1. Prognosis and Reclassification by YKL‐40 in Stable Coronary Artery Disease
- Author
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Jakob Schroder, Janus Christian Jakobsen, Per Winkel, Jørgen Hilden, Gorm Boje Jensen, Ahmad Sajadieh, Anders Larsson, Johan Ärnlöv, Marina Harutyunyan, Julia S. Johansen, Erik Kjøller, Christian Gluud, and Jens Kastrup
- Subjects
CHI3L1 ,cohort study ,coronary atherosclerosis ,YKL‐40 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background The inflammatory biomarker YKL‐40 has previously been studied as a potential risk marker in cardiovascular disease. We aimed to assess the prognostic reclassification potential of serum YKL‐40 in patients with stable coronary artery disease. Methods and Results The main study population was the placebo group of the CLARICOR (Effect of Clarithromycin on Mortality and Morbidity in Patients With Ischemic Heart Disease) trial. The primary outcome was a composite of acute myocardial infarction, unstable angina pectoris, cerebrovascular disease, and all‐cause mortality. We used Cox proportional hazards regression models adjusted for C‐reactive protein level and baseline cardiovascular risk factors. Improvement in prediction by adding serum YKL‐40 to the risk factors was calculated using the Cox‐Breslow method and c‐statistic. A total of 2200 patients were randomized to placebo, with a follow‐up duration of 10 years. YKL‐40 was associated with an increased risk of the composite outcome (hazard ratio per unit increase in (YKL‐40) 1.13, 95% CI 1.03–1.24, P=0.013) and all‐cause mortality (hazard ratio 1.32, 95% CI 1.17–1.49, P
- Published
- 2020
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