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249 results on '"Maeda, Hiroyuki"'

19. p16 Overexpression in Sinonasal Squamous Cell Carcinoma: Association with Human Papillomavirus and Prediction of Survival Outcomes.

Author

Hirakawa, Hitoshi, Ikegami, Taro, Touyama, Masatomo, Ooshiro, Yurika, Higa, Tomoyo, Higa, Teruyuki, Agena, Shinya, Kinjyo, Hidetoshi, Kondo, Shunsuke, Kise, Norimoto, Tanaka, Katsunori, Maeda, Hiroyuki, Tamaki, Tomoko, Wada, Naoki, and Suzuki, Mikio

Subjects
HUMAN papillomavirus, SQUAMOUS cell carcinoma, SURVIVAL rate, GENETIC overexpression, PARANASAL sinuses
Abstract

p16 overexpression is often used as a surrogate marker for human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma but remains an uncertain diagnostic tool for HPV-related sinonasal squamous cell carcinoma (SNSCC). Our study involved 79 consecutive SNSCC patients who were treated at a tertiary referral university hospital during 2006–2021. We retrospectively examined their clinical characteristics and conducted p16 immunohistochemistry and HPV detection. We found that 12.7% of the patients exhibited p16 overexpression, which was significantly more common in the nasal cavity and increased from 2015 onward. The HPV was a high-risk type and viral loads ranged from 4.2 to 1.6 × 106 copies/ng DNA with genome integration. Five-year overall survival (OS) and five-year relapse-free survival (RFS) rates were 74.6% and 69.9%, respectively. Our multivariate analysis showed that T category (T1–4a) and hemoglobin levels (≥13.7) were significant favorable prognostic factors for OS, while T category, performance status, and p16 overexpression were significantly associated with RFS. In patients with p16 overexpression, OS was 100% and RFS was 90%. Our findings suggest that p16 overexpression is a reliable surrogate marker for transcriptionally active HPV infection and predicts a favorable prognosis. [ABSTRACT FROM AUTHOR]

Published
2023
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23. [ 18 F]FES PET Resolves the Diagnostic Dilemma of COVID-19-Vaccine-Associated Hypermetabolic Lymphadenopathy in ER-Positive Breast Cancer.

Author

Nogami, Munenobu, Tsujikawa, Tetsuya, Maeda, Hiroyuki, Kosaka, Nobuyuki, Takahashi, Mizuho, Kinoshita, Naoki, Mori, Tetsuya, Makino, Akira, Kiyono, Yasushi, Murakami, Takamichi, Goi, Takanori, and Okazawa, Hidehiko

Subjects
BREAST cancer, POSITRON emission tomography, LYMPHADENITIS, LYMPHATIC metastasis, CORONAVIRUS diseases, COVID-19, DELTOID muscles
Abstract

Coronavirus disease (COVID-19) vaccination is known to cause a diagnostic dilemma due to false-positive findings on [18F]FDG PET in vaccine-associated hypermetabolic lymphadenopathy. We present two case reports of women with estrogen-receptor (ER)-positive cancer of the breast who were vaccinated for COVID-19 in the deltoid muscle. [18F]FDG positron emission tomography (PET) demonstrated primary breast cancer and multiple axillary lymph nodes with increased [18F]FDG uptake, diagnosed as vaccine-associated [18F]FDG-avid lymph nodes. Subsequent [18F]FES PET revealed single axillary lymph node metastasis in the vaccine-associated [18F]FDG-avid lymph nodes. To the best of our knowledge, this is the first study showing the usefulness of [18F]FES PET in diagnosing axillary lymph node metastasis in COVID-19-vaccinated patients harboring ER-positive breast cancer. Thus, [18F]FES PET has potential applications in the detection of true-positive metastatic lymph nodes in patients with ER-positive breast cancer regardless of the ipsilateral or contralateral side, who have received COVID-19 vaccination. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Biomarkers for Predicting Anti-Programmed Cell Death-1 Antibody Treatment Effects in Head and Neck Cancer.

Author

Tanaka, Katsunori, Hirakawa, Hitoshi, Suzuki, Mikio, Higa, Teruyuki, Agena, Shinya, Hasegawa, Narumi, Kawakami, Junko, Toyama, Masatomo, Higa, Tomoyo, Kinjyo, Hidetoshi, Kise, Norimoto, Kondo, Shunsuke, Maeda, Hiroyuki, and Ikegami, Taro

Subjects
HEAD & neck cancer, DRUG side effects, APOPTOSIS, BIOMARKERS, NUTRITIONAL status
Abstract

In recurrent or metastatic head and neck squamous cell carcinoma (R/M-HNSCC), survival outcomes are significantly better in patients who receive anti-programmed cell death-1 (PD-1) monoclonal antibody therapy than in those who receive standard therapy. However, there is no established biomarker that can predict the anti-PD-1 antibody treatment effect and immune-related adverse events (irAEs) in these patients. This study investigated the inflammatory and nutritional status in 42 patients with R/M-HNSCC and programmed cell death ligand-1 (PD-L1) polymorphisms (rs4143815 and rs2282055) in 35 of the 42 patients. The 1- and 2-year overall survival was 59.5% and 28.6%, respectively; the 1- and 2-year first progression-free survival was 19.0% and 9.5%, respectively, and the respective second progression-free survival was 50% and 27.8%. Performance status and inflammatory and nutritional status (assessed by the geriatric nutritional risk index, modified Glasgow prognostic score, and prognostic nutritional index) were identified as significant indicators of survival outcomes in multivariate analysis. Patients with ancestral alleles in PD-L1 polymorphisms had less frequent irAEs. Performance status and inflammatory and nutritional status before treatment were closely related to survival outcomes after PD-1 therapy. These indicators can be calculated using routine laboratory data. PD-L1 polymorphisms may be biomarkers for predicting irAEs in patients receiving anti-PD-1 therapy. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Two cases of compartment syndrome of the lower extremities during surgery for gynecological malignancies

Author

Kikuchi, Toshihiro and Maeda, Hiroyuki

Subjects
Gynecological surgery -- Complications and side effects -- Patient outcomes -- Research, Compartment syndromes -- Risk factors -- Demographic aspects -- Research, Health
Abstract

Two cases of compartment syndrome of the lower extremities occurring during surgery for gynecological malignancies are reported. In addition to the risk from being in the lithotomy position for over 4 h, these two cases were believed to have been caused by the combined use of a disposable wound retractor and abdominal retractors to secure the operative field. This conclusion is based on the fact that an abrupt increase in partial pressure of end-tidal CO.sub.2 (ETCO.sub.2) was observed when wound drapes and abdominal retractors were removed approximately 4 h after the start of surgery. Prolonged compression of the external iliac vein by a disposable wound retractor and abdominal retractors is believed to have induced congestion of the lower extremities, eventually resulting in compartment syndrome. To verify this, during subsequent surgeries of the same type, changes in the diameters of femoral arteries and veins when a disposable wound retractor and abdominal retractors were used were monitored using an ultrasound device, and the findings confirmed that changes in vascular diameter do occur., Author(s): Toshihiro Kikuchi[sup.1] , Hiroyuki Maeda[sup.2] Author Affiliations: (1) Department of Anesthesiology and Pain Medicine, Juntendo University Nerima Hospital, 3-1-10, Takanodai, Nerima-ku, 177-8521, TokyoJapan (2) Department of Orthopaedic Surgery, Juntendo [...]

Published
2016
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26. Acinar cell carcinoma of the pancreas in childhood

Author

Morikawa, Mitsuhiro, Nakazawa, Toshiyuki, Kato, Shigeru, Fujimoto, Daisuke, Koneri, Kenji, Murakami, Makoto, Hirono, Yasuo, Maeda, Hiroyuki, Goi, Takanori, Katayama, Kanji, Imamura, Yoshiaki, Tanizawa, Akihiko, and Yamaguchi, Akio

Published
2016
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30. Human Papillomavirus Infection and EGFR Exon 20 Insertions in Sinonasal Inverted Papilloma and Squamous Cell Carcinoma.

Author

Hirakawa, Hitoshi, Ikegami, Taro, Kise, Norimoto, Kinjyo, Hidetoshi, Kondo, Shunsuke, Agena, Shinya, Hasegawa, Narumi, Kawakami, Junko, Maeda, Hiroyuki, and Suzuki, Mikio

Subjects
HUMAN papillomavirus, SQUAMOUS cell carcinoma, PAPILLOMAVIRUS diseases, EPIDERMAL growth factor receptors, PARANASAL sinuses
Abstract

This study aimed to clarify the roles of high-risk human papillomavirus (HR-HPV) infection and epidermal growth factor receptor (EGFR) exon 20 mutations in sinonasal inverted papilloma (IP) and sinonasal squamous cell carcinoma (SNSCC). Samples were collected from 20 cases with IP, 7 with IP and squamous cell carcinoma (IP-SCC), and 20 with SNSCC and examined for HPV infection and EGFR exon 20 mutations. Low- or high-risk HPV DNA was observed in 25% of IP, 57.1% of IP-SCC, and 35% of SNSCC cases. Transcriptionally active HR-HPV infections in IP-SCC and SNSCC, accompanied by p16 overexpression, were observed in 28.5% and 25% of cases, respectively. Heterozygous EGFR exon 20 amino acid insertions (ex20ins), located between amino acids 768–774, were observed in 45% of IP, 28.5% of IP-SCC, and 0% of SNSCC and chronic sinusitis cases. EGFR phosphorylation sites were located at tyrosine (Y) 845, Y1068, Y1086, and Y1197 and induced PI3K/AKT/mTOR activation. The phosphorylation pattern of EGFR with ex20ins resembled that of HPV-related SNSCC and oropharyngeal cancer. The transcriptionally active HR-HPV infection and ex20ins might be responsible for the pathogenesis of IP-SCC cases with different fashions. Since IP-SCC might be a multifactorial disease, further investigation is needed to understand IP-SCC etiology. [ABSTRACT FROM AUTHOR]

Published
2023
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31. IoT Software by Dataflow Programming in Mruby Programming Environment

Author

Tanaka, Kazuaki, Tsujino, Chihiro, and Maeda, Hiroyuki

Subjects
IoT, Node-RED, Dataflow programming, Article, Mruby
Abstract

In IoT software development, a method to implement software by focusing on data flow has been proposed, which is called dataflow programming. On the other hand, sensor devices are generally implemented in microcontrollers with limited resources for compactness, power savings and costs, so sensor devices are not suitable for executing data flow programs. In this paper, an environment running the scripting language mruby is described to execute a dataflow program on a small microcontroller. The execution of the data flow program is performed asynchronously by multiple nodes, which handle the sensor data. The execution environment of a dataflow program must support this style of execution. Since mruby can execute multiple programs concurrently, it is well suited to implement dataflow programs. By generating mruby code from a program developed in Node-RED, one of the popular dataflow programming environments, the mruby program is executed on a single-chip microcontroller, which includes mruby virtual machine.

Published
2020

34. Hypopharyngeal cancer risk in Japanese: Genetic polymorphisms related to the metabolism of alcohol- and tobacco-associated carcinogens

Author

Yamashita, Yukashi, Ikegami, Taro, Suzuki, Mikio, Hirakawa, Hitoshi, Maeda, Hiroyuki, Yamada, Satoshi, Deng, Zeyi, Kondo, Shunsuke, Kinjyo, Hidetoshi, Kiyuna, Asanori, Agena, Shinya, Uehara, Takayuki, and Ganaha, Akira

Subjects
Pharyngeal cancer -- Risk factors -- Care and treatment, Smoking -- Health aspects, Body mass index -- Analysis, Genetic research, Cancer research, Cigarettes, Medical records, Drinking (Alcoholic beverages), Cancer, EDTA, Medical research, Xenobiotics, Genetic polymorphisms, Health
Abstract

Byline: Yukashi. Yamashita, Taro. Ikegami, Mikio. Suzuki, Hitoshi. Hirakawa, Hiroyuki. Maeda, Satoshi. Yamada, Zeyi. Deng, Shunsuke. Kondo, Hidetoshi. Kinjyo, Asanori. Kiyuna, Shinya. Agena, Takayuki. Uehara, Akira. Ganaha Background: Several studies [...]

Published
2019

48. Metastatic invasive lobular breast cancer presenting as linitis plastica of the colon: Tumour characterization using [18F]FES PET/MRI.

Author

Tsujikawa, Tetsuya, Takahashi, Mizuho, Maeda, Hiroyuki, Mori, Tetsuya, Makino, Akira, Kiyono, Yasushi, Imamura, Yoshiaki, Goi, Takanori, and Okazawa, Hidehiko

Abstract

Metastatic invasive lobular breast cancer (ILC) to the colon is rare and usually ER‐positive. We present an ER‐negative case of metastatic ILC presenting as linitis plastica of the colon where [18F]FES PET/MRI allowed the evaluation of the ER phenotypic transformation in the colonic metastasis from the ER‐positive breast ILC in vivo. [ABSTRACT FROM AUTHOR]

Published
2022
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