32 results on '"Michael, Julian"'
Search Results
2. Elevated Fungicide and Nutrient Concentrations Change Structure but not Function of Aquatic Microbial Communities.
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Gonçalves, Sara, Feckler, Alexander, Pollitt, Annika, Baschien, Christiane, Michael, Julian, Schreiner, Verena C., Zubrod, Jochen P., and Bundschuh, Mirco
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MICROBIAL communities ,ENVIRONMENTAL toxicology ,AGRICULTURE ,FUNGICIDES ,FUNGAL communities ,FOOD chains ,ECOSYSTEMS ,ENVIRONMENTAL chemistry - Abstract
Leaf decomposition is a key process in stream ecosystems within forested catchments; it is driven by microbial communities, particularly fungi and bacteria. These microorganisms make nutrients and energy bound in leaves available for wider parts of the food web. Leaf‐associated microorganisms are subjected to anthropogenic pressures, such as the increased exposure to nutrients and fungicides associated with land‐use change. We assessed the sensitivity of leaf‐associated microbial communities with differing exposure histories, namely, from pristine (P) streams, and streams impacted by wastewater (W) and agricultural run‐off (vineyards; V). In the laboratory, microbial communities were exposed to elevated nutrient (NO3‐N: 0.2–18.0 mg/L, PO4‐P: 0.02–1.8 mg/L) and fungicide concentrations (sum concentration 0–300 µg/L) in a fully crossed 3 × 4 × 4‐factorial design over 21 days. Leaf decomposition and exoenzyme activity were measured as functional endpoints, and fungal community composition and microbial abundance served as structural variables. Overall, leaf decomposition did not differ between fungicide treatments or exposure histories. Nonetheless, substantial changes in the fungal community composition were observed after exposure to environmentally relevant fungicide concentrations. Elevated nutrient concentrations assisted leaf decomposition, and the effect size depended on the exposure history. The observed changes in the fungal community composition support the principle of functional redundancy, with highly efficient decomposers maintaining leaf decomposition. Environ Toxicol Chem 2024;43:1300–1311. © 2024 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. High-throughput analysis of contact angle goniometry data using DropPy
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Michael Julian Orella, McLain Evan Leonard, Yuriy Román-Leshkov, and Fikile Richard Brushett
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Contact angle goniometry ,High-throughput image analysis ,Automatic edge detection ,Computer software ,QA76.75-76.765 - Abstract
At present, surface wettability measurements are an underutilized segment of the characterization toolkit, in part due to the redundancy inherent in manual analysis. Even so, there have been numerous advances in contact angle data collection and analysis methods. The emergence of inexpensive and powerful hardware in increasingly small form-factors and the development of robust and versatile software packages would enable interrogation of wetting phenomena across a range of platforms. Here, we introduce DropPy, an open-source Python implementation of the classic axisymmetric drop shape analysis technique to fit droplet profiles from images while providing an easy interface through which casual users may interpret their findings.
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- 2021
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- View/download PDF
4. Submerged Carbonate Banks Aggregate Pelagic Megafauna in Offshore Tropical Australia
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Phil J. Bouchet, Tom B. Letessier, Michael Julian Caley, Scott L. Nichol, Jan M. Hemmi, and Jessica J. Meeuwig
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biodiversity ,Northwest Australia ,pelagic species ,geomorphology ,seabed topography ,mid-water BRUVS ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The conservation of marine biodiversity is firmly embedded in national and international policy frameworks. However, the difficulties associated with conducting broad-scale surveys of oceanic environments restrict the evidence base available for applied management in pelagic waters. For example, the Oceanic Shoals Australian Marine Park (AMP) was established in 2012 in a part of Australia’s continental shelf where unique topographic features are thought to support significant levels of biodiversity, yet where our understanding of ecological processes remains limited. We deployed mid-water baited remote underwater video systems (mid-water BRUVS) in the Oceanic Shoals AMP to provide the first non-extractive baseline assessment of pelagic wildlife communities in the area. We used these observations and high-resolution multibeam swaths of the seafloor to explore potential relationships between prominent geomorphological features and the (i) composition, (ii) richness, and (iii) relative abundance of pelagic communities. We documented 32 vertebrate species across three sampling areas, ranging from small baitfish to large sharks and rays, and estimated that up to nearly twice as many taxa may occur within the region as a whole. This highlights the Oceanic Shoals AMP as a reservoir of biodiversity comparable to other documented offshore oceanic hotspots. Our results also confirm the AMP as a possible distant foraging destination for IUCN red listed sea turtles, and a potential breeding and/or nursing ground for a number of charismatic cetaceans. Model outputs indicate that both species richness and abundance increase in proximity to raised geomorphic structures such as submerged banks and pinnacles, highlighting the influence of submarine topography on megafauna distribution. By providing a foundational understanding of spatial patterns in pelagic wildlife communities throughout a little studied region, our work demonstrates how a combination of non-destructive sampling techniques and predictive models can provide new opportunities to support decision-making under data shortage.
- Published
- 2020
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5. Spatio-temporal patterns of event-related potentials related to audiovisual synchrony judgments in older adults
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Chan, Yu Man, Pianta, Michael Julian, Bode, Stefan, and McKendrick, Allison Maree
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- 2017
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- View/download PDF
6. One lump or two? Explaining a major latitudinal transition in reproductive allocation in a viviparous lizard
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Schwarzkopf, Lin, Caley, Michael Julian, and Kearney, Michael R.
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- 2016
7. Neuropeptide receptors and cell signals as targets in the development of novel therapies for small cell lung cancer
- Author
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Seckl, Michael Julian
- Subjects
572 ,Tyrosine phosporylation - Abstract
Neuropeptides including bombesin and its mammalian homologue gastrin releasing peptide, stimulate proliferation and are implicated as growth factors in a variety of biological processes, including autocrine and paracrine growth of small cell lung cancer (SCLC). These peptides bind to seven transmembrane domain receptors which lack intrinsic tyrosine kinase activity and activate second messenger pathways via heterotrimeric G proteins. This thesis covers two main areas of investigation: (1) NEUROPEPTIDES AND TYROSINE PHOSPHORYLATION Recently, neuropeptides including bombesin have been shown to induce tyrosine phosphorylation in Swiss 3T3 cells, a useful model system for elucidating signal transduction pathways. The mechanism by which tyrosine phosphorylation is induced by G protein coupled receptors is unknown. This thesis shows that the non-hydrolyzable GTP analogue, GTP?S, induced tyrosine phosphorylation of multiple proteins including the focal adhesion associated proteins p125 focal adhesion kinase and paxillin in permeabilized Swiss 3T3 cells. The pattern of tyrosine phosphorylation closely resembled that induced by neuropeptides in intact cells. Our results suggest that the small GTP binding protein rhop21 rather than heterotrimeric GTP binding proteins mediates GTP?S induced tyrosine phosphorylation. The role of tyrosine phosphorylation in bombesin mediated mitogenesis is unknown. Here, it is shown that addition of the protein tyrosine kinase inhibitor [(3,4,5,-trihydroxyphenyl)-methylene]-propanedinitrile (tyrphostin) to intact Swiss 3T3 cells reduces bombesin induced tyrosine phosphorylation and inhibits bombesin mediated c-fos expression and DNA synthesis. The results demonstrate that inhibitors of tyrosine kinase activity prevent neuropeptide mediated mitogenesis and may be of therapeutic value for SCLC. (2) NOVEL SCLC THERAPIES Substance P (SP) analogues [DArg1, DPhe5, DTrp7,9, Leu11] SP and [Arg6, DTrp7,9, MePhe8] SP (6-11) inhibit the action of many different calcium mobilizing neuropeptides including vasopressin and bombesin in Swiss 3T3 cells and SCLC cell lines and block the growth of SCLC xenografts in nude mice. However, their mechanism of action is not understood. This thesis shows that these SP analogues reversibly inhibit neuropeptide- but not GTP?S-stimulated inositol phosphate production in permeabilized Swiss 3T3 cells and competitively inhibit ligand binding in intact cells or membrane preparations. The results suggest that these SP analogues block the action of vasopressin and bombesin at the receptor level. Identification of factors which stimulate SCLC cell growth is relevant to the development of novel SCLC therapies. Results presented here demonstrate that although serum mobilizes calcium and stimulates growth of SCLC cells, Ca2+ mobilization is not required for serum induced growth of these cells. The polypeptide growth factors hepatocyte growth factor and stem cell growth factor were found to stimulate colony growth of SCLC cells through a Ca2+ independent pathway. Since tyrphostin is known to inhibit polypeptide receptor tyrosine kinases and inhibits neuropeptide stimulated mitogenesis, the effect of tyrphostin with or without SP analogues was tested on SCLC growth in vitro. It is shown that tyrphostin and SP analogues synergistically inhibit SCLC cell growth.
- Published
- 1995
8. The synthesis and characterisation of some novel mesogens
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Stephens, Michael Julian
- Subjects
541 ,Carbohydrate liquid crystals ,Glucose - Published
- 1993
9. Efficacy of Laser Resurfacing and Facial Plastic Surgery Using Age, Glogau, and Fitzpatrick Rating
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Jose Enrique Barrera, MD, FACS, Michael Julian Adame, BA, Josh A. Lospinoso, PhD, and Thomas M. Beachkofsky, MD, FAAD
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Surgery ,RD1-811 - Abstract
Background:. To assess clinical outcomes based on established rating scales in patients who underwent treatment for rhytids using laser resurfacing with and without facial plastic surgery. Methods:. Retrospective case review of 48 patients treated by the senior author (J.E.B) between 2009 and 2016. Three reviewers assigned ratings to a total of 48 patients using estimated age and Fitzpatrick, Modified Fitzpatrick, and Glogau scales. Reviewers were blinded to patient demographics and before and after photographs. Patients elected to receive laser-only treatment or combination laser plus facial plastic surgery. Participants included forty-eight patients were selected on the basis that they had either laser treatment alone or laser plus facial plastic surgery and pre- and postoperative photographs. Results:. Patients with higher Fitzpatrick scores had a greater reduction in Glogau score (ß = 1.66; SE = 0.59; P < 0.01). With respect to modified Fitzpatrick scores after surgery, patients with higher Glogau scores of 3 or 4 before surgery (P < 0.01) had higher scores after surgery ((ß = 0.07; SE = 0.02; P < 0.01). For estimated age, the average change was -1.7 years after laser resurfacing (P = 0.038; 95% CI, 2.96–3.06 years) and -2.07 years when combined with surgery (P = 0.01; 95% CI, 2.89–3.19 years). Conclusions:. Patients with Fitzpatrick scores of 3, 4, 5, younger patients, and those with less rhytids before surgery tended to have lower Glogau scores after surgery. These findings provide insight on an approach to treating ethnic skin and aging face concerns.
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- 2018
- Full Text
- View/download PDF
10. Efficacy of Laser Resurfacing and Facial Plastic Surgery Using Age, Glogau, and Fitzpatrick Rating
- Author
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Barrera, Jose Enrique, Adame, Michael Julian, Lospinoso, Josh A., and Beachkofsky, Thomas M.
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- 2018
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- View/download PDF
11. What Do NLP Researchers Believe? Results of the NLP Community Metasurvey
- Author
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Michael, Julian, Holtzman, Ari, Parrish, Alicia, Mueller, Aaron, Wang, Alex, Chen, Angelica, Madaan, Divyam, Nangia, Nikita, Pang, Richard Yuanzhe, Phang, Jason, and Bowman, Samuel R.
- Subjects
FOS: Computer and information sciences ,Artificial Intelligence (cs.AI) ,Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,I.2.7 ,Computation and Language (cs.CL) - Abstract
We present the results of the NLP Community Metasurvey. Run from May to June 2022, the survey elicited opinions on controversial issues, including industry influence in the field, concerns about AGI, and ethics. Our results put concrete numbers to several controversies: For example, respondents are split almost exactly in half on questions about the importance of artificial general intelligence, whether language models understand language, and the necessity of linguistic structure and inductive bias for solving NLP problems. In addition, the survey posed meta-questions, asking respondents to predict the distribution of survey responses. This allows us not only to gain insight on the spectrum of beliefs held by NLP researchers, but also to uncover false sociological beliefs where the community's predictions don't match reality. We find such mismatches on a wide range of issues. Among other results, the community greatly overestimates its own belief in the usefulness of benchmarks and the potential for scaling to solve real-world problems, while underestimating its own belief in the importance of linguistic structure, inductive bias, and interdisciplinary science., 31 pages, 19 figures, 3 tables; more information at https://nlpsurvey.net
- Published
- 2022
12. No Austrians in South Tyrol? Why the German-speaking community in Italy’s South Tyrol (Alto Adige) province is not usually called an Austrian minority
- Author
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Michael Julian Emanuel Volkmer
- Subjects
South Tyrol ,Austrian Nationalism ,German minority ,Austrian minority ,Ethnology. Social and cultural anthropology ,GN301-674 ,Political science - Abstract
No Austrians in South Tyrol? Why the German-speaking community in Italy’s South Tyrol (Alto Adige) province is not usually called an Austrian minority The article discusses the question why the German-speakers in Northern Italy’s South Tyrol province are only very rarely referred to as an Austrian minority, in spite of the fact that they were split off from Austria, and not Germany, in the aftermath of World War I. An analysis of the naming of German-speaking South Tyroleans in German, Austrian, Italian and English-speaking news media, which demonstrates a preference for terms such as “German-speaking minority” or “German minority” over “Austrian minority and equivalents, is followed by a discussion of three hypotheses to account for the situation. The author shows how the question of how to name the German-speaking South Tyroleans is closely intertwined with the issue of Austrian national identity and its re-orientation away from Germany in the aftermath of the Second World War. The author comes to the conclusion that the minority is not usually referred to as Austrian both due to the fact that it is difficult to include them in the young (civic) Austrian nation in a logically consistent manner, and due to the German-speaking South Tyroleans’ own inconsistent self-identification as Austrians. Nie ma Austriaków w Tyrolu Południowym? Dlaczego niemieckojęzyczna wspólnota we włoskiej prowincji Tyrol Południowy (Alto Adige) zwykle nie jest nazywana mniejszością austriacką Artykuł podejmuje kwestię, dlaczego niemieckojęzyczna ludność północnowłoskiej prowincji Tyrol Południowy rzadko bywa nazywana mniejszością austriacką, pomimo tego że w efekcie I wojny światowej odłączona została ona od Austrii, a nie od Niemiec. Analiza nazewnictwa odnoszonego do niemieckojęzycznej ludności Tyrolu Południowego, które występuje w informacyjnych środkach przekazu: niemiecko-, austriacko-, włosko- i anglojęzycznych pozwala stwierdzić, że preferowane są określenia takie jak „mniejszość niemieckojęzyczna” lub „mniejszość niemiecka”, zamiast „mniejszość austriacka” i terminy ekwiwalentne. Następnie omówione został trzy hipotezy mogące wyjaśnić tę sytuację. Autor ukazuje, jak ściśle współzależą od siebie kwestia nazewnictwa niemieckojęzycznej ludności Tyrolu Południowego i kwestia austriackiej tożsamości narodowej oraz jej odchodzenia od Niemiec w następstwie II wojny światowej. Autor dochodzi do wniosku, że omawiana tu mniejszość zwykle nie jest uznawana za austriacką zarówno z tego powodu, iż trudno jest umiejscowić ją w młodym (obywatelskim) narodzie austriackim w sposób logicznie konsekwentny, jak i z racji własnej niekonsekwentnej samoidentyfikacji niemieckojęzycznych Tyrolczyków Południowych jako Austriacy.
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- 2016
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13. Middle Ear Packing: Comparison of Materials in an Animal Model of Mucosal Trauma
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Lipan, Michael Julian, Alava, Ibrahim, Abi-Hachem, Ralph, Vernon, Stephen, Van De Water, Thomas R., and Angeli, Simon I.
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- 2011
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14. Studies on power spectrum analysis of the fetal heart rate during labour
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Parker, Michael Julian Reid
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610 ,Medicine - Published
- 1988
15. Estimating global species richness using symbolic data meta‐analysis.
- Author
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Lin, Huan, Caley, Michael Julian, and Sisson, Scott A.
- Subjects
- *
NUMBERS of species , *SPECIES diversity , *HABITAT destruction , *HUMAN settlements , *BIODIVERSITY - Abstract
Global species richness is a key biodiversity metric. Concerns continue to grow over its decline due to overexploitation and habitat destruction by humans. Despite recent efforts to estimate global species richness, the resulting estimates have been highly uncertain and often logically inconsistent. Estimates lower down either the taxonomic or geographic hierarchies are often larger than those above. Further, these estimates have been typically represented in a wide variety of forms, including intervals (a, b), point estimates with no uncertainty, and point estimates with either symmetrical or asymmetrical bounds, making it difficult to combine information across different studies. Here, we develop a Bayesian hierarchical approach to estimate global species richness (we estimate 22.02 m species; 95% highest posterior density (HPD) interval (10.43 million, 35.28 million)) that combines 50 estimates from published studies. The data mix of intervals and point estimates are reconciled using techniques from symbolic data analysis. This approach allows us to recover interval estimates at each species level, even when data are partially or wholly unobserved, while respecting logical constraints, and to determine the effects of estimation on the whole hierarchy of obtaining future estimates for particular taxa at various levels in the hierarchy. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Middle Ear Packing: Comparison Between Merogel and Gelfoam
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Lipan, Michael Julian, Alava, Ibraham, Angeli, Simon I., and Van De Water, Thomas R.
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- 2008
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17. Humans and seasonal climate variability threaten large-bodied coral reef fish with small ranges
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Camille Mellin, Rick D. Stuart-Smith, Ana M. M. Sequeira, Tim R. McClanahan, Graham J. Edgar, Michel Kulbicki, Laurent Wantiez, Michael Julian Caley, Valeriano Parravicini, Russell E. Brainard, Corey J. A. Bradshaw, Alan M. Friedlander, Pascale Chabanet, Damien A. Fordham, Laurent Vigliola, David Mouillot, Australian Institute of Marine Science (AIMS), School of Biological Sciences, University of South Australia [Adelaide], MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), Australian Research Council Centre of Excellence for Coral Reef Studies, James Cook University (JCU)-School of Marine and Tropical Biology, Laboratoire d'Excellence CORAIL (LabEX CORAIL), Université des Antilles (UA)-Institut d'écologie et environnement-Université de la Nouvelle-Calédonie (UNC)-Université de la Polynésie Française (UPF)-Université de La Réunion (UR)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université des Antilles et de la Guyane (UAG)-Institut de Recherche pour le Développement (IRD), Ecologie marine tropicale dans les Océans Pacifique et Indien (ENTROPIE [Réunion]), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Institut de Recherche pour le Développement (IRD), Marine Programs, Wildlife Conservation Society, National Oceanic and Atmospheric Administration (NOAA), Institute for Marine and Antarctic Studies [Horbat] (IMAS), University of Tasmania [Hobart, Australia] (UTAS), Fisheries Ecology Research Lab, University of Hawai‘i [Mānoa] (UHM), National Geographic Society, Centre de Synthése et d'Analyse sur la Biodiversité, Domaine du Petit Arbois, Centre de recherches insulaires et observatoire de l'environnement (CRIOBE), Université de Perpignan Via Domitia (UPVD)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), The UWA Oceans Institute, Laboratoire Insulaire du Vivant et de l'Environnement (LIVE), Université de la Nouvelle-Calédonie (UNC), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Université des Antilles et de la Guyane (UAG)-École des hautes études en sciences sociales (EHESS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de La Réunion (UR)-Université de la Polynésie Française (UPF)-Université de la Nouvelle-Calédonie (UNC)-Institut d'écologie et environnement-Université des Antilles (UA), Institut de Recherche pour le Développement (IRD)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Institute for Marine and Antarctic Studies [Hobart] (IMAS), and Université de Perpignan Via Domitia (UPVD)-École Pratique des Hautes Études (EPHE)
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0106 biological sciences ,Conservation of Natural Resources ,Coral reef fish ,Climate ,[SDE.MCG]Environmental Sciences/Global Changes ,Science ,Biodiversity ,General Physics and Astronomy ,Oceanography ,010603 evolutionary biology ,01 natural sciences ,Article ,General Biochemistry, Genetics and Molecular Biology ,Coral Triangle ,Stress, Physiological ,Animals ,Body Size ,Humans ,14. Life underwater ,Ecosystem ,Multidisciplinary ,geography.geographical_feature_category ,Ecology ,Coral Reefs ,Resilience of coral reefs ,010604 marine biology & hydrobiology ,fungi ,Fishes ,Temperature ,technology, industry, and agriculture ,General Chemistry ,Coral reef ,15. Life on land ,Biological sciences ,Geography ,13. Climate action ,Threatened species ,Seasons ,Conservation biology ,Species richness - Abstract
Coral reefs are among the most species-rich and threatened ecosystems on Earth, yet the extent to which human stressors determine species occurrences, compared with biogeography or environmental conditions, remains largely unknown. With ever-increasing human-mediated disturbances on these ecosystems, an important question is not only how many species can inhabit local communities, but also which biological traits determine species that can persist (or not) above particular disturbance thresholds. Here we show that human pressure and seasonal climate variability are disproportionately and negatively associated with the occurrence of large-bodied and geographically small-ranging fishes within local coral reef communities. These species are 67% less likely to occur where human impact and temperature seasonality exceed critical thresholds, such as in the marine biodiversity hotspot: the Coral Triangle. Our results identify the most sensitive species and critical thresholds of human and climatic stressors, providing opportunity for targeted conservation intervention to prevent local extinctions., Knowing which species traits may confer resilience to human-mediated stressors will help predict future impacts on biodiversity. Here, Mellin et al. show that large bodied fish with small geographic ranges are disproportionately affected by the negative impacts of human disturbance and climate variability.
- Published
- 2016
- Full Text
- View/download PDF
18. Efficacy of Laser Resurfacing and Facial Plastic Surgery Using Age, Glogau, and Fitzpatrick Rating
- Author
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Michael Julian Adame, Jose E. Barrera, Josh A. Lospinoso, and Thomas M. Beachkofsky
- Subjects
medicine.medical_specialty ,business.industry ,Patient demographics ,Laser treatment ,lcsh:Surgery ,lcsh:RD1-811 ,Aging face ,Case review ,Surgery ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Rating scale ,Facial plastic surgery ,medicine ,In patient ,Original Article ,030223 otorhinolaryngology ,business - Abstract
Background:. To assess clinical outcomes based on established rating scales in patients who underwent treatment for rhytids using laser resurfacing with and without facial plastic surgery. Methods:. Retrospective case review of 48 patients treated by the senior author (J.E.B) between 2009 and 2016. Three reviewers assigned ratings to a total of 48 patients using estimated age and Fitzpatrick, Modified Fitzpatrick, and Glogau scales. Reviewers were blinded to patient demographics and before and after photographs. Patients elected to receive laser-only treatment or combination laser plus facial plastic surgery. Participants included forty-eight patients were selected on the basis that they had either laser treatment alone or laser plus facial plastic surgery and pre- and postoperative photographs. Results:. Patients with higher Fitzpatrick scores had a greater reduction in Glogau score (ß = 1.66; SE = 0.59; P < 0.01). With respect to modified Fitzpatrick scores after surgery, patients with higher Glogau scores of 3 or 4 before surgery (P < 0.01) had higher scores after surgery ((ß = 0.07; SE = 0.02; P < 0.01). For estimated age, the average change was -1.7 years after laser resurfacing (P = 0.038; 95% CI, 2.96–3.06 years) and -2.07 years when combined with surgery (P = 0.01; 95% CI, 2.89–3.19 years). Conclusions:. Patients with Fitzpatrick scores of 3, 4, 5, younger patients, and those with less rhytids before surgery tended to have lower Glogau scores after surgery. These findings provide insight on an approach to treating ethnic skin and aging face concerns.
- Published
- 2018
19. High-throughput analysis of contact angle goniometry data using DropPy
- Author
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Orella, Michael Julian, Leonard, McLain Evan, Román-Leshkov, Yuriy, and Brushett, Fikile Richard
- Published
- 2021
- Full Text
- View/download PDF
20. Clinical comparison of hearing impaired patients with DFNB1 against heterozygote carriers of connexin 26 mutations
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Simon I. Angeli, Li Lin Du, Michael Julian Lipan, Xue Zhong Liu, Denise Yan, and Xiaomei Ouyang
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Male ,Pediatrics ,DNA Mutational Analysis ,Audiology ,Connexins ,Hearing Aids ,Otology ,Child ,Aged, 80 and over ,education.field_of_study ,biology ,medicine.diagnostic_test ,Genetic Carrier Screening ,Homozygote ,Middle Aged ,Connexin 26 ,Child, Preschool ,Audiometry, Pure-Tone ,Sensorineural hearing loss ,Female ,medicine.symptom ,GJB6 ,Adult ,medicine.medical_specialty ,Adolescent ,Genotype ,Hearing loss ,Genetic counseling ,Hearing Loss, Sensorineural ,Population ,Article ,Hearing Loss, Bilateral ,Young Adult ,otorhinolaryngologic diseases ,medicine ,Connexin 30 ,Humans ,Genetic Testing ,education ,Alleles ,Genetic testing ,Aged ,business.industry ,Infant ,Heterozygote advantage ,medicine.disease ,Cochlear Implants ,Otorhinolaryngology ,biology.protein ,business - Abstract
Objectives: The aim of the study is to assess clinical characteristics of individuals with nonsyndromic sensorineural hearing loss (NSSNHL) with genetic mutations in GJB2 and/or GJB6. We describe and compare one group with biallelic mutations against a group of heterozygote mutation carriers. Methods: A total of 350 patients between the ages of 3 months and 80 years referred to a tertiary care outpatient otology practice for NSSNHL were screened for genetic mutations. Direct sequencing of GJB2 and polymerase chain reaction analysis of GJB6 was performed and clinical data from history and physical, audiologic testing and radiographic studies were reviewed. Results: Thirty-two patients were found to have biallelic mutations (incidence of 9.1%). Twenty-five patients were found to have only one GJB2 mutation (incidence of 7.1%). Severe to profound hearing loss occurred in 85% of the homozygote group and 38% of the heterozygote group. Both groups similarly had a propensity toward bilateral, symmetric, nonprogressive hearing loss with rare inner ear malformations on radiologic imaging. Conclusions: These two patient populations have similar incidences in a cohort of patients evaluated for NSSNHL, which is higher than general population heterozygote carrier rates. Heterozygote mutation carriers had less hearing impairment, but most other factors demonstrated no differences. These results support the theory of an unidentified genetic factor contributing to hearing loss in some heterozygote carriers. Therefore, genetic counseling should consider the complexity of their genetic factors and the limitations of current screening. Laryngoscope, 2011
- Published
- 2011
21. GUEST COLUMN: Temporary program gets vendors working
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Bond, Michael Julian
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General interest ,News, opinion and commentary - Abstract
Byline: Michael Julian Bond As a child, I remember seeing the 'broom man' make his way through the streets of Vine City, peddling his wares. He was blind, and peddling [...]
- Published
- 2013
22. guest column: Harassment is the real issue
- Author
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Bond, Michael Julian
- Subjects
General interest ,News, opinion and commentary - Abstract
Byline: Michael Julian Bond Just as Vine City, Inman Park, Polar Rock, Loring Heights and West End are communities that make up the diverse fabric of our great city, so [...]
- Published
- 2012
23. Proving infinitary formulas.
- Author
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HARRISON, AMELIA, LIFSCHITZ, VLADIMIR, MICHAEL, JULIAN, Carro, Manuel, and King, Andy
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INFINITARY languages ,PROPOSITIONAL calculus ,COMPUTER programming ,AXIOMATIC set theory ,MATHEMATICAL formulas ,FINITE element method - Abstract
The infinitary propositional logic of here-and-there is important for the theory of answer set programming in view of its relation to strongly equivalent transformations of logic programs. We know a formal system axiomatizing this logic exists, but a proof in that system may include infinitely many formulas. In this note we describe a relationship between the validity of infinitary formulas in the logic of here-and-there and the provability of formulas in some finite deductive systems. This relationship allows us to use finite proofs to justify the validity of infinitary formulas. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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- View/download PDF
24. NO AUSTRIANS IN SOUTH TYROL? WHY THE GERMAN-SPEAKING COMMUNITY IN ITALY'S SOUTH TYROL (ALTO ADIGE) PROVINCE IS NOT USUALLY CALLED AN AUSTRIAN MINORITY.
- Author
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VOLKMER, MICHAEL JULIAN EMANUEL
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MINORITIES , *NATIONALISM - Abstract
The article discusses the question why the German-speakers in Northern Italy's South Tyrol province are only very rarely referred to as an Austrian minority, in spite of the fact that they were split off from Austria, and not Germany, in the aftermath of World War I. An analysis of the naming of German-speaking South Tyroleans in German, Austrian, Italian, and Englishspeaking news media, which demonstrates a preference for terms such as "German-speaking minority" or "German minority" over "Austrian minority" and equivalents, is followed by a discussion of three hypotheses to account for the situation. The author shows how the question of how to name the German-speaking South Tyroleans is closely intertwined with the issue of Austrian national identity and its re-orientation away from Germany in the aftermath of World War II. The author comes to the conclusion that the minority is not usually referred to as Austrian both due to the fact that it is difficult to include them in the young (civic) Austrian nation in a logically consistent manner, and due to the German-speaking South Tyroleans' own inconsistent self-identification as Austrians. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
25. Modeling Blurred Video with Layers.
- Author
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Wulff, Jonas and Black, Michael Julian
- Published
- 2014
- Full Text
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26. What is an expert? A systems perspective on expertise.
- Author
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Caley, Michael Julian, O'Leary, Rebecca A., Fisher, Rebecca, Low-Choy, Samantha, Johnson, Sandra, and Mengersen, Kerrie
- Published
- 2014
- Full Text
- View/download PDF
27. Disassembling Glancing Angle Deposited Films for High-Throughput, Single-Post Growth Scaling Measurements.
- Author
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Siewert, Joshua Morgan Arthur, LaForge, Joshua Michael, Taschuk, Michael Thomas, and Brett, Michael Julian
- Subjects
THIN films ,NANOSTRUCTURED materials ,NANOFILMS ,SUBSTRATES (Materials science) ,SURFACES (Technology) - Abstract
With growing interest in nanostructured thin films produced by glancing angle deposition (GLAD), it becomes increasingly important to understand their overall growth mechanics and nanocolumn structure. We present a new method of isolating the individual nanocolumns of GLAD films, facilitating automated measurement of their broadening profiles. Data collected for α = 81° TiO2 vertical nanocolumns deposited across a range of substrate rotation rates demonstrates that these rates influence growth scaling parameters. Further, individual posts were found in each case that violate predicted Kardar-Parisi-Zhang growth scaling limits. The technique's current iteration is comparable to existing techniques in speed: though data were studied from 10,756 individual objects, the majority could not be confidently used in subsequent analysis. Further refinement may allow high-throughput automated film characterization and permit close examination of subtle growth trends, potentially enhancing control over GLAD film broadening and morphology. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
28. Annealing of GaA1As double heterostructures with homogeneous ruby laser light
- Author
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Brett, Michael Julian
- Subjects
Condensed Matter::Materials Science ,Physics::Optics ,Physics::Atomic Physics ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect - Abstract
The output from a ruby laser was homogenized, and used to laser anneal the active layer of GaA1As double heterostructure wafers in an attempt to improve the radiative efficiency of the active layer. At anneal energies exceeding the estimated threshold for melting of the active layer, the radiative efficiency was reduced by a factor of two. Subsequently, semiconductor laser diodes fabricated from laser annealed heterostructures performed much worse than those fabricated from unannealed heterostructures.
- Published
- 1981
- Full Text
- View/download PDF
29. Stoichiometry control mechanisms of bias sputtered zinc oxide films
- Author
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Brett, Michael Julian
- Abstract
This thesis reports the first detailed study of the stoichiometry control mechanisms and physical properties of ZnO films deposited by dc planar magnetron sputtering of a Zn target in a reactive Ar/0₂ atmosphere. Control of film stoichiometry was achieved using a subsidiary rf discharge at the substrate and a reactive gas baffle surrounding the target. The reactive gas baffle was shown to enhance film oxidation by decreasing the metal flux to the substrate and increasing the oxygen partial pressure near the substrate. Rutherford backscattering analysis of film stoichiometry demonstrated that the effect of the rf discharge was to increase the O/Zn composition ratio. This oxidation was shown to occur through preferential resputtering and preferential evaporation of excess Zn and by activation and ion plating of oxygen species. Resputtering and evaporation rates were found to be enhanced above that expected for bulk Zn, due to the weak bonding of surface adatoms during film growth. Conducting ZnO films produced at various values of the rf-induced substrate bias voltage were characterized for electrical, optical and structural properties using Hall probe,. X-ray diffraction, electron microscope, and visible and infrared spectroscopy techniques. Films deposited at low substrate bias (0 to -50V) were found to have a large Zn excess (15%) resulting in low electron mobilities (1 cm²/Vs), high resistivities (10⁻² Ωcm) and were strongly absorbing in the visible. Films deposited at high substrate bias were nearly stoichiometric, optically transparent and had high electron mobilities (15 cm²/Vs) resulting in low resistivity (10⁻³ Ωcm). The optical properties of transparent conducting films for wavelengths 0.4 to 20 /im were modelled by the Drude theory of free electrons using measured electrical transport properties. The original goal of this work, to develop a heat mirror coating suitable for manufacture, was achieved by bias sputter deposition of ZnO onto uncooled polyester sheet at deposition rates approaching 75 nm/min. The best heat mirror films had a transmission to solar energy of 75% and an 85% reflection of 300 K blackbody radiation.
- Published
- 1985
- Full Text
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30. Antenatal gestational ageing
- Author
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Bennett, Michael Julian, Department of Obstetrics and Gynaecology, and Faculty of Health Sciences
- Published
- 1972
31. Axial resistivity measurement of a nanopillar ensemble using a cross-bridge Kelvin architecture.
- Author
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Lalany, Abeed, Tucker, Ryan Thomas, Taschuk, Michael Thomas, Fleischauer, Michael David, and Brett, Michael Julian
- Subjects
ELECTRICAL resistivity ,NANOSTRUCTURED materials ,KELVIN'S circulation theorem ,ELECTRODES ,SOLAR cells ,CATALYST supports ,ELECTRONIC structure - Abstract
Achieving the full potential of nanopillar electrode based devices, such as next-generation solar cells, catalyst supports, and sensors, requires axial resistivity measurements to optimize electronic performance. Here, the authors demonstrate a technique for direct measurement of the ensemble electrical properties of nanopillar thin films along the structure's longitudinal axis. A cross-bridge Kelvin resistor architecture is adapted to accommodate an indium tin oxide (ITO) nanopillar thin film fabricated by glancing angle deposition (GLAD). As-deposited GLAD ITO nanopillars were found to have a measured resistivity of (1.1 ± 0.3) × 10-2 Ω cm using our technique. Planar ITO films deposited at near normal incidence were found to have a resistivity of (4.5 ± 0.5) × 10-3 Ω cm, determined by the standard four-point-probe technique. These measurements demonstrate the viability of this modified technique for nanopillar characterization, and identify experimental limitations related to device size and edge defects. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
32. Middle ear packing: comparison of materials in an animal model of mucosal trauma.
- Author
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Lipan MJ, Alava I, Abi-Hachem R, Vernon S, Van De Water TR, and Angeli SI
- Subjects
- Animals, Female, Guinea Pigs, Injections, Models, Animal, Mucous Membrane injuries, Biocompatible Materials, Ear, Middle injuries, Gelatin Sponge, Absorbable, Hemostatics, Hyaluronic Acid administration & dosage
- Abstract
Objective: To compare absorbable gelatin sponge (AGS) with an injectable esterified hyaluronic acid (EHA) as middle ear packing material after mucosal trauma., Study Design: Randomized, blinded, and controlled study., Setting: Tertiary university-based hospital., Subjects and Methods: Twenty-three guinea pigs underwent middle ear surgery with mucosal trauma performed on both ears and one ear packed with either EHA or AGS. Contralateral ears were used as nonpacked paired controls. Auditory brainstem response (ABR) thresholds were measured preoperatively and repeated at 1, 2, and 6 weeks postoperatively. Macroscopic and microscopic analysis measured inflammatory reaction in each group., Results: ABR threshold changes from baseline in the EHA and both control groups were minor. Threshold levels were higher in the AGS group compared with the AGS control group. This trend was seen in each frequency tested at each time interval. Macroscopic analysis showed tympanic membrane perforation was rare, effusions were common in the AGS group, mucosal edema was most frequent in the AGS group, and unabsorbed packing was usually detected in the AGS group with little EHA detectable at 6 weeks. Microscopic analysis showed normal mucosal healing in all groups. Two AGS ears demonstrated excessive middle ear packing with exuberant osteoneogenesis., Conclusions: Middle ear function and mucosal healing after surgery occurred similarly between the EHA control group and the EHA group. In contrast, the AGS group demonstrated worse hearing and a greater level of osteoneogenesis compared with the AGS control group. These results support EHA as an alternative middle ear packing material in otologic surgery.
- Published
- 2011
- Full Text
- View/download PDF
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