1. Disulfide-linked gamma delta T cell antigen receptors expressed on T cells derived from patients with primary immunodeficiency disorders
- Author
-
C D Platsoucas, H Seki, Robert A. Good, M Nanno, and N K Day
- Subjects
Macromolecular Substances ,T cell ,T-Lymphocytes ,Receptors, Antigen, T-Cell ,Biology ,Antigens, CD ,medicine ,DiGeorge Syndrome ,Cytotoxic T cell ,Humans ,Disulfides ,Gamma delta T cell ,Immunodeficiency ,Cells, Cultured ,Immunosorbent Techniques ,Common variable immunodeficiency ,T-cell receptor ,Immunologic Deficiency Syndromes ,General Medicine ,T lymphocyte ,medicine.disease ,Virology ,Molecular Weight ,medicine.anatomical_structure ,Antigens, Surface ,Primary immunodeficiency ,Research Article - Abstract
T cell lines or clones from two patients, one with a partial DiGeorge syndrome and one with severe common variable immunodeficiency expressed disulfide-linked gamma delta T cell antigen receptor (TCR) comprised of a gamma-chain polypeptide of 40-43 kD, and a delta-chain polypeptide of 37-40 kD. This gamma delta TCR appears to be similar to that found on T cell clones, and lines derived from peripheral blood lymphocytes from normal donors. Previous studies have shown that T cell lines derived from the peripheral blood of patients with immunodeficiency disorders express non-disulfide-linked gamma delta TCR. In contrast to the latter and coincident with findings in the present study, the vast majority of T cell lines and clones derived from the peripheral blood of normal donors express disulfide-linked gamma delta TCR.
- Published
- 1989