101 results on '"McLachlan, Fiona"'
Search Results
2. Investigating the role of eukaryotic translation elongation factor eEF1A2 in autism, epilepsy and intellectual disability
- Author
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McLachlan, Fiona, Abbott, Catherine, and Cousin, Mike
- Subjects
612.8 ,eEF1A2 ,heterozygous de novo missense mutations ,protein interactions - Abstract
Eukaryotic translation elongation factor eEF1A2 is responsible for delivering aminoacylated tRNAs to the ribosome during protein synthesis. Heterozygous de novo missense mutations in EEF1A2 have been identified in individuals with epilepsy, autism and intellectual disability. The primary aim of this thesis was to assess whether these mutations operated through a loss of function, gain of function or dominant negative mechanism. To investigate this, I analysed eEF1A2 protein interactions, how these interactions varied between mutations and the functional consequences of changes in the interactome. I used affinity purification mass spectrometry to identify the interactome of eEF1A2 and compared the changes resulting from mutations in eEF1A2. Co-immunoprecipitation experiments determined that mutations could be grouped by changes in their interaction with the cognate guanine exchange factor eEF1B. One group showed complete or partial loss of binding to all four subunits of the eEF1B complex, whilst another cluster showed no change in binding compared to wildtype eEF1A2. No specific patterns of clinical features or phenotypic severity could be attributed to these groupings. My results suggested that protein synthesis would be impaired by this disrupted interaction. In vivo and in vitro protein synthesis experiments failed to detect any differences that could be attributed to the presence or absence of the D252H mutation. As no apparent differences in protein synthesis could be detected between muscle tissue from Eef1a2⁻/⁻ and Eef1a2⁺/⁺ mice or between eEF1A2⁻/⁻ and wild-type cells, it is likely that in both cases the protein synthesis assay employed was not performing adequately. Comparative analysis of Eef1a2ᴰ²⁵²ᴴ/ᴰ²⁵²ᴴ and Eef1a2⁻/⁻ mouse phenotypes determined that there is a gain of function or dominant negative element to the eEF1A2ᴰ²⁵²ᴴ mutation, highlighting that this mutation does not operate simply through a loss of function mechanism. Interactome was unable to successfully identify what this might be. In conclusion eEF1A2 mutations may operate via both a loss and gain of function mechanism. Depending on the precise mutation, eEF1A2 may be compromised in its ability to operate in protein synthesis, but at least some mutations may also result in a degree of toxicity.
- Published
- 2020
- Full Text
- View/download PDF
3. Fun the key to playing better golf
- Author
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McLachlan, Fiona
- Published
- 1997
4. 'Am I an Easy Unit?' Challenges of Being and Becoming an Activist Teacher Educator in a Neoliberal Australian Context
- Author
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Luguetti, Carla and McLachlan, Fiona
- Abstract
Over the past decades, a body of scholarship has highlighted the possibilities of critical pedagogies in Health and Physical Education Teacher Education (HPETE) (Fitzpatrick, 2018. What happened to critical pedagogy in physical education? An analysis of key critical work in the field. "European Physical Education Review," 1-18; O'Sullivan, 2018. PETE academics as public intellectuals and activists in a global teacher education context. "Physical Education and Sport Pedagogy," 23(5), 536-543; Walton-Fisette & Sutherland, 2018. Moving forward with social justice education in physical education teacher education. "Physical Education and Sport Pedagogy," 23(5), 461-468). Although we have a body of research on social justice and critical pedagogy in HPETE, there is much to learn about the challenges activist teacher educators face in the process of being and becoming activists, especially in neoliberal contexts. This collaborative self-study explores the challenges of being and becoming an activist teacher educator in a neoliberal Australian context and how those challenges were negotiated. Participants included the lead researcher and a critical friend. Data collected included: (a) lead researcher observations collected as field notes; (b) lead researcher reflective diaries after each teaching episode; (c) meetings between the lead researcher and the critical friend; (d) material produced in the lead researcher's classes. Data analysis involved induction and constant comparison. The lead author faced internal and external challenges. First, the lead author had to negotiate her struggles to share power with students. The teacher educator started to be seen as a 'very cool person', teaching 'an easy unit'. Second, the teacher educator struggled to understand the complexities of teaching in a neoliberal context. The teacher educator [with the help of the critical friend] negotiated those challenges by understanding the importance to set expectations for learning within an activist approach and understanding the power of activist approaches to challenge a neoliberal system. Future studies should continue to explore the challenges activist teacher educators face in a context where students are socialized in neoliberal context, and educator's performance is measured in the same system.
- Published
- 2021
- Full Text
- View/download PDF
5. Subtexts of Research on Diversity in Sport Organizations: Queering Intersectional Perspectives.
- Author
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Knoppers, Annelies, McLachlan, Fiona, Spaaij, Ramón, and Smits, Froukje
- Subjects
- *
DIVERSITY in organizations , *LGBTQ+ organizations , *SPORTS administration , *BINARY gender system , *QUEER theory , *WOMEN leaders , *WOMEN athletes - Abstract
A great deal of research focusing on organizational diversity has explored dynamics that exclude women and minorities from positions of leadership in sport organizations. The relatively little change in diversity in these positions suggests a need to employ ways of engaging in diversity research that do not center on identity categories and primarily focus on practices. Drawing on notions of subtexts and on queer theory, this critical narrative review aims to make visible and to question organizational practices and processes that may contribute to the diversity "problem" within sport organizations. A subtextual analysis of 32 articles published in leading sport management journals reveals how dynamics of organizational culture, such as an uncritical use of the concept of diversity, the invisibility of practices sustaining gender binaries and heteronormativity, and the intersection of heteronormativity and White normativity, contribute to sustaining the status quo in sport organizations. The authors build on these findings to challenge scholars to further explore and address these practices and processes in sport organizations and in their own research by employing queered intersectional approaches. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
6. Inclusive Design and Pedagogy: An Outline of Three Innovations
- Author
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SCOTT, IAIN, MCLACHLAN, FIONA, and BROOKFIELD, KATHERINE
- Published
- 2018
- Full Text
- View/download PDF
7. Being Critical: An Account of an Early Career Academic Working within and against Neoliberalism
- Author
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McLachlan, Fiona
- Abstract
In 2014 I attended a symposium concerning Early Career Academics (ECAs) in the field of physical education and sport pedagogy. I was struck by the dominance of a particular theme at that symposium--that is, how to obtain a position and survive in academia. The aim of this paper is to use an inciting moment that occurred at this symposium as a means to confront some of the broader issues that I thought were at stake. Specifically I seek to interrogate the possible consequences of thinking about ECAs and academia in neoliberal terms, for the future of the field--a field that has a strong critical tradition. To this end I utilise autoethnographic techniques to connect the personal to the cultural and attempt to describe and analyse my story of becoming and being a critical scholar of sport, in a neoliberal context.
- Published
- 2017
- Full Text
- View/download PDF
8. Palladium catalysed reactions in ionic liquids
- Author
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McLachlan, Fiona
- Subjects
541.39 - Published
- 2008
9. Old Rules for New Times: Sportswomen and Media Representation in the COVID-19 Pandemic.
- Author
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McDonald, Brent, McLachlan, Fiona, and Spaaij, Ramón
- Subjects
- *
COVID-19 pandemic , *WOMEN'S sports , *WOMEN athletes , *PROFESSIONAL sports - Abstract
During the first few months of the pandemic, professional sport around the globe stopped, as competitions and leagues were cancelled, postponed, or went into hiatus while sport administrators scrambled to work out ways to reboot their product in a COVID-19 world. Sport media outlets were faced with the task of reporting on sport and filling the void for fans in the absence of any live content. This article is concerned with the content, both in quantity and quality that fans of women's sport could consume in those first months. In the context of the current "boom" in women's professional sports, we draw on the analysis of two online sport media sites to consider the narratives of female athletes that fans had access to. The findings suggest that during the beginning of the pandemic sport stories about women were largely erased and replaced by those appealing to a very different fan market. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. Lustrous wrappings: Complex color and collaborative practices in the contemporary ceramic facade.
- Author
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McLachlan, Fiona, Lyu, Mengmeng, and Leng, Xuechang
- Subjects
- *
CERAMIC materials , *CERAMICS , *GLAZES , *LITERATURE reviews , *TILES , *BUILT environment , *BUILDING-integrated photovoltaic systems - Abstract
Glazed ceramic cladding is a material with a very long history of use in the built environment, whether as roof tiles, wall tiles, or more recently, as part of a rainscreen cladding system. A key factor in the resurgence of interest in ceramic as a cladding material—in addition to its inherent qualities of sustainability, malleability, durability, and fire resistance—is as a means of incorporating color into the facade. Although polychromatic facades are commonly achieved using tessellation of a range of single‐colored elements, this article will focus on complex layered and variegated color and texture within a single component. Historical glazes, such as the blue‐red of Chinese Jun ware pottery from the 12th century CE were produced through carefully controlled reduction kiln processes, yet retained an element of uncertainty in the resultant patterns and remain an inspiration for contemporary ceramic artists. Drawing on historical research, literature review and interviews with ceramic artists and industrial manufacturers, six case studies from the United Kingdom and China are discussed that show collaborative processes at different scales of operation. These combine unique artisan and artistic glazes, with standardized, rigorously tested, and internationally manufactured products. These "fusion glazes" refer to historic hand‐made practices to bring an element of unpredictability, and a layer of complexity in terms of color, texture and luster. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
11. Glycated Haemoglobin (HbA1c) and Future Physical and Mental Functional Health in the European Prospective Investigation into Cancer (EPIC)-Norfolk Population-Based Study.
- Author
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McLachlan, Fiona, Johnstone, Alexandra M., and Myint, Phyo Kyaw
- Subjects
- *
GLYCOSYLATED hemoglobin , *HEMOGLOBINS , *MENTAL health , *GLYCEMIC control , *BLOOD testing - Abstract
Little is understood about the relationship between glycated haemoglobin and future functional health in the general population. In this work, we aimed to assess if glycaemic control is associated with future physical and mental functional health at 18-month follow-up in a UK general population, in those with and without diabetes. This work was a cross-sectional study. Between 1995 and 1997, participants of the European Prospective Investigation into Cancer, Norfolk, attended a health check including blood testing for haemoglobin A1c (HbA1c) and completed a health and lifestyle questionnaire. Eighteen months later, self-reported physical and mental functional health were assessed using short form-36 (SF-36). Outcomes of interest included physical and mental component summary (PCS and MCS, respectively) scores of the SF-36. A total of 7343 participants (56% women, mean (SD) 58.1 ± 9.5 years) were eligible to be included, of whom 167 had prevalent diabetes. In our linear regression analysis, a higher HbA1c (mmol/mol) was found to be associated with a poorer PCS score (coefficient −0.15 (p < 0.0001)) at follow-up. After adjustment for comorbid conditions, including obesity, this association was no longer statistically significant. A higher HbA1c (mmol/mol) was associated with a better MCS score at follow-up; this finding was significant when adjusted for comorbid conditions (coefficient 0.029 (p < 0.05)). Our findings suggest that the association between a higher HbA1c and poorer physical functional health is explained by a higher BMI and comorbidity status in a general population. While higher HbA1c was found to be associated with higher mental functional health at follow-up, the magnitude of this association was small. Healthy responder bias and unmeasured confounding variables may have influenced this result; thus, it should be interpreted with caution. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
12. Modelling of Innovative SANEX Process Maloperations
- Author
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McLachlan, Fiona, Taylor, Robin, Whittaker, Daniel, Woodhead, David, and Geist, Andreas
- Published
- 2016
- Full Text
- View/download PDF
13. Enhancing social inclusion in sport: Dynamics of action research in super-diverse contexts.
- Author
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Spaaij, Ramon, Luguetti, Carla, McDonald, Brent, and McLachlan, Fiona
- Subjects
ACTION research ,SOCIAL integration ,SPORTS participation ,PUBLIC sociology ,COMMUNITIES ,ATHLETIC clubs ,SOCIALIZATION ,CULTURAL pluralism - Abstract
There are systemic and longstanding inequalities in sport participation for culturally and linguistically diverse (CALD) migrants. Drawing on theoretical foundations of critical pedagogy and social justice education, as well as a public sociology perspective, this paper examines the development of an action research (AR) project to support the co-creation of inclusive climates in sports clubs in CALD communities in Melbourne, Australia. We use artefacts from collaborative sessions, interviews, and surveys to analyse the AR's impact on participating community sport leaders' awareness and practice. The findings indicate how the collaborative process of assessing clubs' diversity and inclusion climates affected participants' awareness of inequities and exclusionary practices, and how the co-creation of strategies for change brought together diverse perspectives. We reflect on the implications and limitations of the AR for research practice aimed at promoting equitable social inclusion for CALD migrants in community sport. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. Gendering the Coronavirus Pandemic: Toward a Framework of Interdependence for Sport.
- Author
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Pape, Madeleine and McLachlan, Fiona
- Subjects
COVID-19 pandemic ,WOMEN athletes ,REPRESENTATIVE government ,WOMEN leaders ,PROFESSIONAL athletes ,GENDER inequality - Abstract
A growing body of research suggests that economic crises tend to exacerbate existing gender inequalities, particularly in the realms of paid work and political representation. Translating this to the case of sport, how and why might the impacts of the Coronavirus pandemic be felt unevenly by professional female athletes and women leaders? In this essay, the authors reflect on the classic feminist critique of the gendered construction of dependence and consider how its application in the context of sport might aid scholars in making sense of (a) the persistence of gendered precarity and inequality in sport, (b) the prospect of their exacerbation under conditions of a pandemic, and (c) how the current crisis might enable sport to move toward a model of interdependence in which its vastly unequal structures are changed for the better. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
15. Swimming History after Deconstruction: A Queer Engagement
- Author
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McLachlan, Fiona
- Published
- 2012
- Full Text
- View/download PDF
16. Gender-specific psychosocial stressors influencing mental health among women elite and semielite athletes: a narrative review.
- Author
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Pascoe, Michaela, Pankowiak, Aurélie, Woessner, Mary, Brockett, Camilla L., Hanlon, Clare, Spaaij, Ramón, Robertson, Sam, McLachlan, Fiona, and Parker, Alexandra
- Subjects
MALE athletes ,ATHLETES with disabilities ,CYBERBULLYING ,BODY image ,WOMEN'S mental health ,ELITE athletes ,ECOLOGICAL systems theory ,SPORTS participation - Abstract
Elite and semielite athletes commonly experience mental health concerns and disorders. Compared with men athletes, women athletes are at greater risk of a range of psychological stressors that contribute to health concerns and mental health disorders, which can impact their career satisfaction and longevity. In order to address and improve the mental health of women athletes, it is necessary to simultaneously tackle the gender specific psychosocial stressors that contribute to mental health outcomes. This narrative review examines the gender-specific stressors that affect mental health and well-being in women athletes, some of which are modifiable. Psychosocial stressors identified include exposure to violence, be it psychological, physical or sexual in nature, which can result in a myriad of acute and long-lasting symptoms; and inequities as reflected in pay disparities, under-representation in the media, fewer opportunities in leadership positions and implications associated with family planning and motherhood. Strategies to promote mental health in women athletes should be considered, and where possible, should proactively address gender-specific stressors likely to influence mental health in order to maximise positive outcomes in women athletes. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. 'You can't take a picture of this - it's already gone': erased evidence, political parody, postmodern histories [Paper in special issue: Sport History and the Cultural Turn. Booth, Douglas and Phillips, Murray (eds)]
- Author
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McLachlan, Fiona
- Published
- 2010
18. "You Have to Play Like a Man, But Still be a Woman": Young Female Colombians Negotiating Gender Through Participation in a Sport for Development and Peace (SDP) Organization.
- Author
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Oxford, Sarah and McLachlan, Fiona
- Subjects
- *
WOMEN , *GENDER inequality in sports , *WOMEN & sports , *SOCIAL change , *FEMININITY , *SOCIAL structure - Abstract
Colombian girls are not encouraged from playing sport due to gendered roles that idealize girls as "delicate" and reserve sport as an activity for boys. Since the early and mid-2000s girls living in two marginalized communities in Colombia have had the unique opportunity to participate in a sport for development and peace organization. Drawing on six months of ethnographic research, this paper explores how these young women are negotiating gender through their complex and limited participation in the organization. We argue these young women display an ambivalent position towards femininity and practice implicit feminism, which challenges gender norms. However, despite their feelings of agency and a creation of a "new" normal within their social bubble, evidence reveals traditional social structures continue to maintain the gender status quo. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
19. Who’s Afraid of the Internet?: Swimming in an Infinite Archive
- Author
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Mclachlan, Fiona, author and Booth, Douglas, author
- Published
- 2015
- Full Text
- View/download PDF
20. Close reading through colour
- Author
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McLachlan, Fiona
- Subjects
architecture ,colour - Published
- 2019
21. Nitric Acid Extraction into a TODGA Solvent Modified with Octanol
- Author
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Woodhead, David, McLachlan, Fiona, Taylor, Robin, Müllich, Udo, Geist, Andreas, Wilden, Andreas, and Modolo, Giuseppe
- Subjects
ddc:540 - Abstract
Distribution data for the partition of nitric acid between nitric acid solution and a solventphase comprising various combinations of TODGA, octanol and inert kerosene diluent havebeen generated, covering a range of conditions from 0–9 mol/L HNO3(aq), 0–100% octanol,0–0.4 mol/L TODGA over a temperature range from 10–50 °C. The data have been used toderive a model describing the nitric acid equilibrium between the phases suitable forincorporation in process models of e.g. the innovative SANEX process. For the nitric acid /octanol / diluent system it was found that an accurate prediction of nitric acid distributioncould be achieved using a model allowing 1:1, 1:2 and 1:3 nitric acid / octanol adducts. Forthe nitric acid / TODGA / diluent system the best models were found to be those allowing4:1, 3:1, 2:1, 1:1 and 2:2 nitric acid / TODGA adducts. Superimposing the models for nitricacid distribution into the individual extractants and comparing with experimental results forthe nitric acid / octanol / TODGA system showed systematic differences indicative ofantagonistic and synergistic effects applying in the ranges 0.5–1.5 mol/L HNO3 and >1.5 mol/L HNO3 respectively. These effects were modelled by the inclusion of 0:1:2, 1:1:1,2:1:3 and 3:1:2 nitric acid / TODGA / octanol adducts. The effect of temperature on nitricacid extraction was well described by an Arrhenius type expression with an activation energyof −25.7 kJ/mol. No diluent dependence was found for nitric acid extraction.
- Published
- 2019
22. Destinations and Directions: Colour and wayfinding for a dementia ward
- Author
-
McLachlan, Fiona
- Subjects
genetic structures - Abstract
Guidelines for the design of dementia care facilities tend to focus on colour contrast, often simplistically interpreted as a contrast in hue. Without the involvement of design professionals, the use of guidelines can lead to homogenous, monotonous and under-stimulating environments. Even as spatial orientation declines as the disease progresses, certain abilities, which allow for navigating space, may remain resilient, and it is accepted that further research on wayfinding using colour and 'landmarks' is required. The paper will discuss a live project for a colour installation within the male dementia ward at the Royal Edinburgh Hospital, with reference to the three main user groups: staff, carers and patients. It will suggest that design specificity in response to place and people, supported by knowledge of the potential of colour to modify space, can enhance the everyday lives and well being of long term building users.Keywords: Colour, dementia, wayfinding, design, live project
- Published
- 2018
23. 'These chicks go just as hard as us!' (Un)doing gender in a Dutch CrossFit gym.
- Author
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Schrijnder, Suzanne, van Amsterdam, Noortje, and McLachlan, Fiona
- Subjects
GENDER ,CHICKS ,GENDER inequality ,GYMNASIUMS ,EQUAL pay for equal work ,ORGANIZATIONAL structure ,GESTURE - Abstract
CrossFit is a relatively new fitness movement/sport, where women and men train together in the same space, performing the same athletic movements and gender equality is celebrated in CrossFit marketing, promoting equal opportunities for men and women. This paper explores how the much emphasized gender-equality narrative in CrossFit unfolds in gender performativity in a Dutch CrossFit gym. To this end, we draw from an ethnographic case study through which we examine the gendered narratives and bodily gestures of CrossFitters. Using Butler's heterosexual matrix, we found that gender ideologies emerge in explicit and implicit narratives, materials and organizational structure, and embodied performances in the CrossFit gym. CrossFitters, on the one hand, explicitly challenge gender norms and create a space where women can undertake behaviour that is traditionally considered masculine. However, traditional gender norms, including heterosexual desire, are nonetheless implicitly reproduced through performances, narratives and organizational structures present in CrossFit. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
24. Swimming With the Bicheno "Coffee Club": The Textured World of Wild Swimming.
- Author
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Gould, Shane, McLachlan, Fiona, and McDonald, Brent
- Subjects
- *
SWIMMING , *ANIMAL social behavior , *SOCIAL interaction , *COFFEE , *SWIMMERS - Abstract
Wild swimming is currently experiencing a surge in popularity as people avowedly attempt to reconnect with the natural world. Previous research has positioned wild swimming as a solitary pursuit whereby individuals retreat from society to connect with or overcome nature and better themselves. This article draws on an ethnographic examination of a wild swimming group in Australia and reveals that while being in nature and personal fulfillment are key motivations for these wild swimmers, it is the social interactions that facilitate a deep engagement with their local "bluespace." We argue that rather than swimming away from the world, by "wayfaring" together these swimmers become connected to their environment, and each other, simultaneously. Such findings indicate potential social, health, and environmental benefits of collective wild swimming. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
25. Colour here, there, and in‐between—Placemaking and wayfinding in mental health environments.
- Author
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McLachlan, Fiona and Leng, Xuechang
- Subjects
- *
STUDENT volunteers , *MENTAL health , *WAYFINDING , *HEALTH facilities , *COLOR , *ARCHITECTURAL education - Abstract
Colour design in mental healthcare environments is acutely significant. Sensory acuity may be impaired through age, illness, or heightened stress and anxiety. While research has played a role in the development of guidance on the use of colour in such environments, this article suggests that this tends to be followed in a dogmatic, risk‐averse manner and predominately without professional design input, leading to monotonous and under‐stimulating environments. The article reports on two case study projects by the authors, involving user participation and student volunteers. These colour design installations provide examples of practice‐led applied research within occupied healthcare facilities. The article discusses the significance of site‐specific colour design in relation to place‐making and wayfinding with reference to previous research that considers the role of colour as part of the everyday experience of all users, in contrast to an approach focused solely on the behavior of patients. It concludes that colour design knowledge developed and applied through "real world" live projects, involving students as part of their architectural education can address some of the shortcomings of laboratory or staged colour research. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
26. 'Am I an easy unit?' Challenges of being and becoming an activist teacher educator in a neoliberal Australian context.
- Author
-
Luguetti, Carla and McLachlan, Fiona
- Subjects
- *
ACTIVISM , *TEACHER education , *PHYSICAL education teachers , *HEALTH education teachers , *NEOLIBERALISM - Abstract
Over the past decades, a body of scholarship has highlighted the possibilities of critical pedagogies in Health and Physical Education Teacher Education (HPETE) (Fitzpatrick, 2018. What happened to critical pedagogy in physical education? An analysis of key critical work in the field. European Physical Education Review, 1–18; O'Sullivan, 2018. PETE academics as public intellectuals and activists in a global teacher education context. Physical Education and Sport Pedagogy, 23(5), 536–543; Walton-Fisette & Sutherland, 2018. Moving forward with social justice education in physical education teacher education. Physical Education and Sport Pedagogy, 23(5), 461–468). Although we have a body of research on social justice and critical pedagogy in HPETE, there is much to learn about the challenges activist teacher educators face in the process of being and becoming activists, especially in neoliberal contexts. This collaborative self-study explores the challenges of being and becoming an activist teacher educator in a neoliberal Australian context and how those challenges were negotiated. Participants included the lead researcher and a critical friend. Data collected included: (a) lead researcher observations collected as field notes; (b) lead researcher reflective diaries after each teaching episode; (c) meetings between the lead researcher and the critical friend; (d) material produced in the lead researcher's classes. Data analysis involved induction and constant comparison. The lead author faced internal and external challenges. First, the lead author had to negotiate her struggles to share power with students. The teacher educator started to be seen as a 'very cool person', teaching 'an easy unit'. Second, the teacher educator struggled to understand the complexities of teaching in a neoliberal context. The teacher educator [with the help of the critical friend] negotiated those challenges by understanding the importance to set expectations for learning within an activist approach and understanding the power of activist approaches to challenge a neoliberal system. Future studies should continue to explore the challenges activist teacher educators face in a context where students are socialized in neoliberal context, and educator's performance is measured in the same system. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
27. Bedside echocardiography – are medical trainees falling behind?
- Author
-
McLachlan, Fiona
- Published
- 2021
- Full Text
- View/download PDF
28. The accidental move: accident and authority in design discourse
- Author
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McLachlan, Fiona and Coyne, Richard
- Published
- 2001
- Full Text
- View/download PDF
29. Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice
- Author
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Davies, Faith, Hope, Jilly, McLachlan, Fiona, Nunez, Francis, Doig, Jennifer, Bengani, Hemant, Smith, Colin, and Abbott, Catherine M
- Subjects
Gene Editing ,Genome ,Base Sequence ,Genotype ,Body Weight ,Article ,Death, Sudden ,Mice ,Peptide Elongation Factor 1 ,Gene Expression Regulation ,Spinal Cord ,Seizures ,Mutation ,Nerve Degeneration ,Animals ,CRISPR-Cas Systems ,Alleles - Abstract
De novo heterozygous missense mutations in the gene encoding translation elongation factor eEF1A2 have recently been found to give rise to neurodevelopmental disorders. Children with mutations in this gene have developmental delay, epilepsy, intellectual disability and often autism; the most frequently occurring mutation is G70S. It has been known for many years that complete loss of eEF1A2 in mice causes motor neuron degeneration and early death; on the other hand heterozygous null mice are apparently normal. We have used CRISPR/Cas9 gene editing in the mouse to mutate the gene encoding eEF1A2, obtaining a high frequency of biallelic mutations. Whilst many of the resulting founder (F0) mice developed motor neuron degeneration, others displayed phenotypes consistent with a severe neurodevelopmental disorder, including sudden unexplained deaths and audiogenic seizures. The presence of G70S protein was not sufficient to protect mice from neurodegeneration in G70S/− mice, showing that the mutant protein is essentially non-functional.
- Published
- 2017
- Full Text
- View/download PDF
30. Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
- Author
-
Davies, Faith C J, Hope, Jilly E, McLachlan, Fiona, Marshall, Grant F, Kaminioti-Dumont, Laura, Qarkaxhija, Vesa, Nunez, Francis, Dando, Owen, Smith, Colin, Wood, Emma, MacDonald, Josephine, Hardt, Oliver, and Abbott, Catherine M
- Published
- 2020
- Full Text
- View/download PDF
31. It's Boom Time! (Again): Progress Narratives and Women's Sport in Australia.
- Author
-
McLachlan, Fiona
- Subjects
- *
WOMEN'S sports , *GENDER inequality , *FEMINISM , *SOCIAL change - Abstract
Over the last three years (2015-2017), various media articles have pointed to an apparent "boom time" for women's sport in Australia. Evidence for this boom is drawn from examples such as the introduction of the Women's Australian Rules Football League, the television success of the Women's Big Bash League (cricket), and the rise in interest in soccer due to the international achievement of the Matildas. Such media reports reflect and reinforce a narrative of progress that assumes that gender equality is becoming closer with every decade. This paper employs a critical historical method inspired by the work of Joan W. Scott to analyse articles that have declared or commented on a contemporary boom in women's sport in Australia. The 120 contemporary articles are analysed alongside 400 historical articles that present similar arguments and themes. In identifying similarities between the historical and contemporary articles, this paper raises questions about the reality of the so-called moment of progress we are currently experiencing, and discusses the possible consequences for feminism and social change in sport. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
32. Nitric Acid Extraction into a TODGA Solvent Modified with 1-Octanol.
- Author
-
Woodhead, David, McLachlan, Fiona, Taylor, Robin, Müllich, Udo, Geist, Andreas, Wilden, Andreas, and Modolo, Giuseppe
- Subjects
- *
NITRIC acid , *SOLVENT extraction , *ACTIVATION energy , *DATA distribution , *TEMPERATURE effect , *PARTITION coefficient (Chemistry) - Abstract
Distribution data for the partition of nitric acid between nitric acid solution and a solvent phase comprising various combinations of TODGA, octanol, and inert kerosene diluent have been generated, covering a range of conditions from 0 to 9 mol/L HNO3(aq), 0–100% octanol, 0–0.4 mol/L TODGA over a temperature range from 10°C to 50°C. The data have been used to derive a model describing the nitric acid equilibrium between the phases suitable for incorporation in process models of the innovative SANEX process, for example. For the nitric acid/octanol/diluent system, it was found that an accurate prediction of nitric acid distribution could be achieved using a model allowing 1:1, 1:2, and 1:3 nitric acid/octanol adducts. For the nitric acid/TODGA/diluent system, the best models were found to be those allowing 4:1, 3:1, 2:1, 1:1, and 2:2 nitric acid/TODGA adducts. Superimposing the models for nitric acid distribution into the individual extractants and comparing with experimental results for the nitric acid/octanol/TODGA system showed systematic differences indicative of antagonistic and synergistic effects applying in the ranges 0.5–1.5 mol/L HNO3 and >1.5 mol/L HNO3, respectively. These effects were modelled by the inclusion of 0:1:2, 1:1:1, 2:1:3, and 3:1:2 nitric acid/TODGA/octanol adducts. The effect of temperature on nitric acid extraction was well described by an Arrhenius type expression with an activation energy of −25.7 kJ/mol. No diluent dependence was found for nitric acid extraction. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
33. The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders.
- Author
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McLachlan, Fiona, Sires, Anna Martinez, and Abbott, Catherine M.
- Abstract
The multi‐subunit eEF1 complex plays a crucial role in de novo protein synthesis. The central functional component of the complex is eEF1A, which occurs as two independently encoded variants with reciprocal expression patterns: whilst eEF1A1 is widely expressed, eEF1A2 is found only in neurons and muscle. Heterozygous mutations in the gene encoding eEF1A2, EEF1A2, have recently been shown to cause epilepsy, autism, and intellectual disability. The remaining subunits of the eEF1 complex, eEF1Bα, eEF1Bδ, eEF1Bγ, and valyl‐tRNA synthetase (VARS), together form the GTP exchange factor for eEF1A and are ubiquitously expressed, in keeping with their housekeeping role. However, mutations in the genes encoding these subunits EEF1B2 (eEF1Bα), EEF1D (eEF1Bδ), and VARS (valyl‐tRNA synthetase) have also now been identified as causes of neurodevelopmental disorders. In this review, we describe the mutations identified so far in comparison with the degree of normal variation in each gene, and the predicted consequences of the mutations on the functions of the proteins and their isoforms. We discuss the likely effects of the mutations in the context of the role of protein synthesis in neuronal development. The multi‐subunit eEF1 complex plays a crucial role in de novo protein synthesis. Mutations in subunits of the complex (eEF1A2, eEF1Bα, eEF1Bδ and valyl‐tRNA synthetase) have been identified in individuals with neurodevelopmental disorders. In this review we describe the mutations, their predicted functional consequences, and discuss possible reasons for the particular sensitivity of neurons to perturbations in protein homeostasis. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
34. Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials.
- Author
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He, Yazhou, Li, Xue, Gasevic, Danijela, Brunt, Eleanor, McLachlan, Fiona, Millenson, Marisa, Timofeeva, Maria, Ioannidis, John P.A., Campbell, Harry, and Theodoratou, Evropi
- Subjects
RANDOMIZED controlled trials ,STATINS (Cardiovascular agents) ,MEDICAL care ,CLINICAL trials ,COHORT analysis - Abstract
Background: Many effects of statins on non-cardiovascular disease (non-CVD) outcomes have been reported.Purpose: To evaluate the quantity, validity, and credibility of evidence regarding associations between statins and non-CVD outcomes and the effects of statins on these outcomes.Data Sources: MEDLINE and EMBASE (English terms only, inception to 28 May 2018).Study Selection: Meta-analyses (published in English) of observational studies and of randomized controlled trials (RCTs) that examined non-CVD outcomes of statin intake.Data Extraction: Two investigators extracted data from meta-analyses and individual studies. Credibility assessments based on summary effect sizes from a random-effects model, between-study heterogeneity, 95% prediction interval, small-study effect, excess significance, and credibility ceilings were devised to classify evidence.Data Synthesis: This review explored 278 unique non-CVD outcomes from 112 meta-analyses of observational studies and 144 meta-analyses of RCTs. For observational studies, no convincing (class I) evidence, 2 highly suggestive (class II) associations (decreased cancer mortality in patients with cancer and decreased exacerbation in patients with chronic obstructive pulmonary disease), 21 suggestive (class III) associations, and 42 weak (class IV) associations were identified. One outcome from the RCTs (decreased all-cause mortality in patients with chronic kidney disease) attained a sufficient amount of evidence with no hints of bias. For adverse events, observational studies showed suggestive evidence that statins increase the risk for diabetes and myopathy. Among the RCTs, no statistically significant effects were found on myopathy, myalgia, or rhabdomyolysis.Limitations: Studies with relevant data and outcomes not included in the meta-analyses may have been missed. Credibility assessments relied on several assumptions and arbitrary thresholds.Conclusion: The absence of convincing evidence of an association between statins and non-CVD outcomes supports leaving the current recommendations unchanged.Primary Funding Source: None. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
35. Spent Fuel and Minor Actinide Partitioning Safety Related Research at NNL
- Author
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M. J. Carrott, Flint, Lauren, Gregson, Colin, Griffiths, Tamara, Hodgson, Zara, C. J. Maher, Mason, Chris, Mclachlan, Fiona, Orr, Robin M, Reilly, Stacey, Rhodes, Chris, Sarsfield, Mark John, Sims, Howard E., Shepherd, Daniel, Taylor, Robin John, Webb, Kevin J., Woodall, Sean, and Woodhead, David
- Published
- 2014
- Full Text
- View/download PDF
36. Altered space: The transformative capabilities of colour and light in the architecture of Steven Holl and UN Studio
- Author
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McLachlan, Fiona
- Subjects
architecture ,light ,Colour - Abstract
The paper will explore the transformative capabilities of colour and light in architecture through selected projects of two contemporary architectural practices. Colour, which is generated through the play of light, is never static and has the capability to be used as an instrument to tune and transform architectural space. Coloured glass has been used for centuries, although with the symbolism embodied in the window design as the primary intent and the interaction of the cast colours largely a secondary effect. Drawing on an interview with Ben van Berkel and Caroline Bos of UN Studio, based in Amsterdam, and considering the work of the American architect, Steven Holl, the paper argues that the metaphysical properties of reflected colour can be seen as instrumental to the synergic design of architectural space.
- Published
- 2011
- Full Text
- View/download PDF
37. Thinking, Teaching, Learning: Explorations in Primary School Design
- Author
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McLachlan, Fiona and Hallett, R
- Subjects
curriculum for excellence ,school design - Published
- 2009
38. Chromachronology: Seriality and the Professional Palette
- Author
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McLachlan, Fiona
- Abstract
2. (2009) McLachlan, F. ‘Chromachronology: Seriality and the Professional Palette’ at Seriality and Architecture Symposium, Edinburgh (Mar 2009). Submitted as article for publication to Architecture &, September 2010 (see below). ISBN 978-0-9559706-8-9 Keywords: Colour, palette
- Published
- 2009
39. Cutting the Cloth
- Author
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McLachlan, Fiona
- Abstract
(2008) McLachlan, F. ‘Cutting the Cloth’ invited paper/ speaker RIBA Research Space at Home Symposium 2008, London. Published online at:http://www.architecture.com/TheRIBA/AboutUs/InfluencingPolicy/ResearchAndDevelopment/ResearchSymposium/RIBAResearchSymposium2008.aspx Keywords: housing, space
- Published
- 2008
40. Cutting the cloth: the marketing of domestic space in the UK
- Author
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McLachlan, Fiona
- Subjects
architecture ,domestic architecture - Published
- 2008
41. Being critical: an account of an early career academic working within and against neoliberalism.
- Author
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McLachlan, Fiona
- Subjects
- *
PHYSICAL education teacher education , *PHYSICAL education teachers , *NEOLIBERALISM , *CRITICAL pedagogy , *AUTOETHNOGRAPHY - Abstract
In 2014 I attended a symposium concerning Early Career Academics (ECAs) in the field of physical education and sport pedagogy. I was struck by the dominance of a particular theme at that symposium—that is, how to obtain a position and survive in academia. The aim of this paper is to use an inciting moment that occurred at this symposium as a means to confront some of the broader issues that I thought were at stake. Specifically I seek to interrogate the possible consequences of thinking about ECAs and academia in neoliberal terms, for the future of the field—a field that has a strong critical tradition. To this end I utilise autoethnographic techniques to connect the personal to the cultural and attempt to describe and analyse my story of becoming and being a critical scholar of sport, in a neoliberal context. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
- Full Text
- View/download PDF
42. The Silent Game: A Critical Reading of the History of Netball in Australia.
- Author
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McLachlan, Fiona
- Subjects
NETBALL ,WOMEN'S basketball ,NETBALL players ,WOMEN netball players ,SPORTS - Abstract
Netball is commonly cited as being the national game for females in Australia. Yet the game’s popularity is not reflected in the field of sport history in the breadth or depth of analysis compared to other sports. There are only two major published academic articles pertaining to the origins and development of netball in Australia. In this paper, these articles are critically analyzed. The analysis reveals gaps, limitations, and inconsistencies in the history of netball in Australia. Despite what is said to be known about the history and historical significance of netball in Australia, many important questions remain. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
- View/download PDF
43. Nitric Acid Extraction into the TODGA/TBP Solvent.
- Author
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McLachlan, Fiona, Greenough, Katie, Geist, Andreas, McLuckie, Bliss, Modolo, Giuseppe, Wilden, Andreas, and Taylor, Robin
- Subjects
- *
NITRIC acid , *INORGANIC acids , *NITROGEN compounds , *ACTINIDE elements , *PHOSPHATES , *SOLVENT extraction , *SOLVENTS , *EXTRACTION (Chemistry) - Abstract
The tridentate diglycolamide ligandN,N,N′,N′-tetraoctyl diglycolamide (TODGA) shows many interesting properties and is a very good extractant for the minor actinides (MAs) and lanthanides but, due to its low loading capacity, requires a phase modifier when used in a solvent extraction process. Consequently, applications of TODGA in conjunction with tri-butyl phosphate (TBP) in novel DIAMEX and SANEX processes for recovering MAs have been reported. However, TODGA and TBP also extract nitric acid and this has a significant influence on process performance. Here new distribution data for the extraction of nitric acid into solvent phases containing TODGA and TBP have been collected and modeled using an equilibrium-based approach accounting for nitric acid activities in the aqueous phase. Models for the extraction of nitric acid using the individual extractants were obtained using a variety of complexes and these were then combined to give the extraction of the mixed TODGA and TBP solvent. Using this approach, the nitric acid extraction of the mixed TODGA/TBP system can be reliably reproduced indicating that no significant synergistic or antagonistic complexes are formed in solution. [ABSTRACT FROM PUBLISHER]
- Published
- 2016
- Full Text
- View/download PDF
44. Gender Politics, the Olympic Games, and Road Cycling: A Case for Critical History.
- Author
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McLachlan, Fiona
- Subjects
SEXISM ,OLYMPIC Games & society ,WOMEN & sports ,CYCLING ,HISTORY - Abstract
Sexism is an ongoing problem within the Olympic Games, and in broader society. Historians are well placed to analyze social change over time and have a role to play in transforming gendered meanings that contribute to cultural sexism. However, to have real political effects, historians need to pay greater attention to the contradictory, discontinuous, and complex aspects of gender history, and contextualize women’s experiences within the whole field of gender relations. In this paper, a critical historical approach inspired by Michel Foucault and Joan W. Scott is proposed as a means to achieve this goal. The case of road cycling is used as an example to illustrate how Olympic historians might approach a topic from this critical perspective. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
45. Colour and Contingency: Theory into Practice.
- Author
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McLachlan, Fiona and McLachlan, Ewen
- Subjects
THEORY of knowledge ,SOCIAL action ,SOCIAL theory ,APPLIED psychology ,THEORY-practice relationship - Abstract
Along with physical form, spatial articulation, and the expression of materiality, colour is an essential medium though which buildings are experienced, and its application can mediate the perception of other elements. A number of well-developed colour theories exist, yet their traction in the practice of architectural design appears minimal. This paper considers colour theory in the context of architectural practice, specifically though examples elicited from interviews with a number of practitioners. It reviews particular colour theories and suggests that for such thinking to become more widely integrated into practice, a transactional approach is needed, with both aspects drawing on, and informing, the other. Research that seeks to enhance the understanding of the strategic use of colour within architectural design practice could identify diverse, individual, and empirically based approaches, which may inform the development of post-positivist theoretical models. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
46. Ethereal material: colour and material surface.
- Author
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McLachlan, Fiona
- Published
- 2013
- Full Text
- View/download PDF
47. Plutonium Loading of Prospective Grouped Actinide Extraction (GANEX) Solvent Systems based on Diglycolamide Extractants.
- Author
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Brown, Jamie, McLachlan, Fiona, Sarsfield, Mark, Taylor, Robin, Modolo, Giuseppe, and Wilden, Andreas
- Subjects
- *
AMIDES , *PLUTONIUM , *ACTINIDE elements , *SOLVENT extraction , *NUCLEAR fuels , *PRECIPITATION (Chemistry) , *LONGITUDINAL method - Abstract
The Grouped Actinide Extraction (GANEX) process is being developed for actinide recycling within future nuclear fuel cycles. Interactions between potential solvents and macro-concentrations of plutonium are one of the most important issues in defining the GANEX process. Surprisingly, plutonium loading of diglycolamide (DGA) based solvents such as tetra-octyl DGA (TODGA) causes precipitation rather than a conventional third phase, in direct contrast to results with U(VI), Th(IV) or lanthanide ions. Various DGA based solvent systems have been screened for their plutonium loading capacity and 0.2 M TODGA with 0.5 M DMDOHEMA in a kerosene diluent is selected as the optimum solvent formulation of those tested. Plutonium can be relatively easily stripped from this solvent using aqueous acetohydroxamic acid but this is very acid dependent in the low acidity region. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
48. Is there a role for architects in mainstream private sector house building?
- Author
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Jenkins, Paul and McLachlan, Fiona
- Subjects
ARCHITECTURAL design ,HOUSING developers ,ARCHITECTS ,INDUSTRIAL design - Abstract
The paper draws on a recent research project 'Design at the Heart of Housebuilding', commissioned by the Scottish Government and undertaken in 2006-7; subsequently published in early 2008. This research focused on the conceptions and practice of design within private sector house developers in Scotland, which is used here as a basis for speculatively exploring opposing values between private sector housing developers and architects in housing design. Drawing initially on reviews of this relationship in the initial mass private sector housing provision in the inter-war period in the UK the paper then compares this with the more recent position as evidenced in the research, two generations later. It identifies and analyses the basis for a perpetuated mutual wariness as a way to understand the potential for change in current trends, and ends by highlighting some examples of alternative collaborations, where the skills and values of architects are more fully articulated with those of developers and manufacturers in innovative housing provision, including forms of mass customisation. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
49. Screening of TODGA/TBP/OK solvent mixtures for the grouped extraction of actinides.
- Author
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Brown, Jamie, Carrott, Michael J, Fox, O Danny, Maher, Chris J, Mason, Chris, McLachlan, Fiona, Sarsfield, Mark J, Taylor, Robin J, and Woodhead, Dave A
- Published
- 2010
- Full Text
- View/download PDF
50. Cohesive Narratives: Dissolving Aotearoa/New Zealand's Heroines of Water.
- Author
-
McLachlan, Fiona
- Subjects
SPORTS ,WOMEN swimmers ,ATHLETES -- Biography ,WOMEN in politics ,WOMEN athletes ,WOMEN heroes ,HEROES ,SPORTS literature ,SPORTS stories - Abstract
In this paper, the biographical sporting narratives produced about a selection of New Zealand's most successful women swimmers are interrogated and analyzed. It is argued that biographical narratives, ironically, pay insufficient attention to the complexity and fluidity of 'character'. As such, it is suggested that the interrogation of fictional characters is a useful way of exploring the cultural conditions of possibility which shape the (re)production of sporting heroines. To this end, the narrative of a fictional swimmer, Alex, is compared and contrasted to the biographical sports narratives of New Zealand women swimmers, and the untapped political possibilities of a fictional sports heroine are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF
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