16 results on '"Mannino, Elizabeth"'
Search Results
2. Coronary Artery Calcification and Risk of Cardiac Complication in Geriatric Trauma Population.
- Author
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King, Sarah A., Jenkins, Jacob D., Livesay, James, Ji-Ming Yune, Mannino, Elizabeth, Webb, Jason M., Hill, Haddon C., Baljepally, Raj, Daley, Brian J., and Smith, Lou M.
- Published
- 2024
- Full Text
- View/download PDF
3. The Predictive Value of Shock Index in Rural Trauma Triage, Morbidity, and Mortality.
- Author
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Landis, Ryan M., Mannino, Elizabeth A., Leonard, Matthew, Collins, Hannah, and Burns, James B.
- Subjects
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MEDICAL personnel , *MEDICAL triage , *EMERGENCY medical personnel , *PEARSON correlation (Statistics) , *TRAUMA surgery - Abstract
The article focuses on the utility of Shock Index (SI) in predicting morbidity and mortality in trauma patients transferred from critical access centers to rural level 1 trauma centers. Topics include the calculation and analysis of SI values in different patient cohorts, the correlation between SI and outcomes such as hospital length of stay and mortality, and the comparison of SI values at the transferring facility and upon arrival at the tertiary care facility.
- Published
- 2024
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4. Longitudinal Analysis of “Window Shade” Tympanoplasty Outcomes for Anterior Marginal Tympanic Membrane Perforations
- Author
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Bluher, Andrew E., Mannino, Elizabeth A., and Strasnick, Barry
- Published
- 2019
- Full Text
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5. Impact of Non-Automobile Rollover Accidents on Patient Outcomes at an Appalachian Level I Trauma Center.
- Author
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Mannino, Elizabeth A., Leonard, Matthew, and Burns, Bracken J.
- Subjects
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TRAUMA centers , *ROLLOVER vehicle accidents , *SPINAL injuries - Abstract
The objective of this study was to evaluate outcomes of patients involved in rollover accidents in non-automobile vehicles in a rural level I trauma center. This was a retrospective study including a total of 127 patients over 5 years who were admitted to our level I trauma center following rollover accidents in either of the following: ATV, lawnmower, or tractor. Patients were significantly older in the tractor and lawnmower rollover groups, and patients less than 65 years old were significantly more likely to sustain an injury in a rollover accident when compared to those greater than 65. Patients with extremity fractures secondary to tractor rollovers were more likely to be older, and patients who sustained spinal injuries secondary to tractor rollovers were more likely to be younger. Non-automobile rollovers have the potential to cause traumatic injuries; however, there does not appear to be 1 vehicle type that is more prone to injury. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
6. Surgical Repair of Idiopathic Mid-Forearm Radial Artery Aneurysm Using a Reversed Greater Saphenous Vein Interposition Graft.
- Author
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Mannino, Elizabeth A., Byrnes, Kari Anna, Smith, Lou M., and Hopkins, Steven P.
- Subjects
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RADIAL artery , *SAPHENOUS vein , *ANEURYSMS , *MEDICAL literature , *VASCULAR surgery , *BLOOD vessel prosthesis , *TRANSPOSITION of great vessels - Abstract
Idiopathic, non-traumatic, radial artery aneurysms are rare in medical literature. This report presents the case of a 56-year-old man who was incidentally found to have a 1.01 cm × 1.31 cm left radial artery aneurysm during a carpal tunnel workup. The patient had no other aneurysms, nor any known predisposing diseases that could explain his condition. We proceeded with surgical intervention to prevent future complications. We describe the use of a greater saphenous vein interposition graft for the repair of an idiopathic mid-forearm radial artery aneurysm. The patient had an uncomplicated recovery course following repair. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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7. First data from a parent‐reported registry of 81 individuals with Coffin–Siris syndrome: Natural history and management recommendations.
- Author
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Mannino, Elizabeth A., Miyawaki, Hanae, Santen, Gijs, and Schrier Vergano, Samantha A.
- Abstract
Coffin–Siris syndrome (CSS; MIM 135900) is a multisystem congenital anomaly syndrome caused by mutations in the genes in the Brg‐1 associated factors (BAF) complex. Classically, individuals with CSS have been described with hypo‐ or aplasia of the fifth digit nails or phalanges (hence the term "fifth digit syndrome"). Other physical features seen include growth restriction, coarse facial features, hypertrichosis or hirsutism, sparse scalp hair, dental anomalies, and other organ‐system abnormalities. Varying degrees of developmental and intellectual delay are universal. To date, approximately 200 individuals have been described in the literature. With the advent of large‐scale genetic testing such as whole‐exome sequencing is becoming more available, more individuals are being found to have mutations in this pathway, and the phenotypic spectrum appears to be broadening. We report here a large cohort of 81 individuals with the diagnosis of CSS from the first parent‐reported CSS/BAF complex registry in an effort to describe this variation among individuals, the natural history of the syndrome, and draw some gene–phenotype correlations. We propose that changes in the BAF complex may represent a spectrum of disorders, including both ARID1B‐related nonsyndromic intellectual disability (ARID1B‐ID) and CSS with classic physical features. In addition, we offer surveillance and management recommendations based on the medical issues encountered in this cohort to help guide physicians and patients' families. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
8. Congenital methemoglobinemia type II in a 5‐year‐old boy.
- Author
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Mannino, Elizabeth A., Pluim, Thomas, Wessler, Jacob, Cho, Megan T., Juusola, Jane, and Schrier Vergano, Samantha A.
- Subjects
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LEUKODYSTROPHY , *NEUROLOGICAL errors , *EPILEPSY , *RARE diseases - Abstract
Key Clinical Message: Congenital Methemoglobinemia is a rare neurologic condition which can mimic other diseases such as epilepsy syndromes and leukodystrophies. The responsible gene,
CYB5R3 , is not typically included on commonly order neurologic and epilepsy panels. We recommend that laboratories include this gene on these tests which often precede larger‐scale genetic studies. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
9. Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.
- Author
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Wu, Yaning, Gause, Maria, Xu, Dongbin, Misulovin, Ziva, Schaaf, Cheri A., Mosarla, Ramya C., Mannino, Elizabeth, Shannon, Megan, Jones, Emily, Shi, Mi, Chen, Wen-Feng, Katz, Olivia L., Sehgal, Amita, Jongens, Thomas A., Krantz, Ian D., and Dorsett, Dale
- Subjects
DROSOPHILA genetics ,GENETIC mutation ,INSECT growth ,INSECT memory ,LEARNING ,CIRCADIAN rhythms ,INSECTS - Abstract
Individuals with Cornelia de Lange Syndrome (CdLS) display diverse developmental deficits, including slow growth, multiple limb and organ abnormalities, and intellectual disabilities. Severely-affected individuals most often have dominant loss-of-function mutations in the Nipped-B-Like (NIPBL) gene, and milder cases often have missense or in-frame deletion mutations in genes encoding subunits of the cohesin complex. Cohesin mediates sister chromatid cohesion to facilitate accurate chromosome segregation, and NIPBL is required for cohesin to bind to chromosomes. Individuals with CdLS, however, do not display overt cohesion or segregation defects. Rather, studies in human cells and model organisms indicate that modest decreases in NIPBL and cohesin activity alter the transcription of many genes that regulate growth and development. Sister chromatid cohesion factors, including the Nipped-B ortholog of NIPBL, are also critical for gene expression and development in Drosophila melanogaster. Here we describe how a modest reduction in Nipped-B activity alters growth and neurological function in Drosophila. These studies reveal that Nipped-B heterozygous mutant Drosophila show reduced growth, learning, and memory, and altered circadian rhythms. Importantly, the growth deficits are not caused by changes in systemic growth controls, but reductions in cell number and size attributable in part to reduced expression of myc (diminutive) and other growth control genes. The learning, memory and circadian deficits are accompanied by morphological abnormalities in brain structure. These studies confirm that Drosophila Nipped-B mutants provide a useful model for understanding CdLS, and provide new insights into the origins of birth defects. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
10. A National Survey Assessing the Variability in the Management of Traumatic Cardiac Arrest.
- Author
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Roche, Keelin F., Quinn, Megan, Mannino, Elizabeth A., Ventura, Liane, Brown, Cecelia, Lawson, Christy M., and Burns, Bracken J.
- Subjects
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CARDIAC arrest , *ADVANCED cardiac life support , *INTERPERSONAL conflict , *STATISTICAL hypothesis testing , *CARDIAC resuscitation - Abstract
Background: Resuscitation of traumatic cardiac arrest (TCA) is variable, with approaches that overlap Advanced Trauma Life Support (ATLS) and Advanced Cardiac Life Support (ACLS) algorithms. There is no standard algorithm for TCA, with some withholding ACLS protocols given abysmal outcomes. This study aims to assess surgeon practices and attitudes toward resuscitation practices in TCA. Materials and Methods: A 16-question web-based survey was distributed to the membership of a national trauma association. Respondent demographics and management of TCA were analyzed. Chi-squared tests determined statistical significance. Open-ended responses were coded and analyzed inductively. Results: Two hundred and three surveys were completed. 73.4% of respondents reported utilizing ACLS, while 26.6% reported they never utilized ACLS. A statistically significant difference in the performance of ACLS was found based on number of years in practice (P =.025) and the state of practice (P =.006). There was no significant difference in self-reported survival rates or legal, ethical, or interpersonal conflicts. Qualitative data highlighted themes of interpersonal conflict and futility. Discussion: This study shows that one-quarter of respondents never utilize ACLS in TCA. Of those that utilize ACLS, there was variability in the technique, indication, and duration of resuscitation. Despite significant variability in technique, there appears to be similar survival rates and incidence of conflict. The association between years in practice and ACLS use suggests this may represent an emerging change in practice. The low response rate limits generalizability; however, there is significant variability in practice, highlighting a need for evidence-based guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
11. Directly observed therapy for tuberculosis
- Author
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Mannino, Elizabeth and Hill, Linda
- Subjects
Patient compliance -- Research ,Tuberculosis -- Care and treatment -- Research ,Health ,Care and treatment ,Research - Abstract
From 1985 to 1992, there was an increase in the number of active tuberculosis (TB) cases, from 22,000 to 26,673, reversing a downward trend of three decades. This resurgence in [...]
- Published
- 1996
12. Application of the Geriatric Trauma Outcome Score in a Rural Setting.
- Author
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Archer, Allen D., Hahamyan, Henrik A., White-Archer, Melissa L., Mannino, Elizabeth A., Roche, Keelin F., and Burns, J. Bracken
- Subjects
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ERYTHROCYTES , *TRAUMA registries , *RURAL population , *TRAUMA surgery , *TRAUMA centers - Abstract
Objective: To retrospectively apply the Geriatric Trauma Outcome (GTO) score to the patient population of a rural South Central Appalachian level 1 trauma center and identify the potential utility of the GTO score in guiding goals of care discussions. Methods: Trauma registry data was extracted for 5,627 patients aged 65+ from 2017 to 2021. GTO score was calculated for each patient. Descriptive statistics were calculated for age, Injury Severity Score (ISS), GTO score, receipt of red blood cells, discharge status, and code status. A simple logistic regression model was used to determine the relationship between GTO score and discharge status. The probability of mortality was then calculated using GTO score, and the distribution of code status among patients with ≤50, 51-75%, and >75% probability of mortality was examined. Results: For every 10-point increase in GTO score, odds of mortality increased by 79% (OR = 1.79; P <.001). Patients had an estimated 50% probability of mortality with a GTO score of 156, 75% with 174, and 99% with a score of 234, respectively. Seventeen patients had a GTO score associated with >75% probability of mortality. Of those 17 patients, four retained a full code status. Conclusions: Our analysis demonstrates that the GTO score is a validated measure in a rural setting and can be an easily calculated metric to help determine a geriatric patient's probability of mortality following a trauma. The results of our study also found that GTO score can be used to inform goals of care discussions with patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. F.14. Coronary Artery Abnormalities in Hyperimmunoglobulin E Syndrome
- Author
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Mannino, Elizabeth, Gharib, Ahmed, Hsu, Amy, Heimall, Jennifer, Holland, Steven, and Freeman, Alexandra
- Published
- 2009
- Full Text
- View/download PDF
14. Impact of All-Terrain Vehicle Accidents on Pediatric Patient Outcomes at an Appalachian Children's Hospital.
- Author
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Mannino E, Chambers PL, Wheeler H, Brown S, Burns B Jr, and Leonard M
- Abstract
Introduction The use of all-terrain vehicles (ATVs) has become increasingly popular as an outdoor recreational activity among people living in the United States, particularly in areas such as the southeast. There are significant risks involved with riding ATVs, especially in the pediatric population, due to lack of training and experience. The purpose of this study was to evaluate the outcomes of pediatric patients involved in ATV-associated accidents. Methods This study is a retrospective review of 98 pediatric patients ages 15 years and younger involved in ATV accidents who were admitted to a pediatric hospital between January 2015 and December 2020. Outcomes, including types of injuries sustained, length of hospital stay, length of ICU stay, and injury severity score (ISS) were analyzed between age groups (0-5, 6-10, and 11-15). Results The mean hospital stay across all age groups was 1.7 ± 1.9 days, mean ICU stay was 3.8 ± 4.0 days, and mean injury severity score (ISS) was 5.9 ±4.8. The 11-15-year-old age group had a significantly longer hospital stay and higher ISS scores compared to both of the younger age groups (0-5 and 6-10 years old). There was no difference in ICU days between the age groups. Orthopedic injuries were the most common type of injury, occurring in 55% of all patients, followed by head injuries in 29% of patients, and spinal fractures in 2% of patients. The most common orthopedic fracture in the 11-15-year-old group was tibia/fibula, while humerus fractures were the most common type of fracture in the 0-5 and 6-10 year age groups. Orthopedic procedures were required in 35% of all included patients. There was no statistically significant difference in types of injuries and types of fractures sustained between each group. Chest injuries, including pneumothorax, lung contusions, and rib fractures, occurred most often in the older age group 11-15 years (n=65). Those who experienced chest injuries had a higher ISS, although it was not statistically significant (p=0.06) compared to those who did not have chest injuries. There was no difference in hospital or ICU length of stay in patients with chest injuries. Conclusions The results of this study demonstrate the outcomes of pediatric patients admitted for ATV accidents at a rural Appalachian pediatric hospital and provide an overview of the most common injuries involved in this trauma mechanism. Pediatric patients aged 11-15 years of age involved in ATV accidents are at risk for longer hospital length of stay and higher ISS compared to younger age groups. Additionally, patients ages 11-15 were more susceptible to chest injuries following ATV accidents. The results of this study will be used to develop a standardized trauma protocol for the management of this specific trauma mechanism in the pediatric population based on common injury patterns among each age group., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Mannino et al.)
- Published
- 2022
- Full Text
- View/download PDF
15. Facial Artery Musculomucosal Flap for Nasopharyngeal and Oropharyngeal Reconstruction.
- Author
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Mannino EA, Rubinstein BJ, and Dobratz EJ
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Reoperation, Retrospective Studies, Voice Quality, Facial Muscles blood supply, Facial Muscles transplantation, Nasal Obstruction surgery, Plastic Surgery Procedures methods, Surgical Flaps blood supply, Velopharyngeal Insufficiency surgery
- Abstract
Importance: The facial artery musculomucosal (FAMM) flap is a well vascularized axial flap which has been described for mucosal reconstructions throughout the oral cavity. There are limited data regarding its efficacy in secondary repair of nasopharyngeal stenosis and velopharyngeal insufficiency due previous surgery and scar tissue formation. Objective: This study seeks to demonstrate the efficacy of FAMM flap procedure in patients with nasopharyngeal stenosis and velopharyngeal insufficiency. Design, Setting, and Participants: A retrospective case series included patients treated for nasopharyngeal stenosis or velopharyngeal insufficiency with a FAMM flap at an academic medical center from January 1, 2012 to November 1, 2017. Patients included in the study were those who underwent a FAMM flap procedure by the senior author during the specified time period. Main Outcomes and Measures: Functional outcomes included nasopharyngeal airway patency, nasal regurgitation, and speech quality. Any postoperative complications were recorded, including flap necrosis, infection, flap failure, dehiscence, trismus and need for revision surgery. Results: A total of 6 FAMM flap procedures were performed by the senior author over the study period for the indications of this case series. Three patients had nasopharyngeal stenosis and three had velopharyngeal insufficiency. All had successful, sustained nasopharyngeal airway patency or restored velopharyngeal function. The only postoperative complication noted was trismus at the cheek donor site. There were no patients who suffered flap failure or need for revision surgery of the FAMM flap. Conclusions: The FAMM flap is useful for secondary reconstruction of nasopharyngeal stenosis and velopharyngeal insufficiency due to previous surgery and scarring. This study demonstrates the efficacy and reliability of FAMM flaps for repair of complete/near complete nasopharyngeal stenosis and cases of velopharyngeal insufficiency due to scarring of the pharynx.
- Published
- 2020
- Full Text
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16. Congenital methemoglobinemia type II in a 5-year-old boy.
- Author
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Mannino EA, Pluim T, Wessler J, Cho MT, Juusola J, and Schrier Vergano SA
- Abstract
Congenital Methemoglobinemia is a rare neurologic condition which can mimic other diseases such as epilepsy syndromes and leukodystrophies. The responsible gene, CYB5R3 , is not typically included on commonly order neurologic and epilepsy panels. We recommend that laboratories include this gene on these tests which often precede larger-scale genetic studies.
- Published
- 2017
- Full Text
- View/download PDF
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