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1. Post-transplant cyclophosphamide, calcineurin inhibitor, and mycophenolate mofetil compared to anti-thymocyte globulin, calcineurin inhibitor, and methotrexate combinations as graft-versus-host disease prophylaxis post allogeneic stem cell transplantation from sibling and unrelated donors in patients with acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Swoboda, Ryszard, Schroeder, Thomas, Hamladji, Rose-Marie, Griskevicius, Laimonas, Salmenniemi, Urpu, Rambaldi, Alessandro, Mielke, Stephan, Kulagin, Alexander, Passweg, Jakob, Luft, Thomas, Gedde-Dahl, Tobias, Forcade, Edouard, Helbig, Grzegorz, Stelljes, Matthias, Castilla-Llorente, Cristina, Spyridonidis, Alexandros, Brissot, Eolia, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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6. Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation (a national multicenter study)

Author

Jost, Edgar, Schmid, Christoph, Baurmann, Herrad, Blau, Igor, Holderried, Tobias, Hertenstein, Bernd, Hänel, Mathias, Bornhäuser, Martin, Neidlinger, Helga, Kobbe, Guido, Winkler, Julia, Schroeder, Thomas, Bug, Gesine, Hopfer, Olaf, Finke, Jürgen, Hasenkamp, Justin, Krüger, William, Müller, Lutz, Kröger, Nikolaus, Eder, Matthias, Luft, Thomas, Hilgendorf, Inken, Ringhoffer, Mark, Stölzel, Friedrich, Scheid, Christoph, Platzbecker, Uwe, Wortmann, Friederike, Heinicke, Thomas, Wagner, Eva, Klein, Stefan, Burchert, Andreas, Tischer, Johanna, Stelljes, Matthias, Schäfer-Eckart, Kerstin, Wolff, Daniel, Junghanss, Christian, Ritter, Markus, Kaufmann, Martin, Bethge, Wolfgang, Mytilineos, Joannis, Einsel, Hermann, Sockel, Katja, Neu, Annika, Goeckenjan, Maren, Ditschkowski, Markus, Kröger, Nicolaus, Ayuk, Francis A., Stoelzel, Friedrich, Middeke, Jan Moritz, Bertz, Hartmut, Beverungen, David, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Fraccaroli, Alessia, Fante, Matthias, Scheid, Christof, Holtick, Udo, Blau, Igor Wolfgang, Wulf, Gerald, Schwerdtfeger, Rainer, Kaun, Stephan, Winter, Susann, Theuser, Catrin, Beyersmann, Jan, Bornhaeuser, Martin, Schmeller, Sandra, and Schetelig, Johannes

Published
2024
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11. Comparison of outcomes for HLA-matched sibling and haplo-identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT

Author

Raj, Kavita, Eikema, Dirk-Jan, Sheth, Vipul, Koster, Linda, de Wreede, Liesbeth C., Blaise, Didier, Di Grazia, Carmela, Koc, Yener, Potter, Victoria, Chevallier, Patrice, Lopez- Corral, Lucia, Wu, Depei, Mielke, Stephan, Maertens, Johan, Meijer, Ellen, Huynh, Anne, Passweg, Jakob, Luft, Thomas, Pérez-Simón, Jose Antonio, Ciceri, Fabio, Piekarska, Agnieszka, Hayri Ozsan, G., Kröger, Nicolaus, Robin, Marie, and Yakoub-Agha, Ibrahim

Published
2022
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12. Computing solution spaces for gear box design.

Author

Ziegler, Klara, Demir, Kutay, Luft, Thomas, Mucks, Thomas, Fürst, Marius, Otto, Michael, Stahl, Karsten, Vogel-Heuser, Birgit, and Zimmermann, Markus

Subjects
DESIGN education, NEW product development, ENGINEERING design, GEARING machinery, MATHEMATICAL optimization
Abstract

The design of gear boxes is a complex challenge characterized by conflicting requirements and seemingly circular dependencies. Existing tools support engineers but focus on a single predefined design, often leading to costly iterative processes and non-optimal solutions. Solution Space Engineering (SSE) alleviates this by generating multiple designs represented by solution spaces. For this, a particular model structure is needed, and thus restructuring existing models, e.g., from industry standards. The application of solution spaces to a two-stage gear box is presented. [ABSTRACT FROM AUTHOR]

Published
2024
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16. A prognostic score including mutation profile and clinical features for patients with CMML undergoing stem cell transplantation

Author

Gagelmann, Nico, Badbaran, Anita, Beelen, Dietrich W., Salit, Rachel B., Stölzel, Friedrich, Rautenberg, Christina, Becker, Heiko, Radujkovic, Aleksandar, Panagiota, Victoria, Bogdanov, Rashit, Christopeit, Maximilian, Park, Yong, Nibourel, Olivier, Luft, Thomas, Koldehoff, Michael, Corsten, Maarten, Heuser, Michael, Finke, Jürgen, Kobbe, Guido, Platzbecker, Uwe, Robin, Marie, Scott, Bart L., and Kröger, Nicolaus

Published
2021
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17. CAR T cells or allogeneic transplantation as standard of care for advanced large B-cell lymphoma: an intent-to-treat comparison

Author

Dreger, Peter, Dietrich, Sascha, Schubert, Maria-Luisa, Selberg, Lorenz, Bondong, Andrea, Wegner, Mandy, Stadtherr, Peter, Kimmich, Christoph, Kosely, Florentina, Schmitt, Anita, Pavel, Petra, Liebers, Nora, Luft, Thomas, Hegenbart, Ute, Radujkovic, Aleksandar, Ho, Anthony Dick, Müller-Tidow, Carsten, and Schmitt, Michael

Published
2020
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20. Treosulfan or busulfan plus fludarabine as conditioning treatment before allogeneic haemopoietic stem cell transplantation for older patients with acute myeloid leukaemia or myelodysplastic syndrome (MC-FludT.14/L): a randomised, non-inferiority, phase 3 trial

Author

Beelen, Dietrich Wilhelm, Trenschel, Rudolf, Stelljes, Matthias, Groth, Christoph, Masszi, Tamás, Reményi, Péter, Wagner-Drouet, Eva-Maria, Hauptrock, Beate, Dreger, Peter, Luft, Thomas, Bethge, Wolfgang, Vogel, Wichard, Ciceri, Fabio, Peccatori, Jacopo, Stölzel, Friedrich, Schetelig, Johannes, Junghanß, Christian, Grosse-Thie, Christina, Michallet, Mauricette, Labussiere-Wallet, Hélène, Schaefer-Eckart, Kerstin, Dressler, Sabine, Grigoleit, Goetz Ulrich, Mielke, Stephan, Scheid, Christof, Holtick, Udo, Patriarca, Francesca, Medeot, Marta, Rambaldi, Alessandro, Micò, Maria Caterina, Niederwieser, Dietger, Franke, Georg-Nikolaus, Hilgendorf, Inken, Winkelmann, Nils Rudolf, Russo, Domenico, Socié, Gérard, Peffault de Latour, Régis, Holler, Ernst, Wolff, Daniel, Glass, Bertram, Casper, Jochen, Wulf, Gerald, Menzel, Helge, Basara, Nadezda, Bieniaszewska, Maria, Stuhler, Gernot, Verbeek, Mareike, Grass, Sandra, Iori, Anna Paola, Finke, Juergen, Benedetti, Fabio, Pichlmeier, Uwe, Hemmelmann, Claudia, Tribanek, Michael, Klein, Anja, Mylius, Heidrun Anke, Baumgart, Joachim, Dzierzak-Mietla, Monika, and Markiewicz, Miroslaw

Published
2020
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23. Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations

Author

Pellagatti, Andrea, Armstrong, Richard N., Steeples, Violetta, Sharma, Eshita, Repapi, Emmanouela, Singh, Shalini, Sanchi, Andrea, Radujkovic, Aleksandar, Horn, Patrick, Dolatshad, Hamid, Roy, Swagata, Broxholme, John, Lockstone, Helen, Taylor, Stephen, Giagounidis, Aristoteles, Vyas, Paresh, Schuh, Anna, Hamblin, Angela, Papaemmanuil, Elli, Killick, Sally, Malcovati, Luca, Hennrich, Marco L., Gavin, Anne-Claude, Ho, Anthony D., Luft, Thomas, Hellström-Lindberg, Eva, Cazzola, Mario, Smith, Christopher W.J., Smith, Stephen, and Boultwood, Jacqueline

Published
2018
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27. Late treatment-related mortality versus competing causes of death after allogeneic transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia

Author

Schetelig, Johannes, de Wreede, Liesbeth C., van Gelder, Michel, Koster, Linda, Finke, Jürgen, Niederwieser, Dietger, Beelen, Dietrich, Mufti, G. J., Platzbecker, Uwe, Ganser, Arnold, Heidenreich, Silke, Maertens, Johan, Socié, Gerard, Brecht, Arne, Stelljes, Matthias, Kobbe, Guido, Volin, Liisa, Nagler, Arnon, Vitek, Antonin, Luft, Thomas, Ljungman, Per, Yakoub-Agha, Ibrahim, Robin, Marie, and Kröger, Nicolaus

Published
2019
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34. Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rachlis, Elena, Bug, Gesine, Stelljes, Matthias, Klein, Stefan, Steckel, Nina Kristin, Wolf, Dominik, Ringhoffer, Mark, Czibere, Akos, Nachtkamp, Kathrin, Dienst, Ariane, Kondakci, Mustafa, Stadler, Michael, Platzbecker, Uwe, Uharek, Lutz, Luft, Thomas, Fenk, Roland, Germing, Ulrich, Bornhäuser, Martin, Kröger, Nicolaus, Beelen, Dietrich W., Haas, Rainer, and Kobbe, Guido

Published
2015
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36. Registry Data Indicate a Meaningful Chance for Successful Pregnancies after Allogeneic Stem Cell Transplantation: Results from the German Stem Cell Transplant Registry (DRST)

Author

Sockel, Katja, Frank, Sandra, Neu, Annika, Ditschkowski, Markus, Hilgendorf, Inken, Goeckenjan, Mareen, Stoelzel, Friedrich, Middeke, Jan Moritz, Kröger, Nicolaus, Ayuk, Francis A., Eder, Matthias, Bethge, Wolfgang, Finke, Jürgen, Bertz, Hartmut, Kobbe, Guido, Kaufmann, Martin, Platzbecker, Uwe, Beverungen, David, Schmid, Christoph, von Bonin, Malte, Egger-Heidrich, Katharina, Heberling, Lisa, Trautmann-Grill, Karolin, Teipel, Raphael, Bug, Gesine, Tischer, Johanna, Fraccaroli, Alessia, Holler, Barbara, Wolff, Daniel, Luft, Thomas, Roesler, Wolf, Schäfer-Eckart, Kerstin, Dressler, Sabine, Scheid, Christof, Holtick, Udo, Klein, Stefan, Blau, Igor Wolfgang, Burchert, Andreas, Wulf, Gerald, Hasenkamp, Justin, Schwerdtfeger, Rainer, Kaun, Stephan, Wittke, Christoph, Wortmann, Friederike, Neidlinger, Helga, Bornhaeuser, Martin, Schetelig, Johannes, and of the German Cooperative Transplant Study Group, on Behalf

Published
2022
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37. Venetoclax-Based Salvage Therapy Improves Outcome in Relapsed/Refractory AML Patients Eligible for Intensive Treatment: A Propensity Score Matching Analysis

Author

Unglaub, Julia M., Schlenk, Richard F., Hanoun, Maher, Reinhardt, H. Christian, Middeke, Jan Moritz, Schäfer-Eckart, Kerstin, Steffen, Björn, Krause, Stefan W., Schliemann, Christoph, Kaufmann, Martin, Haenel, Mathias, Jost, Edgar, Crysandt, Martina, Fransecky, Lars, Einsele, Hermann, Kraus, Sabrina, Niemann, Dirk, Neubauer, Andreas, Seggewiss-Bernhardt, Ruth, Scholl, Sebastian, Klein, Stefan, Schmid, Christoph, Schaich, Markus, Platzbecker, Uwe, Baldus, Claudia D., Bornhaeuser, Martin, Serve, Hubert, Röllig, Christoph, Kramer, Michael, Katelari, Elena, Janssen, Maike, Pabst, Caroline, Luft, Thomas, Dreger, Peter, Müller-Tidow, Carsten, and Sauer, Tim

Published
2022
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38. Gvhd Prophylaxis Incorporating Methotrexate in Allo-HCT for Chronic Myeloid Malignancies and sAML: A Retrospective Analysis from the Cmwp of the EBMT

Author

Luft, Thomas, Gras, Luuk, Kostner, Linda, Kröger, Nicolaus, Schroeder, Thomas, Platzbecker, Uwe, Schetelig, Johannes, Peffault de Latour, Régis, Stelljes, Matthias, Sengeloev, Henrik, Ganser, Arnold, Blau, Igor Wolfgang, Dreger, Peter, Yakoub-Agha, Ibrahim, Maertens, Johan, Salmenniemi, Urpu, Bethge, Wolfgang, Mielke, Stephan, Kobbe, Guido, Pouli, Anastasia, de Wreede, Liesbeth C., Raj, Kavita, Drozd-Sokolowska, Joanna, McLornan, Donal P., and Robin, Marie

Published
2022
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41. Statin‐based endothelial prophylaxis and outcome after allogeneic stem cell transplantation.

Author

Pabst, Caroline, Schreck, Nicholas, Benner, Axel, Hegenbart, Ute, Schönland, Stefan, Radujkovic, Aleksandar, Schmitt, Michael, Müller‐Tidow, Carsten, Orsatti, Laura, Dreger, Peter, and Luft, Thomas

Subjects
STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, ENDOTHELIUM diseases, INDOLEAMINE 2,3-dioxygenase, ADVERSE health care events, ENZYME metabolism
Abstract

Background: Allogeneic haematopoietic stem cell transplantation (alloSCT) often remains the only curative therapy for hematologic malignancies. Although the management of transplant‐associated adverse events considerably improved over the last decades, nonrelapse mortality (NRM) remains a challenge, and endothelial dysfunction was identified as a major contributor to NRM. Methods: Statin‐based endothelial prophylaxis (SEP) has been implemented in the standard of care in our transplant centre to reduce NRM caused by endothelial injury. Here, we retrospectively analysed the impact of SEP on clinical outcome in a cohort of 347 alloSCT patients. Results: SEP (n = 209) was associated with significantly reduced NRM (hazard ratio 0.61, 95% CI 0.38–0.96) and better overall survival (OS) after acute graft‐versus‐host disease (HR 0.59, 95% CI 0.37–0.93). Subgroup analyses showed that the NRM benefit was mainly found in patients with an intermediate endothelial activation and stress index (EASIX), while relapse risk was not affected. On day 100 post‐alloSCT, patients receiving SEP had significantly higher levels of the rate‐limiting enzyme of tryptophan metabolism, indoleamine 2,3‐dioxygenase (IDO), higher kynurenine to tryptophan ratios as a proxy of IDO activity and tended to have lower levels of the endothelial injury marker ST2 (p =.055). No significant differences in interferon‐gamma or IL18 levels were observed. These biomarker signatures suggest that the beneficial effects of SEP might be mediated by both endothelial protection and immunomodulation. Conclusions: Together, these data suggest that SEP improves NRM and OS post‐alloSCT in particular in patients with intermediate endothelial risk and provide first mechanistic clues about its potential mode of action. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Improving distributed collaboration for the development of advanced systems.

Author

Duehr, Katharina, Luft, Thomas, Vierbacher, David, Ebner, Lukas, and Albers, Albert

Subjects
CORPORATE culture, ORGANIZATIONAL change, TEAMS in the workplace, LEADERSHIP, QUALITATIVE research
Abstract

Effective and efficient distributed collaboration is essential for the development of advanced systems. This contribution investigates the effects of the application of a method that supports improvement in distributed collaboration in the development of advanced systems at Voith Turbo. Furthermore, it will be examined, whether the improvement of distributed collaboration has an influence on the organizational culture. In total, nine improvement potentials in distributed collaboration were derived. In total, nine improvement potentials in distributed collaboration were identified and addressed through the implementation of measures. Subsequently, the effects of the implemented improvement measures were evaluated by qualitatively, quantitatively, subjective and objective data. Based on that, new potentials were derived. Finally, the results show that improving distributed collaboration positively influences the organizational culture. Iterative and continuous focus on good collaboration and the immediate evaluation ensures an improvement in collaboration and a gradual change in organizational culture. [ABSTRACT FROM AUTHOR]

Published
2022

48. EASIX and Severe Endothelial Complications After CD19-Directed CAR-T Cell Therapy—A Cohort Study.

Author

Korell, Felix, Penack, Olaf, Mattie, Mike, Schreck, Nicholas, Benner, Axel, Krzykalla, Julia, Wang, Zixing, Schmitt, Michael, Bullinger, Lars, Müller-Tidow, Carsten, Dreger, Peter, and Luft, Thomas

Subjects
CELLULAR therapy, CYTOKINE release syndrome, CHIMERIC antigen receptors, COHORT analysis, PROGNOSIS
Abstract

Background: Endothelial dysfunction is associated with two main complications of chimeric antigen receptor T (CAR-T) cell therapy, cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). This study evaluates the Endothelial Activation and Stress Index (EASIX) as a prognostic marker for high-grade CRS and ICANS in patients treated with CD19-directed CAR-T cells. Methods: In this retrospective study, a training cohort of 93 patients from the ZUMA-1 trial and a validation cohort of 121 patients from two independent centers (University Hospital Heidelberg, Charité University Medicine Berlin) were investigated. The primary objective was to assess the predictive capacity of EASIX measured immediately before the start of lymphodepletion (EASIX-pre) for the occurrence of grade ≥3 CRS and/or ICANS. To explore a possible endothelial link, serum levels of endothelial stress markers (angiopoietin-2, suppressor of tumorigenicity-2, soluble thrombomodulin, and interleukin-8) were determined before lymphodepletion and on day 7 after CART infusion in the validation cohort (n = 47). Results: The prognostic effect of EASIX-pre on grade ≥3 CRS and/or ICANS was significant in the training cohort [OR 2-fold increase 1.72 (1.26–2.46)] and validated in the independent cohort. An EASIX-pre cutoff >4.67 derived from the training cohort associated with a 4.3-fold increased odds ratio of severe CRS/ICANS in the independent cohort. Serum endothelial distress markers measured on day+7 correlated with EASIX-pre and associated with severe complications. Conclusions: EASIX-pre is a powerful predictor of severe CRS/ICANS after CD19-directed CART therapy and might be used as a basis for risk-adapted prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2022
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