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3. Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation

Author

Ajaimy, Maria, Al Azzi, Yorg, Annambhotla, Pallavi, Backenson, Bryon, Belden, Katherine, Colovai, Adriana, Coppock, Dagan, Du, Lydia, Estetter, Lindsey, Le, Marie, Martines, Roosecelis B., Pettengill, Matthew, Szymczak, Wendy, Vareechon, Chairut, Gould, Carolyn V, Free, Rebecca J, Bhatnagar, Julu, Soto, Raymond A, Royer, Tricia L, Maley, Warren R, Moss, Sean, Berk, Matthew A, Craig-Shapiro, Rebecca, Kodiyanplakkal, Rosy Priya L, Westblade, Lars F, Muthukumar, Thangamani, Puius, Yoram A, Raina, Amresh, Hadi, Azam, Gyure, Kymberly A, Trief, Danielle, Pereira, Marcus, Kuehnert, Matthew J, Ballen, Vennus, Kessler, Debra A, Dailey, Kimberly, Omura, Charles, Doan, Thuy, Miller, Steve, Wilson, Michael R, Lehman, Jennifer A, Ritter, Jana M, Lee, Elizabeth, Silva-Flannery, Luciana, Reagan-Steiner, Sarah, Velez, Jason O, Laven, Janeen J, Fitzpatrick, Kelly A, Panella, Amanda, Davis, Emily H, Hughes, Holly R, Brault, Aaron C, St George, Kirsten, Dean, Amy B, Ackelsberg, Joel, Basavaraju, Sridhar V, Chiu, Charles Y, and Staples, J Erin

Published
2023
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5. Striking Cholestatic Giant Cell Hepatitis Resulting in Fulminant Liver Failure After Garcinia Cambogia Use.

Author

Flerova, Elizaveta, Ambilil, Manju, Civan, Jesse M., Sass, David A., Maley, Warren R., Pulinthanathu, Rajiv, and Huang, Jialing

Subjects
LIVER failure, GARCINIA, HEPATOLENTICULAR degeneration, HEPATITIS, AUTOIMMUNE hepatitis, BREAST, LIVER regeneration
Abstract

Garcinia cambogia, a weight control herbal, can cause mild liver toxicity with nonspecific histologic changes. Herein, we reported a case of herbal-induced fulminant cholestatic giant cell hepatitis due to garcinia cambogia use. A 65-year-old woman with breast cancer treated 18 years earlier was admitted for obstructive jaundice for 2 weeks. She started using garcinia cambogia 3 months ago for weight loss. Physical exam showed scleral icterus. Serum studies excluded Wilson's disease, systemic infection including COVID-19 (coronavirus disease 2019), autoimmune hepatitis, and metabolic or toxicologic causes. An urgent liver biopsy showed severe giant cell hepatitis in absence of HSV-1/2, cytomegalovirus, HBsAg and HBcAg (immunostain), and EBV (in situ hybridization). Despite supportive therapy, the patient developed grade 2–3 hepatic encephalopathy and necessitated liver transplant. The explanted liver was markedly atrophy, in which the most striking histologic finding was diffuse distribution of multinucleated giant hepatocytes with syncytial pattern in a background of extensive zone-1 accentuated, geographic, hemorrhagic, confluent hepatocytic necrosis, along with remarkable hepatocytic and canalicular cholestasis. Marked hepatocellular and sinusoidal iron orverload present. The patient recovered uneventfully. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Clinical results from transplanting incompatible live kidney donor/recipient pairs using kidney paired donation

Author

Montgomery, Robert A., Zachary, Andrea A., Ratner, Lloyd E., Segev, Dorry L., Hiller, Janet M., Houp, Julie, Kavoussi, Louis, Cooper, Mathew, Jarrett, Thomas, Burdick, James, Maley, Warren R., Melancon, J. Keith, Kozlowski, Tomasz, Simpkins, Christopher E., Phillips, Melissa, Desai, Amol, Collins, Vanessa, Reeb, Brigitte, Kraus, Edward, Warren, Daniel S., Leffell, Mary S., and Rabb, Hamid

Subjects
Kidney diseases -- Diagnosis, Kidney diseases -- Care and treatment, Kidney diseases -- Research, Liver -- Transplantation, Liver -- Research
Abstract

The feasibility and effectiveness of kidney paired donation (KPD) for the management of patients with incompatible donors were determined. Evidence suggests that recipients with incompatible live donors, even those with rare blood type combinations, can receive transplants through KPD with graft survival rates equivalent to directed, compatible liver donor transplants.

Published
2005

22. Operating Room Briefings: Working on the Same Page

Author

Makary, Martin A., Holzmueller, Christine G., Thompson, David A., Rowen, Lisa, Heitmiller, Eugenie S., Maley, Warren R., Martinez, Elizabeth A., Black, James H., Freischlag, Julie A., Stegner, Katherine, Ulatowski, John A., and Pronovost, Peter J.

Published
2006
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25. Acute Liver Failure Requiring Liver Transplantation due to Acute Hepatitis A Virus Infection.

Author

Xie, Chencheng, Fenkel, Jonathan M., Halegoua-DeMarzio, Dina L., Civan, Jesse M., Tholey, Danielle M., Herrine, Steven K., Thapar, Manish, Ambelil, Manju, Arastu, Sanaa, Frank, Adam M., Shah, Ashesh P., Glorioso, Jamie M., Ramirez, Carlo G., Bodzin, Adam S., Maley, Warren R., and Sass, David A.

Subjects
LIVER failure, VIRAL hepatitis, HEPATITIS viruses, VIRUS diseases, LIVER transplantation, PULMONARY aspergillosis, CHRONIC active hepatitis
Abstract

Introduction. Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV. Methods. Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between August 2019 and October 2019 at Thomas Jefferson University Hospital. Results. All four patients presented with acute hepatocellular jaundice and had a positive HAV IgM, and all other causes of ALF were excluded. All four cases met the American Association for the Study of Liver Diseases (AASLD) criteria for ALF. Three of the four cases met King's College Criteria of poor prognosis for nonacetaminophen-induced ALF. All four patients underwent successful LT and were discharged six to twelve days postoperatively. One patient died of disseminated Aspergillus infection five months after LT, while the others have had excellent clinical outcomes shown by one-year follow-ups. All four explants had remarkably similar histological changes, revealing acute hepatitis with massive necrosis accompanied by a prominent lymphoplasmacytic inflammatory infiltrate and bile ductular proliferation. Conclusion. Although rare, patients presenting with acute HAV need close monitoring as they may rapidly progress to ALF. Early referral to a transplant center afforded timely access to LT and yielded overall good one-year survival. Widespread HAV vaccination for high-risk individuals is an essential strategy for preventing disease and curbing such future outbreaks. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Simultaneous liver kidney allocation policy and the Safety Net: an early examination of utilization and outcomes in the United States.

Author

Altshuler, Peter J., Shah, Ashesh P., Frank, Adam M., Glorioso, Jaime, Dang, Hien, Shaheen, Osama, Patel, Keyur, Ramirez, Carlo B., Maley, Warren R., and Bodzin, Adam S.

Subjects
KIDNEYS, KIDNEY transplantation, LIVER, LIVER transplantation, GRAFT survival
Abstract

Summary: Rates of simultaneous liver kidney (SLK) transplantation in the United States have progressively risen. On 8/10/17, the Organ Procurement and Transplantation Network implemented a policy defining criteria for SLK, with a "Safety Net" to prioritize kidney allocation to liver recipients with ongoing renal failure. We performed a retrospective review of the United Network for Organ Sharing (UNOS) database to evaluate policy impact on SLK, kidney after liver (KAL) and kidney transplant alone (KTA). Rates and outcomes of SLK and KAL transplants were compared, as was utilization of high‐quality kidney allografts with Kidney Donor Profile Indices (KDPI) <35%. Here, SLK transplants comprised 9.0% and 4.5% of total postpolicy liver and kidney transplants compared to 10.2% and 5.5% prior. Policy enactment did not affect 1‐year graft or patient survival for SLK and KAL populations. Less postpolicy SLK transplants utilized high‐quality kidney allografts; in all transplant settings, outcomes using high‐quality grafts remained stable. These findings suggest that policy implementation has reduced kidney allograft use in SLK transplantation, although both SLK and KAL rates have recently increased. Despite decreased high‐quality kidney allograft use, SLK and KAL outcomes have remained stable. Additional studies and long‐term follow‐up will ensure optimal organ access and sharing. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Contributors

Author

Abbas, Abbas El-Sayed, Abdullah, Fizan, Abood, Gerard J., Abularrage, Christopher J., AbuRahma, Ali F., AbuRahma, Zachary T., Adams, David B., Afaneh, Cheguevara, Agopian, Vatche G., Ahmed, Ali Karim, Ahrendt, Steven A., Ahuja, Nita, Ahuja, Nitin K., Alarcon, Louis H., Albuja-Cruz, Maria B., Althans, Alison R., Althumairi, Azah A., Alverdy, John C., Anandam, Joselin L., Androes, Mark P., Ansari, Amir Mehdi, Arnaoutakis, Dean J., Arnold, Meghan A., Atallah, Chady I., Auchincloss, Hugh G., Axtell, Andrea L., Ayoung-Chee, Patricia, Azad, Nilofer, Azar, Faris K., Azoury, Saïd C., Bailey, Christina E., Bailey, Ian B., Balch, Charles M., Balch, Glen C., Ball, Chad G., Bandyk, Dennis F., Barie, Philip S., Bates, Andrew, Battafarano, Richard, Beard, Kristin Wilson, Beaulieu, Peter, Beaulieu, Robert J., Bedine, Marshall S., Bedzra, Edo K.S., Beekmann, Susan E., Behrns, Kevin E., Bellistri, John-Paul, Bello, Ricardo J., Benrashid, Ehsan, Berger, David L., Berian, Julia R., Bilimoria, Karl Y., Bjurlin, Marc A., Black, James H., III, Bland, Kirby, Blas, Joseph-Vincent V., Bleier, Joshua I., Blumetti, Jennifer, Bodzin, Adam, Boone, Brian A., Born, Louis J., Boughey, Judy C., Boyett, Daniel, Brady, Justin T., Brennan, Murray F., Brenner, Bruce M., Britt, L.D., Brock, Malcolm, Brownie, Evan R., Brunicardi, F. Charles, Brunt, L. Michael, Burgess, Jessica, Burke, Mark S., Burlew, Clay Cothren, Bush, Errol, Busuttil, Ronald W., Caffrey, Julie, Callender, Glenda G., Cambria, Richard P., Cameron, Andrew M., Camp, Melissa S., Campbell, Kurtis A., Carr, Shamus R., Cavnar, Michael J., Chaikof, Elliot L., Champagne, Bradley J., Haito Chavez, Yamile, Chen, Herbert, Chen, Yen-I, Chi, Albert, Chockalingam, Arun, Cholewczynski, Walter, Choti, Michael A., Christakis, Ioannis A., Christante, Dara H., Cintron, Jose R., Claridge, Jeffrey A., Clark, Damon, Cody, Hiram S., III, Cogbill, Thomas H., Cohan, Jessica N., Cooney, Damon S., Cooper, Zara, Corey, Britney L., Coté, Gregory A., Cox, Morgan L., Crawford, Todd C., Croce, Martin A., Cryer, H. Gill, Cuff, Robert F., Cunningham, Steven C., Dackiw, Alan P.B., Dagher, Nabil N., Dart, Benjamin W., IV, Datta, Jashodeep, Dattilo, Jeffery B., Davis, Bradley, Davis, Donald, Delaney, Conor P., Delman, Keith, DeMatteo, Ronald P., DeMeester, Steven R., DeMeester, Tom R., Dempsey, Daniel T., DiBrito, Sandra R., Dimick, Justin B., Dimou, Francesca M., Dixon, Peter, Donahue, James, Duh, Quan-Yang, Duncan, Mark, Durand, Christine M., Durazo, Francisco A., Earle, David, Edil, Barish H., Efron, David T., Efron, Jonathan E., Ehlert, Bryan A., Eisele, David W., Elliott, David, English, Sean J., Eriksen, Calvin, Eslami, Mohammad H., Esquivel, Jesus, Euhus, David M., Eun, John C., Evans, Douglas B., Evans, Heather L., Fabian, Timothy C., Fabri, Peter J., Fabrizio, Anne C., Fagenholz, Peter J., Fakhry, Carole, Fang, Sandy H., Fantus, Richard J., Feldman, Liane S., Feliciano, David V., Feller-Kopman, David, Ferrada, Paula A., Ferrari, Linda, Ferson, Peter F., Fichera, Alessandro, Fiedler, Amy G., Finnerty, Brendan M., Fischer, Josef E., Fisichella, P. Marco, Fleshman, James W., Fong, Zhi Ven, Forthman, Christopher L., Francone, Todd D., Frankel, Heidi, Franklin, David P., Gahtan, Vivian, Galandiuk, Susan, Gallagher, James J., Gangi, Alexandra, Garvey, Erin M., Gearhart, Susan L., Geiger, Timothy M., Gemignani, Mary L., Georgiades, Christos, Georgoff, Patrick E., Geschwind, Jean-Francois H., Gestring, Mark L., Ghaderi, Iman, Giglia, Joseph S., Giuliano, Armando E., Glebova, Natalia O., Gleisner, Ana L., Goldin, Steven B., Goldstein, Seth, Goodenough, Christopher J., Goussous, Naeem, Graham, Jay A., Grandhi, Miral Sadaria, Grant, Clive S., Gray, Richard J., Gregg, Shea C., Gribovskaja-Rupp, Irena, Griffen, Margaret M., Griffin, James F., Grimm, Joshua C., Guillem, Jose G., Ha, Jinny, Habib, Fahim, Hackam, David, Hamilton, James P., Harken, Alden H., Harmon, John W., Hartney, Mark, Hassoun, Heitham T., Haugen, Christine E., Haut, Elliott R., He, Jin, Hébert-Blouin, Marie-Noëlle, Helmink, Beth A., Henderson, David K., Heniford, B. Todd, Herline, Alan, Herman, Joseph M., Hicks, Caitlin W., Hines, O. Joe, Hogg, Melissa E., Holly, Brian P., Hong, Kelvin, Howley, Isaac W., Hoyler, Margo, Hughes, Kevin S., Hughes, Steven J., Hungness, Eric S., Hunter, John G., Hutcheon, David F., Hutter, Matthew M., Hyman, Neil H., Ignacio, Elizabeth Ann, Ijaz, Nadia, Jacobs, Lisa K., Jakhete, Neha, Jenkins, Donald H., Jensen, Robert T., Jha, Reena, Jobe, Blair A., Johnson, Eric K., Johnson, Lynt B., Joseph, Bellal, Jurkovich, Gregory J., Kadera, Brian, Kahan, Stacie A., Kaldas, Fady M., Kalloo, Anthony N., Kao, Lillian S., Kapadia, Muneera R., Kaplan, Lewis J., Kaups, Krista L., Kebebew, Electron, Kelley, Scott R., Kelly, Ronan, Kent, K. Craig, Khashab, Mouen A., Khouri, Nagi, Kim, Amy K., Kim, Karen M., Kiraly, Laszlo, Kirane, Amanda, Kleiman, David A., Klimberg, V. Suzanne, Klinger, Kerry, Knab, L. Mark, Kowdley, Gopal C., Kozarek, Richard A., Krampitz, Geoffrey W., Krezalek, Monika A., Krontiras, Helen, Krpata, David M., Kugler, Nathan, Kulkarni, Swati A., Kumbhari, Vivek, Kuwada, Timothy, Kuwayama, David, LaFace, Angela, LaMuraglia, Glenn M., Lancaster, R. Todd, Landreneau, Rodney J., Langan, Russell C., Lange, Julie R., Lay, Frank, Ledgerwood, Anna M., Lee, Andrew J., Leeper, W. Robert, Lehenbauer, David, Liddell, Robert P., Lidor, Anne, Lightner, Amy L., Lillemoe, Keith D., Lilley, Elizabeth J., Liu, Jieqiong, Liu, Yuk Ming, Loiacono, Laurie A., Lombardo, KMarie Reid, Lonze, Bonnie E., Loomis, Erica A., Lou, Irene, Lucas, Charles E., Luketich, James D., Lum, Ying Wei, Lunsford, Keri E., Lynch, Kevin, MacGillivray, Thomas E., Mackersie, Robert C., Magnuson, Thomas, Maier, Ronald V., Makary, Martin A., Makris, Konstantinos, Malangoni, Mark A., Malas, Mahmoud B., Maley, Warren R., Manson, Paul N., Mansour, M. Ashraf, Marmor, Rebecca A., Marti, Guy P., Martin, Laura, Martindale, Robert G., Mason, Leonard L., III, Mathew, Sarah Jean, Mathis, Kellie L., Mathisen, Douglas J., Matsangos, Aerielle E., Matthews, Jeffrey B., Maxwell, Robert, McCartan, Damian, McFadden, David W., McHenry, Christopher R., McIntyre, Robert C., Jr., McQuay, Nathaniel, Jr., Melancon, Joseph K., Menaker, Jay, Meneshian, Avedis, Menon, Raman, Meyer, Anthony A., Meyers, William C., Michelassi, Fabrizio, Mier, Fernando, Milner, Stephen M., Miraflor, Emily, Mitchem, Jonathan B., Moalem, Jacob, Modi, Rushabh, Molena, Daniela, Moore, Forrest O'dell, Moore, Scott M., Morse, Christopher R., Mullinax, John, Mureebe, Leila, Murphy, Adrian, Muscarella, Peter, II, Mustain, W. Conan, Myzak, Melinda Cherie, Napolitano, Lena M., Nealon, William Hawe, Netz, Uri, Neumayer, Leigh, Newman, Lisa, Ng, Christopher, Ng, Gladys, Nguyen, Hien T., Nilubol, Naris, Norton, Jeffrey A., O’Connell, Kathleen M., O’Keeffe, Terence, Okolo, Patrick I., III, O’Mara, Charles S., Osgood, Greg, Osgood, Michael J., Pachter, H. Leon, Paniccia, Alessandro, Pappas, Sam G., Pappas, Theodore N., Park, Pauline K., Parker, Catherine, Parthasarathy, Madhumithaa, Pasternak, Jesse D., Patel, Dhaval, Patel, Jayshil J., Patel, Madhukar S., Patel, Nishant, Patel, Shirali T., Paul, Jasmeet Singh, Pawlik, Timothy M., Pegoli, Walter, Jr., Peitzman, Andrew B., Pennathur, Arjun, Perler, Bruce A., Perone, Jennifer A., Perrier, Nancy D., Peters, Walter R., Phelan, Patrick J., Philosophe, Benjamin, Pieracci, Fredric M., Pitt, Henry A., Plichta, Jennifer K., Ponsky, Jeffrey L., Poor, Alexander E., Poruk, Katherine E., Prakash, Priya, Prescott, Jason D., Price, Leigh Ann, Pryor, Aurora D., Puig, Carlos A., Raeburn, Christopher D., Raigani, Siavash, Ramsay, Philip T., Rashidi, Laila, Rattner, David, Reid, Trista, Reifsnyder, Thomas, Reynolds, Jessica K., Riall, Taylor S., Rivere, Amy, Rizvi, Addi Z., Robinson, Bryce R.H., Robinson, Thomas N., Rodriguez, Aurelio, Rodriguez, John H., Rosemurgy, Alexander S., II, Rosen, Michael J., Rosso, Kelly J., Rosson, Gedge D., Rotondo, Michael F., Rueda, Mario, Ryan, Mark L., Ryer, Evan J., Sacks, Justin M., Salles, Arghavan, Santos, Byron F., Sarr, Michael G., Saur, Nicole M., Scalea, Thomas M., Schaetzel, Shaina, Schaheen, Lara, Schimpf, Dennis K., Schlachter, Todd, Schulick, Richard D., Schwartz, Diane A., Schweitzer, Michael A., Sciortino, Christopher, Semaan, Roy, Senagore, Anthony J., Shah, Amar, Shakoor, Aqsa, Shapiro, A.M. James, Shaw, Palma, Shepard, Alexander D., Sheridan, Robert, Shermak, Michele A., Sicklick, Jason K., Silverstein, Melvin, Simmons, Justin M., Sims, Carrie, Sise, Michael, Smith, Barbara L., Soares, Kevin C., Sonntag, David, Sosa, Julie A., Spain, David A., Spinner, Robert J., Stahl, Richard D., Stanley, Gregory A., Stanley, J. Daniel, Steele, Scott R., Stefanidis, Dimitrios, Stein, Sharon, Steurer, Marc P., Stevens, Kent A., Stone, Patrick A., Stonemetz, Jerry, Strasberg, Steven M., Streiff, Michael B., Stulberg, Jonah J., Sugimoto, Motokazu, Susarla, Srinivas M., Swann, Jacob, Swanstrom, Lee L., Talamini, Mark A., Tam, Vernissia, Tanabe, Kenneth K., Tarpley, John L., Taylor, Spence M., Teicher, Erik J., Teitelbaum, Ezra N., Thompson, Jon S., Thorsen, Amy J., Tieu, Alan H., Traverso, L. William, Tsai, Susan, Tsitskari, Maria, Tufaro, Anthony P., Turley, Ryan S., Udelsman, Robert, Umphrey, Heidi, Urist, Marshall, Varma, Madhulika G., Velanovich, Vic, Velmahos, George, Villano, Anthony M., Vito, Courtney A., Vollmer, Charles M., Jr., Vyas, Nilesh A., Wall, Matthew J., Jr., Waltz, Paul, Wang, Tracy S., Watkins, Michael T., Watson, Ryan S., Weaver, M. Libby, Weaver, Mitchell R., Webb, Travis P., Weber, Cynthia E., Weiss, Eric G., Weiss, Matthew J., Werner, Nicole L., Wexner, Steven D., Whyte, Richard, Wick, Elizabeth C., Wiesel, Ory, Wilson, Alison M., Wilson, Jennifer L., Winner, Megan, Witkowski, Elan R., Witkowski, Piotr, Wolf, Joshua H., Wolfgang, Christopher L., Wood, Douglas E., Wright, Cameron D., Yeo, Charles J., Yeo, Heather, Yi, Jeniann, Youngwirth, Linda M., Zarnegar, Rasa, Zeh, Herbert J., III, Zeiger, Martha A., Zenilman, Michael E., Zhan, Luke X., Zosa, Brenda M., Zoumberos, Melissa Silva, Zuberi, Kashif A., Zureikat, Amer H., and Zyromski, Nicholas J.

Published
2017
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47. LAPAROSCOPIC LIVE DONOR NEPHRECTOMY.

Author

Ratner, Lloyd E., Montgomery, Robert A., Maley, Warren R., Cohen, Cynthia, Burdick, James, Chavin, Kenneth D., Kittur, Dilip S., Colombani, Paul, Klein, Andrew, Kraus, Edward S., and Kavoussi, Louis R.

Published
2000
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