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277 results on '"Mizuno, Kei"'

1. Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes

Author

Venkadakrishnan, Varadha Balaji, Presser, Adam G., Singh, Richa, Booker, Matthew A., Traphagen, Nicole A., Weng, Kenny, Voss, Nathaniel C. E., Mahadevan, Navin R., Mizuno, Kei, Puca, Loredana, Idahor, Osasenaga, Ku, Sheng-Yu, Bakht, Martin K., Borah, Ashir A., Herbert, Zachary T., Tolstorukov, Michael Y., Barbie, David A., Rickman, David S., Brown, Myles, and Beltran, Himisha

Published
2024
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2. Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer

Author

Bakht, Martin K., Yamada, Yasutaka, Ku, Sheng-Yu, Venkadakrishnan, Varadha Balaji, Korsen, Joshua A., Kalidindi, Teja M., Mizuno, Kei, Ahn, Shin Hye, Seo, Ji-Heui, Garcia, Maria Mica, Khani, Francesca, Elemento, Olivier, Long, Henry W., Chaglassian, Alain, Pillarsetty, Nagavarakishore, Lewis, Jason S., Freedman, Matthew, Belanger, Anthony P., Nguyen, Quang-De, and Beltran, Himisha

Published
2023
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4. Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer

Author

Kimura, Hiroko, Mizuno, Kei, Shiota, Masaki, Narita, Shintaro, Terada, Naoki, Fujimoto, Naohiro, Ogura, Keiji, Hatano, Shotaro, Iwasaki, Yusuke, Hakozaki, Nozomi, Ishitoya, Satoshi, Sumiyoshi, Takayuki, Goto, Takayuki, Kobayashi, Takashi, Nakagawa, Hidewaki, Kamoto, Toshiyuki, Eto, Masatoshi, Habuchi, Tomonori, Ogawa, Osamu, Momozawa, Yukihide, and Akamatsu, Shusuke

Published
2022
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7. Development and Validation of a Novel Prognostic Model for Predicting Overall Survival in Treatment-naïve Castration-sensitive Metastatic Prostate Cancer

Author

Akamatsu, Shusuke, Kubota, Masashi, Uozumi, Ryuji, Narita, Shintaro, Takahashi, Masahiro, Mitsuzuka, Koji, Hatakeyama, Shingo, Sakurai, Toshihiko, Kawamura, Sadafumi, Ishidoya, Shigeto, Hoshi, Senji, Ishida, Masanori, Mizuno, Kei, Ogura, Keiji, Goto, Takayuki, Terada, Naoki, Kobayashi, Takashi, Yamasaki, Toshinari, Inoue, Takahiro, Tsuchiya, Norihiko, Ohyama, Chikara, Arai, Yoichi, Habuchi, Tomonori, Morita, Satoshi, and Ogawa, Osamu

Published
2019
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9. Molecular features of prostate cancer after neoadjuvant therapy in the phase 3 CALGB 90203 trial.

Author

Sumiyoshi, Takayuki, Wang, Xiaofei, Warner, Evan W, Sboner, Andrea, Annala, Matti, Sigouros, Michael, Beja, Kevin, Mizuno, Kei, Ku, Shengyu, Fazli, Ladan, Eastham, James, Taplin, Mary-Ellen, Simko, Jeffrey, Halabi, Susan, Morris, Michael J, Gleave, Martin E, Wyatt, Alexander W, and Beltran, Himisha

Subjects
PROSTATE cancer, GENE expression, NEOADJUVANT chemotherapy, RADICAL prostatectomy, ANDROGEN deprivation therapy, DNA sequencing
Abstract

Background The phase 3 CALGB 90203 (Alliance) trial evaluated neoadjuvant chemohormonal therapy for high-risk localized prostate cancer before radical prostatectomy. We dissected the molecular features of post-treated tumors with long-term clinical outcomes to explore mechanisms of response and resistance to chemohormonal therapy. Methods We evaluated 471 radical prostatectomy tumors, including 294 samples from 166 patients treated with 6 cycles of docetaxel plus androgen deprivation therapy before radical prostatectomy and 177 samples from 97 patients in the control arm (radical prostatectomy alone). Targeted DNA sequencing and RNA expression of tumor foci and adjacent noncancer regions were analyzed in conjunction with pathologic changes and clinical outcomes. Results Tumor fraction estimated from DNA sequencing was significantly lower in post-treated tumor tissues after chemohormonal therapy compared with controls. Higher tumor fraction after chemohormonal therapy was associated with aggressive pathologic features and poor outcomes, including prostate-specific antigen–progression-free survival. SPOP alterations were infrequently detected after chemohormonal therapy, while TP53 alterations were enriched and associated with shorter overall survival. Residual tumor fraction after chemohormonal therapy was linked to higher expression of androgen receptor–regulated genes, cell cycle genes, and neuroendocrine genes, suggesting persistent populations of active prostate cancer cells. Supervised clustering of post–treated high-tumor-fraction tissues identified a group of patients with elevated cell cycle–related gene expression and poor clinical outcomes.  Conclusions Distinct recurrent prostate cancer genomic and transcriptomic features are observed after exposure to docetaxel and androgen deprivation therapy. Tumor fraction assessed by DNA sequencing quantifies pathologic response and could be a useful trial endpoint or prognostic biomarker. TP53 alterations and high cell cycle transcriptomic activity are linked to aggressive residual disease, despite potent chemohormonal therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Newly developed preclinical models reveal broad‐spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide.

Author

Matsuoka, Takashi, Sugiyama, Aiko, Miyawaki, Yoshifumi, Hidaka, Yusuke, Okuno, Yukiko, Sakai, Hiroaki, Tanaka, Hiroki, Yoshikawa, Kiyotsugu, Fukui, Tomohiro, Mizuno, Kei, Sumiyoshi, Takayuki, Goto, Takayuki, Inoue, Takahiro, Akamatsu, Shusuke, Kobayashi, Takashi, and Nakamura, Eijiro

Abstract

Androgen‐deprivation therapy is a standard treatment for advanced prostate cancer. However, most patients eventually acquire resistance and progress to castration‐resistant prostate cancer (CRPC). In this study, we established new CRPC cell lines, AILNCaP14 and AILNCaP15, from LNCaP cells under androgen‐deprived conditions. Unlike most pre‐existing CRPC cell lines, both cell lines expressed higher levels of androgen receptor (AR) and prostate‐specific antigen (PSA) than parental LNCaP cells. Moreover, these cells exhibited primary resistance to enzalutamide. Since AR signaling plays a significant role in the development of CRPC, PSA promoter sequences fused with GFP were introduced into AILNCaP14 cells to conduct GFP fluorescence‐based chemical screening. We identified flavopiridol, a broad‐spectrum CDK inhibitor, as a candidate drug that could repress AR transactivation of CRPC cells, presumably through the inhibition of phosphorylation of AR on the serine 81 residue (pARSer81). Importantly, this broad‐spectrum CDK inhibitor inhibited the proliferation of AILNCaP14 cells both in vitro and in vivo. Moreover, a newly developed liver metastatic model using AILNCaP15 cells revealed that the compound attenuated tumor growth of CRPC harboring highly metastatic properties. Finally, we developed a patient‐derived xenograft (PDX) model of CRPC and DCaP CR from a patient presenting therapeutic resistance to enzalutamide, abiraterone, and docetaxel. Flavopiridol successfully suppressed the tumor growth of CRPC in this PDX model. Since ARSer81 was found to be phosphorylated in clinical CRPC samples, our data suggested that broad‐spectrum CDK inhibitors might be a potent candidate drug for the treatment of CRPC, including those exhibiting primary resistance to enzalutamide. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cacao Polyphenol-Rich Dark Chocolate Intake Contributes to Efficient Brain Activity during Cognitive Tasks: A Randomized, Single-Blinded, Crossover, and Dose-Comparison fMRI Study.

Author

Sasaki, Akihiro, Kawai, Eriko, Watanabe, Kyosuke, Yamano, Emi, Oba, Chisato, Nakamura, Kentaro, Natsume, Midori, Mizuno, Kei, and Watanabe, Yasuyoshi

Abstract

Cacao polyphenol-enriched dark chocolate may have beneficial effects on human health, such as facilitating maintaining good performance in long-lasting cognitive tasks. This study examined the effects of dark chocolate intake on improving brain function during cognitive tasks using functional magnetic resonance imaging (fMRI). In this randomized, single-blinded, crossover, and dose-comparison study, 26 healthy middle-aged participants ingested dark chocolate (25 g) either with a low concentration (LC) (211.7 mg) or a high concentration (HC) (635 mg) of cacao polyphenols. Thereafter, their brain activities were analyzed during continuous and effortful cognitive tasks relevant to executive functioning using fMRI in two consecutive 15 min sessions (25 and 50 min after ingestion). We observed significant interaction effects between chocolate consumption and brain activity measurement sessions in the left dorsolateral prefrontal cortex and left inferior parietal lobule. After HC chocolate ingestion, these areas showed lower brain activity in the second session than in the first session; however, these areas showed higher activity in the second session after LC chocolate ingestion. These results suggest that cacao polyphenol-enriched dark chocolate enhances the efficient use of cognitive resources by reducing the effort of brain activity. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer.

Author

Yamada, Yasutaka, Venkadakrishnan, Varadha Balaji, Mizuno, Kei, Bakht, Martin, Ku, Sheng-Yu, Garcia, Maria Mica, and Beltran, Himisha

Subjects
DECITABINE, PROSTATE cancer, DNA methylation, DNA methyltransferases, ANTIBODY-drug conjugates, TUMOR growth, METASTASIS
Abstract

Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC). DNA methyltransferases (DNMTs) are highly expressed, and global DNA methylation is dysregulated in NEPC. We identified that deletion of DNMT genes decreases expression of neuroendocrine lineage markers and substantially reduced NEPC tumor development and metastasis in vivo. Decitabine, a pan-DNMT inhibitor, attenuated tumor growth in NEPC patient–derived xenograft models, as well as retinoblastoma gene (RB1)–deficient castration-resistant prostate adenocarcinoma (CRPC) models compared with RB1-proficient CRPC. We further found that DNMT inhibition increased expression of B7 homolog 3 (B7-H3), an emerging druggable target, via demethylation of B7-H3. We tested DS-7300a (i-DXd), an antibody-drug conjugate targeting B7-H3, alone and in combination with decitabine in models of advanced prostate cancer. There was potent single-agent antitumor activity of DS-7300a in both CRPC and NEPC bearing high expression of B7-H3. In B7-H3–low models, combination therapy of decitabine plus DS-7300a resulted in enhanced response. DNMT inhibition may therefore be a promising therapeutic target for NEPC and RB1-deficient CRPC and may sensitize B7-H3–low prostate cancer to DS-7300a through increasing target expression. NEPC and RB1-deficient CRPC represent prostate cancer subgroups with poor prognosis, and the development of biomarker-driven therapeutic strategies for these populations may ultimately help improve patient outcomes. Editor's summary: DNA methyltransferases (DNMTs) are increased in neuroendocrine prostate cancer (NEPC), an aggressive cancer associated with frequent metastases and poor clinical outcomes. Here, Yamada and colleagues deleted DNMT genes in NEPC, leading to reduced tumor development and metastases in mice. The DNMT inhibitor decitabine also attenuated tumor growth in NEPC and RB1-deficient castration-resistant prostate adenocarcinoma (CRPC) preclinical models. Because decitabine treatment increased expression of B7 homolog 3 (B7-H3), the authors combined decitabine treatment with DS-7300a, an antibody-drug conjugate that specifically targets B7-H3, in B7-H3–low prostate cancers, leading to a synergistic response. These findings suggest decitabine as a treatment for NEPC. Further, they suggest that the combination of decitabine with DS-7300a could potentially improve treatment response in those with B7-H3–low tumors. —Melissa L. Norton [ABSTRACT FROM AUTHOR]

Published
2023
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22. The Neural Substrates Associated with Attentional Resources and Difficulty of Concurrent Processing of the Two Verbal Tasks

Author

Mizuno, Kei, Tanaka, Masaaki, Tanabe, Hiroki C., Sadato, Norihiro, and Watanabe, Yasuyoshi

Abstract

The kana pick-out test has been widely used in Japan to evaluate the ability to divide attention in both adult and pediatric patients. However, the neural substrates underlying the ability to divide attention using the kana pick-out test, which requires participants to pick out individual letters (vowels) in a story while also reading for comprehension, thus requiring simultaneous allocation of attention to both activities, are still unclear. Moreover, outside of the clinical area, neuroimaging studies focused on the mechanisms of divided attention during complex story comprehension are rare. Thus, the purpose of the present study, to clarify the neural substrates of kana pick-out test, improves our current understanding of the basic neural mechanisms of dual task performance in verbal memory function. We compared patterns of activation in the brain obtained during performance of the individual tasks of vowel identification and story comprehension, to levels of activation when participants performed the two tasks simultaneously during the kana pick-out test. We found that activations of the left dorsal inferior frontal gyrus and superior parietal lobule increase in functional connectivity to a greater extent during the dual task condition compared to the two single task conditions. In contrast, activations of the left fusiform gyrus and middle temporal gyrus, which are significantly involved in picking out letters and complex sentences during story comprehension, respectively, were reduced in the dual task condition compared to during the two single task conditions. These results suggest that increased activations of the dorsal inferior frontal gyrus and superior parietal lobule during dual task performance may be associated with the capacity for attentional resources, and reduced activations of the left fusiform gyrus and middle temporal gyrus may reflect the difficulty of concurrent processing of the two tasks. In addition, the increase in synchronization between the left dorsal inferior frontal gyrus and superior parietal lobule in the dual task condition may induce effective communication between these brain regions and contribute to more attentional processing than in the single task condition, due to greater and more complex demands on voluntary attentional resources. (Contains 3 tables and 6 figures.)

Published
2012
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24. Effort-Reward Imbalance for Learning Is Associated with Fatigue in School Children

Author

Fukuda, Sanae, Yamano, Emi, Joudoi, Takako, Mizuno, Kei, Tanaka, Masaaki, Kawatani, Junko, Takano, Miyuki, Tomoda, Akemi, Imai-Matsumura, Kyoko, Miike, Teruhisa, and Watanabe, Yasuyoshi

Abstract

We examined relationships among fatigue, sleep quality, and effort-reward imbalance for learning in school children. We developed an effort-reward for learning scale in school students and examined its reliability and validity. Self-administered surveys, including the effort reward for leaning scale and fatigue scale, were completed by 1,023 elementary school students (grades 4-6) and 1,361 junior high school students (grades 7-9) at the end of 2006. Effort-reward imbalance for learning was associated with a high incidence of fatigue and sleep problems in elementary and junior high school students of both genders. A good relationship with family was associated with a low fatigue score in junior high school boys, and a good relationship with friends was associated with a low fatigue score in junior high school girls by multiple regression analysis. Fatigue score was associated with effort-reward imbalance and fatigue and quality of sleep in schoolchildren. Fatigue may lead to a decline in school performance, negative health outcomes, or refusal to attend school. These results suggest that it is desirable to consider social support, quality of sleep, and effort-reward imbalance when managing fatigue in school children. (Contains 3 tables and 1 figure.)

Published
2010
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26. Stress and Coping Styles Are Associated with Severe Fatigue in Medical Students

Author

Tanaka, Masaaki, Fukuda, Sanae, Mizuno, Kei, Kuratsune, Hirohiko, and Watanabe, Yasuyoshi

Abstract

Fatigue is a common complaint among medical students and researchers consider it to be related to poor academic outcomes. The authors' goal in the present study was to determine whether stress and coping strategies were associated with fatigue in medical students. The study group consisted of 73 second-year healthy students attending the Osaka City University Graduate School of Medicine. Participants completed a questionnaire about fatigue (Japanese version of Chalder Fatigue Scale), stress, stress coping (Japanese version of the Coping Inventory for Stressful Situations), overwork, and nocturnal sleeping hours. On univariate and multivariate logistic regression analyses adjusted for age and gender, stress was positively associated with fatigue. In addition, after adjustment for age, gender, and emotion- and task-oriented stress coping activities, avoidance-oriented stress coping activity was associated with fatigue. The results suggest that stress and the coping style are correlated with fatigue in medical students. (Contains 4 tables.)

Published
2009
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29. Up‐regulation of secretory leukocyte protease inhibitor in human samples might have a potential role of predicting prostate cancer recurrence and progression after surgery and hormonal therapy.

Author

Miyazaki, Yu, Goto, Takayuki, Li, Xin, Nakayama, Kenji, Okasho, Kosuke, Takeda, Masashi, Mizuno, Kei, Kimura, Hiroko, Uegaki, Masayuki, Sumiyoshi, Takayuki, Teramoto, Yuki, Akamatsu, Shusuke, Kobayashi, Takashi, Ogawa, Osamu, and Inoue, Takahiro

Subjects
CANCER relapse, PROTEASE inhibitors, HORMONE therapy, PROSTATE cancer, CASTRATION-resistant prostate cancer
Abstract

Using new castration‐resistant prostate cancer (CRPC) cell lines developed from LNCaP cells as a model for CRPC, we searched for novel biomarkers by analyzing the proteins secreted in culture supernatants. The results showed that the levels of secretory leukocyte protease inhibitor (SLPI) in these cell lines were 4.7–6.7 times higher than those secreted in parental LNCaP. Patients with localized prostate cancer (PC) and who expressed SLPI had a significantly lower prostate‐specific antigen (PSA) progression‐free survival rate than those who did not. Multivariate analysis revealed that SLPI expression was an independent risk factor for PSA recurrence. By contrast, when immunostaining of SLPI was performed on consecutive prostate tissue samples obtained from 11 patients, both in hormone naive (HN) and castration resistant (CR) conditions, only one patient expressed SLPI in the HNPC state; however, four of the 11 patients expressed SLPI in the CRPC state. In addition, two of these four patients were resistant to enzalutamide, and there was a discrepancy between their serum PSA levels and radiographic progression of the disease. These results suggest that SLPI can be a predictor of prognosis in patients with localized PC and disease progression in CRPC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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34. PROSTATE-SPECIFIC ANTIGEN DENSITY IS THE MOST APPROPRIATE FACTOR FOR DETECTING UNFAVORABLE PATHOLOGY AFTER RADICAL PROSTATECTOMY IN MEN ELIGIBLE FOR ACTIVE SURVEILLANCE FROM MUTLI-INSTITUTIONAL STUDY: MP57-08

Author

Inoue, Takahiro, Mizuno, Kei, Kinoshita, Hidefumi, Yano, Toshifumi, Kawanishi, Hiroaki, Kanda, Hideki, Terada, Naoki, Kamba, Tomomi, Okumura, Kazuhiro, Kawakita, Mutsushi, Ogura, Keiji, Sugimura, Yoshiki, Matsuda, Tadashi, and Ogawa, Osamu

Published
2016
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42. Machine learning diagnosis by immunoglobulin N‐glycan signatures for precision diagnosis of urological diseases.

Author

Iwamura, Hiromichi, Mizuno, Kei, Akamatsu, Shusuke, Hatakeyama, Shingo, Tobisawa, Yuki, Narita, Shintaro, Narita, Takuma, Yamashita, Shinichi, Kawamura, Sadafumi, Sakurai, Toshihiko, Fujita, Naoki, Kodama, Hirotake, Noro, Daisuke, Kakizaki, Ikuko, Nakaji, Shigeyuki, Itoh, Ken, Tsuchiya, Norihiko, Ito, Akihiro, Habuchi, Tomonori, and Ohyama, Chikara

Abstract

Early diagnosis of urological diseases is often difficult due to the lack of specific biomarkers. More powerful and less invasive biomarkers that can be used simultaneously to identify urological diseases could improve patient outcomes. The aim of this study was to evaluate a urological disease‐specific scoring system established with a machine learning (ML) approach using Ig N‐glycan signatures. Immunoglobulin N‐glycan signatures were analyzed by capillary electrophoresis from 1312 serum subjects with hormone‐sensitive prostate cancer (n = 234), castration‐resistant prostate cancer (n = 94), renal cell carcinoma (n = 100), upper urinary tract urothelial cancer (n = 105), bladder cancer (n = 176), germ cell tumors (n = 73), benign prostatic hyperplasia (n = 95), urosepsis (n = 145), and urinary tract infection (n = 21) as well as healthy volunteers (n = 269). Immunoglobulin N‐glycan signature data were used in a supervised‐ML model to establish a scoring system that gave the probability of the presence of a urological disease. Diagnostic performance was evaluated using the area under the receiver operating characteristic curve (AUC). The supervised‐ML urologic disease‐specific scores clearly discriminated the urological diseases (AUC 0.78–1.00) and found a distinct N‐glycan pattern that contributed to detect each disease. Limitations included the retrospective and limited pathological information regarding urological diseases. The supervised‐ML urological disease‐specific scoring system based on Ig N‐glycan signatures showed excellent diagnostic ability for nine urological diseases using a one‐time serum collection and could be a promising approach for the diagnosis of urological diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Effort-reward imbalance for learning is associated with fatigue in school children

Author

Fukuda, Sanae, Yamano, Emi, Joudoi, Takako, Mizuno, Kei, Tanaka, Masaaki, Kawatani, Junko, Takano, Miyuki, Tomoda, Akemi, Imai-Matsumura, Kyoko, Miike, Teruhisa, and Watanabe, Yasuyoshi

Subjects
Fatigue -- Causes of, Fatigue -- Demographic aspects, Sleep -- Health aspects, Elementary school students -- Health aspects, Learning -- Health aspects, Health, Psychology and mental health
Published
2010

48. Personality and fatigue in medical students

Author

Tanaka, Masaaki, Mizuno, Kei, Fukuda, Sanae, and Watanabe, Yasuyoshi

Subjects
Medical students -- Health aspects, Personality -- Demographic aspects, Personality -- Observations, Psychology and mental health
Abstract

Among medical students, fatigue is a common complaint and is related to poor academic outcomes. Associations of scores on personality traits and fatigue in medical students were examined. A group of 125 healthy second-year medical students completed a questionnaire about fatigue, the Japanese version of the Chalder Fatigue Scale, and the Temperament and Character Inventory. On simple regression analyses, the Temperament and Character Inventory dimension of Harm Avoidance was positively associated with Fatigue scores and those on Self-directedness were negatively associated. Similarly, on multiple regression analyses adjusted for age and sex, scores on the Temperament and Character Inventory dimension of Harm Avoidance were positively associated with Fatigue scores, and those for Self-directedness were negatively associated. These correlations were evident even after adjustment for other Temperament and Character Inventory dimensions. The temperament dimension of Harm Avoidance and the character dimension of Self-directedness were both associated with Fatigue in medical students. DOI 10.2466/PR0.106.2.567-575

Published
2010

49. Abstracts for the 6th Congress of Asian Sleep Research Society

Author

Kim, Seog Ju, Lyoo, In Kyoon, Lee, Yu-Jin, Jeong, Do-Un, Kanai, Hirohiko, Ookubo, Masanori, Yoshimura, Atsushi, Okawa, Masako, Yamada, Noto, Munezawa, Takeshi, Kaneita, Yoshitaka, Osaki, Yoneatsu, Kanda, Hideyuki, Ohtsu, Tadahiro, Minowa, Masumi, Suzuki, Kenji, Hijuchi, Susumu, Suzuki, Hiroyuki, Ohida, Takashi, Abe, Takashi, Komada, Yoko, Asaoka, Shoichi, Inoue, Yuichi, Lee, Jin-Seong, Cho, Sang-Yong, Kumar, Deependra, Mallick, Hruda N., Kumar, Velayudhan M., Kaushik, Mahesh K., Karashima, Akihiro, Katayama, Noiihiro, Nakao, Mitsuyuki, Nagendra, Ravindra P., Sulekha, Sathiamma, Narasappa, Sathyaprabha T., Nityanadan, Pradhan, Kutty, Bindu M., Nirmala, M., Ravindra, P. N., Tubaki, Basavaraj Ramappa, Sathyaprabha, T. N., Sudhakar, D., Lavekar, G. S., Chandrashekar, C. R., Kitaoka, Kazuyoshi, Shimizu, Mika, Chikahisa, Sachiko, Yoshizaki, Kazuo, Sei, Hiroyoshi, Kim, Jong-Won, Takegami, Misa, Yamazaki, Shin, Hayashino, Yasuaki, Ono, Rei, Otani, Koji, Sekiguchi, Miho, Konno, Shinichi, Fukuhara, Shunichi, Jakobson, Antonia J., Fitzgerald, Paul, Conduit, Russell, Li, Xin Shirley, Lam, Siu Ping Joyce, Yu, Wai Man Mandy, Wing, Yun Kwok, Okamoto-Mizuno, Kazue, Mizuno, Koh, Yamamoto, Mituaki, Shirakawa, Shuichiro, Doi, Hirokazu, Kato, Mikako, Shinohara, Kazuyuki, Tamaki, Masako, Matsuda, Shiori, Yamazaki, Katsuo, Hori, Tadao, Ogawa, Keiko, Takahashi, Kazumi, Kitahama, Kunio, Yamazaki, Katuo, Koyama, Yoshimasa, Shioda, Kohei, Ueda, Yugo, Nakamura, Yukiko, Inoue, Clara, Goto, Kazushige, Uchida, Sunao, Morita, Yuko, Honda, Yoshiko, Kodama, Tohru, Hagihara, Mari, Nakajima, Toru, Saito, Masato, Koga, Yoshihiko, Tanaka, Shinichiro, Yamadera, Hiroshi, Takahara, Madoka, Suwa, Sachiko, Onozuka, Minoru, Sato, Sadao, Togo, Fumiharu, Komatsu, Taiki, Mitani, Takeshi, Choi, Jongbae, Zhang, Bin, Sasai, Taeko, Mitsubayashi, Hiromi, Ohtsu, Mitsuhiro, Hasegawa, Isao, Ishii, Tatsuya, Komori, Akira, Suzuki, Asami, Nakahara, Yue, Hiroki, Mitsuyasu, Nakauma, Mariko, Someya, Nobuo, Ochiai, Tomomasa, Komori, Shouhei, Chiang, Rayleigh Ping-Ying, Yeh, Zai-Ting, Kim, Seong T., Yoon, Seung H., Kwon, Jeong S., Choi, Jong H., Ahn, Hyung J., Kim, Youngsoo, Yunren, Bolortuya, Chen, Lichao, Basheer, Radhika, Mccarley, Robert W., Strecker, Robert E., Honda, Makoto, Arai, Tetsuaki, Fukazawa, Miyuki, Honda, Yutaka, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Mignot, Emmanuel, Jung, Ki-Young, Ko, Deokwon, Koo, Yong-Seo, Zhang, Jihui, Ping Lam, Siu, Hong, Seung Chul, Chung, Kyoo In, Lee, Sung Pil, Lee, Chung Tai, Seo, Ho Jun, Jeong, Jong Hyeon, Lim, Hyeon Kuk, Shin, Yoon Kyung, You, Ji Hee, Suzuki, Jun-Ichi, Ogawa, Masahito, Liu, Xianchen, Ye, Wenyu, Watson, Peter, Dube, Sanjay, Wohlreich, Madelaine, Kwan, Benjamin C. H., Joseph, Francoise, Mckenzie, David M., Lee, Bonne, Lee, Sang-Ahm, Lee, Eun-Mi, Kim, Cheon-Sik, Nishijima, Tsuguo, Sakurai, Shigeru, Tokunaga, Jun, Takahashi, Susumu, Kanbayashi, Takashi, Hitomi, Jirou, Shimizu, Tetsuo, Murashima, Koji, Ozaki, Masayuki, Hang, Liang-Wen, Lin, Chen-Liang, Huang, Cheng-Ning, Huang, Wen-Yen, Choi, Ji Ho, Kim, Eun Joong, Kim, Tae Hoon, Lee, Sang Hag, Shin, Chol, Lee, Seung Hoon, Chen, Chia Chi, Lo, Men-Tzung, Lin, Chen, Lee, Min-Ying, Lin, Chia-Mo, Tsuiki, Satoru, Kobayashi, Mina, Takashima, Akiyo, Maeda, Keiko, Matsuura, Masato, Furukawa, Tomokazu, Nakano, Hiroshi, Hirayama, Kenji, Tanahashi, Tokusei, Yoshihara, Kazufumi, Kubo, Chiharu, Sudo, Nobuyuki, Kim, Eui-Joong, Ahn, Young Min, Shin, Hong-Beom, Kim, Jong Won, Matsuo, Akira, Nakai, Takayuki, Tsuiki, Storu, Chiba, Higoshige, Sawada, Koki, Chiba, Shintaro, Endo, Makoto, Moriwaki, Hiroto, Uchida, Ryo, Kim, Sung Wan, Chung, Dae Han, Shin, Seung Youp, Lee, Kun Hee, Cho, Joong Saeng, Tazoe, Mari, Ayuse, Takao, Yamamura, Satoshi, Kirkness, Jason P., Oi, Kumiko, Ishida, Katsunori, Kato, Masahiko, Kato, Yosuke, Yanagihara, Kiyotaka, Kinugasa, Yoshiharu, Sugihara, Shinobu, Hirai, Masayuki, Hamada, Toshihiro, Igawa, Osamu, Hisatome, Ichiro, Shigemasa, Chiaki, Shimizu, Noriyuki, Oura, Masahiro, Usui, Akira, Okajima, Isa, Matsuura, Noriko, Hiroki, Ikeda, Mitsuo, Hayashi, Choi, Jiae, Yoon, Inyoung, Furutani, Maki, Takase, M., Nakayama, K., Kita, Y., Sakohara, T., Yoshimura, H., Satoki, Y., Sakai, Y., Murakami, A., Kouno, K., Ikeda, R., Tanaka, H., Tanaka, Hideki, Yamano, Emi, Fukuda, Sanae, Joudoi, Takako, Mizuno, Kei, Tanaka, Masaaki, Kawatani, Junko, Takano, Miyuki, Tomoda, Akemi, Imai-Matsumura, Kyoko, Miike, Teruhisa, Watanabe, Yasuyoshi, Furihata, Ryuji, Uchiyama, Makoto, Takahashi, Sakae, Suzuki, Masahiro, Konno, Chisato, Ohsaki, Kouichi, Chiang, Hsin Ju, Tsai, Ling Ling, Weng, Chia Ying, Kawauchi, Tomomi, Tanaka, Yuu, Ohira, Hideki, Na, Hae-Ran, Kang, Eun-Ho, Sim, Hyun-Bo, Woo, Jong-Min, Yu, Bum-Hee, Ahmed, Wael, Kitanaka, Takahiro, Nishimura, Yoichi, Ando, Kayoko, Kurahashi, Hiroki, Abe, Akiko, Yamamoto, Ryuichiro, Matsuda, Michikazu, Ogawa, Toru, Ito, Toshimi, Suzuki, Tasuku, Sasaki, Keiichi, Shinno, Hideto, Otsuki, Manabu, Tsuchiya, Satoshi, Oka, Yasunori, Kawada, Seiichi, Innami, Toshihiko, Horikoshi, Tatsuru, Sasaki, Akira, Hineno, Takashi, Sakamoto, Tetsuro, Inami, Yasushi, Yamashita, Hidehisa, Mizuno, Soichi, Nakamura, Yu, Horiguchi, Jun, Iwanaga, Koichi, Kanemura, Takashi, Ohno, Mikako, Kato, Yuichi, Miyazaki, Soichiro, Maritani, Shinji, Ito, Yukihiko, Shen, Manzhen, Takahashi, Satomi, Kajiwara, Nobuko, Satoh, Makoto, Kinouchi, Kaori, Tokuyama, Kana, Akai, Yukiko, Fukuyama, Tomoko, Takahashi, Hiroe, Tanbara, Tadashi, Nishihara, Kyoko, Ozawa, Nobuyuki, Shin, Duk, Sakai, Hiroyuki, Uchiyama, Yuji, Wakita, Toshihiro, Sugi, Takenao, Yoshiyama, Hiroaki, Matsuoka, Genya, Sakai, Kazuhiro, Nakamura, Masatoshi, Cho, Yong Won, Lee, Joo Hwa, Jung, Sang Hun, Cho, Hwa Ra, Yi, Sang Doe, Kobayashi, Masato, Moromugi, Shunji, Sakamoto, Taichi, Ishimatsu, Takakazu, Lee, Jeong Su, Chung, Gih Sung, Park, Kwang Suk, Shin, Won Chul, Yoon, Jung Eun, Jang, Eun Joo, Sung, Min Jee, Cha, Hyun Keuk, Taguchi, T., Nakamori, M., Taneike, R., Hayashi, A., Sugimori, S., Kamiyama, J., Hamada, T., Itoi, H., Koyama, Emi, Kubo, Tomohide, Takahashi, Masaya, Sato, Tomoaki, Sasaki, Takeshi, Oka, Tatsuo, Iwasaki, Kenji, Son, Mia, Yeom, Myeonggul, Harma, Mikko, Wakamura, Tomoko, Tojo, Chiaki, Horita, Sachiko, Takahashi, Ken-Ichi, Sumi, Kensuke, Nakayama-Ashida, Yukiyo, Nakamura, Takaya, Minami, Itunari, Oka, Yasunari, Chin, Kazuo, Kadotani, Hiroshi, Hayashi, Etsuko, Kato, Rumiko, Tanaka, Yu, Yamamoto, Takuro, Yamashita, Shiko, Matsumoto, Masahiro, Nakashima, Yusaku, Soma, Haruhiko, Yasuda, Akio, Kuriki, Ayano, Hayashi, Mituo, MurakI, Takeya, Yamashiro, Keitaro, Aritomi, Ryoji, Sakurai, Shihomi, Kishi, Akifumi, Natelson, Benjamin H., Struzik, Zbigniew R., Yamamoto, Yoshiharu, Terashima, Ryuta, Nakade, Miyo, Murata, Chiyoe, Hirai, Hiroshi, Kondo, Katsunori, Tsutsui, Hideyo, Tsuboi, Hirohito, Ojima, Toshiyuki, Fu, Ying-Hui, He, Ying, Jones, Christopher, Fujiki, Nobuhiro, Nishino, Seiji, Ito, Asao, Fredholm, Bertil B., Hillman, David R., Hayashi, Mitsuo, Kennaway, David J., Mallick, H. 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Published
2009
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50. Stress and coping styles are associated with severe fatigue in medical students

Author

Tanaka, Masaaki, Fukuda, Sanae, Mizuno, Kei, Kuratsune, Hirohiko, and Watanabe, Yasuyoshi

Subjects
Medical students -- Health aspects, Medical students -- Research, Fatigue -- Demographic aspects, Fatigue -- Research, Stress (Psychology) -- Influence, Life style -- Influence, Health, Psychology and mental health
Published
2009

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