Soderberg, M., Song, Y.H., Soni, A., Souder, P., Sousa, A., Spitz, J., Stancari, M., Stavenga, G.C., Steffen, J.H., Stepanyan, S., Stoeckinger, D., Stone, S., Strait, J., Strassler, M., Sulai, I.A., Sundrum, R., Svoboda, R., Szczerbinska, B., Szelc, A., Takeuchi, T., Tanedo, P., Taneja, S., Tang, J., Tanner, D.B., Tayloe, R., Taylor, I., Thomas, J., Thorn, C., Tian, X., Tice, B.G., Tobar, M., Tolich, N., Toro, N., Towner, I.S., Tsai, Y., Tschirhart, R., Tunnell, C.D., Tzanov, M., Upadhye, A., Urheim, J., Vahsen, S., Vainshtein, A., Valencia, E., Van de Water, R.G., Van de Water, R.S., Velasco, M., Vogel, J., Vogel, P., Vogelsang, W., Wah, Y.W., Walker, D., Weiner, N., Weltman, A., Wendell, R., Wester, W., Wetstein, M., White, C., Whitehead, L., Whitmore, J., Widmann, E., Wiedemann, G., Wilkerson, J., Wilkinson, G., Wilson, P., Wilson, R.J., Winter, W., Wise, M.B., Wodin, J., Wojcicki, S., Wojtsekhowski, B., Wongjirad, T., Worcester, E., Wurtele, J., Xin, T., Xu, J., Yamanaka, T., Yamazaki, Y., Yavin, I., Yeck, J., Yeh, M., Yokoyama, M., Yoo, J., Young, A., Zimmerman, E., Zioutas, K., Zisman, M., Zupan, J., and Zwaska, R.

Subjects
Nuclear Theory, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment, Particle Physics - Experiment
Abstract

The Proceedings of the 2011 workshop on Fundamental Physics at the Intensity Frontier. Science opportunities at the intensity frontier are identified and described in the areas of heavy quarks, charged leptons, neutrinos, proton decay, new light weakly-coupled particles, and nucleons, nuclei, and atoms. The Proceedings of the 2011 workshop on Fundamental Physics at the Intensity Frontier. Science opportunities at the intensity frontier are identified and described in the areas of heavy quarks, charged leptons, neutrinos, proton decay, new light weakly-coupled particles, and nucleons, nuclei, and atoms.

Published
2012

22. Interventional Closure of a Patent Ductus Arteriosus Using an Amplatz Canine Duct Occluder in an Alpaca Cria.

Author

Chapel, E.C., Lozier, J., Lakritz, J., and Schober, K.E.

Subjects
*ALPACA, *PATENT ductus arteriosus, *HEART murmurs, *VENTRICULAR septal defects, *SURGICAL anastomosis, *VETERINARY echocardiography, *DISEASES, *THERAPEUTICS
Abstract

A 6-month old female alpaca cria presented to The Ohio State University for evaluation of a cardiac murmur. Echocardiography revealed a left-to-right shunting patent ductus arteriosus, a restrictive left-to-right shunting perimembranous ventricular septal defect, and secondary moderate left atrial and ventricular dilation. Aortic root angiography demonstrated a type IIA patent ductus arteriosus (PDA). Interventional closure of the PDA was successfully performed, without complication, using an Amplatz canine duct occluder. This case report describes the materials and methods used for interventional closure of a PDA in an alpaca cria. [ABSTRACT FROM AUTHOR]

Published
2017
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23. The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion

Author

Read, M., Pak, E., Morgan, R. A., Dutra, A., Zheng, Z., Zhou, N., Nichols, T. C., Lozier, J. N., and Bellinger, D. A.

Subjects
hemic and lymphatic diseases
Abstract

In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. {"type":"entrez-nucleotide","attrs":{"text":"AF361485","term_id":"13991701","term_text":"AF361485"}}AF361485) follows exons 1–22 in the factor VIII transcript in place of exons 23–26. The canine hemophilia 8 locus (ch8) sequence was found in a 140-kb normal dog genomic DNA bacterial artificial chromosome (BAC) clone that was completely outside the factor VIII gene, but not in BAC clones containing the factor VIII gene. The BAC clone that contained ch8 also contained a homologue of F8A (factor 8 associated) sequence, which participates in a common inversion that causes severe hemophilia A in humans. Fluorescence in situ hybridization analysis indicated that exons 1–26 normally proceed sequentially from telomere to centromere at Xq28, and ch8 is telomeric to the factor VIII gene. The appearance of an “upstream” genomic sequence element (ch8) at the end of the aberrant factor VIII transcript suggested that an inversion of genomic DNA replaced factor VIII exons 22–26 with ch8. The F8A sequence appeared also in overlapping normal BAC clones containing factor VIII sequence. We hypothesized that homologous recombination between copies of canine F8A inside and outside the factor VIII gene had occurred, as in human hemophilia A. High-resolution fluorescent in situ hybridization on hemophilia A dog DNA revealed a pattern consistent with this inversion mechanism. We also identified a HindIII restriction fragment length polymorphism of F8A fragments that distinguished hemophilia A, carrier, and normal dogs' DNA. The Chapel Hill hemophilia A dog colony therefore replicates the factor VIII gene inversion commonly seen in humans with severe hemophilia A.

Published
2002
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25. Revisiting comparisons of genetic diversity in stable and declining species: assessing genome-wide polymorphism in North American bumble bees using RAD sequencing.

Author

Lozier, J. D.

Subjects
*BUMBLEBEES, *SPECIES, *INSECT genetics, *GENETIC polymorphisms, *NUCLEOTIDE sequence, *MICROSATELLITE repeats
Abstract

Genetic variation is of key importance for a species' evolutionary potential, and its estimation is a major component of conservation studies. New DNA sequencing technologies have enabled the analysis of large portions of the genome in nonmodel species, promising highly accurate estimates of such population genetic parameters. Restriction site-associated DNA sequencing ( RADseq) is used to analyse thousands of variants in the bumble bee species Bombus impatiens, which is common, and Bombus pensylvanicus, which is in decline. Previous microsatellite-based analyses have shown that gene diversity is lower in the declining B. pensylvanicus than in B. impatiens. RADseq nucleotide diversities appear much more similar in the two species. Both species exhibit allele frequencies consistent with historical population expansions. Differences in diversity observed at microsatellites thus do not appear to have arisen from long-term differences in population size and are either recent in origin or may result from mutational processes. Additional research is needed to explain these discrepancies and to investigate the best ways to integrate next-generation sequencing data and more traditional molecular markers in studies of genetic diversity. [ABSTRACT FROM AUTHOR]

Published
2014
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26. First measurement of muon-neutrino disappearance in NOvA

Author

Adamson, P., Ader, C., Andrews, M., Anfimov, N., Anghel, I., Arms, K., Arrieta-Diaz, E., Aurisano, A., Ayres, D. S., Backhouse, C., Baird, M., Bambah, B. A., Bays, K., Bernstein, R., Betancourt, M., Bhatnagar, V., Bhuyan, B., Bian, J., Biery, K., Blackburn, T., Bocean, V., Bogert, D., Bolshakova, A., Bowden, M., Bower, C., Broemmelsiek, D., Bromberg, C., Brunetti, G., Bu, X., Butkevich, A., Capista, D., Catano-Mur, E., Chase, T. R., Childress, S., Choudhary, B. C., Chowdhury, B., Coan, T. E., Coelho, J. A. B., Colo, M., Cooper, J., Corwin, L., Cronin-Hennessy, D., Cunningham, A., Davies, G. S., Davies, J. P., Del Tutto, M., Derwent, P. F., Deepthi, K. N., Demuth, D., Desai, S., Deuerling, G., Devan, A., Dey, J., Dharmapalan, R., Ding, P., Dixon, S., Djurcic, Z., Dukes, E. C., Duyang, H., Ehrlich, R., Feldman, Gary J., Felt, Nathan Forrest, Fenyves, E. J., Flumerfelt, E., Foulkes, S., Frank, M. J., Freeman, W., Gabrielyan, M., Gallagher, H. R., Gebhard, M., Ghosh, T., Gilbert, W., Giri, A., Goadhouse, S., Gomes, R. A., Goodenough, L., Goodman, M. C., Grichine, V., Grossman, N., Group, R., Grudzinski, J., Guarino, V., Guo, B., Habig, A., Handler, T., Hartnell, J., Hatcher, R., Hatzikoutelis, A., Heller, K., Howcroft, C., Huang, J., Huang, X., Hylen, J., Ishitsuka, M., Jediny, F., Jensen, C., Jensen, D., Johnson, C., Jostlein, H., Kafka, Gareth Kristopher, Kamyshkov, Y., Kasahara, S. M. S., Kasetti, S., Kephart, K., Koizumi, G., Kotelnikov, S., Kourbanis, I., Krahn, Z., Kravtsov, V., Kreymer, A., Kulenberg, Ch., Kumar, A., Kutnink, T., Kwarciancy, R., Kwong, J., Lang, K., Lee, A., Lee, W. M., Lee, K., Lein, S., Liu, J., Lokajicek, M., Lozier, J., Lu, Q., Lucas, P., Luchuk, S., Lukens, P., Lukhanin, G., Magill, S., Maan, K., Mann, W. A., Marshak, M. L., Martens, M., Martincik, J., Mason, P., Matera, K., Mathis, M., Matveev, V., Mayer, N., McCluskey, E., Mehdiyev, R., Merritt, H., Messier, M. D., Meyer, H., Miao, T., Michael, D., Mikheyev, S. P., Miller, W. H., Mishra, S. R., Mohanta, R., Moren, A., Mualem, L., Muether, M., Mufson, S., Musser, J., Newman, H. B., Nelson, J. K., Niner, E., Norman, A., Nowak, J., Oksuzian, Y., Olshevskiy, A., Oliver, John N., Olson, T., Paley, J., Pandey, P., Para, A., Patterson, R. B., Pawloski, G., Pearson, N., Perevalov, D., Pershey, D., Peterson, E., Petti, R., Phan-Budd, S., Piccoli, L., Pla-Dalmau, A., Plunkett, R. K., Poling, R., Potukuchi, B., Psihas, F., Pushka, D., Qiu, X., Raddatz, N., Radovic, A., Rameika, R. A., Ray, R., Rebel, B., Rechenmacher, R., Reed, B., Reilly, R., Rocco, D., Rodkin, D., Ruddick, K., Rusack, R., Ryabov, V., Sachdev, K., Sahijpal, S., Sahoo, H., Samoylov, O., Sanchez, M. C., Saoulidou, N., Schlabach, P., Schneps, J., Schroeter, Raphael, Sepulveda-Quiroz, J., Shanahan, P., Sherwood, B., Sheshukov, A., Singh, J., Singh, V., Smith, A., Smith, D., Smolik, J., Solomey, N., Sotnikov, A., Sousa, A., Soustruznik, K., Stenkin, Y., Strait, M., Suter, L., Talaga, R. L., Tamsett, M. C., Tariq, S., Tas, P., Tesarek, R. J., Thayyullathil, R. B., Thomsen, K., Tian, X., Tognini, S. C., Toner, Ruth, Trevor, J., Tzanakos, G., Urheim, J., Vahle, P., Valerio, L., Vinton, L., Vrba, T., Waldron, A. V., Wang, B., Wang, Z., Weber, A., Wehmann, A., Whittington, D., Wilcer, N., Wildberger, R., Wildman, D., Williams, K., Wojcicki, S. G., Wood, K., Xiao, M., Xin, T., Yadav, N., Yang, S., Zadorozhnyy, S., Zalesak, J., Zamorano, B., Zhao, A., Zirnstein, J., and Zwaska, R.

Abstract

This paper reports the first measurement using the NOvA detectors of νμ disappearance in a νμ beam. The analysis uses a 14 kton-equivalent exposure of 2.74×1020 protons-on-target from the Fermilab NuMI beam. Assuming the normal neutrino mass hierarchy, we measure Δm232=(2.52+0.20−0.18)×10−3 eV2 and sin2θ23 in the range 0.38–0.65, both at the 68% confidence level, with two statistically degenerate best-fit points at sin2θ23=0.43 and 0.60. Results for the inverted mass hierarchy are also presented., Physics

Published
2016
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27. Speech-based cursor control using grids: modelling performance and comparisons with other solutions.

Author

Dai, L, Goldman, R, Sears, A, and Lozier, J

Subjects
SPEECH perception, INFORMATION technology, COMPUTER science, COMPUTER systems, ELECTRONICS
Abstract

Speech recognition can be a powerful tool for use in human?–?computer interaction, especially in situations where the user's hands are unavailable or otherwise engaged. Researchers have confirmed that existing mechanisms for speech-based cursor control are both slow and error prone. To address this, we evaluated two variations of a novel grid-based cursor controlled via speech recognition. One provides users with nine cursors that can be used to specify the desired location while the second, more traditional solution, provides a single cursor. Our results confirmed a speed/accuracy trade-off with a nine-cursor variant allowing for faster task completion times while the one-cursor version resulted in reduced error rates. Our solutions eliminated the effect of distance, and dramatically reduced the importance of target size as compared to previous speech-based cursor control mechanisms. The results are explored through a predictive model and comparisons with results from earlier studies. [ABSTRACT FROM AUTHOR]

Published
2005
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28. Two approaches to indirect potable reuse using membrane technology.

Author

Lozier, J.

Subjects
*MEMBRANE filtration in water purification, *FILTERS & filtration, *REVERSE osmosis, *MEMBRANE reactors
Abstract

Reports on a pilot study conducted at McAllen, Texas, to evaluate two microfiltration technologies for treating secondary effluent from a wastewater treatment plant. Comparison of the ability Memcor and ZeeWeed to pretreat secondary effluent; Subsequent processing by reverse osmosis; Ability of the ZenoGem membrane bioreactor process to directly treat screened, de-gritted wastewater.

Published
2000
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30. Enhancing boron rejection in seawater reverse osmosis facilities.

Author

Huehmer, R. P., Wang, F., Lozier, J., and Henthorne, L.

Subjects
REVERSE osmosis, BORON, SEAWATER, OSMOSIS, BORIC acid, HEALTH
Abstract

Linked to potential health problems and toxicity to crops, boron is present in seawater at concentrations of ranging from 4 to 7 mg/L, and not readily removed by reverse osmosis technology. Commercially available seawater reverse osmosis (SWRO) membranes possess a wide range of rejection characteristics for boron in seawater under ambient temperature and pH, ranging from approximately 50% for low-energy membranes to greater than 90% for the newest high rejection membranes. This level of rejection is typically insufficient to reduce boron concentrations in natural seawater to less than recommended levels. Current World Health Organization (WHO) drinking water concentrations for boron are limited to 0.5-mg/L. Two techniques utilized to mitigate boron concentrations are (1) increasing the dissociation of boric acid by increasing pH prior to SWRO; and, (2) utilizing a second pass reverse osmosis system, potentially coupled with pH adjustment. Utilizing these techniques, the authors tested commercially available SWRO membranes from three different manufacturers utilizing feed water alkalization, coupled with a second pass system. Utilizing feed water alkalization alone, the authors found that all three SWRO membranes were able to produce permeate complying with WHO regulations. Using second pass RO, a boron concentration of less than 0.5 mg/L was achieved for feed pH greater than 6, and less than 0.1-mg/L for pH of 10. [ABSTRACT FROM AUTHOR]

Published
2008
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32. Di- and trinucleotide repeat microsatellites for the parasitoid wasp, Aphidius transcaspicus.

Author

Lozier, J. D., Mills, N. J., and Roderick, G. K.

Subjects
*PARASITOIDS, *APHIDIUS, *PHYSIOLOGICAL control systems, *HYALOPTERUS, *MICROSATELLITE repeats
Abstract

The Mediterranean parasitoid Aphidius transcaspicus is currently under investigation as a potential biological control agent for the mealy plum aphid, Hyalopterus pruni, in California. To better understand the biology of this parasitoid, including the potential existence of distinct strains or geographic races, we have developed a set of nine di- and trinucleotide repeat microsatellite markers. These markers were examined for variability in individuals from throughout the geographic distribution of A. transcaspicus, and we found between three and 19 alleles per locus. These are the first loci developed for A. transcaspicus and they will be of value in studying the population structure of this potential biocontrol agent and for future diagnostics. [ABSTRACT FROM AUTHOR]

Published
2006
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33. Di- and tri-nucleotide repeat microsatellites for the mealy plum aphid, Hyalopterus pruni.

Author

Lozier, J. D., Mills, N. J., Palsbøll, P. J., and Roderick, G. K.

Subjects
*APHIDS, *BIOLOGICAL pest control, *HYALOPTERUS, *MEALY plum aphid, *MICROSATELLITE repeats
Abstract

Hyalopterus pruni is an invasive aphid pest in California. To study the population biology of this pest both in California and its native Mediterranean region, we have developed 11 di- and tri-nucleotide repeat microsatellite markers. Each locus amplified in individuals representing the full range of geographical regions and host plants where Hyalopterus is found. Polymorphism was high, ranging from six to 22 alleles per locus in the individuals screened. These loci represent the first microsatellites developed for Hyalopterus and they should be of great value in studying the invasion biology and population structure of this insect pest. [ABSTRACT FROM AUTHOR]

Published
2005
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37. Removing seasonal affects from pasture plate meter calibrations.

Author

Rayburn, E. B., Shockey, W. L., Smith, B. D., Seymore, D. A., and Lozier, J. D.

Subjects
ROTATIONAL grazing, PASTURES, TREATMENT effectiveness, WHITE clover, GRASSLAND soils, CALIBRATION, REGRESSION analysis, SOIL testing
Abstract

This study was conducted to develop a calibration for paddock mean falling plate meter height (PH), herbage density (HD) and herbage mass (HM) in rotationally stocked pastures under different fertility treatments and to determine if there was a seasonal or treatment effect on the calibration. Accurate, rapid measurement of HM is needed in pasture research and for on-farm pasture budgeting. Four rotationally stocked pastures were sampled for PH using a standardized falling plate meter. Pastures were predominantly orchardgrass, bluegrass, and white clover. Fertility treatments were poultry litter at 4,480 kg/ha/year, poultry litter at 8,960 kg/ha/year, lime and phosphorous as needed based on soil test, and lime only as needed based on soil test. Pastures were walked on established transects and 15 paired PH and HM samples were taken at random and clipped to ground level. For each data pair, HD was calculated by dividing HM by PH. Paddock means for PH, HD and HM were calculated for each paddock and sampling date. Paddocks were sampled just before grazing over a 3 year period as follows (month/number of sampling periods): May/16, June/8, July/5, August/7, September/4, October/11, and November/8. Regressions of paddock mean HD and paddock mean HM as functions of PH were calculated using all paddock sampling dates and fertility treatments. The plate meter calibration regression for HD based on PH was: HD = 264 - 6.6 PH; R2 = 0.29; SDreg = 42. Regression coefficients were significant (P<0.001). Estimating mean pasture HM as the product of PH times HD resulted in a second order function without an intercept and was: HM = 264 PH - 6.6 PH2. Compared to the clipped HM measured this model had an R2 = 0.93; SDreg = 687. Analysis of variance of regression residuals found no significant effect of season or treatment on the accuracy of HD and HM estimates. This method provides one calibration that applies across seasons and fertility treatment for pastures of similar botanical composition and under the same defoliation management. [ABSTRACT FROM AUTHOR]

Published
2006

43. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography.

Author

Park, J. W., Piknova, B., Nghiem, K., Lozier, J. N., and Schechter, A. N.

Subjects
*BLOOD coagulation factors, *PHYSIOLOGICAL effects of nitrites, *THROMBELASTOGRAPHY, *ERYTHROCYTES, *BIOMARKERS, *HEMOSTATICS, *BLOOD platelets
Abstract

Nitric oxide (NO) can be generated by two-step reduction pathway in which nitrate is converted first into nitrite and then into NO via several mechanisms, as well as from arginine by endogenous nitric oxide synthase (NOS). We have recently shown that nitrite ions in the presence of erythrocytes inhibit platelet aggregation and activation, as measured by aggregometry and flow cytometric analysis of P-selectin, through its reduction to NO under partially deoxygenated conditions. In the current study, we investigated how nitrite may affect overall clotting processes via modulating platelet function using thrombelastography (TEG). We measured three major TEG parameters, reaction time (R, time to initial fibrin formation), α angle (velocity of clot growth) and maximum amplitude (MA, maximum clot strength) using blood from healthy volunteers. An NO donor (DEANONOate) showed inhibitory effects on all TEG parameters in platelet rich plasma (PRP) and whole blood, resulting in delayed R, decreased angle, and reduced MA in a dose dependent manner. Nitrite ions also exhibited inhibitory effects in whole blood at 20% hematocrit, and this was greatly enhanced under hypoxic conditions, being demonstrable at 0.1µM concentration. Neither compound changed any TEG parameters in plasma. Our results suggest that nitrite affects overall blood clotting and that TEG may be used to follow this process. Further the physiological effects of factors which determine NO bioavailability, such as endogenous levels of blood and tissue nitrite, may be useful as biomarkers for predicting hemostatic potential. [ABSTRACT FROM AUTHOR]

Published
2014
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44. Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

Author

D. J. Ambrose, N. Yadav, A. Holin, S. K. Kotelnikov, Borun D. Chowdhury, M. Colo, T. Ghosh, M. Y. Gabrielyan, R. B. Patterson, Anjan K. Giri, B. Reed, J. Tripathi, L. Aliaga, P. F. Derwent, K. Bays, W. M. Lee, Gavin Davies, X. Tian, R. J. Nichol, G. K. Kafka, Simon J. Bending, D. Grover, Alec Habig, T. Blackburn, J. M. Paley, Ajay Kumar, T. Nosek, B. Bhuyan, A. Antoshkin, H. R. Gallagher, T. E. Coan, Rukmani Mohanta, Andrew Norman, L. Mualem, D. Rocco, J. Zalesak, V. Bychkov, E. Song, S. Magill, O. Petrova, D. Pershey, F. Jediny, Z. Djurcic, Kamil Augsten, R.A. Rameika, H. Duyang, A. Vold, M. Campbell, Stanley G. Wojcicki, B. Rebel, R. Hatcher, D. P. Méndez, A. Himmel, J. Lozier, R. Murphy, C. Principato, S. Childress, T. Miao, A. Moren, J. Hylen, R. H. Bernstein, S. Kurbanov, B. Zamorano, D. Whittington, S. C. Tognini, Biswaranjan Behera, P. Vahle, K. Sachdev, Ranjan Dharmapalan, J. Smolik, Siqi Yang, P. Shanahan, J. Brown, I. Kourbanis, N. Solomey, R. Ehrlich, E. Catano-Mur, C. Bromberg, C. Backhouse, W. A. Mann, L. Vinton, B. Howard, A. Radovic, J. Hartnell, K. Maan, S. Edayath, Bo Wang, J. K. Nelson, Alexander Olshevskiy, G. Brunetti, M. J. Frank, V. Singh, R. K. Plunkett, L. Corwin, A. Tsaris, S. L. Mufson, Vladimir Grichine, B. V. K. S. Potukuchi, Anatoly Butkevich, M. Muether, Subhasmita Mishra, R. Keloth, Stanislav Luchuk, Karol Lang, A. Bolshakova, Yuri Oksuzian, E. C. Dukes, J. Urheim, G. J. Feldman, M. D. Messier, D. Kalra, K. Matera, Juergen Thomas, D. Cronin-Hennessy, P. Sail, K. Soustruznik, Milos Lokajicek, A. Hatzikoutelis, N. J. Buchanan, Petr Tas, J. Davies, Simon Lin, P. Ding, S. Germani, Jeremy Wolcott, E. Arrieta-Diaz, J. B. Singh, A. Sheshukov, P. Singh, E. Niner, O. Samoylov, H. Meyer, A. Aurisano, Warner A. Miller, J. A. Musser, L. Suter, Bindu A. Bambah, Matthew L Strait, Vipin Bhatnagar, L. Cremonesi, Joao A B Coelho, R. L. Talaga, A. E. Kreymer, Marvin L Marshak, M. Judah, B. Guo, Ken Heller, T. Olson, V. Matveev, S. Phan-Budd, A. Sousa, Jian-Guo Bian, F. Psihas, P. Adamson, Nikolay Anfimov, S. M. S. Kasahara, R. B. Thayyullathil, T. Vrba, J. Cooper, R. Zwaska, T. Lackey, Mcd Sanchez, S. P. Kasetti, R. Schroeter, J. Vasel, L. Kolupaeva, R. A. Gomes, M. Groh, Maury Goodman, P. Rojas, Brajesh C Choudhary, V. A. Ryabov, Matthew Wetstein, Gregory J Pawloski, R. Poling, M. Baird, J.A. Sepulveda-Quiroz, R. Petti, Adamson, P, Aliaga, L, Ambrose, D, Anfimov, N, Antoshkin, A, Arrieta-Diaz, E, Augsten, K, Aurisano, A, Backhouse, C, Baird, M, Bambah, B, Bays, K, Behera, B, Bending, S, Bernstein, R, Bhatnagar, V, Bhuyan, B, Bian, J, Blackburn, T, Bolshakova, A, Bromberg, C, Brown, J, Brunetti, G, Buchanan, N, Butkevich, A, Bychkov, V, Campbell, M, Catano-Mur, E, Childress, S, Choudhary, B, Chowdhury, B, Coan, T, Coelho, J, Colo, M, Cooper, J, Corwin, L, Cremonesi, L, Cronin-Hennessy, D, Davies, G, Davies, J, Derwent, P, Dharmapalan, R, Ding, P, Djurcic, Z, Dukes, E, Duyang, H, Edayath, S, Ehrlich, R, Feldman, G, Frank, M, Gabrielyan, M, Gallagher, H, Germani, S, Ghosh, T, Giri, A, Gomes, R, Goodman, M, Grichine, V, Groh, M, Group, R, Grover, D, Guo, B, Habig, A, Hartnell, J, Hatcher, R, Hatzikoutelis, A, Heller, K, Himmel, A, Holin, A, Howard, B, Hylen, J, Jediny, F, Judah, M, Kafka, G, Kalra, D, Kasahara, S, Kasetti, S, Keloth, R, Kolupaeva, L, Kotelnikov, S, Kourbanis, I, Kreymer, A, Kumar, A, Kurbanov, S, Lackey, T, Lang, K, Lee, W, Lin, S, Lokajicek, M, Lozier, J, Luchuk, S, Maan, K, Magill, S, Mann, W, Marshak, M, Matera, K, Matveev, V, Mendez, D, Messier, M, Meyer, H, Miao, T, Miller, W, Mishra, S, Mohanta, R, Moren, A, Mualem, L, Muether, M, Mufson, S, Murphy, R, Musser, J, Nelson, J, Nichol, R, Niner, E, Norman, A, Nosek, T, Oksuzian, Y, Olshevskiy, A, Olson, T, Paley, J, Patterson, R, Pawloski, G, Pershey, D, Petrova, O, Petti, R, Phan-Budd, S, Plunkett, R, Poling, R, Potukuchi, B, Principato, C, Psihas, F, Radovic, A, Rameika, R, Rebel, B, Reed, B, Rocco, D, Rojas, P, Ryabov, V, Sachdev, K, Sail, P, Samoylov, O, Sanchez, M, Schroeter, R, Sepulveda-Quiroz, J, Shanahan, P, Sheshukov, A, Singh, J, Singh, P, Singh, V, Smolik, J, Solomey, N, Song, E, Sousa, A, Soustruznik, K, Strait, M, Suter, L, Talaga, R, Tas, P, Thayyullathil, R, Thomas, J, Tian, X, Tognini, S, Tripathi, J, Tsaris, A, Urheim, J, Vahle, P, Vasel, J, Vinton, L, Vold, A, Vrba, T, Wang, B, Wetstein, M, Whittington, D, Wojcicki, S, Wolcott, J, Yadav, N, Yang, S, Zalesak, J, Zamorano, B, and Zwaska, R

Subjects
Physics, Sterile neutrino, Particle physics, 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, High Energy Physics::Phenomenology, FOS: Physical sciences, 01 natural sciences, NuMI, High Energy Physics - Experiment, Nuclear physics, Massless particle, High Energy Physics - Experiment (hep-ex), Neutrino detector, 0103 physical sciences, NOvA, sterile neutrino, neutrino mixing, neutral current, neutrino oscillation, High Energy Physics::Experiment, Fermilab, Neutrino, 010306 general physics, Neutrino oscillation, QC, Lepton
Abstract

We report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810\,km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05$\times$10$^{20}$ protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with $83.5 \pm 9.7 \mbox{(stat.)} \pm 9.4 \mbox{(syst.)}$ events predicted assuming mixing only occurs between active neutrino species. No evidence for $\nu_{\mu} \rightarrow \nu_{s}$ transitions is found. Interpreting these results within a 3+1 model, we place constraints on the mixing angles $\theta_{24}, Comment: 8 pages, 4 figures

Published
2017

45. Evaluation of stiffness-matched, 3D-printed, NiTi mandibular graft fixation in an ovine model.

Author

Khattab NR, Olivas-Alanis LH, Chmielewska-Wysocka A, Emam H, Brune R, Jahadakbar A, Khambhampati S, Lozier J, Safaei K, Skoracki R, Elahinia M, and Dean D

Subjects
Animals, Sheep, Alloys chemistry, Mechanical Phenomena, Nickel chemistry, Bone Transplantation, Materials Testing, Biomechanical Phenomena, Titanium chemistry, Mandible surgery, Printing, Three-Dimensional
Abstract

Background: Manually bent, standard-of-care, Ti-6Al-4V, mandibular graft fixation devices are associated with a significant post-operative failure rate. These failures require the patient to endure stressful and expensive re-operation. The approach recommended in this report demonstrates the optimization of graft fixation device mechanical properties via "stiffness-matching" by varying the fixation device's location, shape, and material composition through simulation of the device's post-operative performance. This provides information during pre-operative planning that may avoid future device failure. Optimized performance may combine translation of all loading into compression of the bone graft with the adjacent bone segments and elimination or minimization of post-healing interruption of normal stress-strain (loading) trajectories., Results: This study reports a sheep mandibular graft model where four animals received virtually optimized, experimental nickel-titanium (NiTi) fixation plates fabricated using laser beam powder bed fusion (LPBF) additive manufacturing (AM). The last animal, our control, received a standard-of-care, manually bent, Ti-6Al-4V (aka Ti64) fixation plate. A 17.5-mm mandibular graft healed completely in all four animals receiving the experimental device. Experimental NiTi-implanted sheep experienced mandibular bone healing and restoration. The Ti64 plate, in the control animal, fractured and dislocated shortly after being implanted., Conclusion: The use of stiffness-matched implants, by means of plate material (NiTi) and geometry (porosity) enhanced bone healing and promoted better load transfer to the healed bone when compared to the bulk Ti64 found in the fixation plate that the Control animal received. The design technique and screw orientation and depth planning improved throughout the study leading to more rapid healing. The large animal model reported here provides data useful for a follow-on clinical trial., (© 2024. The Author(s).)

Published
2024
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46. Catheterization for Congenital Heart Disease Adjustment for Risk Method II.

Author

Quinn BP, Gunnelson LC, Kotin SG, Gauvreau K, Yeh MJ, Hasan B, Lozier J, Barry OM, Shahanavaz S, Batlivala SP, Salavitabar A, Foerster S, Goldstein B, Divekar A, Holzer R, Nicholson GT, O'Byrne ML, Whiteside W, and Bergersen L

Subjects
Child, Humans, Infant, Risk Factors, Treatment Outcome, Hemodynamics, Risk Adjustment methods, Cardiac Catheterization adverse effects, Cardiac Catheterization methods, Heart Defects, Congenital diagnosis, Heart Defects, Congenital therapy
Abstract

Background: Current metrics used to adjust for case mix complexity in congenital cardiac catheterization are becoming outdated due to the introduction of novel procedures, innovative technologies, and expanding patient subgroups. This study aims to develop a risk adjustment methodology introducing a novel, clinically meaningful adverse event outcome and incorporating a modern understanding of risk., Methods: Data from diagnostic only and interventional cases with defined case types were collected for patients ≤18 years of age and ≥2.5 kg at all Congenital Cardiac Catheterization Project on Outcomes participating centers. The derivation data set consisted of cases performed from 2014 to 2017, and the validation data set consisted of cases performed from 2019 to 2020. Severity level 3 adverse events were stratified into 3 tiers by clinical impact (3a/b/c); the study outcome was clinically meaningful adverse events, severity level ≥3b (3bc/4/5)., Results: The derivation data set contained 15 224 cases, and the validation data set included 9462 cases. Clinically meaningful adverse event rates were 4.5% and 4.2% in the derivation and validation cohorts, respectively. The final risk adjustment model included age <30 days, Procedural Risk in Congenital Cardiac Catheterization risk category, and hemodynamic vulnerability score (C statistic, 0.70; Hosmer-Lemeshow P value, 0.83; Brier score, 0.042)., Conclusions: CHARM II (Congenital Heart Disease Adjustment for Risk Method II) risk adjustment methodology allows for equitable comparison of clinically meaningful adverse events among institutions and operators with varying patient populations and case mix complexity performing pediatric cardiac catheterization., Competing Interests: None.

Published
2024
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47. CD22 CAR T-cell associated hematologic toxicities, endothelial activation and relationship to neurotoxicity.

Author

Jess J, Yates B, Dulau-Florea A, Parker K, Inglefield J, Lichtenstein D, Schischlik F, Ongkeko M, Wang Y, Shahani S, Cullinane A, Smith H, Kane E, Little L, Chen D, Fry TJ, Shalabi H, Wang HW, Satpathy A, Lozier J, and Shah NN

Subjects
Humans, T-Lymphocytes, Retrospective Studies, Neoplasm Recurrence, Local etiology, Immunotherapy, Adoptive adverse effects, Cytokine Release Syndrome etiology, Hematologic Neoplasms therapy, Thrombocytopenia
Abstract

Background: Hematologic toxicities, including coagulopathy, endothelial activation, and cytopenias, with CD19-targeted chimeric antigen receptor (CAR) T-cell therapies correlate with cytokine release syndrome (CRS) and neurotoxicity severity, but little is known about the extended toxicity profiles of CAR T-cells targeting alternative antigens. This report characterizes hematologic toxicities seen following CD22 CAR T-cells and their relationship to CRS and neurotoxicity., Methods: We retrospectively characterized hematologic toxicities associated with CRS seen on a phase 1 study of anti-CD22 CAR T-cells for children and young adults with relapsed/refractory CD22+ hematologic malignancies. Additional analyses included correlation of hematologic toxicities with neurotoxicity and exploring effects of hemophagocytic lymphohistiocytosis-like toxicities (HLH) on bone marrow recovery and cytopenias. Coagulopathy was defined as evidence of bleeding or abnormal coagulation parameters. Hematologic toxicities were graded by Common Terminology Criteria for Adverse Events V.4.0., Results: Across 53 patients receiving CD22 CAR T-cells who experienced CRS, 43 (81.1%) patients achieved complete remission. Eighteen (34.0%) patients experienced coagulopathy, of whom 16 had clinical manifestations of mild bleeding (typically mucosal bleeding) which generally subsided following CRS resolution. Three had manifestations of thrombotic microangiopathy. Patients with coagulopathy had higher peak ferritin, D-dimer, prothrombin time, international normalized ratio (INR), lactate dehydrogenase (LDH), tissue factor, prothrombin fragment F1+2 and soluble vascular cell adhesion molecule-1 (s-VCAM-1). Despite a relatively higher incidence of HLH-like toxicities and endothelial activation, overall neurotoxicity was generally less severe than reported with CD19 CAR T-cells, prompting additional analysis to explore CD22 expression in the central nervous system (CNS). Single-cell analysis revealed that in contrast to CD19 expression, CD22 is not on oligodendrocyte precursor cells or on neurovascular cells but is seen on mature oligodendrocytes. Lastly, among those attaining CR, grade 3-4 neutropenia and thrombocytopenia were seen in 65% of patients at D28., Conclusion: With rising incidence of CD19 negative relapse, CD22 CAR T-cells are increasingly important for the treatment of B-cell malignancies. In characterizing hematologic toxicities on CD22 CAR T-cells, we demonstrate that despite endothelial activation, coagulopathy, and cytopenias, neurotoxicity was relatively mild and that CD22 and CD19 expression in the CNS differed, providing one potential hypothesis for divergent neurotoxicity profiles. Systematic characterization of on-target off-tumor toxicities of novel CAR T-cell constructs will be vital as new antigens are targeted., Trial Registration Number: NCT02315612., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2023
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48. Guided Bronchoscopy for the Evaluation of Pulmonary Lesions: An Updated Meta-analysis.

Author

Nadig TR, Thomas N, Nietert PJ, Lozier J, Tanner NT, Wang Memoli JS, Pastis NJ, and Silvestri GA

Subjects
Humans, Bronchoscopy methods, Lung diagnostic imaging, Bronchi diagnostic imaging, Endosonography methods, Lung Diseases diagnosis, Lung Neoplasms diagnosis, Lung Neoplasms pathology
Abstract

Background: Guided bronchoscopy is increasingly used to diagnose peripheral pulmonary lesions (PPLs). A meta-analysis published in 2012 demonstrated a pooled diagnostic yield of 70%; however, recent publications have documented yields as low as 40% and as high as 90%., Research Question: Has the diagnostic yield of guided bronchoscopy in patients with PPLs improved over the past decade?, Study Design and Methods: A comprehensive search was performed of studies evaluating the diagnostic yield of differing bronchoscopic technologies used to reach PPLs. Study quality was assessed using the Quality assessment of diagnostic accuracy of studies (QUADAS-2) assessment tool. Number of lesions, type of technology used, overall diagnostic yield, and yield by size were extracted. Adverse events were recorded. Meta-analytic techniques were used to summarize findings across all studies., Results: A total of 16,389 lesions from 126 studies were included. There was no significant difference in diagnostic yield prior to 2012 (39 studies; 3,052 lesions; yield 70.5%) vs after 2012 (87 studies; 13,535 lesions; yield 69.2%) (P > .05). Additionally, there was no significant difference in yield when comparing different technologies. Studies with low risk of overall bias had a lower diagnostic yield than those with high risk of bias (66% vs 71%, respectively; P = .018). Lesion size > 2 cm, presence of bronchus sign, and reports with a high prevalence of malignancy in the study population were associated with significantly higher diagnostic yield. Significant (P < .0001) between-study heterogeneity was also noted., Interpretation: Despite the reported advances in bronchoscopic technology to diagnose PPLs, the diagnostic yield of guided bronchoscopy has not improved., (Copyright © 2023 American College of Chest Physicians. All rights reserved.)

Published
2023
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49. Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas.

Author

Coyne GO, Kummar S, Meehan RS, Do K, Collins JM, Anderson L, Ishii K, Takebe N, Zlott J, Juwara L, Piekarz R, Streicher H, Sharon E, Rubinstein L, Voth AR, Lozier J, Dull AB, Wilsker D, Hinoue T, Laird PW, Ferry-Galow KV, Kinders RJ, Parchment RE, Doroshow JH, and Chen AP

Abstract

Background: TRC102 inhibits base excision repair by binding abasic sites and preventing AP endonuclease processing; it potentiates the activity of alkylating agents, including temozolomide, in murine models. In published xenograft studies, TRC102 enhanced the antitumor effect of temozolomide regardless of cell line genetic characteristics, e.g., O6-methylguanine DNA methyltransferase (MGMT), mismatch repair (MMR), or p53 status., Materials and Methods: We conducted a phase 1 trial of TRC102 with temozolomide given orally on days 1-5 of 28-day cycles in adult patients with refractory solid tumors that had progressed on standard therapy. Tumor induction of nuclear biomarkers of DNA damage response (DDR) γH2AX, pNBs1, and Rad51 was assessed in the context of MGMT and MMR protein expression for expansion cohort patients., Results: Fifty-two patients were enrolled (37 escalation, 15 expansion) with 51 evaluable for response. The recommended phase 2 dose was 125 mg TRC102, 150 mg/m 2 temozolomide QDx5. Common adverse events (grade 3/4) included anemia (19%), lymphopenia (12%), and neutropenia (10%). Four patients achieved partial responses (1 non-small cell lung cancer, 2 granulosa cell ovarian cancer, and 1 colon cancer) and 13 patients had a best response of stable disease. Retrospective analysis of 15 expansion cohort patients did not demonstrate a correlation between low tumor MGMT expression and patient response, but treatment induced nuclear Rad51 responses in 6 of 12 patients., Conclusions: The combination of TRC 102 with temozolomide is active, with 4 of 51 patients experiencing a partial response and 13 of 51 experiencing stable disease, and the side effect profile is manageable., Competing Interests: CONFLICTS OF INTEREST Authors have no conflicts of interest to declare., (Copyright: © 2020 Coyne et al.)

Published
2020
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50. Thrombosis risk factors in PIK3CA-related overgrowth spectrum and Proteus syndrome.

Author

Keppler-Noreuil KM, Lozier J, Oden N, Taneja A, Burton-Akright J, Sapp JC, and Biesecker LG

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Pilot Projects, Prospective Studies, Young Adult, Class I Phosphatidylinositol 3-Kinases genetics, Genetic Predisposition to Disease, Growth Disorders genetics, Proteus Syndrome genetics, Thrombosis genetics
Abstract

Increased risk of thromboembolism has been recognized in individuals with mosaic overgrowth disorders, Proteus syndrome (PS) and PIK3CA-related overgrowth spectrum (PROS), including Klippel-Trenaunay syndrome and CLOVES syndrome. PS and PROS have distinct, yet overlapping clinical findings and are caused by somatic pathogenic variants in the PI3K/AKT gene signaling pathway. PS is caused by a single somatic activating AKT1 c.49G > A p.E17K variant while PROS can be caused one of multiple variants in PIK3CA. The role of prothrombotic factors, endothelial cell adhesion molecules, and vascular malformations in both PS and PROS have not been previously investigated. A pilot study of prospective clinical and laboratory evaluations with the purposes of identifying potential risk factors for thrombosis was conducted. Doppler ultrasounds and magnetic resonance angiogram/ venography (MRA/MRV) scans identified vascular malformations in PS and PROS that were not appreciated on physical examination. Abnormal D-dimers (0.60-2.0 mcg/ml) occurred in half of individuals, many having vascular malformations, but no thromboses. Soluble vascular endothelial markers, including thrombomodulin, soluble vascular adhesion molecule (sVCAM), soluble intercellular adhesion molecule (sICAM), E-selectin, and P-selectin were significantly higher in PS and PROS compared to controls. However, no single attribute was identified that explained the risk of thrombosis. Predisposition to thrombosis is likely multifactorial with risk factors including chronic stasis within vascular malformations, stasis from impaired mobility (e.g., following surgery), decreased anticoagulant proteins, and effects of AKT1 and PIK3CA variants on vascular endothelium. Based on our findings, we propose clinical recommendations for surveillance of thrombosis in PS and PROS., (Published 2019. This article is a U.S. Government work and is in the public domain in the USA.)

Published
2019
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