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566 results on '"McArthur, Justin C."'

1. Neurological Aspects of Substance Use Disorder: An Introduction.

Author

McArthur, Justin C. and Stitt, Derek W.

Subjects
*SUBSTANCE abuse, *MENTAL health services, *NEUROLOGISTS, *DRUG overdose, *MEDICAL education, *DRUGS of abuse
Abstract

This article provides an overview of substance use disorder (SUD) from a neurological perspective. It acknowledges the significant impact of SUD on individuals and society, including drug overdoses and related disruptions. The article covers various aspects of SUD, including neurological disorders associated with substance use, epidemiological trends, legal and policy considerations, and treatment options. It also discusses emerging trends in substance use, such as polysubstance use and the emergence of new drugs. The article emphasizes the importance of destigmatizing SUD and addressing biases in treatment, as well as the role of neurologists in recognizing and treating SUD. It highlights the low percentage of adults with Opioid Use Disorder (OUD) who receive Medication for Opioid Use Disorder (MOUD), particularly among certain groups, and the need to address disparities in MOUD uptake. The article explores harm reduction strategies, potential new treatments, and risk factors for SUD. It concludes by emphasizing the importance of neurologists educating themselves on SUD and its treatment. [Extracted from the article]

Published
2024
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2. Correlates of HIV RNA concentrations in cerebrospinal fluid during antiretroviral therapy: a longitudinal cohort study

Author

Abramson, Ian, Al-Lozi, Muhammad T., Archibald, Sarah L., Atkinson, J. Hampton, Best, Brookie M., Clifford, David B., Collier, Ann C., Cushman, Clint, Dawson, Matthew S., Ellis, Ronald J., Fennema-Notestine, Christine, Franklin, Donald R., Gelman, Benjamin B., Grant, Igor, Head, Eleanor, Heaton, Robert K., Jones, Trudy, Letendre, Scott, Maravilla, Kenneth R., Marcotte, Thomas D., Marra, Christina M., McArthur, Justin C., McCutchan, J. Allen, Mintz, Letty, Morgello, Susan, Naidich, Thomas P., Sacktor, Ned, Simpson, David M., Smith, David M., Stegbauer, Keith C., Tang, Cheuk Y., Teshome, Mengesha, Livelli, Alessandro, Vaida, Florin, Ellis, Ronald J, Ma, Qing, Ferrara, Micol, Clifford, David B, Collier, Ann C, Gelman, Benjamin B, Marra, Christina M, McArthur, Justin C, McCutchan, J Allen, Simpson, David M, and Letendre, Scott L

Published
2019
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6. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

Author

Heaton, Robert K., Franklin, Donald R., Ellis, Ronald J., McCutchan, J. Allen, Letendre, Scott L., LeBlanc, Shannon, Corkran, Stephanie H., Duarte, Nichole A., Clifford, David B., Woods, Steven P., Collier, Ann C., Marra, Christina M., Morgello, Susan, Mindt, Monica Rivera, Taylor, Michael J., Marcotte, Thomas D., Atkinson, J. Hampton, Wolfson, Tanya, Gelman, Benjamin B., McArthur, Justin C., Simpson, David M., Abramson, Ian, Gamst, Anthony, Fennema-Notestine, Christine, Jernigan, Terry L., Wong, Joseph, and Grant, Igor

Subjects
Biomedicine, Neurology, Immunology, Infectious Diseases, Virology, Neurosciences, HIV, Combination antiretroviral therapy, HIV dementia
Abstract

Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be reported. Because large HIV-infected (HIV+) and uninfected (HIV−) groups have not been studied with similar methods in the pre-CART and CART eras, it is unclear whether CART has changed the prevalence, nature, and clinical correlates of HAND. We used comparable methods of subject screening and assessments to classify neurocognitive impairment (NCI) in large groups of HIV + and HIV − participants from the pre-CART era (1988–1995; N = 857) and CART era (2000–2007; N = 937). Impairment rate increased with successive disease stages (CDC stages A, B, and C) in both eras: 25%, 42%, and 52% in pre-CART era and 36%, 40%, and 45% in CART era. In the medically asymptomatic stage (CDC-A), NCI was significantly more common in the CART era. Low nadir CD4 predicted NCI in both eras, whereas degree of current immunosuppression, estimated duration of infection, and viral suppression in CSF (on treatment) were related to impairment only pre-CART. Pattern of NCI also differed: pre-CART had more impairment in motor skills, cognitive speed, and verbal fluency, whereas CART era involved more memory (learning) and executive function impairment. High rates of mild NCI persist at all stages of HIV infection, despite improved viral suppression and immune reconstitution with CART. The consistent association of NCI with nadir CD4 across eras suggests that earlier treatment to prevent severe immunosuppression may also help prevent HAND. Clinical trials targeting HAND prevention should specifically examine timing of ART initiation.

Published
2011

9. The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations

Author

Smith, Shannon M., Dworkin, Robert H., Turk, Dennis C., Baron, Ralf, Polydefkis, Michael, Tracey, Irene, Borsook, David, Edwards, Robert R., Harris, Richard E., Wager, Tor D., Arendt-Nielsen, Lars, Burke, Laurie B., Carr, Daniel B., Chappell, Amy, Farrar, John T., Freeman, Roy, Gilron, Ian, Goli, Veeraindar, Haeussler, Juergen, Jensen, Troels, Katz, Nathaniel P., Kent, Jeffrey, Kopecky, Ernest A., Lee, David A., Maixner, William, Markman, John D., McArthur, Justin C., McDermott, Michael P., Parvathenani, Lav, Raja, Srinivasa N., Rappaport, Bob A., Rice, Andrew S.C., Rowbotham, Michael C., Tobias, Jeffrey K., Wasan, Ajay D., and Witter, James

Published
2017
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13. Anemia and Red Blood Cell Indices Predict HIVAssociated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era

Author

CHARTER Study Group, Kallianpur, Asha R., Wang, Quan, Jia, Peilin, Hulgan, Todd, Zhao, Zhongming, Letendre, Scott L., Ellis, Ronald J., Heaton, Robert K., Franklin, Donald R., Barnholtz-Sloan, Jill, Collier, Ann C., Marra, Christina M., Clifford, David B., Gelman, Benjamin B., McArthur, Justin C., Morgello, Susan, Simpson, David M., McCutchan, J. A., and Grant, Igor

Published
2016

17. Global neurology: It's time to take notice.

Author

Rutkove, Seward B., Poduri, Annapurna, Holloway, Robert G., Pomeroy, Scott L., and McArthur, Justin C.

Subjects
NEUROLOGY, TUBERCULOUS meningitis, CAREER development, PEDIATRIC neurology, EDUCATORS, CULTURAL humility
Abstract

The scope of research being undertaken by this group of neurologists, each having come to Zambia with a commitment to make a difference, was truly remarkable, and even more so because the work included, and was often led, by past or present Zambian neurology trainees. This infrastructure is now in its fifth year and has trained the first generation of Zambian neurologists, including the first seven adult neurologists - Drs. [Extracted from the article]

Published
2023
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18. Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals

Author

Cooley, Sarah A., Paul, Robert H., Fennema-Notestine, Christine, Morgan, Erin E., Vaida, Florin, Deng, Qianqian, Chen, Jie Ashley, Letendre, Scott, Ellis, Ronald, Clifford, David B., Marra, Christina M., Collier, Ann C., Gelman, Benjamin B., McArthur, Justin C., McCutchan, J. Allen, Simpson, David M., Morgello, Susan, Grant, Igor, Ances, Beau M., and for the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group

Published
2016
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24. Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy

Author

Shikuma, Cecilia M., Bennett, Kara, Ananworanich, Jintanat, Gerschenson, Mariana, Teeratakulpisarn, Nipat, Jadwattanakul, Tanate, DeGruttola, Victor, McArthur, Justin C., Ebenezer, Gigi, Chomchey, Nitiya, Praihirunkit, Pairoa, Hongchookiat, Piranun, Mathajittiphun, Pornpen, Nakamoto, Beau, Hauer, Peter, Phanuphak, Praphan, Phanuphak, Nittaya, and for the SEARCH 003 protocol team

Published
2015
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27. Health-Related Quality of Life ‘Well-Being' in HIV Distal Neuropathic Pain is More Strongly Associated with Depression Severity than with Pain Intensity

Author

Keltner, John R., Vaida, Florin, Ellis, Ronald J., Moeller-Bertram, Tobias, Fitzsimmons, Chelsea, Duarte, Nichole A., Robinson-Papp, Jessica, Dworkin, Robert H., Clifford, David B., McArthur, Justin C., Simpson, David M., Collier, Ann C., Marra, Christina M., Atkinson, J. Hampton, and Grant, Igor

Published
2012
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41. Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection

Author

Fennema-Notestine, Christine, Ellis, Ronald J., Archibald, Sarah L., Jernigan, Terry L., Letendre, Scott L., Notestine, Randy J., Taylor, Michael J., Theilmann, Rebecca J., Julaton, Michelle D., Croteau, David J., Wolfson, Tanya, Heaton, Robert K., Gamst, Anthony C., Franklin, Jr., Donald R., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina, McArthur, Justin C., McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, and for the CHARTER Group

Published
2013
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42. Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER

Author

Holzinger, Emily R., Hulgan, Todd, Ellis, Ronald J., Samuels, David C., Ritchie, Marylyn D., Haas, David W., Kallianpur, Asha R., Bloss, Cinnamon S., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina M., McArthur, Justin C., McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Franklin, Donald R., Rosario, Debralee, Selph, Doug, Letendre, Scott, Grant, Igor, and for the CHARTER Group

Published
2012
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44. Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat

Author

Choi, Jun Yong, Hightower, George K., Wong, Joseph K., Heaton, Robert, Woods, Steven, Grant, Igor, Marcotte, Thomas D., Ellis, Ronald J., Letendre, Scott L., Collier, Ann C., Marra, Christina M., Clifford, David B., Gelman, Benjamin B., McArthur, Justin C., Morgello, Susan, Simpson, David M., McCutchan, J. Allen, Richman, Douglas D., Smith, Davey M., and Charter Group

Published
2012
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47. Clinical factors related to brain structure in HIV: the CHARTER study

Author

Jernigan, Terry L., Archibald, Sarah L., Fennema-Notestine, Christine, Taylor, Michael J., Theilmann, Rebecca J., Julaton, Michelle D., Notestine, Randy J., Wolfson, Tanya, Letendre, Scott L., Ellis, Ronald J., Heaton, Robert K., Gamst, Anthony C., Franklin, Jr., Donald R., Clifford, David B., Collier, Ann C., Gelman, Benjamin B., Marra, Christina, McArthur, Justin C., McCutchan, J. Allen, Morgello, Susan, Simpson, David M., Grant, Igor, and for the CHARTER Group

Published
2011
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