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Effect of water stress on leaf water relations and some secondary metabolites in root stem and leaf of Aristolochia bracteolata Lam. has been studied. Mature potted plants were imposed to short term water stress. Moisture content, succulence index, mesophyll succulence index showed a very meager decline under water scarcity thereby showing its ability to maintain water status even under water deficiency. Significant rise in proline content in leaf followed by stem and root observed under water stress. Polyphenol and tannin content has increased considerably in all parts but more pronounced effect is seen in root. Maintenance of high succulence even under water stress and concurrent accumulation of secondary metabolites helps in membrane protection and osmoregulation influences for induction of facultative CAM.

Controlled ovarian stimulation has been an integral part of in vitro fertilisation (IVF) treatment cycles. Availability of different gonadotropins for ovarian stimulation and gonadotropin releasing hormone (GnRH) analogues for prevention of premature rise of leutinising hormone during follicular phase offer an opportunity to utilise them for a successful outcome in women with different subsets of ovarian response. Further, use of GnRH agonist as an alternative for human chorionic gonadotropin improves safety of ovarian stimulation in hyper-responders. Mild ovarian stimulation protocols have emerged as an alternative to conventional protocols in the recent years. Individualisation plays an important role in improving safety of IVF in hyper-responders while efforts continue to improve efficacy in poor responders. Some of the follicular and peri-ovulatory phase interventions may be associated with negative impact on the luteal phase and segmentalisation of the treatment with frozen embryo transfer may be an effective strategy in such a clinical scenario. This narrative review looks at the available evidence on various aspects of ovarian stimulation strategies and their consequences. In addition, it provides a concise summary of the evidence that has emerged from India on various aspects of ovarian stimulation.

Better adjuvants are needed for vaccines against seasonal influenza. TLR7 agonists are potent activators of innate immune responses and thereby may be promising adjuvants. Among the imidazoquinoline compounds, 1-benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (BBIQ) was reported to be a highly active TLR7 agonist but has remained relatively unexplored because of its commercial unavailability. Indeed, in silico molecular modeling studies predicted that BBIQ had a higher TLR7 docking score and binding free energy than imiquimod, the gold standard TLR7 agonist. To circumvent the availability issue, we developed an improved and higher yield method to synthesize BBIQ. Testing BBIQ on human and mouse TLR7 reporter cell lines confirmed it to be TLR7 specific with significantly higher potency than imiquimod. To test its adjuvant potential, BBIQ or imiquimod were admixed with recombinant influenza hemagglutinin protein and administered to mice as two intramuscular immunizations 2 weeks apart. Serum anti-influenza IgG responses assessed by ELISA 2 weeks after the second immunization confirmed that the mice that received vaccine admixed with BBIQ had significantly higher anti-influenza IgG1 and IgG2c responses than mice immunized with antigen alone or admixed with imiquimod. This confirmed BBIQ to be a TLR7-specific adjuvant able to enhance humoral immune responses.

MTO nanodiscs synthesized using the hydrothermal approach were explored for the photocatalytic removal of methylene blue (MB), rhodamine B (RhB), congo red (CR), and methyl orange (MO). The disc-like structures of ~16 nm thick and ~291 nm average diameter of stoichiometric MTO were rhombohedral in nature. The MTO nanodiscs delivered stable and recyclable photocatalytic activity under Xe lamp irradiation. The kinetic studies showed the 89.7, 80.4, 79.4, and 79.4 % degradation of MB, RhB, MO, and CR at the rate constants of 0.011(±0.001), 0.006(±0.001), 0.007(±0.0007), and 0.009 (±0.0001) min−1, respectively, after the 180 min of irradiation. The substantial function of photogenerated holes and hydroxide radicals pertaining to the dye removal phenomena is confirmed by radical scavenger trapping studies. Overall, the present studies provide a way to develop pristine and heterostructure perovskite for photocatalysts degradation of various organic wastes.

Objective: Career choice, one of the most important process in a student's life, has an influence on his/her future life. Hence, it is important to understand student's motives behind choosing a specific career. Hence, the study was designed with an aim to evaluate the factors influencing dental students to choose dentistry as career. Methods: The present cross-sectional survey was conducted on 401 dental students from a dental institute. The data was collected using a structured questionnaire consisting of 13 reasons that possibly influenced students' decision to study dentistry. Data collected was analyzed using SPSS 20 software. Results: Majority of the students participating were female (77.1%). Top four reasons to choose dentistry as a profession were to help poor people (95.5%), to earn prestige and respect (95.0%) followed by self-interest (94.7%) and study of human parts especially teeth (92.8%). Making money was the reason reported by 77.8% of the students. Other reasons reported were inspiration from other dentists (63.3%), did not get admission to medicine (MBBS) course (52.1%), and no doctor in family (51.9%). Family members in medical/dental profession was the least reported reason (36.9%). There were no significant differences among males and females for reported reasons except for one reason, that is, did not get admitted to medicine (MBBS) course (60.9% male and 48.9% female; P = 0.031). Conclusion: Students were mostly influenced by own interest and altruistic nature to opt for dental profession.