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6. The association between human papillomavirus infection, vaginal microecology, and cervical intraepithelial neoplasia in women from Xinjiang, China.

Author

Shi, Yi, Dong, Xiao yang, Yimingjiang, Mai wei li dan, Ma, Wen mei, Ma, Zhi ping, Pang, Xue lian, and Zhang, Wei

Subjects
PAPILLOMAVIRUS diseases, CERVICAL intraepithelial neoplasia, RISK assessment, CERVIX uteri tumors, VAGINA, VIRAL load, VIROLOGY, LOGISTIC regression analysis, EARLY detection of cancer, PSYCHOLOGY of women, REVERSE transcriptase polymerase chain reaction, CHI-squared test, ENZYMES, DESCRIPTIVE statistics, CLINICAL chemistry, GENOTYPES, DISEASE progression, DISEASE risk factors, DISEASE complications
Abstract

Purpose: This study analyzes the relationship between human papillomavirus (HPV) infection, vaginal microecology, and cervical lesions to provide a basis for the prevention and treatment of cervical cancer (CC) in the Xinjiang region. Methods: Real‐time quantitative PCR was used for HPV genotyping and viral load. The Gram staining and dry biochemical enzyme kit were utilized to diagnose vaginal secretions. The χ2 test and Logistic regression analysis were used for statistical analysis. Results: The HPV infection rate among women in the Xinjiang region was 30.29%, of which the single HPV infection accounts for 77%. HPV16 and HPV52 were the main infection types. There was significant differences in the HPV infection rate and infection types among the Han, Uighur, Hui, and Kazakh ethnic groups. The viral load of HPV16 and HPV52 increases with the upgrade of cervical lesions. There were significant differences in vaginal microecology evaluation indicators H2O2, SNA, LE, GUS, trichomonas, clue cells, and lactobacilli among different ethnic groups. HPV negative patients with varying grades of cervical lesions exhibit a notable variance in H2O2 and LE, which is statistically significant. Single HPV infection and high viral load HPV significantly increase the risk of CC. Conclusions: This study indicates that HPV infection and vaginal microecology differ among ethnic groups, which have a strong correlation with the progression of CC, offering guidance on CC screening and interventions in the Xinjiang area. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Synthesis and structure–activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors

Author

Khanwelkar, Rahul R., Chen, Grace Shiahuy, Wang, Hsiao-Chun, Yu, Chao-Wu, Huang, Chiung-Hua, Lee, On, Chen, Chih-Hung, Hwang, Chrong-Shiong, Ko, Ching-Huai, Chou, Nien-Tzu, Lin, Mai-Wei, Wang, Ling-mei, Chen, Yen-Chun, Hseu, Tzong-Hsiung, Chang, Chia-Ni, Hsu, Hui-Chun, Lin, Hui-Chi, Shih, Ying-Chu, Chou, Shuen-Hsiang, Tseng, Hsiang-Wen, Liu, Chih-Peng, Tu, Chia-Mu, Hu, Tsan-Lin, Tsai, Yuan-Jang, and Chern, Ji-Wang

Published
2010
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37. Efficacy and Mechanism of Moxibustion Treatment on Mild Cognitive Impairment Patients: An fMRI Study Using ALFF.

Author

Lai, Ziyan, Zhang, Qingping, Liang, Lingyan, Wei, Yichen, Duan, Gaoxiong, Mai, Wei, Zhao, Lihua, Liu, Peng, and Deng, Demao

Subjects
MILD cognitive impairment, TEMPORAL lobe, MOXIBUSTION, PREFRONTAL cortex, DEFAULT mode network
Abstract

Background: Mild Cognitive Impairment (MCI), as a high risk of Alzheimer's disease (AD), represents a state of cognitive function between normal aging and dementia. Moxibustion may effectively delay the progression of AD, while there is a lack of studies on the treatments in MCI. This study aimed to evaluate the effect of moxibustion treatment revealed by the amplitude of low-frequency fluctuation (ALFF) in MCI. Method: We enrolled 30 MCI patients and 30 matched healthy controls (HCs) in this study. We used ALFF to compare the difference between MCI and HCs at baseline and the regulation of spontaneous neural activity in MCI patients by moxibustion. The Mini-Mental State Examination and Montreal Cognitive Assessment scores were used to evaluate cognitive function. Results: Compared with HCs, the ALFF values significantly decreased in the right temporal poles: middle temporal gyrus (TPOmid), right inferior temporal gyrus, left middle cingulate gyrus, and increased in the left hippocampus, left middle temporal gyrus, right lingual gyrus, and right middle occipital gyrus in MCI patients. After moxibustion treatment, the ALFF values notably increased in the left precuneus, left thalamus, right temporal poles: middle temporal gyrus, right middle frontal gyrus, right inferior temporal gyrus, right putamen, right hippocampus, and right fusiform gyrus, while decreased in the bilateral lingual gyrus in MCI patients. The Mini-Mental State Examination and Montreal Cognitive Assessment scores increased after moxibustion treatment, and the increase in Mini-Mental State Examination score was positively correlated with the increase of ALFF value in the right TPOmid, the right insula, and the left superior temporal gyrus. Conclusion: Moxibustion treatment might improve the cognitive function of MCI patients by modulating the brain activities within the default mode network, visual network, and subcortical network with a trend of increased ALFF values and functional asymmetry of the hippocampus. These results indicate that moxibustion holds great potential in the treatment of MCI. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Propensity score–matched comparison between totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction and conventional laparoscopic surgery with mini-laparotomy in the treatment of ascending colon cancer...

Author

Kong, Fan-Biao, Deng, Qiao-Ming, Deng, Hong-Qiang, Li, Lei, Dong, Chen-Cheng, He, Chun-Gang, Mai, Wei, Wang, Xiao-Tong, Xu, Sheng, and Pang, Li-Ming

Abstract

Now that the debate about the safety and effectiveness of laparoscopic versus open surgery is over, attention has turned to innovations that can verify whether minimizing the impact of laparoscopy on the abdominal wall can further reduce pain, improve patient comfort, lead to superior cosmesis, and reduce morbidity. The aim of this study was to further explore the application value of totally laparoscopic right hemicolectomy with transcolonic natural orifice specimen extraction (NOSE) and to evaluate the short-term efficacy of transcolonic NOSE surgery for resecting specimens of ascending colon cancer. From January 2016 to May 2017, a retrospective study was conducted in Guangxi. Propensity score matching was used to minimize the bias from nonrandomized treatment assignment. Patients were followed up through May 2020. Forty-nine patients underwent totally laparoscopic right hemicolectomy with transcolonic NOSE and 116 patients laparoscopic right hemicolectomy with mini-laparotomy (ML) procedures at our institution. After propensity score matching, each group included 45 patients, and all covariate imbalances were alleviated. The transcolonic NOSE group and the ML group did not differ significantly in terms of baseline clinical characteristics. The transcolonic NOSE group was associated with a shorter time to first flatus (NOSE vs ML: 1.8 ±.5 vs 3.2 ±.8, P =.032), a shorter length of hospital stay (11.3 ± 2.5 days vs 13.0 ± 3.1 days, P =.034), a shorter time to first liquid intake (2.6 ±.8 vs 3.8 ±.9, P =.068), less pain (1.8 ±.8 vs 4.2 ±.7, P =.013), less analgesia requirement (6 [13.3%] vs 21 [46.7%], P =.001), and lower C-reactive protein levels on postoperative day 1 (3.6 ± 1.7 vs 8.2 ± 2.2, P =.001) and postoperative day 3 (NOSE 2.4 ± 1.4 vs M: 4.6 ± 1.7 [ P =.013]) than the ML group. The median follow-up was 28.4 months (interquartile range, 18.0-36.0). The 3-year overall survival rates were similar between the transcolonic NOSE group and the ML group. In total, laparoscopic right hemicolectomy with transcolonic specimen extraction appears to be safe for selected patients with ascending colon cancer as a minimally invasive surgery. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2021
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