Search

Your search keyword '"Moraleda, Cinta"' showing total 188 results
Start Over Author "Moraleda, Cinta" Language english
188 results on '"Moraleda, Cinta"'

2. Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study)

Author

Carrasco Colom, Jaime, Manzanares, Ángela, Álvaro Gómez, Alicia, Serrano Escribano, Isabel, Esquivel, Estrella, Pérez-Rivilla, Alfredo, Moral-Pumarega, Maria Teresa, Aguirre Pascual, Elisa, De Vergas, Joaquín, Reda del Barrio, Sara, Moraleda, Cinta, Epalza, Cristina, Fernández-Cooke, Elisa, Prieto, Luis, Villaverde, Serena, Zamora, Berta, Herraiz, Ignacio, Galindo, Alberto, Folgueira, María Dolores, Delgado, Rafael, and Blázquez-Gamero, Daniel

Published
2023
Full Text
View/download PDF

3. T-Cell Immune Responses in Newborns and Long-Term Sequelae in Congenital Cytomegalovirus Infection (CYTRIC Study)

Author

Hernández, Judith, Pisón, Raquel Pinillos, Arnaiz, Eneritz Velasco, Villaverde, Serena, Vila, Sara, Rojo, Pablo, Epalza, Cristina, Moraleda, Cinta, Cooke, Elisa Fernández, Prieto, Luis, Zamora, Berta, Martínez de Aragón, Ana, Simón, Rogelio, Camacho, Ana, Machín, Fátima, Cabello, Laura, Romero, María Luz, Serna, Miquel, Martín, Marta, Esquivel-De la Fuente, Estrella, Calle, María de la, Rodríguez, Sara Domínguez, Cabanes, María, Gómez-Montes, Enery, Goncé, Anna, Bango, Marta Valdés, Viñuela-Benéitez, M<ce:sup loc='post">a</ce:sup> Carmen, Muñoz-Chápuli Gutiérrez, Mar, Pérez, Irene Cuadrado, Encinas, Begoña, Tagarro, Alfredo, Alcázar, Diana García, Burguillo, Antonio García, Martín, Roser Díez, Calavia, Olga, Salvia, Dolors, Olabarrieta, Iciar, Xiberta, Joan Manel, Jiménez Losa, Luz María, Soriano-Ramos, María, Pedrero-Tomé, Roberto, Giménez-Quiles, Estela, Albert, Eliseo, Baquero-Artigao, Fernando, Rodríguez-Molino, Paula, del Rosal, Teresa, Noguera-Julian, Antoni, Fortuny, Clàudia, Ríos-Barnés, María, Saavedra-Lozano, Jesús, Dueñas, Eva, Sánchez-Mateos, Miguel, Castells, Laura, de la Serna, María, Frick, Marie Antoinette, de Vergas, Joaquín, Núñez-Enamorado, Noemí, Moral-Pumarega, María Teresa, Folgueira, María Dolores, Navarro, David, and Blázquez-Gamero, Daniel

Published
2024
Full Text
View/download PDF

5. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium

Author

Aaron, James R., Adam, Atif, Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., Angoulvant, François, Anthony, Li LLJ., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Panickan, Vidul Ayakulangara, Azevedo, Paula S., Badenes, Rafael, Balshi, James, Batugo, Ashley, Beaulieu-Jones, Brendin R., Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Cattelan, Anna Maria, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, García-Barrio, Noelia, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Goh, Rachel SJ., González, Tomás González, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Guzzi, Pietro H., Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Honerlaw, Jacqueline P., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kainth, Mundeep K., Kate, Kernan F., Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Kernan, Kate F., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Makwana, Simran, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Maripuri, Monika, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mazzotti, Diego R., Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku FM., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Ashley C., Pfaff, Emily R., Pillion, Danielle, Pizzimenti, Sara, Priya, Tanu, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Romero-Garcia, Nekane, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin A., Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Sperotto, Francesca, Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia LM., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma MS., Torti, Carlo, Trecarichi, Enrico M., Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zachariasse, Joany M., Zahner, Janet J., Zambelli, Alberto, Zhang, Harrison G., Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Li, Xiudi, Rofeberg, Valerie N., Elias, Matthew D., Laird-Gion, Jessica, and Newburger, Jane W.

Published
2023
Full Text
View/download PDF

6. Characterization of long COVID temporal sub-phenotypes by distributed representation learning from electronic health record data: a cohort study

Author

Aaron, James R., Agapito, Giuseppe, Albayrak, Adem, Albi, Giuseppe, Alessiani, Mario, Alloni, Anna, Amendola, Danilo F., François Angoulvant, Anthony, Li L.L.J., Aronow, Bruce J., Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Azevedo, Paula S., Balshi, James, Beaulieu-Jones, Brett K., Bell, Douglas S., Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence T., Bradford, Robert L., Brat, Gabriel A., Bréant, Stéphane, Brown, Nicholas W., Bruno, Raffaele, Bryant, William A., Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista Y., Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James J., Colicchio, Tiago K., Cormont, Sylvie, Cossin, Sébastien, Craig, Jean B., Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Dionne, Audrey, Duan, Rui, Dubiel, Julien, DuVall, Scott L., Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert W., Ganslandt, Thomas, Barrio, Noelia García, Garmire, Lana X., Gehlenborg, Nils, Getzen, Emily J., Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Han, Larry, Hanauer, David A., Haverkamp, Christian, Hazard, Derek Y., He, Bing, Henderson, Darren W., Hilka, Martin, Ho, Yuk-Lam, Holmes, John H., Hong, Chuan, Huling, Kenneth M., Hutch, Meghan R., Issitt, Richard W., Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Keller, Mark S., Kennedy, Chris J., Key, Daniel A., Kirchoff, Katie, Klann, Jeffrey G., Kohane, Isaac S., Krantz, Ian D., Kraska, Detlef, Krishnamurthy, Ashok K., L'Yi, Sehi, Le, Trang T., Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, Will Loh, Ne Hooi, Long, Qi, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine E., Mahmood, Sadiqa, Maidlow, Sarah E., Makoudjou, Adeline, Malovini, Alberto, Mandl, Kenneth D., Mao, Chengsheng, Maram, Anupama, Martel, Patricia, Martins, Marcelo R., Marwaha, Jayson S., Masino, Aaron J., Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos F., Moal, Bertrand, Ahooyi, Taha Mohseni, Moore, Jason H., Moraleda, Cinta, Morris, Jeffrey S., Morris, Michele, Moshal, Karyn L., Mousavi, Sajad, Mowery, Danielle L., Murad, Douglas A., Murphy, Shawn N., Naughton, Thomas P., Breda Neto, Carlos Tadeu, Neuraz, Antoine, Newburger, Jane, Ngiam, Kee Yuan, Njoroge, Wanjiku F.M., Norman, James B., Obeid, Jihad, Okoshi, Marina P., Olson, Karen L., Omenn, Gilbert S., Orlova, Nina, Ostasiewski, Brian D., Palmer, Nathan P., Paris, Nicolas, Patel, Lav P., Pedrera-Jiménez, Miguel, Pfaff, Emily R., Pfaff, Ashley C., Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans U., Prudente, Robson A., Prunotto, Andrea, Quirós-González, Víctor, Ramoni, Rachel B., Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina C.C., Sanz Vidorreta, Fernando J., Savino, Maria, Schriver, Emily R., Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil J., Serrano-Balazote, Pablo, Serre, Patricia, Serret-Larmande, Arnaud, Shah, Mohsin, Hossein Abad, Zahra Shakeri, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, South, Andrew M., Spiridou, Anastasia, Strasser, Zachary H., Tan, Amelia L.M., Tan, Bryce W.Q., Tan, Byorn W.L., Tanni, Suzana E., Taylor, Deanne M., Terriza-Torres, Ana I., Tibollo, Valentina, Tippmann, Patric, Toh, Emma M.S., Torti, Carlo, Trecarichi, Enrico M., Tseng, Yi-Ju, Vallejos, Andrew K., Varoquaux, Gael, Vella, Margaret E., Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar B., Waitman, Lemuel R., Wang, Xuan, Wassermann, Demian, Weber, Griffin M., Wolkewitz, Martin, Wong, Scott, Xia, Zongqi, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison G., Zo¨ller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Mesa, Rebecca, and Verdy, Guillame

Published
2023
Full Text
View/download PDF

7. Treatments for multi-system inflammatory syndrome in children — discharge, fever, and second-line therapies

Author

Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Mesa, Juan Miguel, Epalza, Cristina, Grasa, Carlos, Iglesias-Bouzas, María Isabel, Fernández-Cooke, Elisa, Calvo, Cristina, Villaverde, Serena, Torres-Fernández, David, Méndez-Echevarria, Ana, Leoz, Inés, Fernández-Pascual, María, Saavedra-Lozano, Jesús, Soto, Beatriz, Aguilera-Alonso, David, Rivière, Jacques G., Fumadó, Victoria, Martínez-Campos, Leticia, Vivanco, Ana, Pilar-Orive, Francisco Javier, Alcalá, Pedro, Ruiz, Beatriz, López-Machín, Ana, Oltra, Manuel, and Moraleda, Cinta

Published
2023
Full Text
View/download PDF

10. Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children

Author

Tagarro, Alfredo, Cobos-Carrascosa, Elena, Villaverde, Serena, Sanz-Santaeufemia, Francisco-Javier, Grasa, Carlos, Soriano-Arandes, Antoni, Hernanz, Alicia, Navarro, María Luisa, Pino, Rosa, Epalza, Cristina, Batista, Rosa, Rizo, Jana, Iglesias-Bouzas, María-Isabel, Rodríguez-Molino, Paula, Villanueva-Medina, Sara, Carrasco-Colom, Jaime, Alonso-Cadenas, José-Antonio, Mellado, María-José, Herrero, Blanca, Melendo, Susana, De La Torre, Mercedes, Calleja, Lourdes, Calvo, Cristina, Urretavizcaya-Martínez, María, Astigarraga, Itziar, Menasalvas, Ana, Penin, María, Neth, Olaf, Berzosa, Arantxa, De Ceano-Vivas, María, Vidal, Paula, Romero, Isabel, González, Raúl, García, María Luz, Mesa, Juan-Miguel, Ballesteros, Álvaro, Bernardino, María, and Moraleda, Cinta

Published
2022
Full Text
View/download PDF

11. Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial

Author

Rojo, Pablo, Moraleda, Cinta, Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Castillo, Lola Madrid, Tato, Luis Manuel Prieto, López, Aranzazu Sancho, Manukyan, Lilit, Marcy, Olivier, Leroy, Valeriane, Nardone, Alessandra, Burger, David, Bassat, Quique, Bates, Matthew, Moh, Raoul, Iroh Tam, Pui-Ying, Mvalo, Tisungane, Magallhaes, Justina, Buck, W. Chris, Sacarlal, Jahit, Musiime, Victor, Chabala, Chishala, and Mujuru, Hilda Angela

Published
2022
Full Text
View/download PDF

13. Global burden of acute lower respiratory infection associated with human parainfluenza virus in children younger than 5 years for 2018: a systematic review and meta-analysis

Author

Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Arguelles, Vina Lea, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Echavarria, Marcela, Fasce, Rodrigo A, Gentile, Angela, Goswami, Doli, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mathisen, Maria, McLean, Kenneth A, Mira-Iglesias, Ainara, Moraleda, Cinta, Okamoto, Michiko, Oshitani, Histoshi, O'Brien, Katherine L, Owor, Betty E, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Sawatwong, Pongpun, Scott, J Anthony G, Simões, Eric A F, Sotomayor, Viviana, Thea, Donald M, Treurnicht, Florette K, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
Full Text
View/download PDF

14. Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old

Author

Blázquez-Gamero, Daniel, Epalza, Cristina, Cadenas, José Antonio Alonso, Gero, Lourdes Calleja, Calvo, Cristina, Rodríguez-Molino, Paula, Méndez, María, Santos, Maria del Mar, Fumadó, Victoria, Guzmán, María Fernanda, Soriano-Arandes, Antoni, Jiménez, Ana B., Penin, Maria, Cobo-Vazquez, Elvira, Pareja, Marta, Lobato, Zulema, Serna, Miquel, Delgado, Rafael, Moraleda, Cinta, and Tagarro, Alfredo

Published
2021
Full Text
View/download PDF

15. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study

Author

Libster, Romina, Otieno, Grieven, Joundi, Imane, Broor, Shobha, Nicol, Mark, Amarchand, Ritvik, Shi, Ting, López-Labrador, F. Xavier, Baker, Julia M., Jamison, Alexandra, Choudekar, Avinash, Juvekar, Sanjay, Obermeier, Patrick, Schweiger, Brunhilde, Madrid, Lola, Thomas, Elizabeth, Lanaspa, Miguel, Nohynek, Hanna, Nokes, James, Werner, Marta, Danhg, Anh, Chadha, Mandeep, Puig-Barberà, Joan, Caballero, Mauricio T., Mathisen, Maria, Walaza, Sibongile, Hellferscee, Orienka, Laubscher, Matt, Higdon, Melissa M., Haddix, Meredith, Sawatwong, Pongpun, Baggett, Henry C., Seidenberg, Phil, Mwanayanda, Lawrence, Antonio, Martin, Ebruke, Bernard E., Adams, Tanja, Rahman, Mustafizur, Rahman, Mohammed Ziaur, Sow, Samboa O., Baillie, Vicky L., Workman, Lesley, Toizumi, Michiko, Tapia, Milagritos D., Nguyen, Thi hien anh, Morpeth, Susan, Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A, Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A, Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Kotloff, Karen L, Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G, Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P, Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E, Polack, Fernando P, O'Brien, Katherine L, Rasmussen, Zeba A, Rath, Barbara A, Salimi, Vahid, Scott, J Anthony G, Simões, Eric A F, Strand, Tor A, Thea, Donald M, Treurnicht, Florette K, Vaccari, Linda C, Yoshida, Lay-Myint, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2021
Full Text
View/download PDF

16. Cancer is not a risk factor for severe COVID‐19 in children, except in patients with recent allogeneic hematopoietic stem cell transplantation or comorbidities.

Author

Velasco Puyó, Pablo, Tagarro, Alfredo, Garcia‐Obregon, Susana, Villate, Olatz, Moraleda, Cinta, Huerta Aragonés, Jorge, Bardón Cancho, Eduardo J., Faura Morros, Anna, Galán‐Gómez, Víctor, Escobar Fernández, Laura, Lendinez‐Molinos, Francisco, Herrero Velasco, Blanca, Ureña Horno, Laura, Domínguez‐Pinilla, Nerea, Pascual Gazquez, Juan Francisco, Nova Lozano, Cristina, Osuna‐Marco, Marta, Marín‐Cruz, Inés, Gomez Pastrana, Irene, and Garcia de Andoin Barandiaran, Nagore

Published
2024
Full Text
View/download PDF

18. Quality of care and maternal mortality in a tertiary-level hospital in Mozambique: a retrospective study of clinicopathological discrepancies

Author

Menéndez, Clara, Quintó, Llorenç, Castillo, Paola, Fernandes, Fabiola, Carrilho, Carla, Ismail, Mamudo R, Lorenzoni, Cesaltina, Hurtado, Juan Carlos, Rakislova, Natalia, Munguambe, Khátia, Moraleda, Cinta, Maixenchs, Maria, Macete, Eusebio, Mandomando, Inacio, Martínez, Miguel J, Alonso, Pedro L, Bassat, Quique, and Ordi, Jaume

Published
2020
Full Text
View/download PDF

19. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis

Author

Acacio, Sozinho, Alonso, Wladimir J, Antonio, Martin, Ayora Talavera, Guadalupe, Badarch, Darmaa, Baillie, Vicky L, Barrera-Badillo, Gisela, Bigogo, Godfrey, Broor, Shobha, Bruden, Dana, Buchy, Philippe, Byass, Peter, Chipeta, James, Clara, Wilfrido, Dang, Duc-Anh, de Freitas Lázaro Emediato, Carla Cecília, de Jong, Menno, Díaz-Quiñonez, José Alberto, Do, Lien Anh Ha, Fasce, Rodrigo A, Feng, Luzhao, Ferson, Mark J, Gentile, Angela, Gessner, Bradford D, Goswami, Doli, Goyet, Sophie, Grijalva, Carlos G, Halasa, Natasha, Hellferscee, Orienka, Hessong, Danielle, Homaira, Nusrat, Jara, Jorge, Kahn, Kathleen, Khuri-Bulos, Najwa, Kotloff, Karen L, Lanata, Claudio F, Lopez, Olga, Lopez Bolaños, Maria Renee, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Madhi, Shabir A, Mekgoe, Omphile, Moraleda, Cinta, Moyes, Jocelyn, Mulholland, Kim, Munywoki, Patrick K, Naby, Fathima, Nguyen, Thanh Hung, Nicol, Mark P, Nokes, D James, Noyola, Daniel E, Onozuka, Daisuke, Palani, Nandhini, Poovorawan, Yong, Rahman, Mustafizur, Ramaekers, Kaat, Romero, Candice, Schlaudecker, Elizabeth P, Schweiger, Brunhilde, Seidenberg, Phil, Simoes, Eric A F, Singleton, Rosalyn, Sistla, Sujatha, Sturm-Ramirez, Katharine, Suntronwong, Nungruthai, Sutanto, Agustinus, Tapia, Milagritos D, Thamthitiwat, Somsak, Thongpan, Ilada, Tillekeratne, Gayani, Tinoco, Yeny O, Treurnicht, Florette K, Turner, Claudia, Turner, Paul, van Doorn, Rogier, Van Ranst, Marc, Visseaux, Benoit, Waicharoen, Sunthareeya, Wang, Jianwei, Yoshida, Lay-Myint, Zar, Heather J, Li, You, Reeves, Rachel M, Wang, Xin, Bassat, Quique, Brooks, W Abdullah, Cohen, Cheryl, Moore, David P, Nunes, Marta, Rath, Barbara, Campbell, Harry, and Nair, Harish

Published
2019
Full Text
View/download PDF

21. MIS-C, Can Latency Interval Help in Diagnosis?

Author

Mosquera Fernández, Pablo, García García, Sonsoles, Epalza, Cristina, Blázquez-Gamero, Daniel, Carrasco, Jaime, Fernandez-Cook, Elisa, Prieto-Tato, Luis, Torres, David, Villaverde, Serena, Belda, Sylvia, Toral-Vázquez, Belén, and Moraleda, Cinta

Published
2021
Full Text
View/download PDF

22. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

Author

Shi, Ting, McAllister, David A, O'Brien, Katherine L, Simoes, Eric A F, Madhi, Shabir A, Gessner, Bradford D, Polack, Fernando P, Balsells, Evelyn, Acacio, Sozinho, Aguayo, Claudia, Alassani, Issifou, Ali, Asad, Antonio, Martin, Awasthi, Shally, Awori, Juliet O, Azziz-Baumgartner, Eduardo, Baggett, Henry C, Baillie, Vicky L, Balmaseda, Angel, Barahona, Alfredo, Basnet, Sudha, Bassat, Quique, Basualdo, Wilma, Bigogo, Godfrey, Bont, Louis, Breiman, Robert F, Brooks, W Abdullah, Broor, Shobha, Bruce, Nigel, Bruden, Dana, Buchy, Philippe, Campbell, Stuart, Carosone-Link, Phyllis, Chadha, Mandeep, Chipeta, James, Chou, Monidarin, Clara, Wilfrido, Cohen, Cheryl, de Cuellar, Elizabeth, Dang, Duc-Anh, Dash-yandag, Budragchaagiin, Deloria-Knoll, Maria, Dherani, Mukesh, Eap, Tekchheng, Ebruke, Bernard E, Echavarria, Marcela, de Freitas Lázaro Emediato, Carla Cecília, Fasce, Rodrigo A, Feikin, Daniel R, Feng, Luzhao, Gentile, Angela, Gordon, Aubree, Goswami, Doli, Goyet, Sophie, Groome, Michelle, Halasa, Natasha, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R C, Jara, Jorge, Jroundi, Imane, Kartasasmita, Cissy B, Khuri-Bulos, Najwa, Kotloff, Karen L, Krishnan, Anand, Libster, Romina, Lopez, Olga, Lucero, Marilla G, Lucion, Florencia, Lupisan, Socorro P, Marcone, Debora N, McCracken, John P, Mejia, Mario, Moisi, Jennifer C, Montgomery, Joel M, Moore, David P, Moraleda, Cinta, Moyes, Jocelyn, Munywoki, Patrick, Mutyara, Kuswandewi, Nicol, Mark P, Nokes, D James, Nymadawa, Pagbajabyn, da Costa Oliveira, Maria Tereza, Oshitani, Histoshi, Pandey, Nitin, Paranhos-Baccalà, Gláucia, Phillips, Lia N, Picot, Valentina Sanchez, Rahman, Mustafizur, Rakoto-Andrianarivelo, Mala, Rasmussen, Zeba A, Rath, Barbara A, Robinson, Annick, Romero, Candice, Russomando, Graciela, Salimi, Vahid, Sawatwong, Pongpun, Scheltema, Nienke, Schweiger, Brunhilde, Scott, J Anthony G, Seidenberg, Phil, Shen, Kunling, Singleton, Rosalyn, Sotomayor, Viviana, Strand, Tor A, Sutanto, Agustinus, Sylla, Mariam, Tapia, Milagritos D, Thamthitiwat, Somsak, Thomas, Elizabeth D, Tokarz, Rafal, Turner, Claudia, Venter, Marietjie, Waicharoen, Sunthareeya, Wang, Jianwei, Watthanaworawit, Wanitda, Yoshida, Lay-Myint, Yu, Hongjie, Zar, Heather J, Campbell, Harry, and Nair, Harish

Published
2017
Full Text
View/download PDF

24. Twice-Daily Dosing of Dolutegravir in Infants on Rifampicin Treatment: A Pharmacokinetic Substudy of the EMPIRICAL Trial.

Author

Jacobs, Tom G, Mumbiro, Vivian, Cassia, Uneisse, Zimba, Kevin, Nalwanga, Damalie, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Madrid, Lola, Mutata, Constantine, Chitsamatanga, Moses, Bwakura-Dangarembizi, Mutsa, Passanduca, Alfeu, Buck, W Chris, Nduna, Bwendo, Chabala, Chishala, Najjingo, Elizabeth, Musiime, Victor, Moraleda, Cinta, and Colbers, Angela

Subjects
DRUG therapy for tuberculosis, HIV integrase inhibitors, COMBINATION drug therapy, VIRAL load, DRUG side effects, RECEIVER operating characteristic curves, RESEARCH funding, HIV-positive persons, CLINICAL trials, HIV infections, TREATMENT effectiveness, DESCRIPTIVE statistics, CONFIDENCE intervals, RIFAMPIN, CHILDREN
Abstract

Background We evaluated dolutegravir pharmacokinetics in infants with human immunodeficiency virus (HIV) receiving dolutegravir twice daily (BID) with rifampicin-based tuberculosis (TB) treatment compared with once daily (OD) without rifampicin. Methods Infants with HIV aged 1–12 months, weighing ≥3 kg, and receiving dolutegravir BID with rifampicin or OD without rifampicin were eligible. Six blood samples were taken over 12 (BID) or 24 hours (OD). Dolutegravir pharmacokinetic parameters, HIV viral load (VL) data, and adverse events (AEs) were reported. Results Twenty-seven of 30 enrolled infants had evaluable pharmacokinetic curves. The median (interquartile range) age was 7.1 months (6.1–9.9), weight was 6.3 kg (5.6–7.2), 21 (78%) received rifampicin, and 11 (41%) were female. Geometric mean ratios comparing dolutegravir BID with rifampicin versus OD without rifampicin were area under curve (AUC)0–24h 0.91 (95% confidence interval,.59–1.42), Ctrough 0.95 (0.57–1.59), Cmax 0.87 (0.57–1.33). One infant (5%) receiving rifampicin versus none without rifampicin had dolutegravir Ctrough <0.32 mg/L, and none had Ctrough <0.064 mg/L. The dolutegravir metabolic ratio (dolutegravir-glucuronide AUC/dolutegravir AUC) was 2.3-fold higher in combination with rifampicin versus without rifampicin. Five of 82 reported AEs were possibly related to rifampicin or dolutegravir and resolved without treatment discontinuation. Upon TB treatment completion, HIV viral load was <1000 copies/mL in 76% and 100% of infants and undetectable in 35% and 20% of infants with and without rifampicin, respectively. Conclusions Dolutegravir BID in infants receiving rifampicin resulted in adequate dolutegravir exposure, supporting this treatment approach for infants with HIV–TB coinfection. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Prevalence and Clinical Manifestations of Congenital Cytomegalovirus Infection in a Screening Program in Madrid (PICCSA Study)

Author

Blázquez-Gamero, Daniel, Soriano-Ramos, María, Vicente, Marta, Pallás-Alonso, Carmen Rosa, Pérez-Rivilla, Alfredo, García-Álvarez, Mónica, Pinilla Martín, María Teresa, Freire, Xavier, De Vergas, Joaquín, De Aragón, Ana Martínez, Zamora, Berta, Epalza, Cristina, Moraleda, Cinta, Rojo, Pablo, Prieto, Luis, Fernández-Cooke, Elisa, Ruíz-Contreras, Jesús, Delgado, Rafael, and Folgueira, María Dolores

Published
2020
Full Text
View/download PDF

28. First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia.

Author

Chabala, Chishala, Jacobs, Tom G, Moraleda, Cinta, Ndaferankhande, John M, Mumbiro, Vivian, Passanduca, Alfeu, Namuziya, Natasha, Nalwanga, Damalie, Musiime, Victor, Ballesteros, Alvaro, Domínguez-Rodríguez, Sara, Chitsamatanga, Moses, Cassia, Uneisse, Nduna, Bwendo, Bramugy, Justina, Sacarlal, Jahit, Madrid, Lola, Nathoo, Kusum J, Colbers, Angela, and Burger, David M

Subjects
ANTIBIOTICS, DRUG therapy for tuberculosis, HIV-positive persons, PNEUMONIA, HIV infections, ETHAMBUTOL, GLOMERULAR filtration rate, RESEARCH, CO-trimoxazole, PREDNISOLONE, BODY weight, BLOOD plasma, MULTIVARIATE analysis, PYRAZINAMIDE, MULTIPLE regression analysis, PATIENTS, ANTIRETROVIRAL agents, BLOOD collection, HOSPITAL admission & discharge, SEVERITY of illness index, ISONIAZID, ANTITUBERCULAR agents, RESEARCH funding, VALGANCICLOVIR, DESCRIPTIVE statistics, RIFAMPIN, CHILDREN
Abstract

Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

29. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality

Author

Weber, Griffin, Hong, Chuan, Xia, Zongqi, Palmer, Nathan, Avillach, Paul, L’yi, Sehi, Keller, Mark, Murphy, Shawn, Gutiérrez-Sacristán, Alba, Bonzel, Clara-Lea, Serret-Larmande, Arnaud, Neuraz, Antoine, Omenn, Gilbert, Visweswaran, Shyam, Klann, Jeffrey, South, Andrew, Loh, Ne Hooi Will, Cannataro, Mario, Beaulieu-Jones, Brett, Bellazzi, Riccardo, Agapito, Giuseppe, Alessiani, Mario, Aronow, Bruce, Bell, Douglas, Benoit, Vincent, Bourgeois, Florence, Chiovato, Luca, Cho, Kelly, Dagliati, Arianna, Duvall, Scott, Barrio, Noelia García, Hanauer, David, Ho, Yuk-Lam, Holmes, John, Issitt, Richard, Liu, Molei, Luo, Yuan, Lynch, Kristine, Maidlow, Sarah, Malovini, Alberto, Mandl, Kenneth, Mao, Chengsheng, Matheny, Michael, Moore, Jason, Morris, Jeffrey, Morris, Michele, Mowery, Danielle, Ngiam, Kee Yuan, Patel, Lav, Pedrera Jiménez, Miguel, Ramoni, Rachel, Schriver, Emily, Schubert, Petra, Balazote, Pablo Serrano, Spiridou, Anastasia, Tan, Amelia, Tan, Byorn, Tibollo, Valentina, Torti, Carlo, Trecarichi, Enrico, Wang, Xuan, Aaron, James, Albayrak, Adem, Albi, Giuseppe, Balshi, James, Alloni, Anna, Amendola, Danilo, Angoulvant, François, Anthony, Li, Ashraf, Fatima, Atz, Andrew, Azevedo, Paula, Bellasi, Antonio, Beraghi, Michele, Bernal-Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Bhatnagar, Surbhi, Blanco-Martínez, Alvar, Boeker, Martin, Booth, John, Bosari, Silvano, Bradford, Robert, Brat, Gabriel, Bréant, Stéphane, Brown, Nicholas, Bruno, Raffaele, Bryant, William, Bucalo, Mauro, Bucholz, Emily, Burgun, Anita, Cai, Tianxi, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Krista, Chen, Jin, Chiudinelli, Lorenzo, Cimino, James, Colicchio, Tiago, Cormont, Sylvie, Cossin, Sébastien, Craig, Jean, Cruz-Bermúdez, Juan Luis, Cruz-Rojo, Jaime, Daniar, Mohamad, Daniel, Christel, Das, Priyam, Devkota, Batsal, Garmire, Lana, Dionne, Audrey, Duan, Rui, Dubiel, Julien, Esteve, Loic, Estiri, Hossein, Fan, Shirley, Follett, Robert, Ganslandt, Thomas, García-Barrio, Noelia, Gehlenborg, Nils, Getzen, Emily, Geva, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Han, Larry, Haverkamp, Christian, Key, Daniel, Hazard, Derek, He, Bing, Henderson, Darren, Hilka, Martin, Huling, Kenneth, Hutch, Meghan, Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Kennedy, Chris, Kernan, Kate, Kirchoff, Katie, Kohane, Isaac, Krantz, Ian, Kraska, Detlef, Krishnamurthy, Ashok, Le, Trang, Leblanc, Judith, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Long, Qi, Lozano-Zahonero, Sara, Mahmood, Sadiqa, Makoudjou, Adeline, Maram, Anupama, Martel, Patricia, Martins, Marcelo, Marwaha, Jayson, Masino, Aaron, Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos, Moal, Bertrand, Ahooyi, Taha Mohseni, Moraleda, Cinta, Moshal, Karyn, Mousavi, Sajad, Murad, Douglas, Naughton, Thomas, Neto, Carlos Tadeu Breda, Newburger, Jane, Njoroge, Wanjiku, Norman, James, Obeid, Jihad, Okoshi, Marina, Olson, Karen, Orlova, Nina, Ostasiewski, Brian, Paris, Nicolas, Pedrera-Jiménez, Miguel, Pfaff, Ashley, Pfaff, Emily, Pillion, Danielle, Pizzimenti, Sara, Prokosch, Hans, Prudente, Robson, Prunotto, Andrea, Quirós-González, Víctor, Raskin, Maryna, Rieg, Siegbert, Roig-Domínguez, Gustavo, Rojo, Pablo, Rubio-Mayo, Paula, Sacchi, Paolo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi Jebathilagam, Sanchez-Pinto, L. Nelson, Sandrin, Arnaud, Santhanam, Nandhini, Santos, Janaina, Sanz Vidorreta, Fernando, Savino, Maria, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil, Serrano-Balazote, Pablo, Serre, Patricia, Shah, Mohsin, Abad, Zahra Shakeri Hossein, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, Sperotto, Francesca, Strasser, Zachary, Tan, Bryce, Tanni, Suzana, Taylor, Deanne, Terriza-Torres, Ana, Tippmann, Patric, Toh, Emma, Tseng, Yi-Ju, Vallejos, Andrew, Varoquaux, Gael, Vella, Margaret, Verdy, Guillaume, Vie, Jill-Jênn, Vitacca, Michele, Wagholikar, Kavishwar, Waitman, Lemuel, Wassermann, Demian, Wolkewitz, Martin, Wong, Scott, Xiong, Xin, Ye, Ye, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison, Zöller, Daniela, Zuccaro, Valentina, Zucco, Chiara, Harvard Medical School [Boston] (HMS), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Massachusetts General Hospital [Boston], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), University of Michigan [Ann Arbor], University of Michigan System, Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, National University Health System [Singapore] (NUHS), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Università degli Studi di Pavia = University of Pavia (UNIPV), Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), ASST Pavia, University of Cincinnati (UC), University of California [Los Angeles] (UCLA), University of California (UC), VA Boston Healthcare System, Hospital Universitario 12 de Octubre [Madrid], University of Pennsylvania, Great Ormond Street Hospital for Children [London] (GOSH), Harvard School of Public Health, Northwestern University [Chicago, Ill. USA], VA Salt Lake City Health Care System, Boston Children's Hospital, University of Kansas [Kansas City], and National University Hospital [Singapore] (NUH)

Subjects
Health Information Management, Medicine (miscellaneous), Health Informatics, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Computer Science Applications
Abstract

Given the growing number of prediction algorithms developed to predict COVID-19 mortality, we evaluated the transportability of a mortality prediction algorithm using a multi-national network of healthcare systems. We predicted COVID-19 mortality using baseline commonly measured laboratory values and standard demographic and clinical covariates across healthcare systems, countries, and continents. Specifically, we trained a Cox regression model with nine measured laboratory test values, standard demographics at admission, and comorbidity burden pre-admission. These models were compared at site, country, and continent level. Of the 39,969 hospitalized patients with COVID-19 (68.6% male), 5717 (14.3%) died. In the Cox model, age, albumin, AST, creatine, CRP, and white blood cell count are most predictive of mortality. The baseline covariates are more predictive of mortality during the early days of COVID-19 hospitalization. Models trained at healthcare systems with larger cohort size largely retain good transportability performance when porting to different sites. The combination of routine laboratory test values at admission along with basic demographic features can predict mortality in patients hospitalized with COVID-19. Importantly, this potentially deployable model differs from prior work by demonstrating not only consistent performance but also reliable transportability across healthcare systems in the US and Europe, highlighting the generalizability of this model and the overall approach.

Published
2022
Full Text
View/download PDF

32. Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.

Author

Jacobs, Tom G., Mumbiro, Vivian, Chitsamatanga, Moses, Namuziya, Natasha, Passanduca, Alfeu, Domínguez-Rodríguez, Sara, Tagarro, Alfredo, Nathoo, Kusum J., Nduna, Bwendo, Ballesteros, Alvaro, Madrid, Lola, Mujuru, Hilda A., Chabala, Chishala, Buck, W. Chris, Rojo, Pablo, Burger, David M., Moraleda, Cinta, and Colbers, Angela

Published
2023
Full Text
View/download PDF

33. Evolving phenotypes of non-hospitalized patients that indicate long COVID

Author

ESTIRI, Hossein, Strasser, Zachary, Brat, Gabriel, Semenov, Yevgeniy, Patel, Chirag, Murphy, Shawn, Aaron, James, Agapito, Giuseppe, Albayrak, Adem, Alessiani, Mario, Amendola, Danilo, Anthony, Li, Aronow, Bruce, Ashraf, Fatima, Atz, Andrew, Avillach, Paul, Balshi, James, Beaulieu-Jones, Brett, Bell, Douglas, Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Sobrino, José Luis Bernal, Bernaux, Mélodie, Bey, Romain, Martínez, Alvar Blanco, Boeker, Martin, Bonzel, Clara-Lea, Booth, John, Bosari, Silvano, Bourgeois, Florence, Bradford, Robert, Bréant, Stéphane, Brown, Nicholas, Bryant, William, Bucalo, Mauro, Burgun, Anita, Cai, Tianxi, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Jin, Chen, Krista, Chiovato, Luca, Chiudinelli, Lorenzo, Cho, Kelly, Cimino, James, Colicchio, Tiago, Cormont, Sylvie, COSSIN, Sébastien, Craig, Jean, Bermúdez, Juan Luis Cruz, Rojo, Jaime Cruz, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Davoudi, Anahita, Devkota, Batsal, Dubiel, Julien, Esteve, Loic, Fan, Shirley, Follett, Robert, Gaiolla, Paula, Ganslandt, Thomas, Barrio, Noelia García, Garmire, Lana, Gehlenborg, Nils, GEVA, Alon, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Gutiérrez-Sacristán, Alba, Hanauer, David, Haverkamp, Christian, He, Bing, Henderson, Darren, Hilka, Martin, Holmes, John, Hong, Chuan, Horki, Petar, Huling, Kenneth, HUTCH, Meghan, Issitt, Richard, Jannot, Anne Sophie, Jouhet, Vianney, Keller, Mark, Kirchoff, Katie, Klann, Jeffrey, Kohane, Isaac, Krantz, Ian, Kraska, Detlef, Krishnamurthy, Ashok, L’Yi, Sehi, Le, Trang, Leblanc, Judith, Leite, Andressa, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Liu, Molei, LOH, Ne Hooi Will, Lozano-Zahonero, Sara, Luo, Yuan, Lynch, Kristine, Mahmood, Sadiqa, Maidlow, Sarah, Malovini, Alberto, Mandl, Kenneth, Mao, Chengsheng, Maram, Anupama, Martel, Patricia, Masino, Aaron, Mazzitelli, Maria, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos, Moal, Bertrand, Moore, Jason, Moraleda, Cinta, Morris, Jeffrey, MORRIS, Michele, Moshal, Karyn, Mousavi, Sajad, Mowery, Danielle, Murad, Douglas, Naughton, Thomas, Neuraz, Antoine, Ngiam, Kee Yuan, Norman, James, Obeid, Jihad, Okoshi, Marina, Olson, Karen, Omenn, Gilbert, Orlova, Nina, Ostasiewski, Brian, Palmer, Nathan, Paris, Nicolas, Patel, Lav, Jimenez, Miguel Pedrera, Pfaff, Emily, Pillion, Danielle, Prokosch, Hans, Prudente, Robson, González, Víctor Quirós, Ramoni, Rachel, Raskin, Maryna, RIEG, Siegbert, Domínguez, Gustavo Roig, Rojo, Pablo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi, Sandrin, Arnaud, Santos, Janaina, Savino, Maria, SCHRIVER, Emily, Schubert, Petra, Schuettler, Juergen, Scudeller, Luigia, Sebire, Neil, Balazote, Pablo Serrano, Serre, Patricia, Serret-Larmande, Arnaud, Shakeri, Zahra, Silvio, Domenick, Sliz, Piotr, SON, Jiyeon, Sonday, Charles, South, Andrew, Spiridou, Anastasia, Tan, Amelia, Tan, Bryce, Tan, Byorn, Tanni, Suzana, Taylor, Deanne, Terriza Torres, Ana, Tibollo, Valentina, Tippmann, Patric, Torti, Carlo, Trecarichi, Enrico, Tseng, Yi-Ju, Vallejos, Andrew, Varoquaux, Gael, Vella, Margaret, Verdy, Guillaume, Vie, Jill-Jênn, Visweswaran, Shyam, Vitacca, Michele, Wagholikar, Kavishwar, Waitman, Lemuel, Wang, Xuan, Wassermann, Demian, Weber, Griffin, XIA, Zongqi, Yehya, Nadir, Yuan, William, Zambelli, Alberto, Zhang, Harrison, Zoeller, Daniel, Zucco, Chiara, Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), Service d'informatique médicale et biostatistiques [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université de Paris - UFR Médecine Paris Centre [Santé] (UP Médecine Paris Centre), Université de Paris (UP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC), Université Paris Cité - UFR Médecine Paris Centre [Santé] (UPC Médecine Paris Centre), Université Paris Cité (UPC), This work was supported by the National Human Genome Research Institute grant 3U01HG008685-05S2 and the National Library of Medicine grant T15LM007092., École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), and Université Paris Cité (UPCité)

Subjects
medicine.medical_specialty, Neurological disorder, Chest pain, MESH: Phenotype, Article, 03 medical and health sciences, 0302 clinical medicine, Post-Acute COVID-19 Syndrome, Diabetes mellitus, Internal medicine, Machine learning, medicine, Chronic fatigue syndrome, Humans, Electronic health records, Post-acute sequelae of SARS-CoV-2, MESH: COVID-19, 030304 developmental biology, Retrospective Studies, 0303 health sciences, MESH: Humans, business.industry, Medical record, Type 2 Diabetes Mellitus, COVID-19, Retrospective cohort study, MESH: Retrospective Studies, General Medicine, medicine.disease, 3. Good health, Dysgeusia, Phenotypes, Phenotype, Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article, Cohort study
Abstract

Background For some SARS-CoV-2 survivors, recovery from the acute phase of the infection has been grueling with lingering effects. Many of the symptoms characterized as the post-acute sequelae of COVID-19 (PASC) could have multiple causes or are similarly seen in non-COVID patients. Accurate identification of PASC phenotypes will be important to guide future research and help the healthcare system focus its efforts and resources on adequately controlled age- and gender-specific sequelae of a COVID-19 infection. Methods In this retrospective electronic health record (EHR) cohort study, we applied a computational framework for knowledge discovery from clinical data, MLHO, to identify phenotypes that positively associate with a past positive reverse transcription-polymerase chain reaction (RT-PCR) test for COVID-19. We evaluated the post-test phenotypes in two temporal windows at 3–6 and 6–9 months after the test and by age and gender. Data from longitudinal diagnosis records stored in EHRs from Mass General Brigham in the Boston Metropolitan Area was used for the analyses. Statistical analyses were performed on data from March 2020 to June 2021. Study participants included over 96 thousand patients who had tested positive or negative for COVID-19 and were not hospitalized. Results We identified 33 phenotypes among different age/gender cohorts or time windows that were positively associated with past SARS-CoV-2 infection. All identified phenotypes were newly recorded in patients’ medical records 2 months or longer after a COVID-19 RT-PCR test in non-hospitalized patients regardless of the test result. Among these phenotypes, a new diagnosis record for anosmia and dysgeusia (OR 2.60, 95% CI [1.94–3.46]), alopecia (OR 3.09, 95% CI [2.53–3.76]), chest pain (OR 1.27, 95% CI [1.09–1.48]), chronic fatigue syndrome (OR 2.60, 95% CI [1.22–2.10]), shortness of breath (OR 1.41, 95% CI [1.22–1.64]), pneumonia (OR 1.66, 95% CI [1.28–2.16]), and type 2 diabetes mellitus (OR 1.41, 95% CI [1.22–1.64]) is one of the most significant indicators of a past COVID-19 infection. Additionally, more new phenotypes were found with increased confidence among the cohorts who were younger than 65. Conclusions The findings of this study confirm many of the post-COVID-19 symptoms and suggest that a variety of new diagnoses, including new diabetes mellitus and neurological disorder diagnoses, are more common among those with a history of COVID-19 than those without the infection. Additionally, more than 63% of PASC phenotypes were observed in patients under 65 years of age, pointing out the importance of vaccination to minimize the risk of debilitating post-acute sequelae of COVID-19 among younger adults.

Published
2021
Full Text
View/download PDF

36. International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries

Author

Bourgeois, Florence, Gutiérrez-Sacristán, Alba, Keller, Mark, Liu, Molei, Hong, Chuan, Bonzel, Clara-Lea, Tan, Amelia, Aronow, Bruce, Boeker, Martin, Booth, John, Cruz Rojo, Jaime, Devkota, Batsal, García Barrio, Noelia, Gehlenborg, Nils, Geva, Alon, Hanauer, David, Hutch, Meghan, Issitt, Richard, Klann, Jeffrey, Luo, Yuan, Mandl, Kenneth, Mao, Chengsheng, Moal, Bertrand, Moshal, Karyn, Murphy, Shawn, Neuraz, Antoine, Ngiam, Kee Yuan, Omenn, Gilbert, Patel, Lav, Jiménez, Miguel Pedrera, Sebire, Neil, Balazote, Pablo Serrano, Serret-Larmande, Arnaud, South, Andrew, Spiridou, Anastasia, Taylor, Deanne, Tippmann, Patric, Visweswaran, Shyam, Weber, Griffin, Kohane, Isaac, Cai, Tianxi, Avillach, Paul, Cruz-Rojo, Jaime, García-Barrio, Noelia, Pedrera-Jiménez, Miguel, Serrano-Balazote, Pablo, Aaron, James, Agapito, Giuseppe, Albayrak, Adem, Alessiani, Mario, Amendola, Danilo, Angoulvant, François, Anthony, Li Llj, Atz, Andrew, Balshi, James, Beaulieu-Jones, Brett, Bell, Douglas, Bellasi, Antonio, Bellazzi, Riccardo, Benoit, Vincent, Beraghi, Michele, Bernal Sobrino, José Luis, Bernaux, Mélodie, Bey, Romain, Blanco Martínez, Alvar, Bosari, Silvano, Bradford, Robert, Brat, Gabriel, Bréant, Stéphane, Brown, Nicholas, Bryant, William, Bucalo, Mauro, Burgun, Anita, Cannataro, Mario, Carmona, Aldo, Caucheteux, Charlotte, Champ, Julien, Chen, Krista, Chen, Jin, Chiovato, Luca, Chiudinelli, Lorenzo, Cimino, James, Colicchio, Tiago, Cormont, Sylvie, Cossin, Sébastien, Craig, Jean, Cruz Bermúdez, Juan Luis, Dagliati, Arianna, Daniar, Mohamad, Daniel, Christel, Davoudi, Anahita, Dubiel, Julien, Duvall, Scott, Esteve, Loic, Fan, Shirley, Follett, Robert, Gaiolla, Paula Sa, Ganslandt, Thomas, Garmire, Lana, Gradinger, Tobias, Gramfort, Alexandre, Griffier, Romain, Griffon, Nicolas, Grisel, Olivier, Haverkamp, Christian, He, Bing, Henderson, Darren, Hilka, Martin, Holmes, John, Horki, Petar, Huling, Kenneth, Jannot, Anne Sophie, Jouhet, Vianney, Kavuluru, Ramakanth, Kirchoff, Katie, Krantz, Ian, Kraska, Detlef, Krishnamurthy, Ashok, L'Yi, Sehi, Le, Trang, Leblanc, Judith, Leite, Andressa Rr, Lemaitre, Guillaume, Lenert, Leslie, Leprovost, Damien, Loh, Ne Hooi Will, Lynch, Kristine, Mahmood, Sadiqa, Maidlow, Sarah, Malovini, Alberto, Maram, Anupama, Martel, Patricia, Masino, Aaron, Matheny, Michael, Maulhardt, Thomas, Mazzitelli, Maria, Mcduffie, Michael, Mensch, Arthur, Milano, Marianna, Minicucci, Marcos, Moore, Jason, Moraleda, Cinta, Morris, Jeffrey, Morris, Michele, Mousavi, Sajad, Mowery, Danielle, Murad, Douglas, Naughton, Thomas, Norman, James, Obeid, Jihad, Okoshi, Marina, Olson, Karen, Orlova, Nina, Ostasiewski, Brian, Palmer, Nathan, Paris, Nicolas, Pfaff, Emily, Pillion, Danielle, Prokosch, Hans, Prudente, Robson, Quirós González, Víctor, Ramoni, Rachel, Raskin, Maryna, Rieg, Siegbert, Roig Domínguez, Gustavo, Rojo, Pablo, Sáez, Carlos, Salamanca, Elisa, Samayamuthu, Malarkodi, Sandrin, Arnaud, Santos, Janaina Cc, Savino, Maria, Schriver, Emily, Schuettler, Juergen, Scudeller, Luigia, Serre, Patricia, Silvio, Domenick, Sliz, Piotr, Son, Jiyeon, Sonday, Charles, Tan, Bryce Wq, Tan, Byorn Wl, Tanni, Suzana, Terriza Torres, Ana, Tibollo, Valentina, Torti, Carlo, Trecarichi, Enrico, Tseng, Yi-Ju, Vallejos, Andrew, Varoquaux, Gael, Vie, Jill-Jênn, Vitacca, Michele, Wagholikar, Kavishwar, Waitman, Lemuel, Wassermann, Demian, William, Yuan, Xia, Zongqi, Yehya, Nadir, Zambelli, Alberto, Zhang, Harrison, Zucco, Chiara, Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), Université Paris Cité (UPCité), Dr Bourgeois was funded by a grant from the Burroughs Wellcome Fund and supported by the Harvard-MIT Center for Regulatory Science. Mr Keller was funded by grant 5T32HG002295-18 from the National Human Genome Research Institute (NHGRI). Dr Aronow was funded by grant U24 HL148865 from the National Heart, Lung, and Blood Institute (NHLBI). Ms García Barrio was supported by grant PI18/00981 from the Carlos III Health Institute. Dr Gehlenborg was funded by grant T15 LM007092 from the NIH National Library of Medicine. Dr Geva was funded by grant K12 HD047349 from the NIH and Eunice Kennedy Shriver National Institute of Child Health and Human Development. Dr Hanauer was funded by grant UL1TR002240 from the National Center for Advancing Translational Sciences (NCATS). Drs Klann and Murphy were funded by grant 5UL1TR001857-05 from the NCATS and grant 5R01HG009174-04 from the NHGRI. Dr Luo was funded by grant R01LM013337 from the NLM. Mr Patel was funded by grant UL1TR002366 from the NCATS. Dr Gutiérrez-Sacristán was funded by grants K23HL148394 and L40HL148910 from the NIH NHLBI and grant UL1TR001420 from the NIH NCATS. Dr Visweswaran was funded by grant R01LM012095 from the NLM and grant UL1TR001857 from the NCATS. Dr Weber was supported by grants UL1TR002541 and UL1TR000005 from the NIH-NCATS, and grant R01LM013345 from the NLM., CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université de Paris - UFR Médecine Paris Centre [Santé] (UP Médecine Paris Centre), Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC), Université Paris Cité - UFR Médecine Paris Centre [Santé] (UPC Médecine Paris Centre), and Université Paris Cité (UPC)

Subjects
medicine.medical_specialty, MESH: Pandemics, education, Health Informatics, MESH: Global Health, MESH: Hospitalization, Procalcitonin, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, MESH: Child, Epidemiology, medicine, Infection control, MESH: COVID-19, MESH: SARS-CoV-2, 030212 general & internal medicine, health care economics and organizations, MESH: Electronic Health Records, Original Investigation, MESH: Adolescent, Disease surveillance, MESH: Humans, business.industry, Research, MESH: Infant, Newborn, MESH: Child, Preschool, Retrospective cohort study, MESH: Retrospective Studies, General Medicine, medicine.disease, MESH: Infant, MESH: Male, 3. Good health, Online Only, Respiratory failure, Viral pneumonia, Cohort, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract

This cohort study aims to describe international hospitalization trends and key epidemiological and clinical features of children and youth with COVID-19., Key Points Question What are international trends in hospitalizations for children and youth with SARS-CoV-2, and what are the epidemiological and clinical features of these patients? Findings This cohort study of 671 children and youth found discrete surges in hospitalizations with variable trends and timing across countries. Common complications included cardiac arrhythmias and viral pneumonia, and laboratory findings included elevations in markers of inflammation and abnormalities of coagulation; few children and youth were treated with medications directed specifically at SARS-CoV-2. Meaning These findings suggest large-scale informatics-based approaches used to incorporate electronic health record data across health care systems can provide an efficient source of information to monitor disease activity and define epidemiological and clinical features of pediatric patients hospitalized with SARS-CoV-2 infections., Importance Additional sources of pediatric epidemiological and clinical data are needed to efficiently study COVID-19 in children and youth and inform infection prevention and clinical treatment of pediatric patients. Objective To describe international hospitalization trends and key epidemiological and clinical features of children and youth with COVID-19. Design, Setting, and Participants This retrospective cohort study included pediatric patients hospitalized between February 2 and October 10, 2020. Patient-level electronic health record (EHR) data were collected across 27 hospitals in France, Germany, Spain, Singapore, the UK, and the US. Patients younger than 21 years who tested positive for COVID-19 and were hospitalized at an institution participating in the Consortium for Clinical Characterization of COVID-19 by EHR were included in the study. Main Outcomes and Measures Patient characteristics, clinical features, and medication use. Results There were 347 males (52%; 95% CI, 48.5-55.3) and 324 females (48%; 95% CI, 44.4-51.3) in this study’s cohort. There was a bimodal age distribution, with the greatest proportion of patients in the 0- to 2-year (199 patients [30%]) and 12- to 17-year (170 patients [25%]) age range. Trends in hospitalizations for 671 children and youth found discrete surges with variable timing across 6 countries. Data from this cohort mirrored national-level pediatric hospitalization trends for most countries with available data, with peaks in hospitalizations during the initial spring surge occurring within 23 days in the national-level and 4CE data. A total of 27 364 laboratory values for 16 laboratory tests were analyzed, with mean values indicating elevations in markers of inflammation (C-reactive protein, 83 mg/L; 95% CI, 53-112 mg/L; ferritin, 417 ng/mL; 95% CI, 228-607 ng/mL; and procalcitonin, 1.45 ng/mL; 95% CI, 0.13-2.77 ng/mL). Abnormalities in coagulation were also evident (D-dimer, 0.78 ug/mL; 95% CI, 0.35-1.21 ug/mL; and fibrinogen, 477 mg/dL; 95% CI, 385-569 mg/dL). Cardiac troponin, when checked (n = 59), was elevated (0.032 ng/mL; 95% CI, 0.000-0.080 ng/mL). Common complications included cardiac arrhythmias (15.0%; 95% CI, 8.1%-21.7%), viral pneumonia (13.3%; 95% CI, 6.5%-20.1%), and respiratory failure (10.5%; 95% CI, 5.8%-15.3%). Few children were treated with COVID-19–directed medications. Conclusions and Relevance This study of EHRs of children and youth hospitalized for COVID-19 in 6 countries demonstrated variability in hospitalization trends across countries and identified common complications and laboratory abnormalities in children and youth with COVID-19 infection. Large-scale informatics-based approaches to integrate and analyze data across health care systems complement methods of disease surveillance and advance understanding of epidemiological and clinical features associated with COVID-19 in children and youth.

Published
2021
Full Text
View/download PDF

37. Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population.

Author

Moraleda, Cinta, Domínguez-Rodríguez, Sara, Miguel Mesa, Juan, García-Sánchez, Paula, de la Serna, María, Antonio Alonso-Cadenas, José, Bermejo, Amanda, Sabrido, Gema, Martínez-Campos, Leticia, Flavia González-Posada, Aránzazu, Illán-Ramos, Marta, Cobos-Carrascosa, Elena, Ballesteros, Álvaro, Carlos Galán, Juan, Llorente, Francisco, Aguilera-Alonso, David, Belén Jiménez, Ana, Catalán, Pilar, Dahdouh, Elias, and Navarro, Ignacio

Subjects
CHILD patients, SARS-CoV-2, COUGH, WHEEZE
Published
2022
Full Text
View/download PDF

38. Manifestations and clinical phenotypes are not specific enough to predict SARS‐CoV‐2 infection in symptomatic children.

Author

Cobos‐Carrascosa, Elena, Ballesteros, Álvaro, Aguilera‐Alonso, David, Mesa, Juan Miguel, García‐Sánchez, Paula, Navarro, Ignacio, Alonso‐Cadenas, José Antonio, Bermejo, Amanda, Sabrido, Gema, Martinez‐Campos, Leticia, González‐Posada, Aranzazu Flavia, Illán‐Ramos, Marta, Lorente, Jorge, Jiménez, Ana Belén, Del Valle, Rut, Domínguez‐Rodríguez, Sara, Tagarro, Alfredo, and Moraleda, Cinta

Abstract

Keywords: children; COVID-19; SARS-CoV-2 EN children COVID-19 SARS-CoV-2 1974 1977 4 09/13/22 20221001 NES 221001 The massive number of infected individuals who have to be tested for SARS-CoV-2 has attracted the attention to novel diagnostic approaches, focusing on symptom-based screening.1 Some countries have emerged national testing policies, but a large number of positive children do not report any of the included symptoms in those guidelines.2 This study aimed to analyse symptoms/signs associated with SARS-CoV-2 infection among symptomatic children screened for COVID-19 and define clinical phenotypes that could differentiate COVID-19 from other infections. Manifestations and clinical phenotypes are not specific enough to predict SARS-CoV-2 infection in symptomatic children In younger children, no clinical phenotype was associated with the SARS-CoV-2 result, but in older children, the I Flu-like i phenotype was associated with positive SARS-CoV-2 (OR: 1.84 [95% CI: 1.09-3.11], I p i = 0.023) and the I Gastrointestinal i phenotype with negative SARS-CoV-2 (OR: 0.56 [95% CI: 0.34-0.91], I p i = 0.020). [Extracted from the article]

Published
2022
Full Text
View/download PDF

39. Pathophysiology of Anemia in HIV-Infected Children Exposed to Malaria

Author

Moraleda, Cinta, Aguilar, Ruth, Quintó, Llorenç, Nhampossa, Tacilta, Renom, Montserrat, Nhabomba, Augusto, Ruperez, María, Aponte, John J, Achtman, Ariel H, Mañú Pereira, María Del Mar, Schofield, Louis, Alonso, Pedro L, Macete, Eusebio, and Menéndez, Clara

Abstract

Anemia is a common condition in HIV-infected children; however, its pathophysiology and the contribution of frequent causes of anemia such as iron deficiency (ID) and malaria are poorly understood. We carried out an ancillary study on the effect of HIV on anemia as part of a case-control study on risk factors of anemia among Mozambican children aged 1-59 months with documented HIV status. Of them, 390 children were admitted to the hospital with anemia (hemoglobin [Hb] < 11 g/dL), whereas 272 children without anemia (Hb ≥ 11 g/dL) were recruited in the community. We assessed differences by HIV status in the presentation of anemia etiological factors and the effect of HIV infection on the association of each factor with anemia. Among the 99 HIV-infected and 563 uninfected children included, HIV-infected anemic children had an increased risk of undernutrition (P < 0.0001), Epstein-Barr virus infection (P < 0.0001), bacteremia (P = 0.0060), a decreased risk of malaria (P < 0.0001), and a similar risk of ID (P = 0.7371) compared with anemic-uninfected children. HIV-infected children were significantly less likely to have anemia associated with Plasmodium falciparum hyperparasitemia (P = 0.0444) and had a lower prevalence of parasitemia in the bone marrow (BM) (P < 0.0001) than anemic-uninfected children. Levels of BM erythropoiesis and dyserythropoiesis were comparable between groups. These findings suggest that the pathophysiology of anemia among HIV-infected malaria-exposed children is not related to HIV-specific effects. For unclear reasons, HIV-infected children had reduced risk of malaria infection, whereas ID prevalence was comparable in HIV-infected and uninfected children, suggesting that iron supplementation recommendations should not be different in HIV-infected children.

Published
2021

40. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under five years for 2018 : a systematic review and modelling study

Author

Wang, Xin, Li, You, Deloria-Knoll, Maria, Madhi, Shabir A., Cohen, Cheryl, Ali, Asad, Basnet, Sudha, Bassat, Quique, Brooks, W. Abdullah, Chittaganpitch, Malinee, Echavarria, Marcela, Fasce, Rodrigo A., Goswami, Doli, Hirve, Siddhivinayak, Homaira, Nusrat, Howie, Stephen R. C., Kotloff, Karen L., Khuri-Bulos, Najwa, Krishnan, Anand, Lucero, Marilla G., Lupisan, Socorro, Mira-Iglesias, Ainara, Moore, David P., Moraleda, Cinta, Nunes, Marta, Oshitani, Histoshi, Owor, Betty E., Polack, Fernando P., O'Brien, Katherine L., Rasmussen, Zeba A., Rath, Barbara A., Salimi, Vahid, Scott, J Anthony G., Simões, Eric A. F., Strand, Tor A., Thea, Donald M., Treurnicht, Florette K., Vaccari, Linda C., Yoshida, Lay-Myint, Zar, Heather J., Campbell, Harry, Nair, Harish, Respiratory Virus Global Epidemiology Network, and Nokes, D. James

Subjects
viruses, virus diseases, respiratory tract diseases
Abstract

Summary:\ud Human metapneumovirus (hMPV) is one of several important viruses associated with childhood acute lower respiratory infection (ALRI). However, there are currently no global burden estimates for ALRI associated with hMPV in children, and there are no licenced vaccines or drugs for hMPV infections. We estimated age–stratified global morbidity and mortality burden of hMPV–associated ALRI among children under five years using data on laboratory–confirmed hMPV burden from different geographic regions. \ud Methods: We performed a systematic review of hMPV burden studies published between 1 January 2001 and 31 December 2019 and identified a further 40 high–quality unpublished studies. We assessed the risk of bias using a modified Newcastle–Ottawa Scale. Incidence rates, hospital admission rates, and in–hospital case–fatality ratios (hCFRs) of hMPV–associated ALRI (defined as ALRI with laboratory–confirmed hMPV) were analysed using a generalized linear mixed model. We applied incidence and hospital admission rates of hMPV–associated ALRI to population estimates to yield the morbidity burden estimates. We estimated hMPV–associated ALRI in–hospital deaths by combining hospital admissions and hCFRs of hMPV–associated ALRI. We estimated the overall hMPV–associated ALRI deaths (both in–hospital and out–hospital deaths) using the number of in–hospital deaths, population–based childhood pneumonia mortality, and care–seeking for child pneumonia. We also estimated hMPV–attributable ALRI cases, hospital admissions, and deaths (ALRI burden that are causally attributable to hMPV) by combining hMPV–associated burden estimates and attributable fractions of hMPV in laboratory–confirmed hMPV cases and deaths. \ud Findings: We estimated in 2018 that hMPV could be detected in 14.2 million (UR 10.2–20.1) ALRI cases, 643,000 (UR 425,000–977,000) hospital admissions, 7,700 (UR 2,600–48,800) in–hospital deaths, and 16,100 (UR 5,700–88,000) overall ALRI deaths among children under five years globally. Of these cases and deaths, an estimated 11.1 million (UR 8.0–15.7) ALRI cases, 502,000 (UR 332,000–762,000) ALRI hospital admissions, and 11,300 (UR 4,000–61,600) ALRI deaths could be causally attributable to hMPV. hMPV–associated ALRI incidence rate in the community setting did not vary much by age strata, while about 58% of hospital admissions were in infants less than 12 months; 64% of in–hospital deaths occurred 6 in the first six months of life, of which 80% occurred in low– and lower–middle income countries. \ud Interpretation: Infants younger than one year have disproportionately high risks of severe hMPV infections across settings, similar to respiratory syncytial virus and influenza virus. Infants younger than 6 months in low– and lower–middle income countries are at greater risk of death from hMPV–associated ALRI compared with other countries. Our mortality estimates, though likely to be conservative and underestimate the true hMPV mortality burden, demonstrate the importance of intervention strategies for infants across all settings, and warrant continued efforts to improve the outcome of hMPV–associated ALRI among young infants in low– and lower–middle income countries.

Published
2021

42. The Epidemiology and Aetiology of Infections in Children Admitted with Clinical Severe Pneumonia to a University Hospital in Rabat, Morocco

Author

Jroundi, Imane, Mahraoui, Chafiq, Benmessaoud, Rachid, Moraleda, Cinta, Tligui, Houssain, Seffar, Myriam, Kettani, Selma Cherif, Benjelloun, Badr Sououd, Chaacho, Saad, Maaroufi, Abderrahman, Hayes, Edward B., Álvarez-Martínez, Míriam J., Muñoz-Almagro, Carmen, Ruiz, Joaquim, Alonso, Pedro L., and Bassat, Quique

Published
2014
Full Text
View/download PDF

45. Viruses and Mycoplasma pneumoniae are the main etiological agents of community‐acquired pneumonia in hospitalized pediatric patients in Spain.

Author

Otheo, Enrique, Rodríguez, Mario, Moraleda, Cinta, Domínguez‐Rodríguez, Sara, Martín, María D., Herreros, María L., Vázquez, Carmen, Folgueira, María D., Pérez‐Rivilla, Alfredo, Jensen, Julia, López, Agustín, Berzosa, Arantxa, Sanz de Santaeufemia, Francisco J., Jiménez, Ana B., Sainz, Talía, Llorente, Marta, Santos, Mar, Garrote, Elisa, Muñoz, Cristina, and Sánchez, Paula

Published
2022
Full Text
View/download PDF

46. Safety and Acceptance of COVID-19 Vaccination After Multisystem Inflammatory Syndrome in Children (MIS-C) in Spain.

Author

Epalza, Cristina, Prieto-Tato, Luis, Pino, Rosa, Escartín-Paredes, Paula, Leoz, Inés, Grasa, Carlos, Vivanco-Allende, Ana, Rivière, Jacques G, Carrasco-Colom, Jaume, Villate, Olatz, Fumadó, Victoria, Hermoso-Ibañez, Concepción, Herrero, Blanca, Aguilera-Alonso, David, Tagarro, Alfredo, Moraleda, Cinta, and Group, EPICO-AEP Working

Subjects
COVID-19, IMMUNIZATION, MULTISYSTEM inflammatory syndrome, COVID-19 vaccines, CARDIOMYOPATHIES, PATIENTS' attitudes, VACCINE effectiveness, LONGITUDINAL method
Abstract

In this cohort of 42 adolescents with a previous multisystem inflammatory syndrome (MIS-C) diagnosis, 32 (76.2%) were vaccinated with COVID-19 vaccines, with a low incidence of relevant adverse events. More importantly, no new MIS-C or myocarditis occurred after a median of 10 weeks (range 5.3-19.7) post-vaccination. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

47. Prevalence of thrombotic complications in children with SARS-CoV-2.

Author

Aguilera-Alonso, David, Murias, Sara, Martínez-de-Azagra Garde, Amelia, Soriano-Arandes, Antoni, Pareja, Marta, Otheo, Enrique, Moraleda, Cinta, Tagarro, Alfredo, Calvo, Cristina, and EPICO-AEP Working Group

Subjects
SARS-CoV-2, COVID-19, JUVENILE diseases, TEENAGE girls, PEDIATRICS
Abstract

Knowledge of thrombosis in children with SARS-CoV-2 is scarce. In this multicentre national cohort of children with SARS-CoV-2 involving 49 hospitals, 4 patients out of 537 infected children developed a thrombotic complication (prevalence of 0.7% (95% CI: 0.2% to 1.9%) out of the global cohort and 1.1% (95% CI: 0.3% to 2.8%) out of the hospitalised patients). We describe their characteristics and review other published paediatric cases. Three out of the four patients were adolescent girls, and only two cases had significant thrombotic risk factors. In this paediatric cohort, D-dimer value was not specific enough to predict thrombotic complications. Adolescence and previous thrombotic risk factors may be considered when initiating anticoagulant prophylaxis on children with SARS-CoV-2 disease (COVID-19). [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

48. A child presenting with acute renal failure secondary to a high dose of indomethacin: a case report

Author

González Felipe, López-Herce Jesús, and Moraleda Cinta

Subjects
Medicine
Abstract

Abstract Introduction Acute renal failure caused by nonsteroidal anti-inflammatory drugs administered at therapeutic doses is generally mild, non-anuric and transitory. There are no publications on indomethacin toxicity secondary to high doses in children. The aim of this article is to describe acute renal failure secondary to a high dose of indomethacin in a child and to review an error in a supervised drug prescription and administration system. Case presentation Due to a medication error, a 20-day-old infant in the postoperative period of surgery for Fallot's tetralogy received a dose of 10 mg/kg of indomethacin, 50 to 100 times higher than the therapeutic dose. The child presented with acute, oligo-anuric renal failure requiring treatment with continuous venovenous renal replacement therapy, achieving complete recovery of renal function with no sequelae. Conclusion In order to reduce medication errors in critically ill children, it is necessary to develop a supervised drug prescription and administration system, with controls at various levels.

Published
2009
Full Text
View/download PDF

49. Multi-inflammatory Syndrome in Children Related to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Spain.

Author

Moraleda, Cinta, Serna-Pascual, Miquel, Soriano-Arandes, Antoni, Simó, Silvia, Epalza, Cristina, Santos, Mar, Grasa, Carlos, Rodríguez, Maria, Soto, Beatriz, Gallego, Nerea, Ruiz, Yolanda, Urretavizcaya-Martínez, María, Pareja, Marta, Sanz-Santaeufemia, Francisco José, Fumadó, Victoria, Lanaspa, Miguel, Jordan, Iolanda, Prieto, Luis, Belda, Sylvia, and Toral-Vázquez, Belén

Subjects
*RESEARCH, *REVERSE transcriptase polymerase chain reaction, *RNA virus infections, *COVID-19, *SYSTEMIC inflammatory response syndrome, *MEDICAL cooperation, *RESPIRATORY infections, *CYTOKINE release syndrome, *CASE studies, *MIXED infections, *DESCRIPTIVE statistics, *MUCOCUTANEOUS lymph node syndrome, *POLYMERASE chain reaction, *COMORBIDITY, *SYMPTOMS, *CHILDREN
Abstract

Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

50. Pathophysiology Of Anemia In HIV-Infected Children Exposed To Malaria

Author

Moraleda, Cinta

Abstract

BackgroundAnemia is a frequent condition in HIV-infected children, but its pathophysiology and the contribution of common causes of anemia in sub-Saharan Africa like iron deficiency and malaria is poorly understood. In addition, iron supplementation in this population is controversial due to lack of evidence on the contribution of iron deficiency to HIV-related anemia and the fear of harmful effects of iron supplementation. As a consequence almost all HIV-infected children in low-income countries present some degree of anemia. MethodsIn an ancillary study of a case-control study on risk factors of anemia in Mozambican children less than 5 years of age, 390 cases (Hb

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results