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9 results on '"Mareel, Marcus"'

2. REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Author

Lievens, Yolande, van Eijkeren, Marc, Vandecasteele, Katrien, Elhamin, Elhaseen, Ost, Piet, Fonteyne, Valérie, Swimberghe, Martijn, Deseyne, Pieter, De Neve, Wilfried, Duprez, Fréderic, Mareel, Marcus, Monten, Chris, Van Greveling, Annick, Vercauteren, Tom, Paelinck, Leen, Defraene, Gilles, Aerts, Rita, Arredouani, Soumia, Lambrecht, Maarten, Vanneste, Ben, Draghici, Roxana, Giordano, Frank, Herskind, Carsten, Veldwijk, Marlon, Helmbold, Irmgard, Giesche, Ulrich, Stegmaier, Petra, Weiß, Christian, Blaschke, Thomas, Neu, Burkhard, Lozza, Laura, Avuzzi, Barbara, Morlino, Sara, Sangalli, Claudia, Franceschini, Marzia, Rodriguez-Lage, Belina, Fernández-Tajes, Juan, Fuentes-Rios, Olivia, Domínguez-Rios, Isabel, Fajardo-Paneque, Irene, Sosa-Fajardo, Paloma, Torrado-Moya, Laura, Ramos-Albiac, Mónica, Giraldo, Alexandra, Altabas, Manolo, Piqué-Leiva, Bibiana, García-Relancio, David, Seoane-Ramallo, Alejandro, Lavers, Samuel, Wright, Simon, Dobbelaere, Hannah, Appleton, Donna, Kaushik, Monika, Kenny, Frances, Khout, Hazem, Krupa, Jaroslaw, Lambert, Kelly V., Pilgrim, Simon, Shokuhi, Sheila, Valassiadou, Kalliope, Aznar-Garcia, Luis, Boiangui, Ion, Kancherla, Kiran, Kent, Christopher, Sampson, Kufre, Osman, Ahmed, Sridhar, Thiagarajan, Vasanthan, Subramaniam, Faivre-Finn, Corinne, Harrop, Victoria, Keni, Manjusha, Foweraker, Karen, Pascoe, Abigail, Esler, Claire, Stock, Richard, Green, Sheryl, Golchin, Ava, Li, William, Seibold, Petra, Webb, Adam, Aguado-Barrera, Miguel E., Azria, David, Bourgier, Celine, Brengues, Muriel, Briers, Erik, Bultijnck, Renée, Calvo-Crespo, Patricia, Carballo, Ana, Choudhury, Ananya, Cicchetti, Alessandro, Claßen, Johannes, Delmastro, Elena, Dunning, Alison M., Elliott, Rebecca M., Fachal, Laura, Farcy-Jacquet, Marie-Pierre, Gabriele, Pietro, Garibaldi, Elisabetta, Gómez-Caamaño, Antonio, Gutiérrez-Enríquez, Sara, Higginson, Daniel S., Johnson, Kerstie, Lobato-Busto, Ramón, Mollà, Meritxell, Müller, Anusha, Payne, Debbie, Peleteiro, Paula, Post, Giselle, Rancati, Tiziana, Rattay, Tim, Reyes, Victoria, Rosenstein, Barry S., De Ruysscher, Dirk, De Santis, Maria Carmen, Schäfer, Jörg, Schnabel, Thomas, Sperk, Elena, Symonds, R. Paul, Stobart, Hilary, Taboada-Valladares, Begoña, Talbot, Christopher J., Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Ward, Tim, Weißenberger, Christian, West, Catharine M.L., and Chang-Claude, Jenny

Published
2019
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7. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells : phosphatidylinositol 3 '-kinase is a critical mediator of tumor invasion

Author

Kotelevets, Larissa, Noe, V, Bruyneel, Erik, Myssiakine, E, Chastre, E, Mareel, Marcus, and Gespach, C

Subjects
Medicine and Health Sciences
Abstract

This study was designed to characterize platelet-activating factor receptor (PAF-R) expression and function in normal and cancerous human colonic epithelial cells. PAF-R gene transcripts were analyzed by reverse transcription-polymerase chain reaction and Southern blot, using three sets of primers corresponding either to the coding region of the human PAF-R sequence (polymerase chain reaction product: 682 base pairs (bp)) or to the leukocyte-and tissue-type transcripts of 166 and 252 bp, respectively. An elongated splice variant was identified in the 5'-untranslated region of the tissue-type PAF-R transcript (334 bp) in colonic epithelial crypts and tumors. In human colonic PCmsrc cells transformed by c-src oncogene, the hepatocyte growth factor (HGF)-dependent invasiveness of collagen gels was abolished by 0.1 mu M PAF and Pestered by the PAF-R antagonists WEB2086 and SR27417. PAF blocked HGF-induced tyrosine phosphorylation of p125 focal adhesion kinase, The phosphatidylinositol 3'-kinase (PI3'-K) inhibitors wortmannin and LY294002 totally blocked the HGF-induced invasion. Similar effects were observed in ts-srcMDCK kidney epithelial cells transformed by a v-Src temperature-sensitive mutant: (i) PAF and wortmannin exerted additive inhibitory effects on Src-induced invasion and (ii) activated and dominant negative forms of p110 alpha PI3'-K, respectively, amplified and abrogated the Src- and HGF-dependent invasiveness of parental and ts-src-MDCK, cells. We also provided the first evidence for the contribution of rapamycin-insensitive, pertussis toxin-dependent G-protein pathways to the integration of the signals emerging from activated Met and PAF receptors. These results indicate that PI3'-K is a critical transducer of invasiveness and strongly suggest that PAF exerts a negative control on invasion by inhibiting this signaling pathway. A possible beneficial role of PAF analogs on tumor invasion is therefore proposed.

Published
1998

9. Glycosaminoglycans as novel target in antitumor therapy

Author

Jeney, András, Timár, József, Pogány, Gábor, Paku, Sándor, Moczár, Elemér, Mareel, Marcus, Ötvös, László, Kopper, László, and Lapis, Károly

Subjects
Medicine and Health Sciences
Published
1990

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