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322 results on '"MATHIAS, CHRISTOPHER J."'

5. Rate of Change in Cerebral Oxygenation and Blood Pressure in Response to Passive Changes in Posture : A comparison between pure autonomic failure patients and controls

Author

Tachtsidis, Ilias, Elwell, Clare E., Leung, Terence S., Bleasdale-Barr, Katharine, Hunt, Katharine, Toms, Nathan, Smith, Martin, Mathias, Christopher J., Delpy, David T., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Okunieff, Paul, editor, Williams, Jacqueline, editor, and Chen, Yuhchyau, editor

Published
2005
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6. The natural history of multiple system atrophy: a prospective European cohort study

Author

Wenning, Gregor K, Geser, Felix, Krismer, Florian, Seppi, Klaus, Duerr, Susanne, Boesch, Sylvia, Köllensperger, Martin, Goebel, Georg, Pfeiffer, Karl P, Barone, Paolo, Pellecchia, Maria Teresa, Quinn, Niall P, Koukouni, Vasiliki, Fowler, Clare J, Schrag, Anette, Mathias, Christopher J, Giladi, Nir, Gurevich, Tanya, Dupont, Erik, Ostergaard, Karen, Nilsson, Christer F, Widner, Håkan, Oertel, Wolfgang, Eggert, Karla Maria, Albanese, Alberto, del Sorbo, Francesca, Tolosa, Eduardo, Cardozo, Adriana, Deuschl, Günther, Hellriegel, Helge, Klockgether, Thomas, Dodel, Richard, Sampaio, Cristina, Coelho, Miguel, Djaldetti, Ruth, Melamed, Eldad, Gasser, Thomas, Kamm, Christoph, Meco, Giuseppe, Colosimo, Carlo, Rascol, Olivier, Meissner, Wassilios G, Tison, François, and Poewe, Werner

Published
2013
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22. The effect of different physiological stimuli on skin vasomotor reflexes above and below the lesion in human chronic spinal cord injury

Author

Nicotra, Alessia, Young, Tim M., Asahina, Masato, and Mathias, Christopher J.

Subjects
Spinal cord injuries, Blood flow, Nervous system, Autonomic, Psychology and mental health
Abstract

Objective. Spinal cord injury (SCI) results in disruption of descending tonic activation of sympathetic circuits in the spinal cord. The authors determined whether different stimuli that increase sympathetic activity induced [...]

Published
2005

27. Autonomic diseases: management

Author

Mathias, Christopher J.

Subjects
Autonomic neuropathies -- Management -- Drug therapy, Hyperhidrosis -- Management -- Drug therapy, Hypotension -- Influence -- Management -- Drug therapy, Fainting -- Management -- Drug therapy, Health, Psychology and mental health, Company business management, Management, Influence, Drug therapy
Abstract

The management of autonomic disease encompasses a number of aspects. Of immediate and practical importance is alleviation of symptoms. The ideal is to rectify the autonomic deficit and cure the [...]

Published
2003

28. Autonomic diseases: clinical features and laboratory evaluation

Author

Mathias, Christopher J.

Subjects
Autonomic neuropathies -- Management -- Physiological aspects, Heart beat -- Physiological aspects, Neurotransmitters -- Influence -- Evaluation -- Physiological aspects, Hypotension -- Causes of -- Evaluation -- Physiological aspects, Symptomatology -- Evaluation -- Physiological aspects, Fainting -- Causes of -- Evaluation -- Physiological aspects, Health, Psychology and mental health, Company business management, Management, Influence, Evaluation, Physiological aspects, Causes of
Abstract

The autonomic nervous system has a craniosacral parasympathetic and a thoracolumbar sympathetic pathway (fig 1) and supplies every organ in the body. It influences localised organ function and also integrated [...]

Published
2003

34. Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain.

Author

Csecs, Jenny L. L., Iodice, Valeria, Rae, Charlotte L., Brooke, Alice, Simmons, Rebecca, Quadt, Lisa, Savage, Georgia K., Dowell, Nicholas G., Prowse, Fenella, Themelis, Kristy, Mathias, Christopher J., Critchley, Hugo D., and Eccles, Jessica A.

Subjects
TIC disorders, EHLERS-Danlos syndrome, JOINT hypermobility, NEURODIVERSITY, ORTHOSTATIC intolerance, DYSAUTONOMIA, ATTENTION-deficit hyperactivity disorder, PAIN
Abstract

Objectives: Autism, attention deficit hyperactivity disorder (ADHD), and tic disorder (Tourette syndrome; TS) are neurodevelopmental conditions that frequently co-occur and impact psychological, social, and emotional processes. Increased likelihood of chronic physical symptoms, including fatigue and pain, are also recognized. The expression of joint hypermobility, reflecting a constitutional variant in connective tissue, predicts susceptibility to psychological symptoms alongside recognized physical symptoms. Here, we tested for increased prevalence of joint hypermobility, autonomic dysfunction, and musculoskeletal symptoms in 109 adults with neurodevelopmental condition diagnoses. Methods: Rates of generalized joint hypermobility (GJH, henceforth hypermobility) in adults with a formal diagnosis of neurodevelopmental conditions (henceforth neurodivergent group, n = 109) were compared to those in the general population in UK. Levels of orthostatic intolerance and musculoskeletal symptoms were compared to a separate comparison group (n = 57). Age specific cut-offs for GJH were possible to determine in the neurodivergent and comparison group only. Results: The neurodivergent group manifested elevated prevalence of hypermobility (51%) compared to the general population rate of 20% and a comparison population (17.5%). Using a more stringent age specific cut-off, in the neurodivergent group this prevalence was 28.4%, more than double than the comparison group (12.5%). Odds ratio for presence of hypermobility in neurodivergent group, compared to the general population was 4.51 (95% CI 2.17–9.37), with greater odds in females than males. Using age specific cut-off, the odds ratio for GJH in neurodivergent group, compared to the comparison group, was 2.84 (95% CI 1.16–6.94). Neurodivergent participants reported significantly more symptoms of orthostatic intolerance and musculoskeletal skeletal pain than the comparison group. The number of hypermobile joints was found to mediate the relationship between neurodivergence and symptoms of both dysautonomia and pain. Conclusions: In neurodivergent adults, there is a strong link between the expression of joint hypermobility, dysautonomia, and pain, more so than in the comparison group. Moreover, joint hypermobility mediates the link between neurodivergence and symptoms of dysautonomia and pain. Increased awareness and understanding of this association may enhance the management of core symptoms and allied difficulties in neurodivergent people, including co-occurring physical symptoms, and guide service delivery in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Autonomic Dysfunction in Autism Spectrum Disorder.

Author

Owens, Andrew P., Mathias, Christopher J., and Iodice, Valeria

Subjects
DYSAUTONOMIA, AUTISM spectrum disorders, POSTURAL orthostatic tachycardia syndrome, EHLERS-Danlos syndrome, BLOOD pressure, ORTHOSTATIC hypotension
Abstract

Background: There have been previous reports of enhanced sympathoexcitation in autism spectrum disorder (ASD). However, there has been no formal investigation of autonomic dysfunction in ASD. Also, the joint hypermobile form of Ehlers-Danlos syndrome (hE-DS) that maybe overrepresented in ASD and orthostatic related autonomic dysfunction. This study examined the comorbidity of ASD, autonomic dysfunction and hE-DS in two UK autonomic national referral centers. Proven, documented and globally accepted clinical autonomic investigations were used to assess neuro-cardiovascular autonomic function in a cohort of ASD subjects and in age-matched healthy controls. Methods: Clinical data from 28 referrals with a confirmed diagnosis of ASD over a 10-year period were compared with 19 age-matched healthy controls. Autonomic function was determined using methods established in the centers previously described in detail. Results: 20/28 ASD had a diagnosed autonomic condition; 9 had the postural tachycardia syndrome (PoTS), 4 PoTS and vasovagal syncope (VVS), 3 experienced presyncope, 1 essential hyperhidrosis, 1 orthostatic hypotension, 1 VVS alone and 1 a combination of PoTS, VVS and essential hyperhidrosis. 16/20 ASD with autonomic dysfunction had hE-DS. In ASD, basal heart rate and responses to orthostatic tests of autonomic function were elevated, supporting previous findings of increased sympathoexcitation. However, sympathetic vasoconstriction was impaired in ASD. Conclusion: Intermittent neuro-cardiovascular autonomic dysfunction affecting heart rate and blood pressure was over-represented in ASD. There is a strong association with hE-DS. Autonomic dysfunction may further impair quality of life in ASD, particularly in those unable to adequately express their experience of autonomic symptoms. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Unconscious Confusion

Author

Thijs, Roland D., Benditt, David G., Mathias, Christopher J., Schondorf, Ronald, Sutton, Richard, Wieling, Wouter, and van Dijk, Gert J.

Published
2005
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