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Abstract On January 15, 2022, an ongoing eruption at the Hunga-Tonga Hunga-Ha’apai volcano generated a large explosion which resulted in a globally observed tsunami and atmospheric pressure wave. This paper presents time series observations of the event from Australia including 503 mean sea level pressure (MSLP) sensors and 103 tide gauges. Data is provided in its original format, which varies between data providers, and a post-processed format with consistent file structure and time zone. High-pass filtered variants of the data are also provided to facilitate study of the pressure wave and tsunami. For a minority of tide gauges the raw sea level data cannot be provided, due to licence restrictions, but high-pass filtered data is always provided. The data provides an important historical record of the volcanic pressure wave and tsunami in Australia. It will be useful for research on atmospheric and ocean waves associated with large volcanic eruptions.

Among overseas "New Qing History" scholars, the Ming Empire is typically interpreted as an ethnically Han-Chinese regime that lacked the characteristics of Inner Asian polities. This author, however, asserts that this view is incorrect. Like the Qing, the emperors of the Ming ruled as qaghans over their northern steppe subjects and as the incarnation of the bodhisattva Manjusri in the eyes of Tibetan-Mongolian Buddhists. Also like their Qing dynasty counterparts, the Ming Empire produced multilingual documents, combining Chinese and ethnic minority scripts, a potent symbol of their "universal" rule. Lastly, the Ming emperors also actively pursued a policy of promoting governance through religion, creating a cultural and political legacy that would come to directly shape later relations between the Qing empire and the frontier regions of their empire. [ABSTRACT FROM AUTHOR]

Background: Choosing medical careers is complex but the undergraduate period is formative. St George’s University of London (SGUL) students called for greater careers information. Aim: To develop and evaluate students’ careers resources. Design & setting: A quality improvement student–staff project at SGUL, UK. Method: A ‘Plan-Do-Study-Act’ (PDSA) cycle was completed. For the ‘Plan’ element, students’ career intentions and information preferences were surveyed. For the ‘Do’ element, video interviews with clinicians and infographic posters were produced and published on SGUL’s virtual learning environment. For the ‘Study’ element, feedback questionnaires were thematically analysed using Kirkpatrick’s framework. For the ‘Act’ element, the model was rolled out across SGUL programmes. Results: In the ‘Plan’ stage, 79 students ranked interest in specialties, with general practice being the second most popular. Students were unconfident in how to pursue careers and wanted more information. For the ‘Do’ element, 13 careers videos and infographics were created for 10 specialties. The ‘Study’ questionnaire showed changes across three of the four levels in Kirkpatrick’s model of evaluation of training. Level 1 (Response): students found resources helpful and accessible. Level 2 (Learning): students reported increased understanding of careers. Level 3 (Transfer): students planned using checklists and made career comparisons by specialty. Level 4 (Results): students’ career choices were not demonstrated, but there were tentative proxy measures such as copying and modelling career routes and choices. ‘Act’ involved rolling out and regularly updating resources. Conclusion: This PDSA model enabled development of resources by students mapped to students’ needs. Changes were demonstrated in relation to students’ response, learning, and transfer, with tentative suggestions of impact on career choice.

Larvae of the greater wax moth (Galleria mellonella) are susceptible to infection with C. burnetii, an obligate intracellular bacterial pathogen. We show that bacteria are found in hemocytes after infection, and occupy vacuoles which are morphologically similar to Coxiella-containing vacuoles seen in infected mammalian phagocytes. We characterized the infection by transcriptome profiling of bacteria isolated from the hemocytes of infected larvae and identified 46 highly upregulated genes. The encoded proteins are predicted to be involved in translation, LPS biosynthesis, biotin synthesis, scavenging of reactive oxygen species, and included a T4SS effector and 30 hypothetical proteins. Some of these genes had previously been shown to be upregulated in buffalo green monkey (BGM) cells or in mice, whilst others appear to be regulated in a host-specific manner. Altogether, our results demonstrate the value of the G. mellonella model to study intracellular growth and identify potential virulence factors of C. burnetii.

Severe tropical cyclone (TC) Debbie made landfall on the northern Queensland coast of Australia on 27 March 2017 after crossing the Great Barrier Reef as a slow-moving Category 4 system. Groups from industry, government and academia collected coastal hazard and impact data before, during and after the event and shared these data to produce a holistic picture of TC Debbie at the coast. Results showed the still water level exceeded the highest astronomical tide by almost a metre. Waves added a further 16 % to water levels along the open coast, and were probably unprecedented for this area since monitoring began. In most places, coastal barriers were not breached and as a result there was net offshore sand transport. If landfall had occurred 2 h earlier with the high tide, widespread inundation and overwash would have ensued. This paper provides a case study of effective cross-sector data sharing in a natural hazard context. It advocates for a shared information platform for coastal extremes in Australia to help improve the understanding and prediction of TC-related coastal hazards in the future.

This study investigates the determinants of salary for operations management scholars. Is it as some opine that the only thing that matters is the publication count in "A" journals? How do the full range of activities: research, teaching, service, and administration, affect salary? The present research seeks to shed light on these questions and is predicated on a data set that consists of the research, teaching, and service outcomes, along with salary, for a full census of operations management faculty at 22 public universities (227 faculty) for base, 9-month salary and a subset of 15 universities (150 faculty) for total annual compensation. The results demonstrate partial support for the hypotheses that only "A" publications are financially rewarded, with publications in Production and Operations Management having the highest correlation with salary. The salary reward for publishing in "A" journals is unaffected by number of coauthors. Publications in other academic journals, top-tier practitioner journals, and top journals in sister-fields, and measures of impact, such as citations, H -index, and research awards provide no additional explanatory value of salary. Likewise, service and teaching awards do not add explanatory value. Female Full Professors are paid roughly $23,000 less in base salary than their male counterparts. Non-publishing factors that significantly contribute to salary include changing university affiliations (only for Associate and Full Professors), taking on administrative duties, as well as certain qualitative measures such as achieving Fellow status at the Production and Operations Management Society. [ABSTRACT FROM AUTHOR]

Voltammetric sensor using a symmetrical derivative of anthrone3 (1,7-diamino-3,9-dibutyl benzo[1,2,3-de:4,5,6-d’e’]diquinoline-2,8(3H,9H)-dione) (SPE-A) has been developed as a probe for Hg(II) ions. Performance of the probe as screen-printed electrode modified with the receptor (SPE-A) has been compared with anthrone3 in solution phase, using 1:1 water-acetonitrile solvent system. Anthrone3 displayed an electrochemically quasi-reversible nature in voltammograms with both the systems and is presented as a novel disposable voltammetric sensor for mercury ions. Upon interaction with cations, both the electrode systems showed sensitivity towards Hg2+ ions with a lower detection limit of 0.61 µM. The magnitude of the voltammetric current with the SPE-A exhibited three times the current obtained with a bare glassy carbon electrode (GC). Kinetic performance of the SPE-A electrode is better than the GC electrode. The morphological studies indicate reusability of the electrodes.

Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available human vaccine, Q-Vax, is effective but has a high risk of severe adverse reactions, limiting its use as a countermeasure to contain outbreaks. Therefore, it is essential to identify new drug targets to treat this infection. Macrophage infectivity potentiator (Mip) proteins catalyse the folding of proline-containing proteins through their peptidyl prolyl cis-trans isomerase (PPIase) activity and have been shown to play an important role in the virulence of several pathogenic bacteria. To date the role of the Mip protein in C. burnetii pathogenesis has not been investigated. This study demonstrates that CbMip is likely to be an essential protein in C. burnetii. The pipecolic acid derived compounds, SF235 and AN296, which have shown utility in targeting other Mip proteins from pathogenic bacteria, demonstrate inhibitory activities against CbMip. These compounds were found to significantly inhibit intracellular replication of C. burnetii in both HeLa and THP-1 cells. Furthermore, SF235 and AN296 were also found to exhibit antibiotic properties against both the virulent (Phase I) and avirulent (Phase II) forms of C. burnetii Nine Mile Strain in axenic culture. Comparative proteomics, in the presence of AN296, revealed alterations in stress responses with H2O2 sensitivity assays validating that Mip inhibition increases the sensitivity of C. burnetii to oxidative stress. In addition, SF235 and AN296 were effective in vivo and significantly improved the survival of Galleria mellonella infected with C. burnetii. These results suggest that unlike in other bacteria, Mip in C. burnetii is required for replication and that the development of more potent inhibitors against CbMip is warranted and offer potential as novel therapeutics against this pathogen. Author summary: The bacterium Coxiella burnetii is a highly infectious organism that is found worldwide and can cause debilitating disease in both animals and humans. Treatment of chronic infections remains very difficult and therefore it is essential to identify new drug targets to treat this infection. The Macrophage infectivity potentiator (Mip) protein has been reported as an attractive anti-virulence target in several pathogenic bacteria but its role has not been investigated in C. burnetii. This study demonstrates that inhibitors of the Mip protein from C. burnetii reduce replication inside host cells, increase the sensitivity of the bacteria to oxidative stress, and exhibit antibiotic properties against both the virulent and avirulent forms of C. burnetii. Furthermore, using a moth larvae infection model, the inhibitors demonstrated protective activity. These results suggest that, unlike other studied bacterial pathogens, C. burnetii requires Mip for replication, and that the further development of potent inhibitors against Mip offer potential as novel therapeutics to treat this infection. [ABSTRACT FROM AUTHOR]

Cobalt phthalocyanine (CoPC) compounds have been reported to provide electrocatalytic performances towards a substantial number of analytes. In these configurations, electrodes are typically constructed via drop casting the CoPC onto a supporting electrode substrate, while in other cases the CoPC complex is incorporated within the ink of a screen-printed sensor, providing a one-shot economical and disposable electrode configuration. In this paper we critically compare CoPC modified electrodes prepared by drop casting CoPC nanoparticles (nano-CoPC) onto a range of carbon based electrode substrates with that of CoPC bulk modified screen-printed electrodes in the sensing of the model analytes L-ascorbic acid, oxygen and hydrazine. It is found that no “electrocatalysis” is observed towards L-ascorbic acid using either of these CoPC modified electrode configurations and that the bare underlying carbon electrode is the origin of the obtained voltammetric signal, which gives rise to useful electroanalytical signatures, providing new insights into literature reports where “electrocatalysis” has been reported with no clear control experiments undertaken. On the other hand true electrocatalysis is observed towards hydrazine, where no such voltammetric features are witnessed on the bare underlying electrode substrate.

Business operating decisions and procedures can differ depending on the religious beliefs of either employees or customers. We provide examples of religion affecting operations in the topical areas of location, layout, shift scheduling, and operational compliance, among others. These issues are especially salient for global corporations extending operations overseas utilizing expatriate management.