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The purpose of this study was to determine norms against which the characteristics of community library services could be tested. The five oldest community libraries in the Pinetown (South Africa) public library system were examined. Results showed that certain public library systems, like Pinetown, have made significant progress toward becoming active, service-oriented community libraries. (Author/AEF)

To be academically successful a university student is required to read extensively on topics related to his or her field of study. The current proliferation and availability of electronic academic reading materials on various online platforms require academic staff to gain an understanding of their impact on the format preference and reading behaviour of students. Knowledge of emerging trends can guide academic staff to provide reading materials in the format best suited to the reading preferences of students. To establish the current format and reading behaviour trends a multiple case study design was employed targeting undergraduate students from the University of Zululand, South Africa and Delta State University, Nigeria. A questionnaire was used to collect data from a sample of 237 students. A combined return rate of 69.9% was achieved. The findings revealed a strong preference for reading textbooks in printed format. The preference for reading documents in electronic or print format was influenced by factors such as the length of the document, the purpose of reading the document, and whether the document is written in the student's native language or not. External factors such as access to electronic gadgets and data, and the cost thereof, as well as peer pressure also influenced preference for a specific format. The study recommends that regular surveys should be conducted in academic institutions to keep track of current and changing trends in the format preferences and resultant reading behaviour of the students to enable academics to adapt their prescribed reading materials to a format best suited to the students' preferences. [ABSTRACT FROM AUTHOR]

This paper explores the applicability of the social model of disability and Wilson's model of information seeking behaviour for effective service delivery to students with disabilities in the context of academic libraries. The paper is based on a literature review based on Oliver''s social model of disability and Wilson's model of information seeking behaviour in relation to service provision to students with disabilities in academic libraries. The literature review provided a background to the two models and their criticisms and implications to academic libraries. This paper shows that despite their respective weaknesses, using the social model of disability and Wilson's model of information seeking behaviour in the academic library context offers an opportunity for academic libraries to re-look at their systems and services in order to address the different barriers faced by students with disabilities in their day to day information seeking. As libraries acquire and organise their resources, the needs of students with disabilities should always be prioritised. Academic libraries as a key information source in any academic setting have a responsibility to provide information in various formats using various facilities for easy accessibility and use by their diverse users. Access to any form of information is a fundamental human right. Academic libraries must identify and remove barriers that may inhibit information seeking for students with disabilities. Additionally, academic libraries should use multiple facilities to provide information. This will ensure that information needs for users with disabilities are catered for. [ABSTRACT FROM AUTHOR]

Members of the Federation of Boxer Clubs in Southern Africa (FBCSA) have participated in official recording for many years. The aim of the study was to estimate genetic parameters and trends for preweaning survival and to assess inbreeding in the South African Boxer, based on performance and pedigree data. Fitness records were included from 2138 litters recorded between 1988 and 2012 and pedigree information of 32 029 Boxer dogs recorded from 1950 to 2012. The average litter size was 6.14 ± 2.43. More male puppies were born per litter (3.23 ± 1.79) than female puppies (2.91 ± 1.72), with an increase in the proportion of males in larger litter sizes. Heritability values of 0.23 ± 0.08 and 0.25 ± 0.08 were estimated for litter size (LS) and number of puppies alive at two weeks after birth (NA), respectively. Litters larger than five tended to have more puppies born dead or with low survivability. Number of puppies born dead or that died within two weeks after birth increased from 0.43/litter at first parity to 0.82/litter at fifth parity, with a substantial increase of 2.25/litter with low survivability at seventh parity. Average inbreeding levels of the Boxer breed were above 10%, with an inbreeding rate of 0.14%/year since 1982. These results indicate that FBCSA should focus on lowering the levels of inbreeding by avoiding mating closely related animals. The complete recording of fitness traits is encouraged for effective genetic management of the breed. [ABSTRACT FROM AUTHOR]

Background:Despite good outcomes for many, a substantial group of patients undergoing metastasectomy for isolated liver metastases from colorectal cancer (CRC) experience early recurrence. We have investigated whether circulating tumour cell (CTC) detection can identify patients developing disease recurrence within 1 year after liver metastasectomy.Methods:In CRC patients undergoing liver metastasectomy, 30 ml peripheral blood was withdrawn preoperatively. CTCs were detected by the CellSearch system after a density-gradient-based enrichment step.Results:One hundred and seventy-three samples from 151 individual patients were analysed. In 75 samples (43%), CTCs were detected, 16% had ⩾3 CTCs/7.5 ml of blood. Eighty-two patients (47%) experienced early disease recurrence (<1 year). The 1-year recurrence rate between patients with or without detectable CTCs were similar (47% vs 48%) or with a low or high CTC count (<3 or ⩾3 CTCs/7.5 ml of blood) (50% vs 47%). Also disease-free and overall survival were similar between patients with or without CTCs.Conclusions:The presence of CTCs in preoperative peripheral blood samples does not identify patients at risk for early disease recurrence after curative resection of colorectal liver metastases. Other parameters are needed to better identify patients at high risk to relapse after liver metastasectomy for CRC. [ABSTRACT FROM AUTHOR]

Mud crab (Scylla serrata) burrows in an estuarine mangrove intertidal zone were identified as potential microhabitats for small fishes. The pool-like habitats, created by these burrows, were sampled for fishes during nocturnal and diurnal low tide events, over the new moon period. A total of 1103 fish, comprising a single gobiid species (Redigobius dewaali), were collected from eight burrow-pools. The utilisation of these burrow-pools by large numbers of a single ichthyofaunal species suggests that there is a degree of commensalism between S. serrata and R. dewaali in these intertidal habitats. This work presents further evidence for the ecological importance of burrowing crabs in mangrove ecosystems. Mud crab (Scylla serrata) burrows in an estuarine mangrove intertidal zone were identified as microhabitats for a specific gobiid (Redigobius dewaali). The utilisation of these burrows by large numbers of a single fish species suggests that there is a degree of commensalism between S. serrata and R. dewaali in these intertidal habitats. [ABSTRACT FROM AUTHOR]

Agriculture plays a pivotal role in the economies of many developing economies because it contributes significantly to their Gross Domestic Product (GDP), labour force, sustenance and exports. The sector accounts for more than 30% of the GDP and 60% of total employment in sub-Saharan Africa, excluding South Africa. Zimbabwe is no exception; agriculture provides an income to over 75% of the country's population. This paper reports on a study that examined agricultural information and the role that is played by researchers and extension workers as intermediaries for farmers. The study focused on researchers and extension workers in the public sector, covering 16 research institutes and 44 districts. A questionnaire was used to collect data, most of which was analysed using the Statistical Package for Social Sciences (SPSS), with content analysis used in the case of open-ended questions. Although three different sets of data were collected through questionnaires, interviews and observation, this paper reports only on the results of the questionnaire which was distributed to researchers and extension workers. The study revealed that the information needs of the researchers and extension workers aligned with the major agricultural disciplines and that respondents were using various sources of information in fulfilling their information needs, ranging from libraries to Internet sources (including databases and other electronic sources), consulting colleagues, workshops and seminars, and personal collections. [ABSTRACT FROM AUTHOR]

The SA Dairy Swiss population could not previously be incorporated into the National Dairy Genetic Evaluation System, owing to inadequate population numbers and data structures. However, in recent years participation in Milk Recording has improved sufficiently to allow for genetic evaluation of the population. The aim of the study was therefore to estimate genetic parameters for the SA Dairy Swiss for production traits and somatic cell score in order to estimate breeding values routinely from the National Dairy Genetic Evaluation System. After editing procedures, a dataset of 25 621 test-day records for milk, butterfat and protein yields and a dataset of 10 438 test-day records for somatic cell count were obtained for further analysis. (Co)variance components for milk (kg), butterfat and protein yields (kg), as well as for somatic cell score, were estimated using a fixed regression multi-lactation animal model, based on test-day records of the first three lactations. Records from the various lactations were included as repeated measures. A multi-trait evaluation was performed for the production traits, while a single trait evaluation was done for somatic cell score, using the software package VCE4. Heritability estimates were 0.19 for milk, 0.16 for butterfat, and 0.16 for protein yields. The heritability estimate for somatic cell score was lower, at 0.07. The genetic correlations between the production traits were lowest for milk and butterfat (0.83), and were similar for milk and protein (0.94) and butterfat and protein yields (0.94). These values compare favourably with those of the other South African dairy breeds, based on the same model. The (co)variances were then implemented for estimation of breeding values for the SA Dairy Swiss population. Genetic trends were favourable for milk production traits with milk yield, butterfat and protein yields increasing by 25.13 kg/year, 0.96 kg/year and 0.79 kg/year, respectively; while the trend for somatic cell score was unfavourable, increasing by 0.86 units/year, since 1983. The SA Dairy Swiss could therefore be incorporated into the National Dairy Genetic Evaluation System of South Africa, using these covariance components and model. [ABSTRACT FROM AUTHOR]

Informal sector entrepreneurs, particularly women, are providers of livelihoods in many poor and marginalised communities, especially in developing countries, including South Africa. These entrepreneurs are linked largely with the tourism industry by exchanging their goods, services, skills and knowledge with the industry. They are, however, prohibited from trading in some designated areas. This prohibition is closely related to the nature of the sector and types of business activities performed. This article aims to establish whether women entrepreneurs from the informal sector contribute significantly to the tourism industry and thus to the economy of the eThekwini Metropolitan Municipality. Focus-group discussions, interviews, observations and content analysis were used to collect data from these entrepreneurs and leaders in the eThekwini Municipality. The findings suggest that the tourism industry is a crucial sector in the eThekwini Metropolitan Municipality in terms of its contribution to the economy and is closely supported by informal sector entrepreneurs. However, even though these women entrepreneurs are regarded as contributing significantly to the tourism industry in this Municipality, their contribution is limited by a variety of reasons ranging from a lack of business skills and knowledge and the nature of their businesses to the by-laws of the municipality. A proper understanding of the importance of the informal sector entrepreneurs to the tourism industry and the revision of by-laws to accommodate issues involving these entrepreneurs will give this sector an opportunity to strengthen the tourism industry and thus the economic base of the eThekwini Metropolitan Municipality. [ABSTRACT FROM AUTHOR]

Calving interval (CI) is a fertility trait that can be used in selection programmes to minimize the negative effects that selection for production have on fertility. CI can be derived from milk recording data, therefore this fertility trait can easily be implemented in the National Dairy Genetic Evaluations of South Africa. The aim of this study was to estimate genetic parameters for CI for estimation of breeding values and genetic trends to enable South African dairy breeders to assess and select for improved fertility. Breeds included in the study were Ayrshire, Guernsey, Holstein and Jersey. Genetic parameters and trends were based on the first three CIs for all breeds. The genetic software package, VCE4, was used to estimate genetic parameters for CI. Heritabilities ranged from 0.011 for CI1 to 0.069 for CI2, both for the Guernsey breed. Genetic correlations ranged from 0.606 between CI2 and CI3 for the Guernsey breed, to 0.810 between CI1 and CI2 for the Ayrshire breed. Breeding value estimation was done using the genetic software package, PEST. The estimated breeding values were combined into an index value, using weighting factors based on the amount of information available for each trait. Genetic trends were calculated by averaging the CIindices of measured cows per year of birth. These genetic trends indicated that CI increased genetically for all breeds. The genetic parameters will now be implemented for the estimation of CI breeding values, which can be included in selection programmes for improvement of fertility of dairy breeds in South Africa. [ABSTRACT FROM AUTHOR]

The informal sector women entrepreneur is a major contributor to the income of a household, and also contributes to the Gross Domestic Product (GDP) of the country. To establish and sustain profitable businesses this group needs access to business information. Given the low educational levels that characterise the informal sector women entrepreneurs, information provided to them needs to be repackaged to levels appropriate to their understanding. The primary objectives of the study was to determine whether an institution like the public library plays any meaningful role in information provision to informal sector women entrepreneurs, and also to establish the demographic profile of this largely marginalised group. The major findings revealed that access to information is a real problem, and that information sources and channels currently used -- such as friends or relatives -- are not providing the needed information. They are also completely unaware of the library as an information provider. The libraries themselves seem to be unprepared to service this group of potential clients, preferring them to come to the library to seek information, rather than reaching out to them in their workplaces. [ABSTRACT FROM AUTHOR]

Procedures have been developed for calculation of a Persistency Index for South African dairy breeds. This index is based on the Canadian Persistency Index, which is simple and easy to understand. Data used in this study were test-day records of the first three lactations, as included in the National Dairy Genetic Evaluations of South Africa, of the Ayrshire, Guernsey, Holstein and Jersey breeds. Interpolation, using the Wilmink curve, was done on these test-day records to calculate 60-day and 280-day yields for each cow and lactation. Variance components have been estimated for these yields to be used in breeding value estimations, using bivariate evaluations and a repeatability model. To obtain independence of persistency from total milk yield, 305-day milk yield estimated breeding values were included as covariates in the genetic model for estimation of breeding values for 60- and 280-day yields. The Persistency Index will be released for sires with progeny following each national dairy genetic evaluation, allowing the South African dairy industry to select for changes in persistency in future. [ABSTRACT FROM AUTHOR]

Parliamentary libraries are important in their principal role as information providers to parliamentarians. They are expected to offer a wide variety of specialized services, often under very pressing conditions. Despite not being very effective on the African continent, the South African parliamentary libraries are valued service centers known to actively disseminate information. This study aimed to determine their role as information providers. A survey, in the form of a questionnaire, was used to obtain data about the libraries and the services they provide. It was found that depending on the staff available the libraries offered a number of services to parliamentarians, which ranged from lending services to providing in-depth reports on issues of the day. Library collections ranged from printed sources to electronic and audiovisual records. Computers are used in all the libraries, both for administrative purposes and for information acquisition and dissemination. Numerous innovative methods have been adopted to in form users about the available services, and presently, the electronic medium is also used as an alerting tool. [ABSTRACT FROM AUTHOR]

South Africa implemented test-day models for genetic evaluations of production traits, using a Fixed Regression Test-Day Model (FRTDM), which assumes equal variances of the response variable at different days in milk, the explanatory variable. Data at the beginning and at the end of lactation period, have higher variances than tests in the middle of the lactation. Furthermore, first lactations have lower mean and variances compared to second and third lactations. This is a deviation from the basic assumptions required for the application of repeatability models. A modification was therefore implemented to reduce the effect of deviating from this assumption. Test-day milk, butterfat and protein yield records of Jersey cows, participating in the South African Milk Recording Scheme, were therefore pre-adjusted such that the variances are on the same scale. Variance components estimated using the adjusted records were higher than using unadjusted records. Convergence of breeding value estimation is reached significantly faster when using adjusted data (± 4000 iterations) compared to unadjusted records (± 15 000 iterations). Although cow and bull rankings were not influenced much, significant changes in breeding values for individual animals and genetic trends of especially young animals, were found. [ABSTRACT FROM AUTHOR]

A comparison of breeding values and genetic trends of production traits from two models is made. One set of breeding values and trends was estimated by the September/October 2003 South African National Genetic Evaluation, using a Lactation Model (LM). The other set was obtained in the 2004 South African National Genetic Evaluation, using a Fixed Regression Test-day Model (TDM). This comparison is made for Ayrshire, Guernsey, Holstein and Jersey cows participating in the South African Dairy Animal Improvement Scheme. Specific differences between the two models were documented, with differences in statistical methodology and inclusion of test-day records of the first three parities in the TDM vs. only first lactation 305-day yields in the LM, as the main differences. Significant reranking of especially cows and unproven sires occurred between the models. Genetic trends of the TDM were not as steep as those from the LM, as the trait that was selected was first lactation yield, while the TDM trends reflect genetic progress over the first three parities. [ABSTRACT FROM AUTHOR]

Variance components and breeding values of production traits and somatic cell score of South African Guernsey, Ayrshire, Holstein and Jersey breeds have been estimated using a multi-lactation repeatability test-day model, including tests of the first three lactations as repeated measures and fitting the permanent environmental effect across lactations. Multitrait evaluations were done for the production traits (milk, butterfat and protein) and single trait evaluations for somatic cell score. Heritability estimates were comparable with yield and somatic cell score estimates obtained by test-day models from other countries (17-24% for milk yield; 10-13% for butterfat yield; 14-19% for protein yield and 6-8% for somatic cell score). Proofs of qualifying sires were sent to the International Bull Evaluation Service (INTERBULL) for participation in the March 2005 test runs. Genetic correlations between South Africa and other participating countries, estimated by INTERBULL, compared well with those amongst the other participating countries. Trend validation tests were successful using this methodology for all traits and breeds except for somatic cell score of the Guernsey breed, due to insufficient data for this trait. South Africa can now participate in routine INTERBULL evaluations to obtain Multiple Across Country Evaluation (MACE) breeding values, using this methodology. [ABSTRACT FROM AUTHOR]

Two fixed regression testday models were applied for variance component estimation and prediction of breeding values for somatic cell score, using testday records of the first three lactations of South African Holstein and Jersey cows. The first model (ML-model) considered the testdays of the different lactations as different traits in a multiple-trait animal model and the second analysis (RM-model) treated later lactation records as repeated measures of the first lactation. Heritabilities from the RM-model were more in the range of literature estimates compared to that of the ML-model, i.e. 0.19 ± 0.003 for the Holstein breed and 0.18 ± 0.003 for the Jersey breed. Rank correlations indicated that minor changes occur in the ranking of proven sires between breeding values obtained from the ML- and RM-models. Although genetic correlations between parities are not unity, the RM-model estimates more competitive variances and requires extensively less computer time to predict breeding values compared to the ML-model and are therefore recommended for breeding value estimation on a national basis. [ABSTRACT FROM AUTHOR]

Methodology has been developed to implement testday models in the national genetic evaluation of dairy breeds for production traits in South Africa. Positive definite covariance matrices have been estimated, using multitrait, multi-lactation, fixed regression testday BLUP animal models, including testday records of the first three lactations as repeated measures for the Holstein and Jersey breeds. Heritability estimates were 0.40 ± 0.007 for milk yield, 0.25 ± 0.006 for butterfat yield and 0.37 ± 0.006 for protein yield for the Holstein breed and 0.39 ± 0.004 for milk yield, 0.21 ± 0.002 for butterfat yield and 0.34 ± 0.002 for protein yield for the Jersey breed. These estimates are well in the range of estimates reported by countries participating in INTERBULL evaluations. [ABSTRACT FROM AUTHOR]

Several ethical issues can impact the process of providing access to information materials for utilisation by the public. This study used the Privacy, Accuracy, Property and Accessibility (PAPA) model to investigate these ethical issues as they pertain to Nigeria. A survey research design using qualitative research method was employed through using interviews to collect data. Public library directors and publishers were targeted, and their responses were thematically analysed. Findings showed that publishing houses adhere to privacy requirements of authors and strive to ensure accuracy of information. Accessibility is provided for by libraries, though specific permissions are sometimes required to use information. Several challenges, such as plagiarism and piracy, were identified. Recommendations include the implementation of legal frameworks regulating the publishing process and the introduction of ethical course in the library school curricula. [ABSTRACT FROM AUTHOR]

In South Africa, the Dairy Swiss breed, which originated in Switzerland, consists of 27 breeders and 1135 breeding cows. Pedigree information on the breed was analysed to determine its effective population size (Ne) and rate of inbreeding. The rate of inbreeding was 0.08% per year and 0.38% per generation. It was estimated that in 2008, over 90% of the animals were inbred. This is within the acceptable recommendation for an effective population size of 50 - 100, with an Ne value of 89. However, the high percentage of inbred animals may start to have a detrimental impact on the effective population size and breeders need to exercise caution in their breeding decisions. [ABSTRACT FROM AUTHOR]

Data obtained from the Friesian Horse Studbook of Southern Africa and Friesian Horse Breeders' Society of South Africa were analyzed to describe and evaluate the population regarding inbreeding and morphological body measurements. Eight different body measurements (height at withers, height of back, height of croup, body length, length of cannon forelimb and hind limb, circumference of cannon bone fore- and hind limb) recorded on 232 horses were included for analyses. The pedigrees of 696 horses were used for estimation of inbreeding coefficients. A total of 25% of the horses included in the data was inbred, with inbreeding coefficients ranging from 0.07% to 27.8%. A positive trend in the average inbreeding per year was observed, but the rate of inbreeding was relatively low. Recording of pedigree information will be essential for long-term evaluation of inbreeding in the Friesian Horse and the recording of objective body measurements is recommended for inclusion in selection programs. [ABSTRACT FROM AUTHOR]

Pedigree information on the registered South African Ayrshire (n = 47 116), Guernsey (n = 18 766), Holstein (n = 892 458) and Jersey (n = 314 403) breeds was analyzed to determine the rate of inbreeding and effective population sizes for the period 1960 to 2003. Inbreeding coefficients were calculated using the Animal Breeder's Tool Kit. The mean inbreeding coefficients for 2003 were 2.02%, 2.04%, 2.30%, and 3.05% for the Ayrshire, Guernsey, Holstein and Jersey, respectively. The corresponding rates of inbreeding per year were 0.05%, 0.05%, 0.06%, and 0.07% indicating that inbreeding is accumulating at a slightly higher rate in Jersey compared to the other three breeds. However, the rates of inbreeding in the current study are still considerably lower than the acceptable rate of less than 0.5% per year. Estimates of effective population sizes were 148, 165, 137, and 108 for the Ayrshire, Guernsey, Holstein and Jersey, respectively. Results indicate that the impact of inbreeding on genetic variability is still minimal. However, the impact of inbreeding on phenotypic performance on traits of economic importance was not investigated in the current study and should therefore receive future consideration. [ABSTRACT FROM AUTHOR]

The article cites a detailed hydrographic and biological survey conducted in the region of the Subtropical Convergence (STC) in the Indian sector of the Southern Ocean in April 2007. Hydrographic data revealed that the subsurface expression of the STC appeared to meander considerably between 41°S and 42°15'S. Total surface chlorophyll-a concentration was low and was always dominated by the pico- and nano-size classes. No significant correlation was found between the total integrated chlorophyll-a concentration and temperature and salinity.

Background: The FLOT4 trial demonstrated superior survival of perioperative chemotherapy with 5-fluorouracil, oxaliplatin, and docetaxel (FLOT) compared to anthracycline triplets for resectable gastric cancer. These results were presented at the American Society of Clinical Oncology (ASCO) congress in June 2017 and published in April 2019. However, adoption of novel treatments in clinical practice often encounters delays. This study assesses the patterns of perioperative chemotherapy utilization and FLOT uptake in clinical practice within the Netherlands., Materials and Methods: A retrospective cohort study was conducted with resectable gastric cancer patients (cT 1-4a,X cN all cM 0 ) between 2015-2020 from the Netherlands Cancer Registry. Descriptive statistics, Cochran-Armitage tests, Fisher's exact or unpaired T-tests, and Jonckheere-Terpstra tests were used to analyze chemotherapy trends and FLOT uptake across hospitals., Results: Among 3290 included patients, 42.9 % received neoadjuvant treatment. In 2015, 43.6 % of patients received perioperative chemotherapy versus 43.5 % in 2020 (p = 0.63). 40 out of 62 hospitals (64.5 %) adopted FLOT between the ASCO presentation and the full publication. FLOT increased from 42.9 % before publication to 86.8 % after publication (p < 0.0001), while anthracycline triplet use decreased to 0.9 % (p < 0.0001). Higher hospital volume was associated with fewer days to adoption (p = 0.04) but not with adoption of FLOT before publication (p = 0.14)., Conclusion: Timing of FLOT adoption varied among Dutch hospitals, leading to unequal patient access to effective treatments. Establishing (inter)national guidelines on provisional treatment adjustment pending publication is crucial to reduce variation in access. Moreover, rapid publication of final trial results is imperative to reduce variation in practice and ensure fair patient treatment., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Grard A.P. Nieuwenhuijzen: consultant or advisory role Medtronic. Camiel Rosman: consultant DEKRA medical BV, research funding from Johnson&Johnson, Medtronic, and ZonMw. Hanneke W.M. van Laarhoven: consultant or advisory role: Amphera, AstraZeneca, Beigene, BMS, Daiichy-Sankyo, Dragonfly, Eli Lilly, MSD, Nordic Pharma, Servier, Research funding and/or medication supply: Bayer, BMS, Celgene, Janssen, Incyte, Eli Lilly, MSD, Nordic Pharma, Philips, Roche, Servier, Speaker role: Astellas, Benecke, Daiichy-Sankyo, JAAP, Medtalks, Novartis, Travel Congress Management. B.V. Rob H.A. Verhoeven: Research grant for Bristol Myers Squib and consultant for Daiichi-Sankyo, all paid to institution. Bas P.L. Wijnhoven: research funding from BMS; consulting/advisory for BMS and Medtronic. Bianca Mostert: research funding from Sanofi, Pfizer and BMS; consulting/advisory for Lilly, Servier, BMS, Amgen and AstraZeneca. All remaining authors have declared no conflicts of interest., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Despite trimodality treatment, 10% to 20% of patients with esophageal cancer experience interval metastases after surgery. Restaging may identify patients who should not proceed to surgery, as well as a subgroup with limited metastases for whom long-term disease-control can be obtained. This study aimed to determine the proportion of patients with interval metastases after neoadjuvant chemoradiotherapy (nCRT) and to evaluate treatment and survival., Methods: Patients who had cT2-4aN0-3M0 esophageal cancer treated with nCRT were identified from a trial database. Metastases detected up to 14 weeks after nCRT on 18 F-FDG-PET/CT or during surgery were categorized as oligometastases (≤3 lesions located in one single organ or one extra-regional lymph node station) or as non-oligometastases. The primary outcome was the proportion of patients with metastases after nCRT. The secondary outcomes were overall survival (OS) and the site and treatment of metastases., Results: Between 2013 and 2021, 973 patients received nCRT, and 10.3% had interval metastases. Of 100 patients, 30 (30%) had oligometastases, located mostly in non-regional lymph nodes (33.3%) or bones (26.7%). The median OS of this group was 13.8 months (95% confidence interval [CI] 9.2-27.1 months). Of 30 patients, 12 (40%) with oligometastases underwent potentially curative treatment, with a median OS of 22.8 months (95% CI 10.4-NA). The patients with non-oligometastases underwent mostly systemic therapy or BSC and had a median OS of 9 months (95% CI 7.4-10.9 months)., Conclusions: Interval metastases were detected in about 10% of patients after nCRT, underscoring the importance of re-staging with 18 F-FDG-PET/CT for those who proceed to surgery. A favorable survival might be accomplished for a subgroup of patients with oligometastases., (© 2024. The Author(s).)

Definitive chemoradiotherapy (dCRT) is a potentially curative therapy for esophageal cancer. As indications for dCRT differ widely, it is challenging to draw conclusions on outcomes and survival. The aim of this study was to evaluate overall survival (OS) and recurrence patterns according to indications for treatment. Patients who underwent dCRT (50.4 Gy concomitant with carboplatin/paclitaxel) for esophageal cancer between 2012 and 2022 were identified. Indications for dCRT were: cervical tumor, irresectable disease, unfit for surgery, and patient and/or physician preference. The primary endpoint was OS calculated with the Kaplan-Meier method. Secondary endpoints included the proportion of patients that completed the dCRT regimen, 30- and 90-day mortality, and disease recurrence. One hundred and fifty-seven patients were included (72.6% esophageal squamous cell carcinoma) with a median follow-up of 20 months (IQR 10.0-43.9). The full dCRT regimen was completed by 116 patients (73.9%). Thirty- and 90-day mortality were 2.5% and 8.3%, respectively. Median and 5-year OS for all patients were 22.9 months (95% CI 18.0-27.9) and 31.4%, respectively. The median OS per indication was 23.7 months (95% CI 6.5-40.8) for patients with cervical tumors, 10.9 months (95% 0.0-23.2) for irresectable disease, 28.2 months (95% CI 12.3-44.0) for unfit patients, and 22.9 months (95% CI 15.4-30.5) for patients' preference for dCRT (P = 0.11). Disease recurrence was observed in 74 patients (46%), located locoregionally (46%), distant (19%), or combined (35%). Patients who underwent dCRT had a 5-year OS of 31.4%, but OS differed according to indications for treatment with patients who had irresectable disease having the worst prognosis., (© The Author(s) 2024. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus.)