594 results on '"Merino C"'
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2. Preparation and characterization of stable methyl myristate−in−water nanoemulsions as advanced working fluids for cooling systems
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Cabaleiro, D., Hermida−Merino, C., Losada−Barreiro, S., Agresti, F., Lugo, L., Hermida−Merino, D., and Piñeiro, M.M.
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- 2024
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3. Obstructive sleep apnea and periodic limb movement in children: is there really an association?
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González-Merino, C., Martínez-Cayuelas, E., Ladrón-Guevara, A., López-Gómez, R., Esteban-Amarilla, C., and del-Río Camacho, G.
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- 2024
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4. Biocompatibility enhancement of PLA by the generation of bionanocomposites with fish collagen derivatives
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Moya-Lopez, C., Valcarcel, J., Vázquez, José A., Bourson, P., Chapron, D., Solano, E., Piñeiro, M. M., Hermida-Merino, C., and Hermida-Merino, D.
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- 2022
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5. Combined gelatin-chondroitin sulfate hydrogels with graphene nanoparticles
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Hermida-Merino, C., Valcarcel, J., Vázquez, José A., Cabaleiro, D., Moya-Lopez, C., Piñeiro, M. M., and Hermida-Merino, D.
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- 2022
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6. Comparison of three different methodologies for the identification of high atmospheric turbidity episodes
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Mateos, D., Cachorro, V.E., Velasco-Merino, C., O'Neill, N.T., Burgos, M.A., Gonzalez, R., Toledano, C., Herreras, M., Calle, A., and de Frutos, A.M.
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- 2020
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7. Intratumoral delivery of tavokinogene telseplasmid yields systemic immune responses in metastatic melanoma patients
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Algazi, A., Bhatia, S., Agarwala, S., Molina, M., Lewis, K., Faries, M., Fong, L., Levine, L.P., Franco, M., Oglesby, A., Ballesteros-Merino, C., Bifulco, C.B., Fox, B.A., Bannavong, D., Talia, R., Browning, E., Le, M.H., Pierce, R.H., Gargosky, S., Tsai, K.K., Twitty, C., and Daud, A.I.
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- 2020
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8. Graphitized Carbon Nanofibers: new additive for the Negative Active Material of Lead Acid Batteries
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Blecua, M., Fatas, E., Ocon, P., Gonzalo, B., Merino, C., de la Fuente, F., Valenciano, J., and Trinidad, F.
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- 2017
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9. Effect of aluminium on mineralization of water extractable organic matter and microbial respiration in southern temperate rainforest soils
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Merino, C., Fontaine, S., Palma, G., and Matus, F.
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- 2017
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10. Convergence palsy secondary to amoxicillin
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Pérez-Roca, F., Alfaro Juárez, A., Sánchez Merino, C., and Navarro Mingorance, A.
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- 2016
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11. Hadroproduction of neutral K*-mesons up to LHC energies
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Arakelyan, G. H., Merino, C., and Shabelski, Yu. M.
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- 2019
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12. Production of φ Mesons on Nuclear Targets in the Quark–Gluon String Model
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Arakelyan, G. H., Merino, C., and Shabelski, Yu. M.
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- 2017
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13. Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium/reactive oxygen and nitrogen species cross-talk signaling
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Marques-da-Silva, D. and Gutierrez-Merino, C.
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- 2014
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14. Multi-temporal assessment of a wildfire chronosequence by remote sensing
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Nájera De Ferrari, F., Duarte, E., Smith-Ramírez, C., Rendon-Funes, A., Sepúlveda Gonzalez, V., Sepúlveda Gonzalez, N., Levio, M.F., Rubilar, R., Stehr, A., Merino, C., Jofré, I., Rojas, C., Aburto, F., Kuzyakov, Y., Filimonenko, E., Dörner, J., Pereira, P., and Matus, F.
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- 2024
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15. 20653. USO DE LA CLASIFICACIÓN MNCD EN PACIENTES CON ENFERMEDAD DE PARKINSON TRATADOS CON PERFUSIÓN DE LEVODOPA/CARBIDOPA/ENTACAPONA. MONITORIZACIÓN DE LA RESPUESTA EN PRÁCTICA CLÍNICA
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Reyes Toboso, D., Santos García, D., López Manzanares, L., Muro, I., Lorenzo, P., García Ramos, R., Fernández Valle, T., Morata Martínez, C., Baviera Muñoz, R., Martínez Torres, I., Álvarez Sauco, M., Alonso Modino, D., Legarda, I., Valero García, M., Suárez Muñoz, J., Martínez Castrillo, J., Perona, A., Salom, J., Cubo, E., Valero Merino, C,., López Ariztegui, N., Sánchez Alonso, P., Novo Ponte, S., Gamo Gómez, E., Martín García, R., Espinosa, R., Carmona, M., Feliz, C., García Ruíz, P., Muñoz Ruiz, T., Fernández Rodríguez, B., and Mata, M.
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- 2024
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16. 20604. LA CLASIFICACIÓN MNCD CORRELACIONA MEJOR CON LA CALIDAD DE VIDA Y SITUACIÓN FUNCIONAL EN LOS PACIENTES CON ENFERMEDAD DE PARKINSON QUE EL HOEHN Y YAHR
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Gallego González, L., Santos García, D., de Deus Fonticoba, T., Jesús Maestre, S., Cosgaya, M., García Caldentey, J., Caballol Pons, N., Legarda, I., Hernández Vara, J., Cabo, I., López Manzanares, L., González Aramburu, I., Ávila Rivera, M., Gómez Mayordomo, V., Nogueira Fernández, V., García Soto, J., Borrué Fernández, C., Solano Vila, B., Álvarez Sauco, M., Vela, L., Escalante, S., Cubo, E., Mendoza, Z., Pareés, I., Sánchez Alonso, P., Alonso Losada, M., López Ariztegui, N., Gastón, I., Kulisevsky, J., Seijo Martínez, M., Valero Merino, C., Alonso Redondo, R., Ordás, C., Menéndez González, M., Martínez Martín, P., and Mir Rivera, P.
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- 2024
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17. Centrality dependence of multistrange baryon production in high-energy heavy-ion collisions
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Arakelyan, G. H., Merino, C., and Shabelski, Yu. M.
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Phenomenology (hep-ph) ,FOS: Physical sciences - Abstract
We consider the experimental data on the production of strange Lambdas, and multistrange baryons (Xi, Omega), and antibaryons, on nuclear targets, at the energy region from SPS up to LHC, in the framework of the Quark-Gluon String Model. One remarkable result of this analysis is the significant dependence on the centrality of the collision of the experimental ratios bar(Xi)+/bar(Lambda) and bar(Omega)+/bar(Lambda) ratios in heavy-ion collisions, at SPS energies., 4 pages, 2 figures, 1 table Contribution to the 51th International Symposium on Multiparticle Dynamics (ISMD2022), Pitlochry, Scotland, UK, July 31st-August 5th (2022)
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- 2022
18. The Social Anxiety Questionnaire for Children: Cross-Cultural Assessment with a New Self-Report Measure
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Caballo, Vicente E., Salazar, Isabel C., Arias, Benito, Calderero, Marta, Irurtia, María J., Ollendick, Thomas H., Colussa, P., Flores, C., Brandani, L., Chiapetti, N., Fernandes, K., Lourenço, L., Rocha, C., Senra, L., Chesta, S., López, N., Vásquez, C., Veliz, A., Aldaz, L., Amorocho, P., Aristizabal, L., Benavides, A., Betancourt, S., Buitrago, L., Cárdenas, S., Coconubo, F., Cuspoca, Y., Díaz, P., Echeverry, C., Escobar, R., Estupiñán, L., Forero, J., González, J., Higuera, R., Jurado, D., Martínez, G., Martínez, M., Montenegro, Z., Ortega, M., Ospina, A., Pérez, M., Perilla, M., Pinto, B., Puerta, I., Quintero, H., Rivera, A., Rodao, D., Rojas, L., Romero, Y., Ruiz, L., Santamaría, L., Santander, R., Taborda, J., Gómez, V., Vindas, J., Ortega, L., Zúniga, A., Andreu, R., Bueno, B., de Haro, V., Ardón, R., Barcelata, B., Bonilla, M., Caballero, J., Castillo, D., Estrada-Martínez, S., Freyre, M., Garay, J., Hernández, L., Lara, E., Lechuga, A., Leija, G., Lira, J., Maldona, E., Martínez, G., Martínez, R., Meave, S., Mendoza, A., Moysén, A., Porras, A., Rentería, A., Rossano, B., Ruiz, G., Juan, A. San, Serrano, M., Servin, J., Silva, M., Stange, I., Villarruel, M., Virseda, J., Zalazar, B., Zarazua, M., Barreda, A., Beltrán, N., Calderón, M., Candelario, Y., Castillo, K., Cueva, J., Dorival, M., Huaynates, M., Maguiña, J., Merino, C., Segura, C., Tiburcio, G., Valdivia, A., Vallejos, J., Piña, C., and CISO-A Research Team
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- 2016
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19. High expression of cytochrome b 5 reductase isoform 3/cytochrome b 5 system in the cerebellum and pyramidal neurons of adult rat brain
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Samhan-Arias, A. K., López-Sánchez, C., Marques-da-Silva, D., Lagoa, R., Garcia-Lopez, V., García-Martínez, V., and Gutierrez-Merino, C.
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- 2016
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20. Flexible gas sensor array with an embedded heater based on metal decorated carbon nanofibres
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Claramunt, S., Monereo, O., Boix, M., Leghrib, R., Prades, J.D., Cornet, A., Merino, P., Merino, C., and Cirera, A.
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- 2013
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21. Flexible sensor based on carbon nanofibers with multifunctional sensing features
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Monereo, O., Claramunt, S., Marigorta, M. Martínez de, Boix, M., Leghrib, R., Prades, J.D., Cornet, A., Merino, P., Merino, C., and Cirera, A.
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- 2013
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22. 1936P Treatment outcomes of patients with anaplastic thyroid carcinoma (atc): Multicentric data from spanish national registry (regetne-tiroides)
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Rodellar, J.M., Hernando Cubero, J., Garcia Alvarez, A., Ceballos Lenza, I., Plana Serrahima, M., Gallardo, E., Bella, M.R., Jimenez Fonseca, P., Lopez, C., Jimeno Mate, R., Martinez Lago, N., Ayala de Miguel, P., Molina Cerrillo, J., Granados, A.R., Gonzalez Merino, C., Viana Aragonés, M., González Martín, G., Capdevila Castillon, J., and Alonso Gordoa, T.
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- 2024
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23. 1849P Clinical predictors of long-term responses to immune checkpoint inhibitors (ICI) in a multi-tumor cohort
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Albarrán Fernández, V., Guerrero, P., Gonzalez Merino, C., García de Quevedo Suero, C., Chamorro-Perez, J., Rosero Rodriguez, D.I., Barrill Corpa, A.M., Sotoca-Rubio, P., Alia Navarro, V., Pérez de Aguado, P., Calvo, J.C., Moreno, J., San Roman Gil, M.V., Alvarez Ballesteros, P., Cortes Salgado, A., Olmedo Garcia, M.E., Gomez Rueda, A., Garrido Lopez, P., Soria Rivas, A., and Gajate, P.
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- 2024
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24. 1162P Transcriptomic analysis of gastroenteropancreatic neuroendocrine tumours with carcinoid syndrome
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Pozas Perez, J., Alonso Gordoa, T., Ruz-Caracuel, I., Caniego-Casas, T., Gonzalez Merino, C., San Roman Gil, M.V., Albarrán Fernández, V., Granados, A.R., Rodellar, J.M., Viana Aragonés, M., Palacios Calvo, J., Garrido Lopez, P., and Molina Cerrillo, J.
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- 2024
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25. 1063P Influence of infusion timing on the outcomes of immunotherapy in a multi-tumor cohort
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Albarrán Fernández, V., Rosero Rodriguez, D.I., Chamorro-Perez, J., Guerrero, P., Gonzalez Merino, C., García de Quevedo Suero, C., Sotoca-Rubio, P., Barrill Corpa, A.M., Alia Navarro, V., Moreno, J., Calvo, J.C., Pérez de Aguado, P., San Roman Gil, M.V., Alvarez Ballesteros, P., Saavedra Serrano, C., Soria Rivas, A., Olmedo Garcia, M.E., Garrido Lopez, P., Cortes Salgado, A., and Gajate, P.
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- 2024
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26. Midrapidity hyperon production in pp and pA collisions from low to LHC energies
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Arakelyan, G. H., Merino, C., and Shabelski, Yu. M.
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- 2016
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27. The investigation and design for a unique architectural space – The Chillida Cavern, Mount Tindaya, Fuerteventura
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Macklin, S.R., Varley, P., Varona, P., and Merino, C.
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- 2012
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28. Repair of a leaking bleb filtration with conjunctival and amniotic membrane transplantation
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García-Serrano, J.L., García-Robles, P., Sánchez-Merino, C., and Rodríguez-Escobar, J.J.
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- 2011
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29. Advanced Performances In Gas Sensors: Stretchable, Flexible, Wireless, Wearable
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Monereo, O., Boix, M., Claramunt, S., Prades, J.D., Cornet, A., Cirera, A., Merino, P., and Merino, C.
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- 2011
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30. Characterization of prostate neuroendocrine cancers and therapeutic management: a literature review
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Sargos, P, Ferretti, L, Gross-Goupil, M, Orre, M, Cornelis, F, Henriques de Figueiredo, B, Houédé, N, Merino, C, Roubaud, G, Dallaudiére, B, Richaud, P, and Fléchon, A
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- 2014
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31. Proton and Λ hyperon production in nucleus-nucleus collisions
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Arakelyan, G. H., Merino, C., and Shabelski, Yu. M.
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- 2014
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32. Conductive CNF-reinforced hybrid composites by injection moulding
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Morales, G., Barrena, M.I., Salazar, J.M. Gómez de, Merino, C., and Rodríguez, D.
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- 2010
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33. Changes in Villin Synthesis and Subcellular Distribution during Intestinal Differentiation of HT29-18 Clones
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Dudouet, B., Robine, S., Huet, C., Sahuquillo-Merino, C., Blair, L., Coudrier, E., and Louvard, D.
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- 1987
34. Can Villin be Used to Identify Malignant and Undifferentiated Normal Digestive Epithelial Cells?
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Robine, S., Huet, C., Moll, R., Sahuquillo-Merino, C., Coudrier, E., Zweibaum, A., and Louvard, D.
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- 1985
35. On the Evaluation of the Tutte Polynomial at the Points (1, –1) and (2, –1)
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Goodall, A. J., Merino, C., de Mier, A., and Noy, M.
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- 2013
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36. Feynman scaling violation on baryon spectra in pp collisions at LHC and cosmic ray energies
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Arakelyan, G. H., Merino, C., Pajares, C., and Shabelski, Yu. M.
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- 2013
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37. Production of secondaries in soft p+Pb collisions at LHC and Alice data
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Merino, C., Pajares, C., and Shabelski, Yu. M.
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- 2013
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38. Elastic pp scattering at LHC energies
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Merino, C. and Shabelski, Y. M.
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- 2012
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39. Inclusive production at LHC energies
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Merino, C., Pajares, C., and Shabelski, Yu. M.
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- 2011
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40. Production of strange secondaries in high-energy Σ− A collisions
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Arakelyan, G. H., Kaidalov, A. B., Merino, C., and Shabelski, Yu. M.
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- 2011
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41. Vanadium and cadmium in vivo effects in teleost cardiac muscle: Metal accumulation and oxidative stress markers
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Soares, S.S., Martins, H., Gutiérrez-Merino, C., and Aureliano, M.
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- 2008
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42. Heavy-flavor production in pp and heavy-ion collisions in QCD up-to-LHC energies
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Merino, C., Pajares, C., Ryzhinskiy, M. M., Shabelski, Yu. M., and Shuvaev, A. G.
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- 2010
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43. On Polygons Enclosing Point Sets II
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Hurtado, F., Merino, C., Oliveros, D., Sakai, T., Urrutia, J., and Ventura, I.
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- 2009
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44. Possible odderon effects in inclusive hadron production
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Merino, C., Ryzhinskiy, M. M., and Shabelski, Yu. M.
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- 2009
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45. Production of secondaries in high-energy d+Au collisions
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Merino, C., Pajares, C., and Shabelski, Yu. M.
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- 2009
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46. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study
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James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, 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C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
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Aged, 80 and over ,Male ,Critical Care ,SARS-CoV-2 ,International Cooperation ,COVID-19 ,Middle Aged ,Cohort Studies ,Logistic Models ,Postoperative Complications ,Elective Surgical Procedures ,Neoplasms ,Outcome Assessment, Health Care ,Humans ,Female ,Epidemics ,Aged - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
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- 2021
47. Midrapidity production of secondaries in pp collisions at RHIC and LHC energies in the quark–gluon string model
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Arakelyan, G.H., Merino, C., Pajares, C., and Shabelski, Y.M.
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- 2008
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48. Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
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Kos, Z., Roblin, E., Kim, R. S., Michiels, S., Gallas, B. D., Chen, W., van de Vijver, K. K., Goel, S., Adams, S., Demaria, S., Viale, G., Nielsen, T. O., Badve, S. S., Symmans, W. F., Sotiriou, C., Rimm, D. L., Hewitt, S., Denkert, C., Loibl, S., Luen, S. J., Bartlett, J. M. S., Savas, P., Pruneri, G., Dillon, D. A., Cheang, M. C. U., Tutt, A., Hall, J. A., Kok, M., Horlings, H. M., Madabhushi, A., van der Laak, J., Ciompi, F., Laenkholm, A. -V., Bellolio, E., Gruosso, T., Fox, S. B., Araya, J. C., Floris, G., Hudecek, J., Voorwerk, L., Beck, A. H., Kerner, J., Larsimont, D., Declercq, S., Van den Eynden, G., Pusztai, L., Ehinger, A., Yang, W., Abduljabbar, K., Yuan, Y., Singh, R., Hiley, C., Bakir, M., Lazar, A. J., Naber, S., Wienert, S., Castillo, M., Curigliano, G., Dieci, M. -V., Andre, F., Swanton, C., Reis-Filho, J., Sparano, J., Balslev, E., Chen, I. -C., Stovgaard, E. I. S., Pogue-Geile, K., Blenman, K. R. M., Penault-Llorca, F., Schnitt, S., Lakhani, S. R., Vincent-Salomon, A., Rojo, F., Braybrooke, J. P., Hanna, M. G., Soler-Monso, M. T., Bethmann, D., Castaneda, C. A., Willard-Gallo, K., Sharma, A., Lien, H. -C., Fineberg, S., Thagaard, J., Comerma, L., Gonzalez-Ericsson, P., Brogi, E., Loi, S., Saltz, J., Klaushen, F., Cooper, L., Amgad, M., Moore, D. A., Salgado, R., Hyytiainen, A., Hida, A. I., Thompson, A., Lefevre, A., Gown, A., Lo, A., Sapino, A., Moreira, A. M., Richardson, A., Vingiani, A., Bellizzi, A. M., Guerrero, A., Grigoriadis, A., Garrido-Castro, A. C., Cimino-Mathews, A., Srinivasan, A., Acs, B., Singh, B., Calhoun, B., Haibe-Kans, B., Solomon, B., Thapa, B., Nelson, B. H., Ballesteroes-Merino, C., Criscitiello, C., Boeckx, C., Colpaert, C., Quinn, C., Chennubhotla, C. S., Solinas, C., Drubay, D., Sabanathan, D., Peeters, D., Zardavas, D., Hoflmayer, D., Johnson, D. B., Thompson, E. A., Perez, E., Elgabry, E. A., Blackley, E. F., Reisenbichler, E., Chmielik, E., Gaire, F., F. -I., Lu, Azmoudeh-Ardalan, F., Peale, F., Hirsch, F. R., Acosta-Haab, G., Farshid, G., Broeckx, G., Koeppen, H., Haynes, H. R., Mcarthur, H., Joensuu, H., Olofsson, H., Cree, I., Nederlof, I., Frahm, I., Brcic, I., Chan, J., Ziai, J., Brock, J., Weseling, J., Giltnane, J., Lemonnier, J., Zha, J., Ribeiro, J., Lennerz, J. K., Carter, J. M., Hartman, J., Hainfellner, J., Le Quesne, J., Juco, J. W., van den Berg, J., Sanchez, J., Cucherousset, J., Adam, J., Balko, J. M., Saeger, K., Siziopikou, K., Sikorska, K., Weber, K., Steele, K. E., Emancipator, K., El Bairi, K., Allison, K. H., Korski, K., Buisseret, L., Shi, L., Kooreman, L. F. S., Molinero, L., Estrada, M. V., Van Seijen, M., Lacroix-Triki, M., Sebastian, M. M., Balancin, M. L., Mathieu, M. -C., van de Vijver, M., Rebelatto, M. C., Piccart, M., Goetz, M. P., Preusser, M., Khojasteh, M., Sanders, M. E., Regan, M. M., Barnes, M., Christie, M., Misialek, M., Ignatiadis, M., de Maaker, M., Van Bockstal, M., Harbeck, N., Tung, N., Laudus, N., Sirtaine, N., Burchardi, N., Ternes, N., Radosevic-Robin, N., Gluz, O., Grimm, O., Nuciforo, P., Jank, P., Kirtani, P., Watson, P. H., Jelinic, P., Francis, P. A., Russell, P. A., Pierce, R. H., Hills, R., Leon-Ferre, R., de Wind, R., Shui, R., Leung, S., Tabbarah, S., Souza, S. C., O'Toole, S., Swain, S., Dudgeon, S., Willis, S., Ely, S., Bedri, S., Irshad, S., Liu, S., Hendry, S., Bianchi, S., Braganca, S., Paik, S., Luz, S., Gevaert, T., D'Alfons, T., John, T., Sugie, T., Kurkure, U., Bossuyt, V., Manem, V., Camaea, V. P., Tong, W., Tran, W. T., Wang, Y., Allory, Y., Husain, Z., Bago-Horvath, Z., Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Division of Pathology and Laboratory Medicine, Università degli Studi di Milano [Milano] (UNIMI)-European Institute of Oncology [Milan] (ESMO), Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Charité, Institute of Pathology, Translational Tumorpathology Unit, German Breast Group, University of the Sunshine Coast (USC), European Institute of Oncology [Milan] (ESMO), Breakthrough Breast Cancer Centre, London Institute of Cancer, Department of Pathology, The Netherlands Cancer Institute, Division of Experimental Therapy, The Netherlands Cancer Institute NKI/AvL, Odense University Hospital, Unité de génétique et biologie des cancers (U830), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Breast Medical Oncology [Houston], The University of Texas M.D. Anderson Cancer Center [Houston], Helsingborg Hospital, Division of Experimental Therapeutics [Milan, Italy], Département de médecine oncologique [Gustave Roussy], Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Memorial Sloane Kettering Cancer Center [New York], Herlev and Gentofte Hospital, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Southern Queensland (USQ), Pharmacogenomics Unit [Paris], Department of Genetics [Paris], Institut Curie [Paris]-Institut Curie [Paris], Instituto de Física Teórica UAM/CSIC (IFT), Universidad Autonoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ctr Biomol Struct & Org, University of Maryland [College Park], University of Maryland System-University of Maryland System, The University of Sydney, Breast Cancer Translational Research Laboratory, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB)-Faculté de Médecine [Bruxelles] (ULB), Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Int Immuno-Oncology Biomarker, Graduate School, CCA - Cancer biology and immunology, Pathology, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Milano = University of Milan (UNIMI)-European Institute of Oncology [Milan] (ESMO), German Breast Group (GBG), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Universidad Autónoma de Madrid (UAM)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Gallas, Brandon D [0000-0001-7332-1620], van de Vijver, Koen K [0000-0002-2026-9790], Demaria, Sandra [0000-0003-4426-0499], Badve, Sunil S [0000-0001-8861-9980], Symmans, W Fraser [0000-0002-1526-184X], Rimm, David L [0000-0001-5820-4397], Savas, Peter [0000-0001-5999-428X], Hall, Jacqueline A [0000-0003-0708-1360], Horlings, Hugo M [0000-0003-4782-8828], van der Laak, Jeroen [0000-0001-7982-0754], Bellolio, Enrique [0000-0003-0079-5264], Araya, Juan Carlos [0000-0003-3501-8203], Floris, Giuseppe [0000-0003-2391-5425], Hudeček, Jan [0000-0003-1071-5686], Ehinger, Anna [0000-0001-9225-7396], Lazar, Alexander J [0000-0002-6395-4499], Castillo, Miluska [0000-0002-0111-3176], Curigliano, Giuseppe [0000-0003-1781-2518], Sparano, Joseph [0000-0002-9031-2010], Braybrooke, Jeremy P [0000-0003-1943-7360], Hanna, Matthew G [0000-0002-7536-1746], Willard-Gallo, Karen [0000-0002-1150-1295], Sharma, Ashish [0000-0002-1011-6504], Comerma, Laura [0000-0002-0249-4636], Gonzalez-Ericsson, Paula [0000-0002-6292-6963], Loi, Sherene [0000-0001-6137-9171], Cooper, Lee [0000-0002-3504-4965], Apollo - University of Cambridge Repository, Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Medicum, Gallas, Brandon D. [0000-0001-7332-1620], van de Vijver, Koen K. [0000-0002-2026-9790], Badve, Sunil S. [0000-0001-8861-9980], Symmans, W. Fraser [0000-0002-1526-184X], Rimm, David L. [0000-0001-5820-4397], Hall, Jacqueline A. [0000-0003-0708-1360], Horlings, Hugo M. [0000-0003-4782-8828], Lazar, Alexander J. [0000-0002-6395-4499], Braybrooke, Jeremy P. [0000-0003-1943-7360], and Hanna, Matthew G. [0000-0002-7536-1746]
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Oncology ,[SDV]Life Sciences [q-bio] ,THERAPY ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,Prognostic markers ,0302 clinical medicine ,Breast cancer ,Medicine and Health Sciences ,Pharmacology (medical) ,Lymphocytes ,Stromal tumor ,health care economics and organizations ,0303 health sciences ,CHEMOTHERAPY ,Sciences bio-médicales et agricoles ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,3. Good health ,Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] ,PROGNOSTIC VALUE ,Clinical Practice ,030220 oncology & carcinogenesis ,Educational resources ,Immunosurveillance ,medicine.medical_specialty ,3122 Cancers ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,IMMUNITY ,lcsh:RC254-282 ,Article ,Limfòcits ,Càncer de mama ,03 medical and health sciences ,Gastrointestinal cancer ,SDG 3 - Good Health and Well-being ,Internal medicine ,692/53/2422 ,medicine ,Radiology, Nuclear Medicine and imaging ,Càncer gastrointestinal ,030304 developmental biology ,Predictive biomarker ,Tumor-infiltrating lymphocytes ,business.industry ,Médecine pathologie humaine ,medicine.disease ,Cancérologie ,Human medicine ,business ,SYSTEM ,631/67/580/1884 - Abstract
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls., info:eu-repo/semantics/published
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- 2020
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49. 1066P Negative impact of steroids on the efficacy of immunotherapy in a multi-tumor cohort of patients: time and dose-dependent
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Albarrán, V., Guerrero, P., Gonzalez Merino, C., García de Quevedo, C., Barrill Corpa, A.M., Sotoca-Rubio, P., Alia Navarro, V., Pérez de Aguado, P., Calvo, J.C., Moreno, J., Chamorro-Perez, J., Rosero Rodriguez, D.I., Alvarez Ballesteros, P., Serrano, J.J., Saavedra Serrano, C., Ruiz, Á., Gomez Rueda, A., Soria Rivas, A., Garrido Lopez, P., and Gajate Borau, P.
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- 2023
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50. 2224P Identifying prognostic factors in patients with radioiodine-refractory differentiated thyroid carcinoma (RR-DTC) treated with tyrosine kinase inhibitors (TKI): Data from REGETNE registry
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San Roman Gil, M.V., Hernando, J., Granados, A.R., Carmona, A., Marquina Ospina, G., Bella, M.R., Castelo, B., Campos Ramirez, S.E., Molina Cerrillo, J., Ruz-Caracuel, I., Valderrabano, P., Luengo Pierrard, P., Roca Herrera, M., Garcia Alvarez, A., Pozas Perez, J., Gonzalez Merino, C., Alonso Gordoa, T., and Capdevila Castillon, J.
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- 2023
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