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262 results on '"Malafosse, Alain"'

8. Distinguishing the relevant features of frequent suicide attempters

Author

Lopez-Castroman, Jorge, Perez-Rodriguez, Maria de las Mercedes, Jaussent, Isabelle, Alegria, Analucia A., Artes-Rodriguez, Antonio, Freed, Peter, Guillaume, Sébastien, Jollant, Fabrice, Leiva-Murillo, Jose Miguel, Malafosse, Alain, Oquendo, Maria A., de Prado-Cumplido, Mario, Saiz-Ruiz, Jeronimo, Baca-Garcia, Enrique, and Courtet, Philippe

Published
2011
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13. Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattle

Author

Blümel Jürgen, Boichard Didier, Averdunk Gottfried, Reents Reinhard, Reinhardt Fritz, Brenig Bertram, Russ Ingolf, Förster Martin, Medjugorac Ivica, Erhardt Georg, Weimann Christina, Hiendleder Stefan, Schwerin Manfred, Brockmann Gudrun A, Kühn Christa, Looft Christian, Xu Ningying, Thomsen Hauke, Malafosse Alain, Levéziel Hubert, Grohs Cécile, Reinsch Norbert, Bennewitz Jörn, and Kalm Ernst

Subjects
QTL mapping, granddaughter design, combined analysis, QTL confirmation, dairy cattle, Animal culture, SF1-1100, Genetics, QH426-470
Abstract

Abstract A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on average 231 sires per grandsire. Genetic maps were calculated for 133 markers distributed over nine chromosomes. QTL analyses were performed separately for each design and each trait. The results revealed QTL for milk production on chromosome 14, for milk yield on chromosome 5, and for fat content on chromosome 19 in both the ADR- and the Inra-design (confirmed within this study). Some QTL could only be mapped in either the ADR- or in the Inra-design (not confirmed within this study). Additional QTL previously undetected in the single designs were mapped in the JOINT-design for fat yield (chromosome 19 and 26), protein yield (chromosome 26), protein content (chromosome 5), and somatic cell score (chromosome 2 and 19) with genomewide significance. This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs.

Published
2003
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15. Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter

Author

Ruef, Anne, Curtis, Logos, Moy, Guenael, Bessero, Severine, Ba, Maryse Badan, Lazeyras, Francois, Lovblad, Karl-Olof, Haller, Sven, Malafosse, Alain, Giannakopoulos, Panteleimon, and Merlo, Marco

Subjects
Brain -- Physiological aspects, Teenage boys -- Psychological aspects, Magnetic resonance imaging -- Usage, Psychoses -- Diagnosis -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. Methods: We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. Results: We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. Limitations: The modest sample size and the absence of women in our series could limit the impact of our results. Conclusion: Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis., Introduction Altered connectivity referring to abnormal functional integration between different brain regions has been considered a cardinal feature of schizophrenia. (1) In line with the idea of an early default [...]

Published
2012
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21. Haplotype study of West European and North African Unverricht-Lundborg chromosomes: evidence for a few founder mutations

Author

Moulard, Bruno, Genton, Pierre, Grid, Djamel, Jeanpierre, Marc, Ouazzani, Réda, Mrabet, Amel, Morris, Mike, LeGuern, Eric, Dravet, Charlotte, Mauguière, François, Utermann, Barbara, Baldy-Moulinier, Michel, Belaidi, Halima, Bertran, Françoise, Biraben, Arnaud, Ali Chérif, André, Chkili, Taieb, Crespel, Arielle, Darcel, Françoise, Dulac, Olivier, Geny, Christian, Humbert-Claude, Véronique, Kassiotis, Philippe, Buresi, Catherine, and Malafosse, Alain

Published
2002
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22. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32

Author

Steffens, Michael, Leu, Costin, Ruppert, Ann-Kathrin, Zara, Federico, Striano, Pasquale, Robbiano, Angela, Capovilla, Giuseppe, Tinuper, Paolo, Gambardella, Antonio, Bianchi, Amedeo, La Neve, Angela, Crichiutti, Giovanni, de Kovel, Carolien G.F., Kasteleijn-Nolst Trenité, Dorothée, de Haan, Gerrit-Jan, Lindhout, Dick, Gaus, Verena, Schmitz, Bettina, Janz, Dieter, Weber, Yvonne G., Becker, Felicitas, Lerche, Holger, Steinhoff, Bernhard J., Kleefu-Lie, Ailing A., Kunz, Wolfram S., Surges, Rainer, Elger, Christian E., Muhle, Hiltrud, von Spiczak, Sarah, Ostertag, Philipp, Helbig, Ingo, Stephani, Ulrich, Møller, Rikke S., Hjalgrim, Helle, Dibbens, Leanne M., Bellows, Susannah, Oliver, Karen, Mullen, Saul, Scheffer, Ingrid E., Berkovic, Samuel F., Everett, Kate V., Gardiner, Mark R., Marini, Carla, Guerrini, Renzo, Lehesjoki, Anna-Elina, Siren, Auli, Guipponi, Michel, Malafosse, Alain, Thomas, Pierre, Nabbout, Rima, Baulac, Stephanie, Leguern, Eric, Guerrero, Rosa, Serratosa, Jose M., Reif, Philipp S., Rosenow, Felix, Mörzinger, Martina, Feucht, Martha, Zimprich, Fritz, Kapser, Claudia, Schankin, Christoph J., Suls, Arvid, Smets, Katrin, De Jonghe, Peter, Jordanova, Albena, Caglayan, Hande, Yapici, Zuhal, Yalcin, Destina A., Baykan, Betul, Bebek, Nerses, Ozbek, Ugur, Gieger, Christian, Wichmann, Heinz-Erich, Balschun, Tobias, Ellinghaus, David, Franke, Andre, Meesters, Christian, Becker, Tim, Wienker, Thomas F., Hempelmann, Anne, Schulz, Herbert, Rüschendorf, Franz, Leber, Markus, Pauck, Steffen M., Trucks, Holger, Toliat, Mohammad R., Nürnberg, Peter, Avanzini, Giuliano, Koeleman, Bobby P.C., and Sander, Thomas

Published
2012
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32. Impaired Decision Making in Suicide Attempters

Author

Jollant, Fabrice, Bellivier, Frank, Leboyer, Marion, Astruc, Bernard, Torres, Stéphane, Verdier, Régis, Castelnau, Didier, Malafosse, Alain, and Courtet, Philippe

Published
2005

38. Association Between Bipolar Disorder and Monoamine Oxidase A Gene Polymorphisms: Results of a Multicenter Study

Author

Preisig, Martin, Bellivier, Frank, Fenton, Brenda T., Baud, Patrick, Berney, Alexandre, Courtet, Philippe, Hardy, Patrick, Golaz, Jean, Leboyer, Marion, Mallet, Jacques, Matthey, Marie-Louise, Mouthon, Dominique, Neidhart, Elisabeth, Nosten-Bertrand, Marika, Stadelmann-Dubuis, Emmanuelle, Guimon, Jose, Ferrero, François, Buresi, Catherine, and Malafosse, Alain

Published
2000

43. Collecting Saliva by Mail for Genetic and Cotinine Analyses in Participants Recruited through the Internet

Author

Etter, Jean-François, Neidhart, Elisabeth, Bertrand, Sonia, Malafosse, Alain, and Bertrand, Daniel

Abstract

The authors assessed whether collection by mail of saliva and buccal cells for genetic analysis was feasible in participants recruited through the Internet. In 2003, 14,773 visitors of a smoking cessation website were invited by e-mail to take part in the study. Salivettes (plastic vials containing a cotton roll) were mailed to participants, for collection of saliva and buccal cells. Because of limited resources, the authors stopped recruitment when 392 participants (3% of 14,733) were registered. They received 315 saliva samples back (80% of 392). Salivary cotinine was analyzed in 145 daily smokers. Cotinine concentration could be assessed in 141 samples (97%) (range 0.7-899ng/ml, median 260ng/ml). DNA extraction was achieved in all the 285 samples in which it was attempted. Quality of DNA was assessed by optical density measurements and by polymerase chain reaction amplification of a gene coding for the α-4 nicotinic receptor, with the detection of a known polymorphism. Successful results were obtained in 235 samples (82% of 285). Thus collecting saliva by mail for cotinine and DNA analysis in participants recruited through the internet produced samples of good quality at a reasonable cost. This approach should be valuable for genetic epidemiology and pharmacogenetic research

Published
2018

45. Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattle

Author

Bennewitz, Jörn, Reinsch, Norbert, Grohs, Cécile, Levéziel, Hubert, Malafosse, Alain, Thomsen, Hauke, Xu, Ningying, Looft, Christian, Kühn, Christa, Brockmann, Gudrun A, Schwerin, Manfred, Weimann, Christina, Hiendleder, Stefan, Erhardt, Georg, Medjugorac, Ivica, Russ, Ingolf, Förster, Martin, Brenig, Bertram, Reinhardt, Fritz, Reents, Reinhard, Averdunk, Gottfried, Blümel, Jürgen, Boichard, Didier, and Kalm, Ernst

Published
2003
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48. Genetic predictors of response to serotonergic and noradrenergic antidepressants in major depressive disorder: a genome-wide analysis of individual-level data and a meta-analysis

Author

Tansey, Katherine E., Guipponi, Michel, Perroud, Nader, Bondolfi, Guido, Domenici, Enrico, Evans, David, Hall, Stephanie K., Hauser, Joanna, Henigsberg, Neven, Hu, Xiaolan, Jerman, Borut, Maier, Wolfgang, Mors, Ole, O'Donovan, Michael, Peters, Tim J., Placentino, Anna, Rietschel, Marcella, Souery, Daniel, Aitchison, Katherine J., Craig, Ian, Farmer, Anne, Wendland, Jens R., Malafosse, Alain, Holmans, Peter, Lewis, Glyn, Lewis, Cathryn M., Stensbol, Tine Bryan, Kapur, Shitij, McGuffin, Peter, and Uher, Rudolf

Subjects
Meta-analysis -- Research, Major depressive disorder -- Physiological aspects -- Genetic aspects -- Development and progression, Genomics -- Research, Antidepressants -- Physiological aspects -- Genetic aspects -- Health aspects, Biological sciences
Abstract

Background: it has been suggested that outcomes of antidepressant treatment for major depressive disorder could be significantly improved if treatment choice is informed by genetic data. This study aims to test the hypothesis that common genetic variants can predict response to antidepressants in a clinically meaningful way. Methods and Findings: The NEWMEDS consortium, an academia-industry partnership, assembled a database of over 2,000 European-ancestry individuals with major depressive disorder, prospectively measured treatment outcomes with serotonin reuptake inhibiting or noradrenaline reuptake inhibiting antidepressants and available genetic samples from five studies (three randomized controlled trials, one part-randomized controlled trial, and one treatment cohort study). After quality control, a dataset of 1,790 individuals with high-quality genome-wide genotyping provided adequate power to test the hypotheses that antidepressant response or a clinically significant differential response to the two classes of antidepressants could be predicted from a single common genetic polymorphism. None of the more than half million genetic markers significantly predicted response to antidepressants overall, serotonin reuptake inhibitors, or noradrenaline reuptake inhibitors, or differential response to the two types of antidepressants (genome-wide significance p < 5 x [10.sup.- 8]). No biological pathways were significantly overrepresented in the results. No significant associations (genome-wide significance p < 5 x [10.sup.-8]) were detected in a meta-analysis of NEWMEDS and another large sample (STAR * D), with 2,897 individuals in total. Polygenic scoring found no convergence among multiple associations in NEWMEDS and STAR * D. Conclusions: No single common genetic variant was associated with antidepressant response at a clinically relevant level in a European-ancestry cohort. Effects specific to particular antidepressant drugs could not be investigated in the current study. Please see later in the article for the Editors' Summary., Introduction Major depressive disorder (MDD) is a disabling illness, affecting a high proportion of individuals at some point in their life [1]. Prescription of antidepressants is the most common initial [...]

Published
2012
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49. HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters

Author

Guillaume, Sebastien, Perroud, Nader, Jollant, Fabrice, Jaussent, Isabelle, Olié, Emilie, Malafosse, Alain, Courtet, Philippe, Urgence et post-urgence psychiatrique, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de Psychiatrie, Geneva University Hospital (HUG)-Hôpital Belle-Idée, McGill Group for Suicide Studies, McGill University = Université McGill [Montréal, Canada]-Douglas Mental Health University Institute, Department of Medical Genetics and Laboratory, Geneva University Hospital (HUG), This study received financial support from CHU Montpellier (PHRC UF 7653), Agence Nationale de la Recherche (ANR NEURO 2007 'GENESIS) and by the Swiss National Fund (Grants 320030-112084)., and Guillaume, Sebastien

Subjects
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Gene Environment Interaction, Stress, Attempted suicide, Child abuse, Decision-making
Abstract

International audience; Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the effect of childhood trauma and its interaction with HPA-axis related genes on decision-making abilities in adulthood among a sample of suicide attempters. The Iowa Gambling Task (IGT) was used to assess decision-making in 218 patients with a history of suicide attempt. Participant fulfilled the Childhood Trauma Questionnaire to report traumatic childhood experiences. Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes. Patients with a history of sexual abuse had significantly lower IGT scores than non-sexually abused individuals. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence IGT performance. In conclusion, childhood sexual abuse and emotional neglect may have long-term effects on decision-making through an interaction with key HPA axis genes. Even if these results need to be replicated in other sample, impaired decision-making may thus be the dimension through which child maltreatment, in interaction with HPA axis related genes, may have a sustained negative impact on adult mental health.

Published
2012

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