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1. The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children

Author

Florence Buseyne, Marianne Burgard, Daniel Scott-Algara, Nassima Bellal, C. Rouzioux, Stéphane Blanche, Yves Rivière, Immunopathologie Virale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Biologie des Rétrovirus, Institut Pasteur [Paris], Laboratoire de Virologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fédération de Pédiatrie, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP]

Subjects
Male, Aging, MESH: CD4 Lymphocyte Count, viruses, Retroviridae Proteins, HIV Infections, MESH : Viral Load, CD8-Positive T-Lymphocytes, MESH : Child, Preschool, Lymphocyte Activation, MESH: Antiretroviral Therapy, Highly Active, MESH: HIV-1, 0302 clinical medicine, MESH : Child, Interferon, Antiretroviral Therapy, Highly Active, MESH: Child, Immunology and Allergy, Cytotoxic T cell, MESH : Female, Interferon gamma, MESH: Aging, Child, 0303 health sciences, biology, MESH: Infant, Newborn, virus diseases, MESH : Infant, MESH : Interferon Type II, MESH: HIV Infections, Viral Load, MESH : Adult, MESH : CD8-Positive T-Lymphocytes, MESH: Infant, MESH: CD8-Positive T-Lymphocytes, 3. Good health, Infectious Diseases, Child, Preschool, MESH: RNA, Viral, Lentivirus, RNA, Viral, Female, Viral disease, MESH: Viral Load, Viral load, MESH : HIV-1, medicine.drug, Adult, Adolescent, MESH: Interferon Type II, MESH : Male, MESH : Infant, Newborn, Virus, Interferon-gamma, 03 medical and health sciences, MESH : Retroviridae Proteins, Antigen, MESH : Adolescent, MESH : CD4 Lymphocyte Count, MESH : HIV Infections, medicine, Humans, MESH : RNA, Viral, MESH: Lymphocyte Activation, MESH : Lymphocyte Activation, 030304 developmental biology, MESH: Adolescent, MESH: Humans, MESH : Humans, MESH: Child, Preschool, Infant, Newborn, Infant, MESH: Adult, MESH: Retroviridae Proteins, MESH : Antiretroviral Therapy, Highly Active, biology.organism_classification, Virology, MESH : Aging, MESH: Male, CD4 Lymphocyte Count, Immunology, HIV-1, MESH: Female, 030215 immunology
Abstract

Ex vivo interferon (IFN)- gamma -producing CD8 T cells specific for human immunodeficiency virus (HIV) Env, Gag, and Pol antigens were measured in the peripheral blood of 55 children not receiving highly active antiretroviral therapy (HAART) and 70 children receiving HAART. In children not receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was positively correlated with age and was not associated with plasma viral load or CD4 T cell levels. In children receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was directly correlated with plasma viral load, and its association with age remained significant. In conclusion, the frequency of HIV-specific IFN- gamma -producing CD8 T cells in children is primarily determined by both age and plasma viral load.

Published
2005
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2. Arterial stiffness and endothelial dysfunction in HIV-infected children

Author

Damien Bonnet, Yacine Aggoun, Isabelle Szezepanski, Stéphane Blanche, and Nassima Bellal

Subjects
Adult, Male, Brachial Artery, Endothelium, Adolescent, Anti-HIV Agents, Carotid Artery, Common, Immunology, HIV Infections, Acquired immunodeficiency syndrome (AIDS), Anti-HIV Agents/pharmacology, medicine, Carotid Artery, Common/drug effects/physiopathology/ultrasonography, Immunology and Allergy, Humans, Endothelial dysfunction, Risk factor, Child, HIV Infections/drug therapy/physiopathology, Ultrasonography, ddc:618, Anthropometry, Vascular disease, business.industry, Confounding, Vascular Resistance/drug effects, medicine.disease, Vasodilation, Infectious Diseases, medicine.anatomical_structure, Cross-Sectional Studies, Child, Preschool, Brachial Artery/physiopathology, Arterial stiffness, Vascular Resistance, Endothelium, Vascular/drug effects/physiopathology, Female, Endothelium, Vascular, business, Artery
Abstract

The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors.To study vascular function in HIV-infected children.Cross-sectional study of 49 HIV-infected children (34 receiving antiretroviral therapy and 15 never treated) and if 24 age- and sex-matched controls.Automatic, computerized, ultrasonic procedure evaluation of geometric and mechanical properties of the common carotid artery, and of the endothelium-dependent dilation and endothelium-independent dilation.Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Cross-sectional compliance and distensibility were also significantly lower. Wall stiffness, assessed as the incremental elastic modulus, was larger in HIV-infected children. Endothelium-dependent dilation was lower in HIV-infected children but non-endothelium-dependent dilation was similar to that in controls. We did not find differences for any of the vascular variables between HIV-infected children receiving antiretroviral therapy and those never treated. All arterial variables were similar in children with and without dyslipidemia.HIV-infected children had a vascular dysfunction in the absence of cardiovascular risk factors. In this short series, no additional detrimental effects were observed after a mean of 5 years of antiretroviral therapy.

Published
2004

4. Not All Tetramer Binding CD8+ T Cells Can Produce Cytokines and Chemokines Involved in the Effector Functions of Virus-Specific CD8+ T Lymphocytes in HIV-1 Infected Children.

Author

DANIEL SCOTT-ALGARA, FLORENCE BUSEYNE, FRANÇOISE PORROT, BEATRICE CORRE, NASSIMA BELLAL, CHRISTINE ROUZIOUX, STEPHANE BLANCHE, and YVES RIVIERE

Abstract

Abstract In the pediatric human immunodeficiency virus type-1 (HIV-1) infection, the presence of cytotoxic T lymphocytes (CTL) is associated with a slow progression to AIDS. The secretion of cytokines by CTLs may be critical in the control of viral infection. We used the combination of cell surface and intracellular staining to study the functionality of tetramer binding CD8+ T cells recognizing two HIV-1 immunodominant epitopes, in peripheral blood mononuclear cells from HIV-1-infected children. A fraction of tetramer positive CD8+ T cells produce cytokines (IFN-?, TNF-a) or chemokines (CCL4, CCL5) after ex vivo stimulation with the cognate peptide. There was a negative correlation between the plasma viral load and the percentage of CD8+ Tetramer Gag+ T cells secreting IFN-?. This is the first report in the context of pediatric HIV-1 infection showing that only a fraction of HIV-1-specific CD8+ T cells have the capacity to produce cytokines and chemokines implicated in their antiviral functions. [ABSTRACT FROM AUTHOR]

Published
2005

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