11 results on '"Mannino, L."'
Search Results
2. Sicilian Wine’s Effect on Consumers’ Identity-Behavioral Intentions: The Mediation Effect of Subjective Norms and Social Activity
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Scuderi V, Mannino L, and Santisi G
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products ,lcsh:TP500-660 ,subjective norms ,social activity ,consumption ,business ,intensity ,lcsh:Fermentation industries. Beverages. Alcohol - Abstract
Vittorio Scuderi, Letizia Mannino, Giuseppe Santisi Department of Educational Sciences, University of Catania, Catania, ItalyCorrespondence: Giuseppe Santisi Email gsantisi@unict.itPurpose: Wine has a purely symbolic connotation in the eyes of consumers and the market. Therefore, it could lead to a different consideration and perception of buying local wine which could be sensed as a social experience rather than an automatic action. The research aim is to highlight the bond between customers and the product (Sicilian DOC wine) by overcoming the utilitarian limit and showing the social one. This study has the purpose of understanding in depth how individual behavior and social relationships are able to influence people’s behavioral intentions which lead to an increase in wine consumption.Methods: The sample was characterized by 302 consumers of Sicilian DOC wine who gave their consent to participate to the research to verify how the social aspects may lead to the behavioral Intentions of purchase. The cross-sectional research has been conducted using an online survey which was available to be filled in by participants from May 2019 to December 2019. Data were analyzed using SPSS.Results: The results show how subjective norms and social activity constitute two crucial dimensions for consumption behavior through mediating the effect of individuals identification with people that tend to choose and consume Sicilian DOC wine (social identity) on the behavioral intention of that product to fulfill their desire. Both indirect effects of social identity on behavioral intentions (IE = 0.04; C.I. = 0.01– 0.05; IE = 0.02; C.I. = 0.005– 0.03) are significant and mediated by subjective norms and social activity.Conclusion: Social activities and subjective norms influence people’s intention to purchase a Sicilian DOC wine for purely social and symbolic purposes.Keywords: social activity, subjective norms, business, consumption, products, intensity
- Published
- 2020
3. Consensus conference on laparoscopic appendectomy: development of guidelines
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Vettoretto, N., Gobbi, S., Corradi, A., Belli, F., Piccolo, D., Pernazza, G., and Mannino, L.
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- 2011
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4. Generation of 3D brain organoids to recapitulate hippocampal structure
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Ciarpella, F., Zamfir, R., Campanelli, A., Dichio, M., Pedrotti, G., Dolci, S., Mannino, L., Fumagalli, G., Giulia Curia, Panuccio, G., Palazzolo, G., and Decimo, I.
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- 2019
5. An experiment at sea on the reflection of the wind waves
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Boccotti, P., Barbaro, G., Fiamma, V., Mannino, L., and Rotta, A.
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- 1993
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6. Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury
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Sissi Dolci, Loris Mannino, Emanuela Bottani, Alessandra Campanelli, Marzia Di Chio, Stefania Zorzin, Giulia D’Arrigo, Alessia Amenta, Agnese Segala, Giuseppe Paglia, Vanna Denti, Guido Fumagalli, Enzo Nisoli, Alessandra Valerio, Claudia Verderio, Giuseppe Martano, Francesco Bifari, Ilaria Decimo, Dolci, S, Mannino, L, Bottani, E, Campanelli, A, Di Chio, M, Zorzin, S, D'Arrigo, G, Amenta, A, Segala, A, Paglia, G, Denti, V, Fumagalli, G, Nisoli, E, Valerio, A, Verderio, C, Martano, G, Bifari, F, and Decimo, I
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Pharmacology ,Cell metabolism ,Spinal cord injury ,Axons ,Microglia ,Mitochondrial metabolism ,Neural regeneration ,Mice ,Spinal Cord ,Animals ,Energy Metabolism ,Spinal Cord Injuries ,cell metabolism ,microglia ,mitochondrial metabolism ,neural regeneration - Abstract
Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the damaged tissue suffers from a severe metabolic impairment, which aggravates axonal degeneration and neuronal loss. Impaired cellular energetic, tricarboxylic acid (TCA) cycle and oxidative phosphorylation metabolism in neuronal cells has been demonstrated to be a major cause of neural tissue death and regeneration failure following SCI. Therefore, rewiring the spinal cord cell metabolism may be an innovative therapeutic strategy for the treatment of SCI. In this study, we evaluated the therapeutic effect of the recovery of oxidative metabolism in a mouse model of severe contusive SCI. Oral administration of TCA cycle intermediates, co-factors, essential amino acids, and branched-chain amino acids was started 3 days post-injury and continued until the end of the experimental procedures. Metabolomic, immunohistological, and biochemical analyses were performed on the injured spinal cord sections. Administration of metabolic precursors enhanced spinal cord oxidative metabolism. In line with this metabolic shift, we observed the activation of the mTORC1 anabolic pathway, the increase in mitochondrial mass, and ROS defense which effectively prevented the injury-induced neural cell apoptosis in treated animals. Consistently, we found more choline acetyltransferase (ChAT)-expressing motor neurons and increased neurofilament-positive corticospinal axons in the spinal cord parenchyma of the treated mice. Interestingly, oral administration of the metabolic precursors increased the number of activated microglia expressing the CD206 marker suggestive of a pro-resolutive, M2-like phenotype. These molecular and histological modifications observed in treated animals ultimately led to a significant, although partial, improvement of the motor functions. Our data demonstrate that rewiring the cellular metabolism can represent an effective strategy to treat SCI.
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- 2022
7. Epidemiology, clinical and microbiology characteristic of multiresistant Acinetobacter spp. bacteremia in a pediatric hospital in Argentina
- Author
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Ruvinsky, S., Fiorilli, G., Perez, G., Juzielewski, B., Mannino, L., Casimir, L., Rosanova, M.T., Lopardo, H., and Bologna, R.
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- 2010
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8. Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury.
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Dolci S, Mannino L, Bottani E, Campanelli A, Di Chio M, Zorzin S, D'Arrigo G, Amenta A, Segala A, Paglia G, Denti V, Fumagalli G, Nisoli E, Valerio A, Verderio C, Martano G, Bifari F, and Decimo I
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- Animals, Axons physiology, Energy Metabolism, Mice, Spinal Cord metabolism, Microglia metabolism, Spinal Cord Injuries drug therapy, Spinal Cord Injuries pathology
- Abstract
Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the damaged tissue suffers from a severe metabolic impairment, which aggravates axonal degeneration and neuronal loss. Impaired cellular energetic, tricarboxylic acid (TCA) cycle and oxidative phosphorylation metabolism in neuronal cells has been demonstrated to be a major cause of neural tissue death and regeneration failure following SCI. Therefore, rewiring the spinal cord cell metabolism may be an innovative therapeutic strategy for the treatment of SCI. In this study, we evaluated the therapeutic effect of the recovery of oxidative metabolism in a mouse model of severe contusive SCI. Oral administration of TCA cycle intermediates, co-factors, essential amino acids, and branched-chain amino acids was started 3 days post-injury and continued until the end of the experimental procedures. Metabolomic, immunohistological, and biochemical analyses were performed on the injured spinal cord sections. Administration of metabolic precursors enhanced spinal cord oxidative metabolism. In line with this metabolic shift, we observed the activation of the mTORC1 anabolic pathway, the increase in mitochondrial mass, and ROS defense which effectively prevented the injury-induced neural cell apoptosis in treated animals. Consistently, we found more choline acetyltransferase (ChAT)-expressing motor neurons and increased neurofilament-positive corticospinal axons in the spinal cord parenchyma of the treated mice. Interestingly, oral administration of the metabolic precursors increased the number of activated microglia expressing the CD206 marker suggestive of a pro-resolutive, M2-like phenotype. These molecular and histological modifications observed in treated animals ultimately led to a significant, although partial, improvement of the motor functions. Our data demonstrate that rewiring the cellular metabolism can represent an effective strategy to treat SCI., (Copyright © 2022. Published by Elsevier Ltd.)
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- 2022
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9. Nitric Oxide in Selective Cerebral Perfusion Could Enhance Neuroprotection During Aortic Arch Surgery.
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Linardi D, Mani R, Murari A, Dolci S, Mannino L, Decimo I, Tessari M, Martinazzi S, Gottin L, Luciani GB, Faggian G, and Rungatscher A
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Background: Hypothermic circulatory arrest (HCA) in aortic arch surgery has a significant risk of neurological injury despite the newest protective techniques and strategies. Nitric oxide (NO) could exert a protective role, reduce infarct area and increase cerebral perfusion. This study aims to investigate the possible neuroprotective effects of NO administered in the oxygenator of selective antegrade cerebral perfusion (SCP) during HCA., Methods: Thirty male SD adult rats (450-550 g) underwent cardiopulmonary bypass (CPB), cooling to 22°C body core temperature followed by 30 min of HCA. Rats were randomized to receive SCP or SCP added with NO (20 ppm) administered through the oxygenator (SCP-NO). All animals underwent CPB-assisted rewarming to a target temperature of 35°C in 60 min. At the end of the experiment, rats were sacrificed, and brain collected. Immunofluorescence analysis was performed in blind conditions., Results: Neuroinflammation assessed by allograft inflammatory factor 1 or ionized calcium-binding adapter molecule 1 expression, a microglia activation marker was lower in SCP-NO compared to SCP (4.11 ± 0.59 vs. 6.02 ± 0.18%; p < 0.05). Oxidative stress measured by 8oxodG, was reduced in SCP-NO (0.37 ± 0.01 vs. 1.03 ± 0.16%; p < 0.05). Brain hypoxic area extent, analyzed by thiols oxidation was attenuated in SCP-NO (1.85 ± 0.10 vs. 2.74 ± 0.19%; p < 0.05). Furthermore, the apoptotic marker caspases 3 was significantly reduced in SCP-NO (10.64 ± 0.37 vs. 12.61 ± 0.88%; p < 0.05)., Conclusions: Nitric oxide administration in the oxygenator during SCP and HCA improves neuroprotection by decreasing neuroinflammation, optimizing oxygen delivery by reducing oxidative stress and hypoxic areas, finally decreasing apoptosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Linardi, Mani, Murari, Dolci, Mannino, Decimo, Tessari, Martinazzi, Gottin, Luciani, Faggian and Rungatscher.)
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- 2022
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10. Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.
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Hosseini AA, Brown T, Mannino L, Gran B, Junaid K, and Mukaetova-Ladinska EB
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- Aged, Amyloid beta-Peptides cerebrospinal fluid, Biomarkers cerebrospinal fluid, Female, Humans, Male, Peptide Fragments cerebrospinal fluid, tau Proteins cerebrospinal fluid, Alzheimer Disease diagnosis, Cognitive Dysfunction cerebrospinal fluid, Cognitive Dysfunction diagnostic imaging
- Abstract
Background: The differentiation of a preclinical or prodromal Alzheimer's disease (AD) is challenging particularly in patients with early onset Alzheimer's or related dementias (EOARD). We report our experience on diagnostic lumbar puncture to diagnose EOARD at a tertiary neurocognitive referral center in Nottingham, England from March 2018 to October 2020., Objective: To assess amyloid-β42 (Aβ42), total tau, and Thr181-phosphorylated tau (p-tau) measurements in the cerebrospinal fluid (CSF) in patients with mild cognitive impairment (MCI) and in relation to their follow-up cognitive performance., Methods: Thirty participants aged 32-68 years old (mean 59 years; 57% female) were included. Clinical diagnosis was based on clinical presentation, neurocognitive profile, neuroradiological features (MRI, FDG-PET CT) and CSF Aβ42, total tau, and p-tau measurements., Results: Patients with MCI who progressed to AD (prodromal AD) had significantly higher CSF total (797.63 pg/ml) and p-tau (82.31 pg/ml), and lower Aβ42 levels (398.94 pg/ml) in comparison to their counterparts with stable MCI (total tau 303.67 pg/ml, p-tau 43.56 pg/ml, Aβ42 873.44 pg/ml) (p < 0.01 for CSF total and p-tau measures and p < 0.0001 for CSF Aβ42 measures). None of the CSF biomarkers correlated with any of the cognitive performance measures. Principal component analysis confirmed that the clinical diagnosis of MCI secondary to AD, namely prodromal AD (as per NIA-AA criteria) in younger adults, was associated with decreased CSF Aβ42., Conclusion: In early onset AD, low levels of CSF Aβ42 appear to be more sensitive than total and p-tau measures in differentiating AD MCI from other forms of dementia. Further work on larger samples of EOARD in clinical practice will address the cost effectiveness of making an earlier diagnosis.
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- 2022
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11. Diffusion of laparoscopic appendectomies in Italy: a national audit.
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Vettoretto N, Gobbi S, Belli F, Corradi A, Mannino L, Ricciardelli L, Vinciguerra M, and Piccolo D
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- Adult, Age Factors, Aged, Appendectomy statistics & numerical data, Appendicitis pathology, Female, Humans, Italy, Laparoscopy statistics & numerical data, Male, Medical Audit, Patient Selection, Surveys and Questionnaires, Appendectomy methods, Appendicitis surgery, Laparoscopy methods, Practice Patterns, Physicians' statistics & numerical data
- Abstract
A national audit focused on laparoscopic appendectomy was promoted by the Italian Association of Hospital Surgeons (ACOI). Four-hundred and sixty surgical practices received an e-mail questionnaire. Data concerning epidemiology, timetable, surgeon's age, selection of patients, laparotomic conversion, behaviour in the case of a normal appendix, and technical aspects were investigated. The response rate was 51.7%. The median number of appendectomies performed is 50-100 each year in a surgery ward. Laparoscopic operations are very common (93%), but mostly performed in less than 50% of the observed cases. There is no significant difference between the number of operations during the day vs. at night, and they are performed by a limited (<30%) group of surgeons, equally composed of physicians aged above and below 40. The majority of surgeons adopt an "all comers" policy regarding laparoscopic appendectomy, including selected older patients (>70 years old). There are no standard indications for conversion, while the behaviour in the presence of a normal appendix is generally removal. Even if laparoscopic appendectomy is not yet considered a gold standard, it is widely diffused in Italy, and the audit's data show different behaviours between subgroups.
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- 2012
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