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Your search keyword '"Marjonneke J. Mook-Kanamori"' showing total 3 results
Start Over Author "Marjonneke J. Mook-Kanamori" Language english
3 results on '"Marjonneke J. Mook-Kanamori"'

1. The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for advanced glycation end product accumulation.

Author

Robert P van Waateringe, Marjonneke J Mook-Kanamori, Sandra N Slagter, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Helen L Lutgers, Karsten Suhre, Mohammed M El-Din Selim, Dennis O Mook-Kanamori, and Bruce H R Wolffenbuttel

Subjects
Medicine, Science
Abstract

BackgroundSkin autofluorescence, a biomarker for advanced glycation end products (AGEs) accumulation, has been shown to predict diabetes-related cardiovascular complications and is associated with several environmental and lifestyle factors. In the present study, we examined the association between various smoking behaviors and skin autofluorescence, as well as the association between several cotinine biomarkers and skin autofluorescence, using both epidemiological and metabolomics data.MethodsIn a cross-sectional study, we evaluated participants from the LifeLines Cohort Study and the Qatar Metabolomics Study on Diabetes (QMDiab). In the LifeLines Cohort Study smoking behavior and secondhand smoking were assessed in 8,905 individuals including 309 individuals (3.5%) with type 2 diabetes. In QMDiab, cotinine biomarkers were measured in saliva, plasma and urine in 364 individuals of whom 188 (51%) had type 2 diabetes. Skin autofluorescence was measured non-invasively in all participants using the AGE Reader.ResultsSkin autofluorescence levels increased with a higher number of hours being exposed to secondhand smoking. Skin autofluorescence levels of former smokers approached levels of never smokers after around 15 years of smoking cessation. Urinary cotinine N-oxide, a biomarker of nicotine exposure, was found to be positively associated with skin autofluorescence in the QMDiab study (p = 0.03).ConclusionsIn the present study, we have demonstrated that secondhand smoking is associated with higher skin autofluorescence levels whereas smoking cessation has a beneficial effect on skin autofluorescence. Finally, urinary cotinine N-oxide might be used as an alternative way for questionnaires to examine the effect of (environmental) tobacco smoking on skin autofluorescence.

Published
2017
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2. A systems view of type 2 diabetes-associated metabolic perturbations in saliva, blood and urine at different timescales of glycaemic control

Author

Sara Abdul Kader, Edward D. Karoly, Mohammed M. El-Din Selim, Khoulood A.S. Al-Mahmoud, Noha A. Yousri, Cindy McKeon, Kieu Thinh Do, Dennis O. Mook-Kanamori, Marjonneke J. Mook-Kanamori, Ulrich Neumaier, Ahmed H. Takiddin, Gabi Kastenmüller, Hala Al-Homsi, Omar Chidiac, Wadha A. Al Muftah, Karsten Suhre, Jillian Rowe, and Jan Krumsiek

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Saliva, Arab Population, Asian Population, Blood Metabolomics, Gaussian Graphical Modelling, Glycaemic Control, Metabolic Dysregulation, Partial Correlation, Saliva Metabolomics, Systems Biology, Type 2 Diabetes, Urine Metabolomics, Endocrinology, Diabetes and Metabolism, Systems biology, Partial correlation, Physiology, Type 2 diabetes, Urine, Gaussian graphicalmodelling, Biology, Article, Young Adult, Metabolomics, Internal medicine, Diabetes mellitus, Glycaemic control, Internal Medicine, medicine, Humans, Arab population, Aged, Saliva metabolomics, Gaussian graphical modelling, Urine metabolomics, Asian population, Human physiology, Middle Aged, Blood metabolomics, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Metabolic dysregulation, Female, Erratum, Biomarkers
Abstract

Aims/hypothesis Metabolomics has opened new avenues for studying metabolic alterations in type 2 diabetes. While many urine and blood metabolites have been associated individually with diabetes, a complete systems view analysis of metabolic dysregulations across multiple biofluids and over varying timescales of glycaemic control is still lacking. Methods Here we report a broad metabolomics study in a clinical setting, covering 2,178 metabolite measures in saliva, blood plasma and urine from 188 individuals with diabetes and 181 controls of Arab and Asian descent. Using multivariate linear regression we identified metabolites associated with diabetes and markers of acute, short-term and long-term glycaemic control. Results Ninety-four metabolite associations with diabetes were identified at a Bonferroni level of significance (p

Published
2015

3. 1,5-Anhydroglucitol in Saliva Is a Noninvasive Marker of Short-Term Glycemic Control

Author

Edward D. Karoly, Thomas Kocher, Wadha A. Al Muftah, Sara Abdul Kader, Karsten Suhre, Mohammed M. El-Din Selim, Marjonneke J. Mook-Kanamori, Cindy McKeon, Jillian Rowe, Dennis O. Mook-Kanamori, Hala Al-Homsi, Mahmoud Zirie, Omar Chidiac, Noha A. Yousri, Khoulood A.S. Al-Mahmoud, Wafaa Sekkal Gherbi, Ahmed H. Takiddin, and Amina Al-Obaidli

Subjects
Adult, Blood Glucose, Male, Saliva, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Urine, Type 2 diabetes, Deoxyglucose, Biochemistry, Mass Spectrometry, chemistry.chemical_compound, Young Adult, Endocrinology, Diabetes mellitus, Internal medicine, Blood plasma, Medicine, Humans, Metabolomics, Glycemic, Aged, business.industry, Biochemistry (medical), Middle Aged, medicine.disease, Cross-Sectional Studies, chemistry, Diabetes Mellitus, Type 2, Case-Control Studies, 1,5-Anhydroglucitol, Female, business, Biomarkers
Abstract

Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 x 10(-13)). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studies have already established 1,5-AG in blood as a reliable marker of short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.

Published
2014
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