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Https://doi.org/10.1093/ced/llac079 Dear Editor, We read with interest the paper published in I Clinical and Experimental Dermatology i by Kurihara I et al i . describing a patient with diffuse plane xanthoma arising from regressed tumours of folliculotropic mycosis fungoides (MF). PUVA might have accelerated galectin-7 expression and rendered the lesions ready to generate NCXs 74 F Normolipaemic Tumour-stage MF 1 year Diffuse plane xanthomas around brownish-red nodules MF lesions; foamy histiocytes After PUVA treatment. 20121137 M Hypercholesterolaemia and hypertriglyceridaemia Patch-stage MF 10 years Yellowish discolouration of MF patches; foamy histiocytes Yellowish discolouration of MF patches developed gradually over the previous 2 years before MF diagnosis. PUVA might have accelerated galectin-7 expression and rendered the lesions ready to generate NCXs 74 F Normolipaemic Tumour-stage MF 1 year Diffuse plane xanthomas around brownish-red nodules MF lesions; foamy histiocytes After PUVA treatment. [Extracted from the article]

Keywords: allergic contact dermatitis; case report; cutaneous pseudolymphoma; irritative contact dermatitis; lymphomatoid contact dermatitis EN allergic contact dermatitis case report cutaneous pseudolymphoma irritative contact dermatitis lymphomatoid contact dermatitis 410 412 3 04/05/23 20230501 NES 230501 CASE REPORT Lymphomatoid contact dermatitis (LCD) is an uncommon inflammatory disorder classified as cutaneous pseudolymphoma (CPSL). Chronic allergic contact dermatitis (ACD) of numerous allergens has been reported to be associated with LCD.[1] However, LCD secondary to an acute irritative contact dermatitis (ICD) has never been described before. Allergic contact dermatitis, case report, cutaneous pseudolymphoma, irritative contact dermatitis, lymphomatoid contact dermatitis. [Extracted from the article]

The article presents a study on perichondrities and cutaneous inflammation on piercings and tattoo site. Topics discussed include the number of cases of monkeypox from July 6 to 19, 2022, the transmission of the disease after piercing or tattooing at the parlor, and clinical features of cutaneous inflammation.

Background: The exact role of IV contrast-enhanced computed tomography (CT) in the diagnosis of necrotizing soft tissue infections (NSTIs) has not yet been established. We aimed to explore the role of CT in patients with clinical suspicion of NSTI and assess its sensitivity and specificity for NSTI. Methods: The medical records of patients admitted between 2009 and 2016, who received IV contrast-enhanced CT to rule out NSTI, were reviewed. CT was considered positive in case of: (a) gas in soft tissues, (b) multiple fluid collections, (c) absence or heterogeneity of tissue enhancement by the IV contrast, and (d) significant inflammatory changes under the fascia. NSTI was confirmed only by the presence of necrotic tissue during surgical exploration. NSTI was considered absent if surgical exploration failed to identify necrosis, or if the patient was successfully treated non-operatively. Results: Of the 184 patients, 17 had a positive CT and hence underwent surgical exploration with NSTI being confirmed in 13 of them (76%). Of the 167 patients that had a negative CT, 38 (23%) underwent surgical exploration due to the high clinical suspicion for NSTI and were all found to have non-necrotizing infections; the remaining 129 (77%) were managed non-operatively with successful resolution of symptoms. The sensitivity of CT in identifying NSTI was 100%, the specificity 98%, the positive predictive value 76%, and the negative predictive value 100%. Conclusions: A negative IV contrast-enhanced CT scan can reliably rule out the need for surgical intervention in patients with initial suspicion of NSTI. [ABSTRACT FROM AUTHOR]

In the Central Andean region of Argentina, we found gravimetric and geomorphological evidence of an uplifting of the crystalline basement of Pie de Palo range. Within this zone, we observed a positive gravimetric anomaly in the extreme South of Pie de Palo, extending towards the South of Pampean ranges. By means of the geophysical technics, it was possible to determine the magnitude and geometrical form of the anomalous body. The evidence of a tectonic uplifting is also clearly manifested in the LandSat images, by observing the displacement of the course of the San Juan River towards the South. The study region is one of the major cortical and lithospheric regions with seismic activity in the country, where three of the most devastating earthquakes occurred over the last 73 years. The results would indicate that this region will continue to be one of the major seismically generating potential, significantly implying seismic dangers. The seismic risk studies indicate that the greatest hazard zone is found between the Pre-Cordillera and the Pie de Palo Range. The highest maximum acceleration values (PGA) are 242, 393, and 543 gal for return periods of 72, 475, and 2475 years, respectively. [ABSTRACT FROM AUTHOR]

Emergency department (ED) overcrowding remains a significant problem in many hospitals, and results in multiple negative effects on patient care outcomes and operational metrics. We sought to test whether implementing a quality improvement project could decrease ED LOS for trauma patients requiring an ICU admission from the ED, specifically by directly admitting critically ill trauma patients from the ED CT scanner to an ICU bed. This was a retrospective study comparing patients during the intervention period (2013-2014) to historical controls (2011-2013). Critically ill trauma patients requiring a CT scan, but not the operating room (OR) or Interventional Radiology (IR), were directly admitted from the CT scanner to the ICU, termed the "One-way street (OWS)". Controls from the 2011-2013 Trauma Registry were matched 1:1 based on the following criteria: Injury Severity Score; mechanism of injury; and age. Only patients who required emergent trauma consult were included. Our primary outcome was ED LOS, defined in minutes. Our secondary outcomes were ICU LOS, hospital LOS and mortality. Paired t test or Wilcoxon signed rank test were used for continuous univariate analysis and Chi square for categorical variables. Logistic regression and linear regressions were used for categorical and continuous multivariable analysis, respectively. 110 patients were enrolled in this study, with 55 in the OWS group and 55 matched controls. Matched controls had lower APACHE II score (12 vs. 15, p = 0.03) and a higher GCS (14 vs. 6, p = 0.04). ED LOS was 229 min shorter in the OWS group (82 vs. 311 min, p < 0.0001). The time between CT performed and ICU disposition decreased by 230 min in the OWS arm (30 vs. 300 min, p < 0.001). There was no difference in ED arrival to CT time between groups. Following multivariable analysis, mortality was primarily predicted by the APACHE II score (OR 1.29, p < 0.001), and not ISS, mechanism of injury, or age. After controlling for APACHE II score, there was no difference in mortality between the two cohorts (OR = 0.49, p = 0.28). Expedited admission of critically ill trauma patients immediately following CT imaging significantly reduced ED LOS by 3.82 h (229 min), without a change in ICU LOS, hospital LOS, or mortality. Further studies are needed to assess the impact of expedited admission on morbidity and mortality. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 81-year-old woman with a history of hepatitis c virus-related cirrhosis and hepatocellular carcinoma.

The La Rioja Valley is a sedimentary basin in the Pampean Ranges, a region of basement uplifts and broad valleys in the Andean foreland. The present study advances understanding of the genesis of the basin by providing subsurface data on its geometry and characteristics. Gravity and topographic data, including a newly completed gravity survey, were integrated to create a complete Bouguer anomaly map. Euler and Werner deconvolution techniques sum with traditional potential-fields methods and sparse independent data from seismic and magnetotelluric methods to test and constrain the subsurface geophysical characterization of the La Rioja Valley Basin. The residual anomaly, obtained through upward continuation, was inverted to obtain the best 3D gravity model of the La Rioja Valley Basin, which Shows the first-order geometry of the basin. This reveals that the basin is asymmetric, with up to 6000 m of low-density basin fill in a depocenter located in the west-central sector of the valley. Second-order features of the basin include a southeast-trending basement high, likely a fault zone that subdivides the basin, which has been revealed by a suite of analytical methods (3D model of depth to basement, a 2D inverse model, and Werner deconvolution solutions). [ABSTRACT FROM AUTHOR]

Geothermal energy resources are necessary to meet the increasing energy requirements worldwide and reduce the impact of climate change, particularly in developing countries. The aim of this study is the investigation of the low-enthalpy geothermal system of Pismanta, in the Central Andes of Argentina, to evaluate the possibility of power generation or direct use applications. Results indicate a circulation of meteoric water to the reservoir located in the Iglesia Basin, reaching a maximum depth of 2500 m. A background heat flow of 60 mW/m2 raises the temperature of the reservoir to approximately 95 °C resulting in a mean thermal gradient of 30 °C/km. The preliminary evaluation of four binary cycle energy conversion plants suggests a gross power generation range of 30–280 kW and the capacity of using the remaining heat for direct use applications such as drying of fruits, greenhouses, food processing and membrane distillation processes to solve arsenic problems in freshwater, among others. [Display omitted] • Characterization of geothermal resources prior to expensive drilling actions. • Integrative models provide essential information about geothermal reservoir characteristics. • Power generation or direct use applications of thermal water in the Pismanta system is proposed. [ABSTRACT FROM AUTHOR]

Objective: To compare the efficacy of infliximab (IFX) versus adalimumab (ADA) as a first-line biologic drug over 1 year of treatment in a large series of patients with refractory uveitis due to Behçet's disease (BD)., Methods: We conducted an open-label multicenter study of IFX versus ADA for BD-related uveitis refractory to conventional nonbiologic treatment. IFX or ADA was chosen as the first-line biologic agent based on physician and patient agreement. Patients received 3-5 mg/kg intravenous IFX at 0, 2, and 6 weeks and every 4-8 weeks thereafter, or 40 mg subcutaneous ADA every other week without a loading dose. Ocular parameters were compared between the 2 groups., Results: The study included 177 patients (316 affected eyes), of whom 103 received IFX and 74 received ADA. There were no significant baseline differences between treatment groups in main demographic features, previous therapy, or ocular sign severity. After 1 year of therapy, we observed an improvement in all ocular parameters in both groups. However, patients receiving ADA had significantly better outcomes in some parameters, including improvement in anterior chamber inflammation (92.31% versus 78.18% for IFX; P = 0.06), improvement in vitritis (93.33% versus 78.95% for IFX; P = 0.04), and best-corrected visual acuity (mean ± SD 0.81 ± 0.26 versus 0.67 ± 0.34 for IFX; P = 0.001). A nonsignificant difference was seen for macular thickness (mean ± SD 250.62 ± 36.85 for ADA versus 264.89 ± 59.74 for IFX; P = 0.15), and improvement in retinal vasculitis was similar between the 2 groups (95% for ADA versus 97% for IFX; P = 0.28). The drug retention rate was higher in the ADA group (95.24% versus 84.95% for IFX; P = 0.042)., Conclusion: Although both IFX and ADA are efficacious in refractory BD-related uveitis, ADA appears to be associated with better outcomes than IFX after 1 year of follow-up., (© 2019, American College of Rheumatology.)

Purpose: To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent., Design: Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants., Subjects: Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months. ADA was optimized in 23 (35.4%) of them. This biologic agent was maintained at a dose of 40 mg/subcutaneously/2 weeks in the remaining 42 patients., Methods: After remission, based on a shared decision between the patient and the treating physician, ADA was optimized. When agreement between patient and physician was reached, optimization was performed by prolonging the ADA dosing interval progressively. Comparison between optimized and nonoptimized patients was performed., Main Outcome Measures: Efficacy, safety, and cost-effectiveness in optimized and nonoptimized groups. To determine efficacy, intraocular inflammation (anterior chamber cells, vitritis, and retinal vasculitis), macular thickness, visual acuity, and the sparing effect of glucocorticoids were assessed., Results: No demographic or ocular differences were found at the time of ADA onset between the optimized and the nonoptimized groups. Most ocular outcomes were similar after a mean ± standard deviation follow-up of 34.7±13.3 and 26±21.3 months in the optimized and nonoptimized groups, respectively. However, relevant adverse effects were only seen in the nonoptimized group (lymphoma, pneumonia, severe local reaction at the injection site, and bacteremia by Escherichia coli, 1 each). Moreover, the mean ADA treatment costs were lower in the optimized group than in the nonoptimized group (6101.25 euros/patient/year vs. 12 339.48; P < 0.01)., Conclusion: ADA optimization in BD uveitis refractory to conventional therapy is effective, safe, and cost-effective., (Copyright © 2018 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)