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3. Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial

Author

Bardymova, Tatiana, Barrientos Perez, Margarita, Bethin, Kathleen, Bjornstad, Petter, Bondar, Irina, Chen, Mimi, Choi, Jin-Ho, Clements, Mark A, Colomar, Javier Ricardo, Daniels, Mark, Deerochanawong, Chaicharn, Desai, Vivek S, Desmangles, Jean-Claude G, Dillon, Robert G, Dixit, Naznin M, Du, Hongwei, Edelen, Rachel, Espinoza Peralta, Diego, Felipe Gacioppo, María Verónica, Ferraz, Tania Maria Bulcão Lousada, Galkina, Galina, Gallagher, Mary Patricia, George, Minu, Gonzalez, Edgar, Gottschalk, Michael Everett, Guido, Giancarlo, Hassan, Amir Ali, Hershkovitz, Eli, Huerta-Saenz, Lina P, Hwang, Jin Soon, Ibarra Gomez, Jaime Orlando, Irizarry Gonzalez, Lydia, Jain, Nina, Jelley, David H, Kim, Ho-Seong, Kovalenko, Tatiana, Laffel, Lori Michelle B, Leichter, Steven B, Liberatore Jr, Raphael Del Roio, Lynch, Jane, Mahmud, Farid Hussain, Malievskiy, Oleg Arturovich, Muir, Andrew, Nelson, Bryce A, Nevarez Ruiz, Luis Alejandro, Olson, Micah L, Pelayo Orozco, Emilia Susana, Peterkova, Valentina, Ramírez Mendoza, Fernando Ramón, Reddy, Konda Mohan, Rodriguez, Henry, Saenz, Javier Andres, Samoilova, Julia, Schwab, Karl-Otfried, Shah, Sejal H, Shehadeh, Naim, Shoemaker, Ashley H, Skorodok, Yulia, Sobolev, Aleksandr, Solís, Silvana Ernestina, Srinivasan, Shylaja, Tamborlane, William V, Tsalikian, Eva, Valeeva, Farida, Vance, Carl D, Velasquez-Mieyer, Pedro A, Violante Ortiz, Rafael Margarito, Votyakova, Olga, Wei, Haiyan, Weinstock, Ruth S, Wheeler, Mark D, Wicklow, Brandy Alexandra, Willi, Steven M, Wintergerst, Kupper A, Wolf, Risa M, Wood, Jamie Ruth, Yaliwal, Chandan, Yupanqui Lozno, Hernán, Laffel, Lori M, Danne, Thomas, Klingensmith, Georgeanna J, Willi, Steven, Zeitler, Philip, Neubacher, Dietmar, and Marquard, Jan

Published
2023
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8. Configuring the strategic orientation of manufacturing firms for economic sustainability : a study of the UK touring caravan industry

Author

Lynch, Jane

Subjects
658.7, HC Economic History and Conditions, HD Industries. Land use. Labor, TS Manufactures
Abstract

The main purpose of this research is to examine the role of strategic orientation for effective supply chain management (SCM). A form of strategic orientation which focusses on a process-base, supply chain orientation (SCO) has already been established as a pre-requisite for SCM (Mentzer et al. 2001; Min and Mentzer, 2004, Esper et al. 2010) but as a key concept, SCO research is less developed than SCM. This research contributes to fulfilling this shortfall by identifying SCO as a multiple construct requiring the alignment of three other strategic orientations which are all function-based: purchasing orientation, marketing orientation and production1orientation. This study investigates why it is important for an organisation to retain a configuration, meaning an alignment of strategic orientation approaches, not just to rely on one approach. Existing studies have identified that individually, these three function-based strategic orientation approaches support the necessary flows, such as product, capital and information flows, within the organisation for effective SCO and SCM. To achieve SCO, Esper et al. (2010) acknowledged the importance of managing specific behaviours, such as cooperation and trust. This study examines how these behaviours form the organisational culture to create important linkages and dependencies between purchasing orientation, market orientation and production orientation that can contribute towards achieving SCO. Utilising a case study approach, empirical evidence was gathered between 2009 and 2015 from a single industry, the UK touring caravan manufacturing industry. The UK touring caravan manufacturing industry had not previously been the focus of an academic supply chain study, thus it provided an original platform to conduct the research. The initial data collection period was between 2009 and 2011, a time when manufacturing managers were facing a period of economic hyper-turbulence. During such times, senior managers of UK manufacturing organisations struggled to align the internal business strategy with the business environment which was being shaped by multiple challenging factors: hyper-competition, economic hyper-turbulence and globalisation. Thus, there was a need for managers to go beyond the strategy level and to re-examine the way their businesses were fundamentally orientated. Systems Theory (Biology), as a single theoretical approach, has been frequently applied in supply chain research. This research explores how in order to manage a system effectively, two additional theoretical pillars; Resource Dependence Theory (Strategic Management) and Resource Based View (Strategic Management), may be relevant. These theoretical lenses underpin the investigation which is framed by three research questions:  RQ1: How does supply chain orientation support supply chain management?  RQ2: How may supply chain orientation be applied as a strategic orientation?  RQ3: What is the role of strategic orientation? This research mainly builds on the SCO study by Esper et al. (2010), acknowledged in Chapter II as the first authors to conceptualise SCO. It contributes eight new research contributions, which are offered to further develop the understanding of SCO and the concept of strategic orientation: 1. The research offers a new Strategic Orientation Pyramid framework for better understanding the components of strategic orientation. 1 Production replaces operations in manufacturing context ii 2. A new Research Model improves understanding of the likely variables for measuring SCO. 3. There are new theoretical developments in understanding the relationship between SCO and SCM by defining the role of strategic orientation in the supply chain context. 4. The case study findings from this research suggest that optimally configuring and harmonising the firm's internal function-based strategic orientations is a pre-requisite for managing SCO as an antecedent for SCM in pursuing a more sustainable competitive advantage. 5. The research proposes that in order for the manufacturing organisation to manage its supply chain effectively through SCO, the purchasing, marketing and production functions should be seen as operating interdependently. The evidence from this research suggests that this interdependence MUST be supported by specific behaviours such as trust, commitment and cooperation amongst all employees from all three strategic business functions. 6. Building on the existing purchasing literature, the purchasing function is this research has been observed as being the first area to be adversely affected during periods of economic uncertainty. Therefore, in wider context of manufacturing, the purchasing function may need to be strategically elevated and aligned with marketing and production functions to support the firm’s SCO and SCM. This would become important when managers are forced to adapt their manufacturing strategy due to variations in demand levels which affects their management of the supply chain. 7. Case study findings indicate that strategic purchasing can play an important intermediary role in smoothing over the conflicting strategies between marketing and production. 8. Similarities are found between the manufacturer’s MRPII system and SCO in that the purchasing, marketing and production functions need to be strategically aligned and coordinated to enable effective strategic planning, forecasting, managing the supply chain, ordering of the materials and implementing caravan production for meeting customer demands. In addition to these theoretical developments, the research offers four methodological contributions and gives practical guidance for managers in understanding the important role of strategic orientation, which affects the organisation’s success or failure.

Published
2015

9. Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children

Author

Mummidi, Srinivas, Farook, Vidya S., Reddivari, Lavanya, Hernandez-Ruiz, Joselin, Diaz-Badillo, Alvaro, Fowler, Sharon P., Resendez, Roy G., Akhtar, Feroz, Lehman, Donna M., Jenkinson, Christopher P., Arya, Rector, Lynch, Jane L., Canas, Jose A., DeFronzo, Ralph A., Hale, Daniel E., Blangero, John, Lopez-Alvarenga, Juan Carlos, Duggirala, Ravindranath, and Vanamala, Jairam K. P.

Published
2021
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10. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Author

McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S.M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y.K., Yasuda, P., Levitt Katz, L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D.M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S.M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O'Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., Silverstein, J., Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Levitt Katz, Lorraine E., Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, and Lima, Joao A.C.

Published
2018
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11. Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children

Author

Farook, Vidya S, Reddivari, Lavanya, Mummidi, Srinivas, Puppala, Sobha, Arya, Rector, Lopez-Alvarenga, Juan Carlos, Fowler, Sharon P, Chittoor, Geetha, Resendez, Roy G, Kumar, Birunda Mohan, Comuzzie, Anthony G, Curran, Joanne E, Lehman, Donna M, Jenkinson, Christopher P, Lynch, Jane L, DeFronzo, Ralph A, Blangero, John, Hale, Daniel E, Duggirala, Ravindranath, and Vanamala, Jairam KP

Published
2017
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12. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance

Author

He, Sijia, Ryu, Jiyoon, Liu, Juanhong, Luo, Hairong, Lv, Ying, Langlais, Paul R., Wen, Jie, Dong, Feng, Sun, Zhe, Xia, Wenjuan, Lynch, Jane L., Duggirala, Ravindranath, Nicholson, Bruce J., Zang, Mengwei, Shi, Yuguang, Zhang, Fang, Liu, Feng, Bai, Juli, and Dong, Lily Q.

Subjects
Glycoproteins -- Health aspects, Obesity -- Genetic aspects -- Complications and side effects -- Care and treatment, Insulin resistance -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

Dysregulation in adipokine biosynthesis and function contributes to obesity- induced metabolic diseases. However, the identities and functions of many of the obesity-induced secretory molecules remain unknown. Here, we report the identification of leucine-rich alpha-2-glycoprotein 1 (LRG1) as an obesity- associated adipokine that exacerbates high fat diet-induced hepatosteatosis and insulin resistance. Serum levels of LRG1 were markedly elevated in obese humans and mice compared with their respective controls. LRG1 deficiency in mice greatly alleviated diet-induced hepatosteatosis, obesity, and insulin resistance. Mechanistically, LRG1 bound with high selectivity to the liver and promoted hepatosteatosis by increasing de novo lipogenesis and suppressing fatty acid p-oxidation. LRG1 also inhibited hepatic insulin signaling by downregulating insulin receptor substrates 1 and 2. Our study identified LRG1 as a key molecule that mediates the crosstalk between adipocytes and hepatocytes in diet-induced hepatosteatosis and insulin resistance. Suppressing LRG1 expression and function may be a promising strategy for the treatment of obesity-related metabolic diseases., Introduction Adipose tissue dysfunction plays a critical role in the development of insulin resistance (IR), a major risk factor for type 2 diabetes, fatty liver diseases, and cardiovascular complication (1, [...]

Published
2021
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15. Pulling Together

Author

Daresh, John and Lynch, Jane

Abstract

Schools today require many individuals to work together to attain learning goals since no school functions without broad, active involvement of all community members. In addition, successful school improvement efforts operate well when there is a coherent vision for student achievement. While principals are aware of the need to include disparate voices in school discussions, there is often a glaring absence of key participants such as support personnel, including secretaries and clerks, paraprofessionals, custodians, security personnel, and cafeteria managers. To prove this point, textbooks about school leadership rarely address the role support personnel play. Instead, custodians, secretaries, and others are often depicted solely as people who school administrators need to deal with as part of their work each day. However, it is nearly impossible for a principal to lead a school toward being a true learning community without the involvement of all, including non-certificated staff who are often relegated to second-class status. Principals must appreciate the importance of everyone who works in a school feeling valued, listened to, and above all, respected as a contributor to the success of the school. Office workers, custodial staff, and food service workers are a school's invisible heroes. In this article, the authors present some of their concerns, derived from many conversations with staff members, and ways that principals can ensure that schools maximize their contributions to successful schools.

Published
2011

18. Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY Study

Author

Gidding, Samuel S., Bacha, Fida, Bjornstad, Petter, Katz, Lorraine E. Levitt, Levitsky, Lynne L., Lynch, Jane, Tryggestad, Jeanie B., Weinstock, Ruth S., El ghormli, Laure, Lima, Joao A.C., McKay, S., Haymond, M., Anderson, B., Bush, C., Gunn, S., Holden, H., Jones, S. M., Jeha, G., McGirk, S., Thamotharan, S., Cuttler, L., Abrams, E., Casey, T., Dahms, W., Ievers-Landis, C., Kaminski, B., Koontz, M., MacLeish, S., McGuigan, P., Narasimhan, S., Geffner, M., Barraza, V., Chang, N., Conrad, B., Dreimane, D., Estrada, S., Fisher, L., Fleury-Milfort, E., Hernandez, S., Hollen, B., Kaufman, F., Law, E., Mansilla, V., Miller, D., Muñoz, C., Ortiz, R., Ward, A., Wexler, K., Xu, Y. K., Yasuda, P., Katz, Levitt L., Berkowitz, R., Boyd, S., Johnson, B., Kaplan, J., Keating, C., Lassiter, C., Lipman, T., McGinley, G., McKnight, H., Schwartzman, B., Willi, S., Arslanian, S., Bacha, F., Foster, S., Galvin, B., Hannon, T., Kriska, A., Libman, I., Marcus, M., Porter, K., Songer, T., Venditti, E., Goland, R., Gallagher, D., Kringas, P., Leibel, N., Ng, D., Ovalles, M., Seidman, D., Laffel, L., Goebel-Fabbri, A., Hall, M., Higgins, L., Keady, J., Malloy, M., Milaszewski, K., Rasbach, L., Nathan, D. M., Angelescu, A., Bissett, L., Ciccarelli, C., Delahanty, L., Goldman, V., Hardy, O., Larkin, M., Levitsky, L., McEachern, R., Norman, D., Nwosu, D., Park-Bennett, S., Richards, D., Sherry, N., Steiner, B., Tollefsen, S., Carnes, S., Dempsher, D., Flomo, D., Whelan, T., Wolff, B., Weinstock, R., Bowerman, D., Bristol, S., Bulger, J., Hartsig, J., Izquierdo, R., Kearns, J., Saletsky, R., Trief, P., Zeitler, P., Abramson, N., Bradhurst, A., Celona-Jacobs, N., Higgins, J., Kelsey, M., Klingensmith, G., Nadeau, K., Witten, T., Copeland, K., Boss, E., Brown, R., Chadwick, J., Chalmers, L., Chernausek, S., Hebensperger, A., Macha, C., Newgent, R., Nordyke, A., Olson, D., Poulsen, T., Pratt, L., Preske, J., Schanuel, J., Sternlof, S., Lynch, J., Amodei, N., Barajas, R., Cody, C., Hale, D., Hernandez, J., Ibarra, C., Morales, E., Rivera, S., Rupert, G., Wauters, A., White, N., Arbeláez, A., Jones, J., Jones, T., Sadler, M., Tanner, M., Timpson, A., Welch, R., Caprio, S., Grey, M., Guandalini, C., Lavietes, S., Rose, P., Syme, A., Tamborlane, W., Hirst, K., Edelstein, S., Feit, P., Grover, N., Long, C., Pyle, L., Linder, B., Marcovina, S. M., Harting, J., Shepherd, J., Fan, B., Marquez, L., Sherman, M., Wang, J., Nichols, M., Mayer-Davis, E., Liu, Y., Lima, J., Gidding, S., Puccella, J., Ricketts, E., Danis, R., Domalpally, A., Goulding, A., Neill, S., Vargo, P., Wilfley, D., Aldrich-Rasche, D., Franklin, K., Massmann, C., O’Brien, D., Patterson, J., Tibbs, T., Van Buren, D., Palmert, M., Ratner, R., Dremaine, D., and Silverstein, J.

Published
2018
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21. HNPCC (Lynch Syndrome): Differential Diagnosis, Molecular Genetics and Management - a Review

Author

Lynch Henry T, Lynch Jane F, Shaw Trudy G, and Lubiński Jan

Subjects
hereditary cancer, cancer genetics, colorectal cancer, Lynch syndrome, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Genetics, QH426-470
Abstract

Abstract HNPCC (Lynch syndrome) is the most common form of hereditary colorectal cancer (CRC), wherein it accounts for between 2-7 percent of the total CRC burden. When considering the large number of extracolonic cancers integral to the syndrome, namely carcinoma of the endometrium, ovary, stomach, hepatobiliary system, pancreas, small bowel, brain tumors, and upper uroepithelial tract, these estimates of its frequency are likely to be conservative. The diagnosis is based upon its natural history in concert with a comprehensive cancer family history inclusive of all anatomic sites. In order for surveillance and management to be effective and, indeed, lifesaving, among these high-risk patients, the linchpin to cancer control would be the physician, who must be knowledgeable about hereditary cancer syndromes, their molecular and medical genetics, genetic counseling, and, most importantly, the natural history of the disorders, so that the entirety of this knowledge can be melded to highly-targeted management.

Published
2003
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24. The Insulin-Only Bionic Pancreas Pivotal Trial Extension Study: A Multi-Center Single-Arm Evaluation of the Insulin-Only Configuration of the Bionic Pancreas in Adults and Youth with Type 1 Diabetes.

Author

Lynch, Jane, Kanapka, Lauren G., Russell, Steven J., Damiano, Edward R., El-Khatib, Firas H., Ruedy, Katrina J., Balliro, Courtney, Calhoun, Peter, and Beck, Roy W.

Subjects
*TYPE 1 diabetes, *BIONICS, *PANCREAS, *GLYCEMIC control, *DIABETIC acidosis
Abstract

Objective: To evaluate a transition from standard-of-care (SC) management of type 1 diabetes (any insulin delivery method including hybrid closed-loop systems plus real-time continuous glucose monitoring [CGM]) to use of the insulin-only configuration of the iLet® bionic pancreas (BP) in 90 adults and children (age 6–71 years). Research Design and Methods: After the SC group completed the randomized controlled trial (RCT) portion of the Insulin-Only BP Pivotal Trial, 90 of the 107 participants participated in a 13-week study using the BP. The key outcomes were change from baseline in HbA1c and CGM metrics after 13 weeks on the BP. Results: Using the BP, mean HbA1c decreased from 7.7% ± 1.0% (61 ± 10.9 mmol/mol) at baseline to 7.1% ± 0.6% (54 ± 6.6 mmol/mol) at 13 weeks (mean change −0.55% ± 0.72% [−6 ± 7.9 mmol/mol], P < 0.001), time in range 70–180 mg/dL increased by 12.0% ± 12.5% (from 53% ± 17% to 65% ± 9%, P < 0.001), and mean glucose decreased by −18 ± 23 mg/dL (from 182 ± 32 to 164 ± 15 mg/dL, P < 0.001). The higher the baseline HbA1c level, the greater the change in HbA1c. Results were similar in the adult (N = 42) and pediatric (N = 48) cohorts. Time <70 mg/dL decreased from baseline over the 13 weeks by −0.50% ± 1.86% (P = 0.02), and time <54 mg/dL was similar (change from baseline −0.08% ± 0.59%, P = 0.24). Two severe hypoglycemia events (in same participant) and one diabetic ketoacidosis event occurred. Conclusions: Glycemic control improved after adult and pediatric participants in the SC arm in the Insulin-Only BP Pivotal Trial transitioned to use of the BP. Improvement using the BP was of similar magnitude to that observed during the RCT. ClinicalTrials.gov number, NCT04200313. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Genetic epidemiology of cardiometabolic risk factors and their clustering patterns in Mexican American children and adolescents: the SAFARI Study

Author

Fowler, Sharon P., Puppala, Sobha, Arya, Rector, Chittoor, Geetha, Farook, Vidya S., Schneider, Jennifer, Resendez, Roy G., Upadhayay, Ram Prasad, VandeBerg, Jane, Hunt, Kelly J., Bradshaw, Benjamin, Cersosimo, Eugenio, VandeBerg, John L., Almasy, Laura, Curran, Joanne E., Comuzzie, Anthony G., Lehman, Donna M., Jenkinson, Christopher P., Lynch, Jane L., DeFronzo, Ralph A., Blangero, John, Hale, Daniel E., and Duggirala, Ravindranath

Published
2013
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35. Familial myeloma

Author

Lynch, Henry T., Ferrara, Kelly, Barlogie, Bart, Coleman, Elizabeth A., Lynch, Jane F., Weisenburger, Dennis, Sanger, Warren, Watson, Patrice, Nipper, Henry, Witt, Vinetta, and Thorne, Stephan

Subjects
Multiple myeloma -- Genetic aspects, Multiple myeloma -- Case studies, Multiple myeloma -- Care and treatment, Blood protein electrophoresis -- Usage
Abstract

The symptoms, causes and treatment methodology used for multiple myeloma are discussed from a case study of a family with five cases of multiple myeloma, three cases of monoclonal gammopathy of undetermined significance and five cases of prostrate cancer in two generations.

Published
2008

38. A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States

Author

Lynch, Henry T., Coronel, Stephanie M., Okimoto, Ross, Hampel, Heather, Sweet, Kevin, Lynch, Jane F., Barrows, Ali, Wijnen, Juul, Klift, Heleen van der, Franken, Patrick, Wagner, Anja, Fodde, Riccardo, and Chapelle, Albert de la

Subjects
Genomics -- Evaluation, Colorectal cancer -- Prevention, Colorectal cancer -- Genetic aspects, Colorectal cancer -- Diagnosis
Abstract

The existence of a large genomic deletion encompassing exons 1 to 6 of the MSH2 as a result of a founder effect is described. Its implications for the early detection and prevention of cancers associated with hereditary nonpolyposis colorectal cancer (HNPCC) are discussed.

Published
2004

41. Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene

Author

Wagner, Anja, Barrows, Alicia, Wijnen, Juul Th., van der Klift, Heleen, Franken, Patrick F., Verkuijlen, Paul, Nakagawa, Hidewaki, Geugien, Marjan, Jaghmohan-Changur, Shantie, Breukel, Cor, Meijers-Heijboer, Hanne, Morreau, Hans, van Puijenbroek, Marjo, Burn, John, Coronel, Stephany, Kinarski, Yulia, Okimoto, Ross, Watson, Patrice, Lynch, Jane F., de la Chapelle, Albert, Lynch, Henry T., and Fodde, Riccardo

Subjects
Colorectal cancer -- Genetic aspects, Genetic disorders -- Research, Gene mutations -- Research, Biological sciences
Published
2003

43. Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.

Author

BjornstadPetterEl ghormliLaureHughanKara S.LaffelLori M.NadeauKristen J.RayasMariaTesfaldetBereketTollefsenSherida E.WilliSteven M.LynchJane, Bjornstad, Petter, El ghormli, Laure, Hughan, Kara S., Laffel, Lori M., Nadeau, Kristen J., Rayas, Maria, Tesfaldet, Bereket, Tollefsen, Sherida E., Willi, Steven M., Lynch, Jane, and TODAY Study Group

Abstract

Objective: To describe the longitudinal effects of sex, race-ethnicity, and metabolic factors on the risk of developing diabetic kidney disease (DKD) in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort.Research Design and Methods: Urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were assessed annually for up to 15 years after study entry. Markers of DKD included micro- and macroalbuminuria (UACR ≥30 mg/g and ≥300 mg/g, respectively), hyperfiltration (eGFR ≥135 mL/min/1.73 m2), and rapid eGFR annual decline (>3 mL/min/1.73 m2 and/or ≥3.3%). The relationships between risk factors and DKD were evaluated longitudinally using time-to-event models.Results: Data were available on 677 participants, average age at baseline 14 years, with a mean ± SD follow-up of 10.2 ± 4.5 years. Each 1% increment in HbA1c conferred higher risk of microalbuminuria (hazard ratio 1.24 [95% CI 1.18, 1.30]), macroalbuminuria (1.22, [1.11, 1.34]), hyperfiltration (1.11, [1.05, 1.17]), and rapid eGFR decline (1.12, [1.04, 1.20]). Higher systolic blood pressure and baseline serum uric acid, and lower indices of β-cell function (C-peptide index and oral disposition index [oDI]), increased the risk of microalbuminuria, while higher triglycerides increased risk of micro- and macroalbuminuria. Lower oDI levels, female sex, and Hispanic ethnicity were associated with higher risk of hyperfiltration.Conclusions: Elevated HbA1c was a shared risk factor among all phenotypes of DKD in this longitudinal cohort of adolescents and young adults with youth-onset type 2 diabetes. Other risk factors included elevated blood pressure, triglycerides, serum uric acid, and β-cell dysfunction. [ABSTRACT FROM AUTHOR]

Published
2022
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