1. DNA adducts and lung cancer risk: a prospective study
- Author
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H. Bas Bueno-de-Mesquita, Herman Autrup, Heiner Boeing, Paolo Vineis, Armelle Munnia, Aurelio Barricarte, Ole Raaschou-Nielsen, Seymour Garte, Carlos González, Fabrizio Veglia, Petra H.M. Peeters, Carmen Martinez, Carmen Navarro, J. Ramón Quirós, Elio Riboli, Antonia Trichopoulou, Emmanuelle Gormally, Merethe Kumle, Göran Berglund, Dimitrios Trichopoulos, Salvatore Panico, Timothy J. Key, Lars Janzon, Vittorio Krogh, Kim Overvad, Luisa Airoldi, Rudolf Kaaks, Michal Krzyzanowski, Pierre Hainaut, Giuseppe Matullo, Bengt Järvholm, Marco Peluso, Alison M. Dunning, Gerard Hoek, Rosario Tumino, Françoise Clavel-Chapelon, Anna Kaladidi, Christian Malaveille, Nicholas E. Day, Domenico Palli, J. Linseisen, Rodolfo Saracci, Miren Dorronsoro, Peluso, M, Munnia, A, Hoek, G, Krzyzanowski, M, Veglia, F, Airoldi, L, Autrup, H, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Gormally, E, Matullo, G, Overvad, K, RAASCHOU NIELSEN, O, CLAVEL CHAPELON, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, BUENO DE MESQUITA, Hb, Peeters, Ph, Kumle, M, Gonzalez, Ca, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, Jr, Berglund, G, Janzon, L, Jarvholm, B, Day, Ne, Key, Tj, Saracci, R, Kaaks, R, Riboli, E, Vineis, P., and Faculteit Diergeneeskunde
- Subjects
Adult ,Male ,pharynx ,Cancer Research ,medicine.medical_specialty ,Lung Neoplasms ,Gastroenterology ,lung ,DNA Adducts ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,DNA adduct ,medicine ,Humans ,air pollutants ,ddc:610 ,Prospective Studies ,Risk factor ,Prospective cohort study ,Lung cancer ,Aged ,030304 developmental biology ,larynx ,0303 health sciences ,business.industry ,Respiratory disease ,Cancer ,Odds ratio ,Middle Aged ,Diergeneeskunde (DGNK) ,medicine.disease ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Dna adducts ,bladder cancer ,Oncology ,13. Climate action ,Case-Control Studies ,030220 oncology & carcinogenesis ,Immunology ,Female ,business - Abstract
Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using 32P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O3 indicates a possible role for photochemical smog in determining DNA damage.
- Published
- 2016