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We present highly-excited charmonium, $\textit{D}$$_{s}$ and $\textit{D}$ meson spectra from dynamical lattice QCD calculations with light quarks corresponding to $\textit{M}$$_{π}$ ∼ 240 MeV and compare these to previous results with $\textit{M}$$_{π}$ ∼ 400 MeV. Utilising the distillation framework, large bases of carefully constructed interpolating operators and a variational procedure, we extract and reliably identify the continuum spin of an extensive set of excited mesons. These include states with exotic quantum numbers which, along with a number with non-exotic quantum numbers, we identify as having excited gluonic degrees of freedom and interpret as hybrid mesons. Comparing the spectra at the two different $\textit{M}$$_{π}$ , we find only a mild light-quark mass dependence and no change in the overall pattern of states., GC is supported by the Cambridge European Trust, the U.K. Science and Technology Facilities Council (STFC) and St. John's College, Cambridge. COH acknowledges support from the School of Mathematics at Trinity College Dublin. GM acknowledges support the Herchel Smith Fund at the University of Cambridge. SMR acknowledges support from Science Foundation Ireland [RFP-PHY-3201]. CET acknowledges support from the STFC [grant ST/L000385/1]. DT is supported by the Irish Research Council Government of Ireland Postgraduate Scholarship Scheme [grant GOIPG/2014/65]. For further information please visit the publisher's website.

We present the first lattice QCD study of coupled-channel $D\pi$, $D\eta$ and $D_{s}\bar{K}$ scattering in isospin-1/2 in three partial waves. Using distillation, we compute matrices of correlation functions with bases of operators capable of resolving both meson and meson-meson contributions to the spectrum. These correlation matrices are analysed using a variational approach to extract the finite-volume energy eigenstates. Utilising L\"uscher's method and its extensions, we constrain scattering amplitudes in $S$, $P$ and $D$-wave as a function of energy. By analytically continuing the scattering amplitudes to complex energies, we investigate the $S$-matrix singularities. Working at $m_\pi \approx 391$ MeV, we find a pole corresponding to a $J^{P} = 0^{+}$ near-threshold bound state with a large coupling to $D\pi$. We also find a deeply bound $J^{P} = 1^{-}$ state, and evidence for a $J^{P} = 2^{+}$ narrow resonance coupled predominantly to $D\pi$. Elastic $D\pi$ scattering in the isospin-$3/2$ channel is studied and we find a weakly repulsive interaction in $S$-wave., GM acknowledges support from the Herchel Smith Fund at the University of Cambridge and the Deutsche Forschungsgemeinschaft (DFG) under contract KN 947/1-2. SMR acknowledges support from Science Foundation Ireland [RFP-PHY-3201]. CET acknowledges support from the U.K. Science and Technology Facilities Council (STFC) [grant ST/L000385/1] and the Isaac Newton Trust/University of Cambridge Early Career Support Scheme [RG74916]. The software codes Chroma [58] and QUDA [59, 60] were used to perform this work at Jeerson Laboratory under the USQCD Initiative and the LQCD ARRA project, and on the Lonsdale cluster maintained by the Trinity Centre for High Performance Computing funded through grants from Science Foundation Ireland (SFI). This work also used the DiRAC Data Analytic system at the University of Cambridge, operated by the University of Cambridge High Performance Computing Service on behalf of the STFC DiRAC HPC Facility (www.dirac.ac.uk). This equipment was funded by BIS National E-infrastructure capital grant ST/K001590/1, STFC capital grants ST/H008861/1 and ST/H00887X/1, and STFC DiRAC Operations grant ST/K00333X/1. DiRAC is part of the National E-Infrastructure. This research also used the Wilkes GPU cluster at the University of Cambridge High Performance Computing Service (http://www.hpc.cam.ac.uk/), provided by Dell Inc., NVIDIA and Mellanox, and part funded by STFC with industrial sponsorship from Rolls Royce and Mitsubishi Heavy Industries. Gauge con gurations were generated using resources awarded from the U.S. Department of Energy INCITE program at Oak Ridge National Laboratory, the NSF Teragrid at the Texas Advanced Computer Center and the Pittsburgh Supercomputer Center, as well as at Jeerson Lab., This is the final version of the article. It first appeared from Springer via https://doi.org/10.1007/JHEP10(2016)011

Oestrogen receptor status has been determined by an immunocytochemical assay using fine-needle aspiration samples of primary breast cancers in elderly patients. In a prospective study 56 patients were treated with tamoxifen only. Satisfactory assays were achieved in 49 patients. Disease was controlled by tamoxifen in 32 of 35 (91%) patients with oestrogen receptor positive tumours, compared with only 1 (7%) of 14 who were receptor negative. Immunocytochemical assay on fine-needle aspiration samples is relatively non-invasive and simple to perform, it accurately predicts response to tamoxifen in elderly patients and can be used to select patients for tamoxifen only therapy.