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688 results on '"Marzi, I."'

4. The new timing in acute care surgery (new TACS) classification: a WSES Delphi consensus study

Author

De Simone B., Kluger Y., Moore E. E., Sartelli M., Abu-Zidan F. M., Coccolini F., Ansaloni L., Tebala G. D., Di Saverio S., Di Carlo I., Sakakushev B. E., Bonavina L., Sugrue M., Galante J. M., Ivatury R., Picetti E., Chirica M., Wani I., Bala M., Sall I., Kirkpatrick A. W., Shelat V. G., Pikoulis E., Leppäniemi A., Tan E., Broek R. P. G. t., Gurmu Beka S., Litvin A., Chouillard E., Coimbra R., Cui Y., De’ Angelis N., Sganga G., Stahel P. F., Agnoletti V., Rampini A., Shelat V., Damaskos D., Carcoforo P., Biffl W. L., Hecker A., Kirkpatrick A., Di Salomone S., Balogh Z., Beka S. G., Broek R. T., Velmahos G., Sakakushev B., Ceresoli M., Chiara O., Stahel P., Leppaniemi A., Marzi I., Inaba K., Khokha V., Reva V., Khan M., Toro A., de’ Angelis N., Malangoni M., Scozzafava E., Civil I., Maier R., Weber D., Chiarugi M., Soreide K., Testini M., Bravi F., Maier R. V., Catena F., De Simone, B, Kluger, Y, Moore, E, Sartelli, M, Abu-Zidan, F, Coccolini, F, Ansaloni, L, Tebala, G, Di Saverio, S, Di Carlo, I, Sakakushev, B, Bonavina, L, Sugrue, M, Galante, J, Ivatury, R, Picetti, E, Chirica, M, Wani, I, Bala, M, Sall, I, Kirkpatrick, A, Shelat, V, Pikoulis, E, Leppäniemi, A, Tan, E, Broek, R, Gurmu Beka, S, Litvin, A, Chouillard, E, Coimbra, R, Cui, Y, De’ Angelis, N, Sganga, G, Stahel, P, Agnoletti, V, Rampini, A, Damaskos, D, Carcoforo, P, Biffl, W, Hecker, A, Di Salomone, S, Balogh, Z, Beka, S, Velmahos, G, Ceresoli, M, Chiara, O, Leppaniemi, A, Marzi, I, Inaba, K, Khokha, V, Reva, V, Khan, M, Toro, A, de’ Angelis, N, Malangoni, M, Scozzafava, E, Civil, I, Maier, R, Weber, D, Chiarugi, M, Soreide, K, Testini, M, Bravi, F, and Catena, F

Subjects
Healthcare system, Delay in surgery, Operating room management, Delphi method, Emergency surgery, Priority, Time to surgery, Timing in acute care surgery (TACS), Triage, Classification
Abstract

Background: Timely access to the operating room for emergency general surgery (EGS) indications remains a challenge across the globe, largely driven by operating room availability and staffing constraints. The “timing in acute care surgery” (TACS) classification was previously published to introduce a new tool to triage the timely and appropriate access of EGS patients to the operating room. However, the clinical and operational effectiveness of the TACS classification has not been investigated in subsequent validation studies. This study aimed to improve the TACS classification and provide further consensus around the appropriate use of the new TACS classification through a standardized Delphi approach with international experts. Methods: This is a validation study of the new TACS by a selected international panel of experts using the Delphi method. The TACS questionnaire was designed as a web-based survey. The consensus agreement level was established to be ≥ 75%. The collective consensus agreement was defined as the sum of the percentage of the highest Likert scale levels (4–5) out of all participants. Surgical emergency diseases and correlated clinical scenarios were defined for each of the proposed classes. Subsequent rounds were carried out until a definitive level of consensus was reached. Frequencies and percentages were calculated to determine the degree of agreement for each surgical disease. Results: Four polling rounds were carried out. The new TACS classification provides 6 colour-code classes correlated to a precise timing to surgery, defined scenarios and surgical condition. The WHITE colour-code class was introduced to rapidly (within a week) reschedule cancelled or postponed surgical procedures. Haemodynamic stability is the main tool to stratify patients for immediate surgery or not in the presence of sepsis/septic shock. Fifty-one surgical diseases were included in the different colour-code classes of priority. Conclusion: The new TACS classification is a comprehensive, simple, clear and reproducible triage system which can be used to assess the severity of the patient and the surgical disease, to reduce the time to access to the operating room, and to manage the emergency surgical patients within a “safe” timeframe. By including well-defined surgical diseases in the different colour-code classes of priority, validated through a Delphi consensus, the new TACS improves communication among surgeons, between surgeons and anaesthesiologists and decreases conflicts and waste and waiting time in accessing the operating room for emergency surgical patients.

Published
2023

17. Lung failure after thoracic trauma in the elderly – a retrospective analysis from the German TraumaRegister

Author

Vollrath, JT, Marzi, I, Lefering, R, Störmann, P, and DGU TraumaRegister, Sektion NIS der DGU, Berlin, Germany

Subjects
ddc: 610, Medicine and health
Abstract

Objective: In Germany and developed countries worldwide the number of higher aged patients is increasing. Pulmonary complications are common in multiple traumatized patients with chest injury. We assessed whether geriatric patients develop lung failure following multiple trauma with concomitant thoracic [for full text, please go to the a.m. URL]

Published
2021
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26. Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence.

Author

Teuben, Michel Paul Johan, Pfeifer, Roman, Horst, Klemens, Simon, Tim-Philipp, Heeres, Marjolein, Kalbas, Yannik, Blokhuis, Taco, Hildebrand, Frank, Koenderman, Leo, Pape, Hans-Christoph, Leenen, Luke, TREAT-Research Collaboration, Auner, B., Störmann, P., Relja, B., Marzi, I., Simon, T. P., Marx, G., Haug, A., and Egerer, L.

Subjects
BIOPROSTHESIS, FLOW cytometry, ANIMAL experimentation, SWINE, NEUTROPHILS, RANDOMIZED controlled trials, GENE expression, COMPARATIVE studies, FRACTURE fixation, BLOOD circulation, STATISTICAL sampling, FEMORAL fractures
Abstract

Purpose: Intramedullary nailing (IMN) of fractures is associated with increased rates of inflammatory complications. The pathological mechanism underlying this phenomenon is unclear. However, polymorphonuclear granulocytes (PMNs) seem to play an important role. We hypothesized that a femur fracture and standardized IMN in pigs is associated with altered appearance of PMNs in circulation and enhanced activation status of these cells. Methods: A porcine model including a femur fracture and IMN was utilized. Animals were randomized for control [anesthesia + mechanical ventilation only (A/MV)] and intervention [A/MV and unilateral femur fracture (FF) + IMN] conditions. PMN numbers and responsiveness, integrin (CD11b), L-selectin (CD62L) and Fcγ-receptor (CD16 and CD32)-expression levels were measured by flowcytometry of blood samples. Animals were observed for 72 h. Results: Circulatory PMN numbers did not differ between groups. Early PMN-responsiveness was retained after insult. PMN-CD11b expression increased significantly upon insult and peaked after 24 h, whereas CD11b in control animals remained unaltered (P = 0.016). PMN-CD16 expression levels in the FF + IMN-group rose gradually over time and were significantly higher compared with control animals, after 48 h (P = 0.016) and 72 h (P = 0.032). PMN-CD62L and CD32 expression did not differ significantly between conditions. Conclusion: This study reveals that a femur fracture and subsequent IMN in a controlled setting in pigs is associated with enhanced activation status of circulatory PMNs, preserved PMN-responsiveness and unaltered circulatory PMN-presence. Indicating that monotrauma plus IMN is a specific and substantial stimulus for the cellular immune system. Early alterations of circulatory PMN receptor expression dynamics may be predictive for the intensity of the post traumatic response. [ABSTRACT FROM AUTHOR]

Published
2022
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28. The German national TBI-registry – preliminary data from the pilot period

Author

Younsi, A, Unterberg, AW, Czorlich, P, Hussam, AH, Lindner, D, Luchtmann, M, Lustenberger, T, Maegele, M, Marzi, I, Mauer, UM, Schmieder, K, Strowitzki, M, Uhl, E, Westermaier, T, Wolf, S, and Steudel, WI

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Objective: Since nationwide data on the epidemiology, treatment characteristics and long-term outcome of severe traumatic brain injury (TBI) in Germany are lacking, neurosurgeons from the German Neurosurgery Society (DGNC) and traumatologists from the German Trauma Society (DGU) joined forces in 2016[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Published
2020
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30. Cardiac Depression in Pigs after Multiple Trauma – Characterization of Posttraumatic Structural and Functional Alterations

Author

Kalbitz, M., Schwarz, S., Weber, B., Bosch, B., Pressmar, J., Hoenes, F M., Braun, C K., Horst, K., Simon, T P., Pfeifer, R., Störmann, P., Hummler, H., Gebhard, F., Pape, H C., Huber-Lang, M., Hildebrand, F., TREAT Research Group, Auner, B., Relja, B., Marzi, I., Marx, G., Haug, A., Egerer, L., Griensven, M V., Tolba, R., Reiss, K., Uhlig, S., Teuben, M., Almahmoud, K., Kalbas, Y., Lüken, H., University of Zurich, and Kalbitz, M

Subjects
0301 basic medicine, Cardiac function curve, Male, Pathology, medicine.medical_specialty, Swine, Heart Ventricles, Interleukin-1beta, lcsh:Medicine, 610 Medicine & health, Apoptosis, 030204 cardiovascular system & hematology, Lung injury, Article, Desmin, Histones, 03 medical and health sciences, 0302 clinical medicine, Cytosol, Troponin I, Medicine, Animals, Actinin, Myocytes, Cardiac, lcsh:Science, Femur fracture, 1000 Multidisciplinary, Multidisciplinary, Ejection fraction, business.industry, Multiple Trauma, lcsh:R, medicine.disease, Polytrauma, 10021 Department of Trauma Surgery, 030104 developmental biology, medicine.anatomical_structure, Heart Injuries, Ventricle, Echocardiography, Connexin 43, Zonula Occludens-1 Protein, lcsh:Q, business, Fatty Acid Binding Protein 3
Abstract

Scientific reports 7(1), 17861 (2017). doi:10.1038/s41598-017-18088-1, Published by Nature Publishing Group, London

Published
2017

38. Increased functional abnormalities in neutrophils are caused by a phenotypic shift of three different subsets after trauma

Author

Janicová, A, Xu, B, Störmann, P, Marzi, I, and Relja, B

Subjects
ddc: 610, neutrophils, phagocytosis, ROS, polytrauma, 610 Medical sciences, Medicine
Abstract

Objectives: Severely injured patients (TP) are prone to the development of secondary infectious complications due to imbalanced immune response. Neutrophils as a first line defence against invading pathogens were recently subdivided into three subsets with possible functional diversity. Since phenotypic[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2019)

Published
2019
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