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Your search keyword '"Mickaël Marloye"' showing total 2 results
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2 results on '"Mickaël Marloye"'

1. Current patent and clinical status of stimulator of interferon genes (STING) agonists for cancer immunotherapy

Author

Sean E. Lawler, Gilles Berger, and Mickaël Marloye

Subjects
business.industry, Nucleotides, medicine.medical_treatment, Membrane Proteins, General Medicine, Immunotherapy, Nucleotidyltransferases, Patents as Topic, Cancérologie, Sting, Immune system, Antineoplastic Agents, Immunological, Cancer immunotherapy, Stimulator of interferon genes, Neoplasms, Immunology, Medicine, Animals, Humans, Interferon Regulatory Factor-3, Signal transduction, business, Cyclic dinucleotides, Signal Transduction
Abstract

info:eu-repo/semantics/published

Published
2019

2. Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy

Author

Mickaël Marloye, Gilles Berger, and Sean E. Lawler

Subjects
0301 basic medicine, medicine.medical_treatment, T cell, Immunomodulation, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Antineoplastic Agents, Immunological, Cancer immunotherapy, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Biomarkers, Tumor, Animals, Humans, Molecular Targeted Therapy, Molecular Biology, Innate immune system, business.industry, Cancer, Membrane Proteins, Biologie moléculaire, Immunotherapy, medicine.disease, Nucleotidyltransferases, Immune checkpoint, eye diseases, Sting, 030104 developmental biology, medicine.anatomical_structure, Stimulator of interferon genes, Cancer research, Molecular Medicine, business, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction
Abstract

The advent of immunotherapy in recent years has shown the potential to revolutionize the treatment of cancer. Unleashing antitumor T cell responses via immune checkpoint blockade has led to remarkable responses in previously untreatable tumors. The master regulator of interferon-mediated antiviral responses – stimulator of interferon genes (STING) – has now emerged as a critical mediator of innate immune sensing of cancer, and is a promising target for local immunostimulation, promoting intratumoral inflammation, and facilitating antitumor T cell responses. Pharmacological activation of the STING pathway can lead to T cell-mediated tumor regression in preclinical tumor models, and novel STING activating small molecules are now being tested in clinical trials. Here we will introduce the STING pathway and review the current state of drug development., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2019

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