209 results on '"Nakasa T"'
Search Results
2. Quantitative evaluation of the vertical mobility of the first tarsometatarsal joint during stance phase of gait
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Maeda, N., Ikuta, Y., Tashiro, T., Arima, S., Tsutsumi, S., Kaneda, K., Ishihara, H., Nakasa, T., Adachi, N., and Urabe, Y.
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- 2022
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3. The role of miRNA-26A in cartilage development and osteoarthritis
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Sanada, Y., Ikuta, Y., Ishikawa, M., Nakasa, T., Lotz, M.K., Adachi, N., and Miyaki, S.
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- 2020
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4. Senescence accelerated mice as a new mouse model for spontaneous osteoarthritis
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Sanada, Y., Miyaki, S., Ikuta, Y., Ishitobi, H., Shinohara, M., Nagira, K., Ishikawa, M., Nakasa, T., Matsubara, K., Lotz, M.K., and Adachi, N.
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- 2018
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5. Anatomic feature of deltoid ligament attachment in posteromedial osteochondral lesion of talar dome
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Nakasa, T., Sawa, M., Ikuta, Y., Yoshikawa, M., Tsuyuguchi, Y., and Adachi, N.
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- 2017
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6. New safe technique for anterior ankle portal placement using a peripheral vein illumination device
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Tsuyuguchi, Y., Nakasa, T., Ishikawa, M., Ikuta, Y., Sawa, M., Yoshikawa, M., and Adachi, N.
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- 2017
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7. Outcome of autologous bone grafting to osteochondral lesion of the talus with subchondral cyst
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Sawa, M., Nakasa, T., Yoshikawa, M., Tsuyuguchi, Y., and Adachi, N.
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- 2017
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8. New screening method for hallux valgus with using smartphone
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Shibuya, H., Tanaka, H., Nakasa, T., Yoshikawa, M., Sawa, M., Tsuyuguchi, Y., and Adachi, N.
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- 2017
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9. Finite element analysis for investigation of the etiology of osteochondritis dissecans in medial femoral condyle
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Ishikawa, M., Nakamae, A., Nakasa, T., Sumida, Y., and Adachi, N.
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- 2017
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10. Japanese experience of evolving nurses' roles in changing social contexts.
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Kanbara, S., Yamamoto, Y., Sugishita, T., Nakasa, T., and Moriguchi, I.
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COMMUNITY health nursing ,DISASTERS ,NURSES ,PUBLIC health ,WORLD health ,OCCUPATIONAL roles - Abstract
Aim To discuss the evolving roles of Japanese nurses in meeting the goals and concerns of ongoing global sustainable development. Background Japanese nurses' roles have evolved as the needs of the country and the communities they served, changed over time. The comprehensive public healthcare services in Japan were provided by the cooperation of hospitals and public health nurses. Introduction The nursing profession is exploring ways to identify and systemize nursing skills and competencies that address global health initiatives for sustainable development goals. Methods This paper is based on the summary of a symposium, (part of the 2015 annual meeting of the Japan Association for International Health) with panel members including experts from Japan's Official Development Assistance. Findings The evolving role of nurses in response to national and international needs is illustrated by nursing practices from Japan. Japanese public health nurses have also assisted overseas healthcare plans. In recent catastrophes, Japanese nurses assumed the roles of community health coordinators for restoration and maintenance of public health. Discussion The Japanese experience shows that nursing professionals are best placed to work with community health issues, high-risk situations and vulnerable communities. Their cooperation can address current social needs and help global communities to transform our world. Conclusion Nurses have tremendous potential to make transformative changes in health and bring about the necessary paradigm shift. They must be involved in global sustainable development goals, health policies and disaster risk management. A mutual understanding of global citizen and nurses will help to renew and strengthen their capacities. Implications Nursing professionals can contribute effectively to achieve national and global health goals and make transformative changes. [ABSTRACT FROM AUTHOR]
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- 2017
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11. The role of tetraspanin Cd9 in pathogenesis of osteoarthritis
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Sumiyoshi, N., Miyaki, S., Takada, T., Ishitobi, H., Nakasa, T., and Ochi, M.
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- 2014
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12. Bach1 deficient mice reduce severity of age-related and experimental osteoarthritis
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Takada, T., Miyaki, S., Ishitobi, H., Nakasa, T., Lotz, M.K., and Ochi, M.
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- 2014
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13. The transverse ligament as a landmark for tibial sagittal insertions of the anterior cruciate ligament: a cadaveric study.
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Kongcharoensombat W, Ochi M, Abouheif M, Adachi N, Ohkawa S, Kamei G, Okuhara A, Shibuya H, Niimoto T, Nakasa T, Nakamae A, and Deie M
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- 2011
14. Responses of microRNAs 124a and 223 following spinal cord injury in mice.
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Nakanishi, K, Nakasa, T, Tanaka, N, Ishikawa, M, Yamada, K, Yamasaki, K, Kamei, N, Izumi, B, Adachi, N, Miyaki, S, Asahara, H, and Ochi, M
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SPINAL cord injuries , *GENE expression , *GENETIC regulation , *LABORATORY mice - Abstract
Study design:We investigated microRNA (miRNA) expression after spinal cord injury (SCI) in mice.Objectives:The recent discovery of miRNAs suggests a novel regulatory control over gene expression during plant and animal development. MiRNAs are short noncoding RNAs that suppress the translation of target genes by binding to their mRNAs, and play a central role in gene regulation in health and disease. The purpose of this study was to examine miRNA expression after SCI.Setting:Department of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University.Methods:We examined the expression of miRNA (miR)-223 and miR-124a in a mouse model at 6 h, 12 h, 1 day, 3 days and 7 days after SCI using quantitative PCR. The miRNA expression was confirmed by in situ hybridization.Results:Quantitative PCR revealed two peaks of miR-223 expression at 6 and 12 h and 3 days after SCI. MiR-124a expression decreased significantly from 1 day to 7 days after SCI. In situ hybridization demonstrated the presence of miR-223 around the injured site. However, miR-124a, which was present in the normal spinal cord, was not observed at the injured site.Conclusion:Our results indicate a time-dependent expression pattern of miR-223 and miR-124a in a mouse model of SCI. In this study, the time course of miRNA-223 expression may be related to inflammatory responses after SCI, and the time course of decreased miR-124a expression may reflect cell death. [ABSTRACT FROM AUTHOR]
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- 2010
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15. Exosomes from osteoarthritic synovial fibroblasts promote angiogenesis
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Nakamura, Y., Kato, T., Takada, T., Nakasa, T., Higashi, Y., Lotz, M., Ochi, M., and Miyaki, S.
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- 2012
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16. 423 EVALUATION OF THE ARTICULAR CARTILAGE OF OSTEOARTHRITIC KNEE IN T2 MAPPING LOADING MRI
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Okuhara, A., Deie, M., Nakamae, A., Nakasa, T., Shibuya, H., Adachi, N., and Ochi, M.
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- 2011
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17. 49 EXOSOMES CONTAINING MICRORNAS FUNCTION IN A NOVEL COMMUNICATION PATHWAY AMONG JOINT TISSUE CELLS
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Takada, T., Kato, T., Nakasa, T., Asahara, H., Lotz, M., Ochi, M., and Miyaki, S.
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- 2011
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18. 067 CARTILAGE-SPECIFIC MICRORNA-140 REGULATES TISSUE HOMEOSTASIS AND PROTECTS AGAINST OSTEOARTHRITIS-LIKE PATHOLOGY
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Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Yamashita, S., Nakasa, T., Lotz, M.K., Kudo-Ueno, H., and Asahara, H.
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- 2010
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19. 065 MiR-140 IS EXPRESSED IN DIFFERENTIATED HUMAN ARTICULAR CHONDROCYTES AND MODULATES IL-1 RESPONSES
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Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S.P., Higashiyama, R., Inoue, A., Kato, Y., Sato, T., Lotz, M.K., and Asahara, H.
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- 2009
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20. Comprehensive maternal health data of Islamabad capital territory
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Mahmud, G., Nakasa, T., Haq, A., and Khan, S.
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- 2000
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21. MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patients
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Niimoto Takuya, Nakasa Tomoyuki, Ishikawa Masakazu, Okuhara Atsushi, Izumi Bunichiro, Deie Masataka, Suzuki Osami, Adachi Nobuo, and Ochi Mitsuo
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Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Interleukin (IL)-17 is an important factor in rheumatoid arthritis (RA) pathogenesis. MicroRNA (miRNA)s are a family of non coding RNAs and associated with human diseases including RA. The purpose of this study is to identify the miRNAs in the differentiation of IL-17 producing cells, and analyze their expression pattern in the peripheral blood mononuclear cells (PBMC) and synovium from RA patients. Methods IL-17 producing cells were expanded from CD4+T cell. MiRNA microarray was performed to identify the miRNAs in the differentiation of IL-17 producing cells. Quantitative polymerase chain reaction was performed to examine the expression patterns of the identified miRNAs in the PBMC and synovium from RA and osteoarthritis (OA) patients. Double staining combining in situ hybridization and immunohistochemistry of IL-17 was performed to analyze the expression pattern of identified miRNA in the synovium. Results Six miRNAs, let-7a, miR-26, miR-146a/b, miR-150, and miR-155 were significantly up regulated in the IL-17 producing T cells. The expression of miR-146a and IL-17 was higher than in PBMC in the patients with low score of Larsen grade and short disease duration. MiR-146a intensely expressed in RA synovium in comparison to OA. MiR-146a expressed intensely in the synovium with hyperplasia and high expression of IL-17 from the patients with high disease activity. Double staining revealed that miR-146a expressed in IL-17 expressing cells. Conclusion These results indicated that miR-146a was associated with IL-17 expression in the PBMC and synovium in RA patients. There is the possibility that miR-146a participates in the IL-17 expression.
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- 2010
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22. The effect of an external magnetic force on cell adhesion and proliferation of magnetically labeled mesenchymal stem cells
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Nakamae Toshio, Adachi Nobuo, Kobayashi Takaaki, Nagata Yoshihiko, Nakasa Tomoyuki, Tanaka Nobuhiro, and Ochi Mitsuo
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Sports medicine ,RC1200-1245 - Abstract
Abstract Background As the strategy for tissue regeneration using mesenchymal stem cells (MSCs) for transplantation, it is necessary that MSCs be accumulated and kept in the target area. To accumulate MSCs effectively, we developed a novel technique for a magnetic targeting system with magnetically labeled MSCs and an external magnetic force. In this study, we examined the effect of an external magnetic force on magnetically labeled MSCs in terms of cell adhesion and proliferation. Methods Magnetically labeled MSCs were plated at the bottom of an insert under the influence of an external magnetic force for 1 hour. Then the inserts were turned upside down for between 1 and 24 hours, and the number of MSCs which had fallen from the membrane was counted. The gene expression of MSCs affected magnetic force was analyzed with microarray. In the control group, the same procedure was done without the external magnetic force. Results At 1 hour after the inserts were turned upside down, the average number of fallen MSCs in the magnetic group was significantly smaller than that in the control group, indicating enhanced cell adhesion. At 24 hours, the average number of fallen MSCs in the magnetic group was also significantly smaller than that in control group. In the magnetic group, integrin alpha2, alpha6, beta3 BP, intercellular adhesion molecule-2 (ICAM-2), platelet/endothelial cell adhesion molecule-1 (PECAM-1) were upregulated. At 1, 2 and 3 weeks after incubation, there was no statistical significant difference in the numbers of MSCs in the magnetic group and control group. Conclusions The results indicate that an external magnetic force for 1 hour enhances cell adhesion of MSCs. Moreover, there is no difference in cell proliferation after using an external magnetic force on magnetically labeled MSCs.
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- 2010
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23. Bach1 deficient mice reduce severity of age-related osteoarthritis.
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Takada, T., Miyaki, S., Ishitobi, H., Nakamura, Y., Kato, T., Nakasa, T., Igarashi, K., Lotz, M., and Ochi, M.
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- 2013
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24. The difference in second - third metatarsal length is associated with the risk of dislocation or arthritic change in the second metatarsophalangeal joint in patients with hallux valgus.
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Moriwaki D, Nakasa T, Ikuta Y, Kawabata S, Sakurai S, Ishibashi S, and Adachi N
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Background: Chronic mechanical stress on the second metatarsal head (2 MH) can be a risk factor for osteoarthritis (OA) and dislocation of the second metatarsophalangeal joint (2MTPJ) in hallux valgus (HV). This study aimed to investigate the stress distribution of the 2 MH in HV patients and determine the factors associated with dislocation and OA of the 2MTPJ., Methods: In total, 115 feet with HV were retrospectively reviewed and divided into two groups: those with subluxation or dislocation of the 2MTPJ (group D, 27 feet) and those without (group N, 88 feet). The control group (group C) included 33 feet without HV. Group N was divided into OA and non-OA (NOA) groups according to the presence or absence of OA of the 2MTPJ. The Hounsfield Unit (HU) value of the subchondral bone of the 2 MH was measured on sagittal slices of the preoperative computed tomography images and divided by the HU value of the navicular region (HU ratio). The relationship between the HU ratios and radiographic parameters was compared., Results: The HU ratios were significantly higher in group N than those in groups C and D. In group N, the protrusion of the second metatarsal relative to the third and fourth metatarsals (M2-M3, M2-M4) was positively correlated with the dorsal and central HU ratios, respectively. Group D had a significantly larger HV angle (HVA) and M2-M3 than group N. HVA, the first-second intermetatarsal angle, M2-M3, M2-M4, and dorsal and central HU ratios were significantly larger in the OA group than in the NOA group. The cutoff value of M2-M3 was 5.5 mm when comparing groups D and N, and 4.4 mm when comparing the OA and NOA groups., Conclusions: Severe HV and a longer M2-M3 and M2-M4 may be associated with a high risk of dislocation and OA of the 2MTPJ., Level of Evidence: Ⅲ., Competing Interests: Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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25. CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model.
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Yimiti D, Uchibe K, Toriyama M, Hayashi Y, Ikuta Y, Nakasa T, Akiyama H, Watanabe H, Kondoh G, Takimoto A, Shukunami C, Adachi N, and Miyaki S
- Abstract
Heterotopic ossification (HO) in Achilles tendon often arises due to endochondral ossification during the healing process following trauma. Retinoic acid receptor γ (RARγ) plays a critical role in this phenomenon. This study aims to elucidate the therapeutic effects of CD1530, an RARγ selective agonist, along with the contributing cells, in Achilles tendon healing, utilizing a cell lineage tracing system. Local injection of CD1530 facilitated histological tendon healing by inhibiting chondrification in a mouse Achilles rupture model. Resident Scleraxis (Scx)
+ cells in Achilles tendon were not found to be actively involved in HO or tendon healing following injury. Instead, these processes were primarily driven by tendon stem/progenitor cells (TSPC)-like cells. Furthermore, an in vitro assay revealed that CD1530 attenuated inflammation in injured Achilles tendon-derived tendon fibroblasts (iATF) and inhibited the chondrogenesis of iATF. This dual effect suggests the potential of CD1530 in effectively modulating the healing environment during tendon healing. Together, the present study demonstrated that the local administration of CD1530 accelerated tendon healing by modulating the healing environment, including reducing chondrification via targeting TSPC-like cells in a mouse Achilles tendon rupture model. These results suggest that CD1530 may have the potential to be a novel tendon therapy that offers benefits via the inhibition of chondrogenesis., (© 2024 Orthopaedic Research Society.)- Published
- 2024
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26. Comparison of the distance between the talus and lateral malleolus during the stance phase with and without chronic ankle instability.
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Onoue S, Maeda N, Ikuta Y, Tashiro T, Arima S, Ishihara H, Ishida A, Brand A, Nakasa T, Adachi N, Tsutsumi S, Komiya M, and Urabe Y
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- Humans, Female, Male, Young Adult, Cross-Sectional Studies, Biomechanical Phenomena, Adult, Ultrasonography, Range of Motion, Articular, Joint Instability physiopathology, Joint Instability diagnostic imaging, Ankle Joint physiopathology, Ankle Joint diagnostic imaging, Talus diagnostic imaging, Talus physiopathology, Gait physiology
- Abstract
The level of dynamic mechanical instability between the bony parts of the ankle joint provides important information on biomechanical function. However, the dynamics of the distance between the talus and lateral malleolus during gait remain unclear. This study aimed to compare the distance between the talus and lateral malleolus and the ankle joint angles during the stance phase of gait between individuals with chronic ankle instability (CAI) and healthy adults. The comparison was conducted using a synchronized ultrasound (US) imaging with a three-dimensional motion analysis (MA) system. This cross-sectional study included 12 participants (5 males, 7 females; age, 20.5 ± 1.8 years; height, 166.6 ± 9.4 cm; body weight, 60.2 ± 5.3 kg; body mass index, 21.7 ± 2.0 kg/m
2 ; 16 feet) with CAI and 10 healthy controls (4 males, 6 females; age, 21.2 ± 1.6 years; height, 164.6 ± 10.5 cm; body weight, 56.8 ± 11.3 kg; body mass index, 20.8 ± 2.6 kg/m2 ; 20 feet). The distance between the talus and lateral malleolus during gait was significantly increased in the CAI group compared with that in the control group throughout the stance phase. The ankle dorsiflexion angle was smaller in the CAI group during the middle and terminal stance phases. Additionally, the ankle inversion angle was greater in the CAI group than in the control group. Our findings show the application of the synchronized US and MA system in the assessment of mechanical instability in CAI group, which may be used to determine treatment efficacy., (© 2024. The Author(s).)- Published
- 2024
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27. Clinical significance of posterior talofibular ligament injury in chronic lateral ankle instability.
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Nakasa T, Ikuta Y, Kawabata S, Sakurai S, Moriwaki D, Ishibashi S, Silan AA, and Adachi N
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- Humans, Male, Female, Adult, Young Adult, Chronic Disease, Ankle Joint surgery, Ankle Joint diagnostic imaging, Middle Aged, Adolescent, Retrospective Studies, Clinical Relevance, Joint Instability surgery, Joint Instability diagnostic imaging, Joint Instability etiology, Lateral Ligament, Ankle injuries, Lateral Ligament, Ankle surgery, Lateral Ligament, Ankle diagnostic imaging, Ankle Injuries surgery, Ankle Injuries diagnostic imaging, Ankle Injuries complications, Arthroscopy methods, Magnetic Resonance Imaging
- Abstract
Purpose: Although arthroscopic repair of the anterior talofibular ligament (ATFL) is widely performed, the effect of posterior talofibular ligament (PTFL) injury on clinical outcomes remains unclear. This study aimed to evaluate the magnetic resonance imaging (MRI) findings of the PTFL in chronic lateral ankle instability (CLAI) and determine whether the presence or absence of PTFL injury affected the postoperative outcomes of arthroscopic ATFL repair., Materials and Methods: Forty ankles of 35 patients who underwent arthroscopic repair for CLAI were included in this study as the experimental group, together with 25 ankles of 24 patients without CLAI as the control group. The PTFL thickness (PTFLT) and PTFL cross-sectional area (PTFLCSA) were measured using MRI and compared between the control and CLAI groups. The clinical outcomes of arthroscopic repair were compared between ankles with and without PTFL injuries., Results: The mean PTFLT and PTFLCSA values were significantly higher in the CLAI group than in the control group. The PTFLT and PTFLCSA in the PTFL injury group were significantly larger than those in the non-injury group in the CLAI group. Postoperatively, there were no significant differences in clinical scores and talar tilt angles on stress radiographs between ankles with and without PTFL injury; however, instability recurrence was frequently observed in ankles with PTFL injury (32.1%) compared to the ankles without PTFL injury (16.7%). Poor-quality ATFL remnant, ATFL inferior fascicle, and calcaneofibular ligament injuries were frequently observed in ankles with PTFL injuries., Conclusions: Our findings indicate that PTFL injury is highly associated with CLAI but it does not affect postoperative clinical scores. However, postoperative instability recurrence was more often observed in ankles with PTFL injuries, given that they frequently have poor-quality ATFL remnants and CFL injuries., Evidence Level: Level III., Competing Interests: Declarations. Conflict of interest: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Ethical approval: We obtained institutional review board approval for this study. Ethical approval for this study was obtained from the ethics committee of Hiroshima University (Approval number: E-14). Informed consent: Informed consent was obtained from all individual participants., (© 2024. The Author(s).)
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- 2024
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28. The Hounsfield Unit Values of Talar Subchondral Bone Predict Articular Cartilage Degeneration in Patients With Ankle Osteoarthritis.
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Ishibashi S, Nakasa T, Ikuta Y, Kawabata S, Moriwaki D, Sakurai S, and Adachi N
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- Humans, Middle Aged, Male, Female, Aged, Ankle Joint diagnostic imaging, Ankle Joint pathology, Ankle Joint surgery, Adult, Cartilage, Articular pathology, Cartilage, Articular diagnostic imaging, Talus diagnostic imaging, Talus pathology, Osteoarthritis diagnostic imaging, Osteoarthritis pathology, Tomography, X-Ray Computed
- Abstract
Background: Therapeutic strategies for ankle osteoarthritis (OA) are determined based on OA staging, alignment, and articular cartilage conditions. However, it is difficult to evaluate the degeneration of the remaining cartilage using imaging modalities. Subchondral bone plays a crucial role in maintaining cartilage homeostasis. Measurement of local Hounsfield unit (HU) values allows for the quantitative assessment of small changes in the subchondral bone. This study aimed to evaluate a relationship between the HU values of the subchondral bone and the histologic findings of articular cartilage in ankle OA., Methods: The talar articular surface was harvested from 14 ankles during arthroplasty. The talus was divided into anterior, middle, and posterior parts, and histologic specimens were prepared. Safranin O staining was performed and histologic findings were evaluated using the modified Mankin score. The regions of interest (ROIs) were set in the medial, central, and lateral regions of the specimens and computed tomography (CT) images, and the relationship between the HU values and histologic findings was analyzed., Results: As OA progressed, cartilage defects increased. In conjunction with cartilage degeneration, the subchondral bone plate thickened, and the HU values increased. The HU value significantly and positively correlated with the modified Mankin score ( r = 0.756), subchondral bone thickness ( r = 0.674, P < .01), and trabecular bone area ( r = 0.637). The cutoff HU values were 594 (sensitivity, 0.813; specificity, 0.944) for 3 points and 727 (sensitivity, 0.929; specificity, 0.782) for 11 points on the modified Mankin score., Conclusion: Significant correlations between HU values and cartilage degeneration in ankle OA were noted. Measuring HU values on CT images can be useful for evaluating the joint surface condition, including histologic findings of the remaining cartilage., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosure forms for all authors are available online.
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- 2024
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29. Quantitative evaluation of calcaneofibular ligament injury on the oblique coronal view of magnetic resonance imaging in chronic lateral ankle instability.
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Nekomoto A, Nakasa T, Ikuta Y, Shimamura Y, Kitamura N, Sumii J, Kawabata S, and Adachi N
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- Humans, Male, Female, Adult, Young Adult, Chronic Disease, Retrospective Studies, Middle Aged, Adolescent, Ankle Joint diagnostic imaging, Sensitivity and Specificity, Joint Instability diagnostic imaging, Joint Instability etiology, Magnetic Resonance Imaging methods, Lateral Ligament, Ankle injuries, Lateral Ligament, Ankle diagnostic imaging, Ankle Injuries diagnostic imaging
- Abstract
Background: In the treatment of chronic lateral ankle instability (CLAI), the repair of the calcaneofibular ligament (CFL) and anterior talofibular ligament (ATFL) is still being discussed, possibly due to the difficulty in assessing CFL injuries. In particular, it is challenging to evaluate the extent of CFL deficiency quantitively. We hypothesized that CFL tension change would alter morphology of the CFL on magnetic resonance imaging (MRI) and that measuring this morphological change allows assessing CFL injury quantitatively. Thus, this study aimed to analyze the feasibility of quantitatively assessing CFL injuries using MRI., Methods: Sixty-four ankles with CLAI were included and divided into two groups: with (ATFL and CFL group, 31 ankles) or without CFL repair (ATFL group, 33 ankles) in addition to arthroscopic ATFL repair. The angle between the CFL and calcaneal axis (CFLCA) and the bending angles of the CFL was defined as the flexed CFL angle (FCA) were measured on the oblique CFL view of preoperative MRI. The diagnostic abilities of these angles for CFL injury and correlations between these angles and stress radiographs were analyzed., Results: The sensitivity and specificity of CFLCA were 86.7 % and 88.7 %, and those of FCA were 63.3 % and 77.4 %, respectively. The combination of CFLCA and FCA improved the sensitivity to 93.3 %. The cutoff points of CFLCA and FCA were 3.8° and 121.2°, respectively. There were significant moderate and weak correlations between the talar tilting angle and CFLCA or FCA (rs = -0.533, and rs = -0.402, respectively). The CFLCA and FCA were significantly smaller in the ATFL and CFL group than those in the other groups., Conclusions: Measurement of CFLCA and FCA in oblique CFL view on MRI could be useful for the quantitative evaluation of CFL injury in patients with CLAI. LEVEL OF EVIDENCE: Level IV. case-control study., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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30. An Evidence-Based Update on Fixation Procedures for Acute and Chronic Osteochondral Lesions of the Talus.
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Nakasa T, Ikuta Y, Haraguchi N, Park CH, Weber CD, Rikken QGH, Dahmen J, Stufkens SAS, Kerkhoffs GMMJ, and Takao M
- Abstract
Osteochondral lesions of the talus (OLT) involve the subchondral bone and the overlying articular cartilage. Various surgical treatments for these lesions are available, such as bone marrow stimulation (BMS), autologous osteochondral grafting, and fixation of an osteochondral fragment. Treatment choice depends on the condition of the lesion, which includes lesion size, morphology, location, and the presence of cysts. Among the surgical procedures available to date, in situ fixation of the osteochondral fragment has the advantage of restoring the articular surface while preserving the native hyaline cartilage and its subchondral bone. Fixation for OLT has been shown to be clinically successful for the treatment of both acute and chronic lesions. Moreover, the indication for osteochondral fragment fixation is expanding as recent studies have found good clinical outcomes in relatively small-sized lesions. The present article describes the current evidence on fixation for acute and chronic OLT., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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31. Morphology and deformity of the distal phalanx in hallux valgus.
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Kanemitsu M, Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, Deie M, and Adachi N
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- Humans, Female, Male, Middle Aged, Aged, Adult, Retrospective Studies, Metatarsal Bones diagnostic imaging, Metatarsal Bones surgery, Weight-Bearing, Hallux Valgus diagnostic imaging, Hallux Valgus surgery, Tomography, X-Ray Computed, Toe Phalanges diagnostic imaging, Toe Phalanges surgery
- Abstract
Background: Studies have shown that the first metatarsal contributes to hallux valgus. The proximal phalanx, another factor that defines the hallux valgus angle, also contributes to the development of hallux valgus. There have been no reports on the use of computed tomography to evaluate bone morphology of the proximal phalanx. The purpose of this study was to analyze the morphology and deformity of the proximal phalanx and its relationship to hallux valgus using computed tomography, and to consider the indications for proximal phalanx surgery in hallux valgus., Methods: Patients who consulted at our clinic for foot and ankle disorders and underwent both weight-bearing radiography and computed tomography between May 2019 and March 2022 were included in the study. The hallux valgus angle, sesamoid subluxation, first metatarsal length, proximal phalanx length, metatarsal-proximal phalanx ratio, proximal phalanx valgus angle, metatarsal-proximal phalanx angle, proximal phalanx rotation angle, and distal phalanx-proximal phalanx angle were measured. These parameters were compared between the hallux valgus and control groups. In the hallux valgus group, the hallux valgus and proximal phalanx valgus angles were measured and compared using weight-bearing radiographs., Results: A total of 83 feet in 65 patients were diagnosed with hallux valgus (hallux valgus group; mean age of 68.0 ± 13.8 years) and 30 feet in 22 patients without hallux valgus (control group; mean age of 67.0 ± 25.8 years) were included in the study. The proximal phalanx length, metatarsal-proximal phalanx ratio and angle, and distal phalanx-proximal phalanx angle were significantly greater in the hallux valgus group than in the control group. However, the proximal phalanx valgus and rotation angles were not significantly different between the groups., Conclusion: Since there was no significant difference in the proximal phalanx morphology, except length, between the hallux valgus and control groups, the indications for osteotomy of the proximal phalanx should be carefully considered., Competing Interests: Declaration of competing interest None., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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32. Development of osteophytes and joint space narrowing is associated with cartilage degeneration of the osteochondral fragment in the osteochondral lesion of the talus.
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Nakasa T, Ikuta Y, Kawabata S, Sakurai S, Moriwaki D, and Adachi N
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- Humans, Male, Female, Adult, Middle Aged, Retrospective Studies, Tomography, X-Ray Computed, Young Adult, Aged, Ankle Joint diagnostic imaging, Ankle Joint surgery, Ankle Joint pathology, Adolescent, Talus diagnostic imaging, Talus pathology, Talus surgery, Osteophyte diagnostic imaging, Osteophyte pathology, Osteophyte surgery, Cartilage, Articular diagnostic imaging, Cartilage, Articular pathology, Cartilage, Articular surgery, Arthroscopy methods, Osteoarthritis diagnostic imaging, Osteoarthritis surgery, Osteoarthritis pathology
- Abstract
Background: During surgery for osteochondral lesions of the talus (OLT), preservation or excision of the osteochondral fragment is chosen based on the cartilage condition which influences the indication and clinical outcomes of surgical treatments. However, it is difficult to predict arthroscopic and histological findings of the cartilage on osteochondral fragments by radiographic evaluation. We focused on osteoarthritis (OA) changes on plain radiographs to predict the cartilage condition of the OLT. This study aimed to evaluate whether OA changes, including osteophyte and joint space narrowing, could predict arthroscopic and histological findings of the cartilage in OLT., Methods: Seventy ankles with OLT were included in this study. Osteophytes and joint space narrowing were scored on plain radiographs. Lesion sizes were measured on computed tomography images. The cartilage surfaces of fragments were arthroscopically assessed using the International Cartilage Repair Society (ICRS) grade. Biopsy specimens from 32 ankles were histologically analyzed using the Mankin score. The relationships between OA scores, lesion size, ICRS grades, and Mankin score were analyzed., Results: OA changes were frequently observed with increasing ICRS grades, especially in the medial tibiotalar joint. OA scores in patients with ICRS grade 1 were significantly lower than those in ICRS grades 2,3, and 4. The lesion sizes in patients with ICRS grade 3 and 4 were significantly smaller than those in patients with ICRS grade 1 and 2. Histological analysis showed increasing Mankin scores as the ICRS grade worsened. A mild correlation existed between the OA and Mankin scores (rs = 0.494)., Conclusions: OA changes, such as osteophyte formation and joint space narrowing, are associated with arthroscopic findings of the articular surface and cartilage degeneration in osteochondral fragment in OLT. Articular cartilage conditions can be predicted by OA changes on plain radiographs, which is useful for choosing the appropriate treatment for patients with OLT., Level of Evidence: Level Ⅳ, case series., Competing Interests: Declaration of competing interest No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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33. The Relationship Between Calcaneofibular Ligament Injury and Ankle Osteoarthritis Progression: A Comprehensive Analysis of Stress Distribution and Osteophyte Formation in the Subtalar Joint.
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Sakurai S, Nakasa T, Ikuta Y, Kawabata S, Moriwaki D, Ishibashi S, Silan AA, and Adachi N
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- Humans, Retrospective Studies, Female, Male, Adult, Magnetic Resonance Imaging, Middle Aged, Disease Progression, Joint Instability physiopathology, Joint Instability diagnostic imaging, Ankle Injuries physiopathology, Ankle Injuries complications, Ankle Injuries diagnostic imaging, Young Adult, Ankle Joint physiopathology, Ankle Joint diagnostic imaging, Tomography, X-Ray Computed, Aged, Osteophyte diagnostic imaging, Subtalar Joint diagnostic imaging, Subtalar Joint physiopathology, Subtalar Joint injuries, Osteoarthritis diagnostic imaging, Osteoarthritis physiopathology, Osteoarthritis etiology, Lateral Ligament, Ankle injuries, Lateral Ligament, Ankle physiopathology, Lateral Ligament, Ankle diagnostic imaging
- Abstract
Background: Ankle osteoarthritis (OA) mainly arises from trauma, particularly lateral ligament injuries. Among lateral ligament injuries, ankles with calcaneofibular ligament (CFL) injuries exhibit increased instability and can be a risk factor ankle OA progression. However, the relationship between CFL injury and OA progression remains unclear. Therefore, this study aims to assess the relationship between CFL injuries and ankle OA by investigating stress changes and osteophyte formation in subtalar joint., Methods: We retrospectively reviewed the magnetic resonance imaging (MRI) and plain radiographic evaluations of 100 ankles of 91 patients presenting with chronic ankle instability (CAI), ankle OA, or other ankle conditions. The association between CFL injuries on the oblique view of MRI and the severity of ankle OA (based on Takakura-Tanaka classification) was statistically evaluated. Additionally, 71 ankles were further subjected to CT evaluation to determine the association between the CFL injuries and the Hounsfield unit (HU) ratios of the subtalar joint and medial gutter, and the correlation between the subtalar HU ratios and osteophyte severity were statistically evaluated., Results: CFL injury was observed in 35.9% (14/39) of patients with stage 0, 42.9% (9/21) with stage 1, 50.0% (10/20) with stage 2, 100% (9/9) with stage 3a, and 90.9% (10/11) with stage 3b. CFL-injured ankles exhibited higher HU ratios in the medial gutter and lower ratios in the medial posterior subtalar joint compared to uninjured ankles. A negative correlation was observed between medial osteophyte severity and the medial subtalar joint HU ratio., Conclusion: Our findings suggest that CFL injuries are common in severe ankle OA impairing the compensatory function of the subtalar joint through abnormal stress distribution and osteophyte formation., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosure forms for all authors are available online.
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- 2024
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34. Development of a novel approach for restoration of the meniscus using silk-elastin in a rabbit meniscus injury model.
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Inoue T, Kano T, Nakasa T, Ishikawa M, Inoue K, Kawabata S, Miyaki S, Kamei N, and Adachi N
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- Animals, Rabbits, Menisci, Tibial surgery, Cell Movement, Proof of Concept Study, Male, Cells, Cultured, Tibial Meniscus Injuries surgery, Disease Models, Animal, Wound Healing drug effects, Silk
- Abstract
Background: Limited healing potential of the meniscus remains a burden for the successful repair of meniscus injuries in the orthopaedic fields. Silk-elastin (SE) is a novel recombinant protein with favorable properties for wound healing. This proof-of-concept study aimed to investigate the therapeutic effect of silk-elastin in a rabbit meniscal defect model., Methods: A migration assay using rabbit meniscus and synovial cells with various concentrations of SE in a culture medium was conducted to investigate the mechanism of meniscal healing by SE. Additionally, cylindrical defects with a 1.5 mm diameter were created at the anterior horn of the medial meniscus of rabbits. The animals were divided into three groups: 1) the Blank group; defect only, 2) the Col I group; implantation of type I atelocollagen sponge, and 3) the SE group; implantation of SE (150 mg/ml) sponge. Whole medial menisci were harvested at 4, 8, 12, and 24 weeks after surgery. Histological analyses including immunohistochemical staining were performed to assess meniscal healing., Results: In vitro study, Migration assay demonstrated a significantly higher number of migrated cells only in synovial cells. Especially, the SE concentration of 10 µg/mL demonstrated the highest number of migrated cells compared with other concentrations. In vivo study, the SE group exhibited significantly higher Ishida scores than other groups at all time points. Furthermore, the SE group showed higher synovial coverage scores than the Col I group at 4 and 8 weeks. Immunohistochemical staining demonstrated higher type II collagen staining in the SE group compared to other groups at 12 weeks. Implanted SE was efficiently replaced by safranin-O staining positive tissue within 8 weeks., Conclusions: SE could effectively repair a meniscal defect by inducing coverage of synovial cells. SE has the potential to be a useful material for meniscal repair., (© 2024. The Author(s).)
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- 2024
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35. High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8.
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Ding C, Yimiti D, Sanada Y, Matsubara Y, Nakasa T, Matsubara K, Adachi N, and Miyaki S
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- Animals, Mice, Male, Aging pathology, Apoptosis, Chondrocytes pathology, Chondrocytes metabolism, Diet, High-Fat adverse effects, Obesity complications, Obesity pathology, Obesity physiopathology, Disease Progression, Osteoarthritis etiology, Osteoarthritis pathology, Osteoarthritis physiopathology, Disease Models, Animal
- Abstract
Objectives: Ageing and obesity are major risk factors for osteoarthritis (OA), a widespread disease currently lacking efficient treatments. Senescence-accelerated mouse prone 8 (SAMP8) display early onset ageing phenotypes, including OA. This study investigates the impacts of high-fat diet (HFD)-induced obesity on OA development in SAMP8., Methods: SAMP8 at 5 weeks were fed either a normal chow diet or an HFD for 10 weeks to induce obesity. Parameters related to obesity, liver function, and lipid and glucose metabolism were analysed. At 14 weeks of age, knee joint pathology, bone mineral density, and muscle strength were assessed. Immunohistochemistry and TUNEL staining were performed to evaluate markers for cartilage degeneration and chondrocyte apoptosis., Results: At 14 weeks of age, HFD-induced obesity increased liver and adipose tissue inflammation in SAMP8 without further exacerbating diabetes. Histological scoring revealed aggravated cartilage, menisci deterioration, and synovitis, while no further loss of bone mineral density or muscle strength was observed. Increased chondrocyte apoptosis was detected in knee joints following HFD feeding., Conclusions: Ten weeks of HFD feeding promotes spontaneous OA progression in 14-week-old SAMP8, potentially via liver damage that subsequently leads to chondrocyte apoptosis. This ageing-obese mouse model may prove valuable for further exploration of spontaneous OA pathophysiology., (© Japan College of Rheumatology 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2024
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36. Hounsfield Unit values on the subchondral bone are related to clinical outcomes in bone marrow stimulation for osteochondral lesions of the talus.
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Kawabata S, Nakasa T, Ikuta Y, Sumii J, Nekomoto A, and Adachi N
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- Humans, Male, Female, Adult, Middle Aged, Retrospective Studies, Treatment Outcome, Young Adult, Bone Marrow diagnostic imaging, Adolescent, Aged, Talus diagnostic imaging, Tomography, X-Ray Computed
- Abstract
Background: Poor clinical outcomes in bone marrow stimulation (BMS) for the osteochondral lesion of the talus (OLT) are caused by subchondral bone deterioration. It is reported that microfracture induces endochondral ossification in the subchondral bone, which may affect the subchondral bone condition after BMS. This study analyzed osteosclerotic patterns of the bed in OLTs on computed tomography (CT) images and the relationship between the subchondral bone condition and clinical outcomes of BMS., Methods: Sixty-nine ankles in 61 patients with OLT were included. Hounsfield unit (HU) on the bed of OLTs was measured on CT images and the pattern of osteosclerosis or absorption in the bed was analyzed. In these patients, 25 ankles in 24 patients underwent BMS. They were divided into 2 groups according to the presence of bone marrow edema (BME) one year after surgery, and clinical outcomes were compared., Results: HUs in the anterior region were significantly higher than those of other areas. In patients with BMS, the JSSF scale for BME positive group (88.0 ± 7.7 points) was significantly lower than that for BME negative group (95.0 ± 6.1 points) (p < 0.05) at the final follow-up. On preoperative CT images, HU values of the central region in the BME-positive group were significantly lower than those in the BME-negative group (p < 0.05)., Conclusion: Osteosclerotic changes in the anterior part of the bed were frequently observed, and BMS for the area with low HU values decreased clinical outcomes. BMS should be performed with attention to subchondral bone condition to obtain good clinical outcomes., Level of Evidence: 4, case series., Competing Interests: Declaration of Competing Interest No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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37. Correction effects of peroneus longus contraction on hallux valgus radiographic parameters.
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Ikuta Y, Nakasa T, Nekomoto A, Sumii J, Kawabata S, and Adachi N
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- Humans, Male, Female, Middle Aged, Aged, Treatment Outcome, Muscle Contraction physiology, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal physiopathology, Adult, Hallux Valgus diagnostic imaging, Hallux Valgus physiopathology, Radiography
- Abstract
Background: Hypermobility of the first tarsometatarsal joint plays an important role in hallux valgus pathogenesis. The peroneus longus is recognized as a dynamic stabilizer of the first tarsometatarsal joint. However, the association between the peroneus longus function and the hallux valgus deformity remains unknown. This study aimed to determine the effect of peroneus longus contraction induced by electrical muscle stimulation on the correction of hallux valgus radiographic parameters in patients with hallux valgus., Methods: Thirty-five patients with hallux valgus (47 feet; 2 men, 33 women; mean age 64.9 years) were included. Non-weight-bearing dorsoplantar radiographs of the foot were obtained with and without electrical muscle stimulation of the peroneus longus. Radiographic parameters of hallux valgus deformities, including the hallux valgus angle, intermetatarsal angle, first metatarsal protrusion distance, and distance between the first and second metatarsal bases, were measured and compared between the two conditions., Results: All hallux valgus radiographic parameters were significantly improved by contraction of the peroneus longus. The median hallux valgus angle decreased by 13.2°. Fewer changes in the hallux valgus angle were identified in patients with severe deformity and geriatric patients., Conclusions: Although the peroneus longus muscle has received little attention in the management of hallux valgus, our findings suggest that it has the potential to be a novel conservative approach for treating mild-to-moderate hallux valgus., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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38. Augmentation of the medial collateral ligament using suture tape reduces the recurrence after corrective surgery for severe hallux valgus.
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Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, Wira Yudha Luthfi AP, and Adachi N
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- Humans, Middle Aged, Male, Female, Aged, Severity of Illness Index, Retrospective Studies, Recurrence, Treatment Outcome, Collateral Ligaments surgery, Suture Techniques, Suture Anchors, Follow-Up Studies, Metatarsophalangeal Joint surgery, Metatarsophalangeal Joint diagnostic imaging, Hallux Valgus surgery, Hallux Valgus diagnostic imaging, Osteotomy methods
- Abstract
Background: The severity of hallux valgus (HV) deformity is associated with recurrence after corrective surgery because of the degenerative change of the medial capsule including the medial collateral ligament (MCL) at the metatarsophalangeal joint. This study aimed to assess the effectiveness of the MCL augmentation using a suture tape anchor of the recurrence of HV and to evaluate the histological changes of the medial joint capsule in HV patients., Methods: Thirty-four feet with severe hallux valgus were included and divided into 2 groups. Seventeen feet had the MCL reconstruction using suture tape anchor with a combination of the corrective osteotomy as the suture tape group (mean age, 64.0 years), and other seventeen feet had the corrective osteotomy without MCL reconstruction as the control group (mean age, 62.0 years). HV angle (HVA) and intermetatarsal angle (IMA) on the weight-bearing radiograms and the Japanese Society for Surgery of the Foot (JSSF) score in both groups were compared at the final follow-up. The medial capsule was harvested from other 20 feet with HV and the relationship between the severity of HV and the histological findings was analyzed., Results: HVA, IMA, and JSSF scores in both groups were significantly improved from preoperatively to the final follow-up (P < 0.01). At the final follow-up, HVA in the suture tape group (9.2°) was significantly smaller than that in the control (15.4°) (P < 0.01). There were no significant differences in the IMA and the JSSF score at the final follow-up between both groups. Histological scores in HV with ≥40° HVA was significantly worse than those in <40°., Conclusion: The medial joint capsule in severe HV deformity showed the degenerative change and the MCL reconstruction using suture tape combined with osteotomy provides a strong medial constraint to prevent the recurrence of the deformity in severe hallux valgus., Level of Clinical Evidence: 3., Competing Interests: Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2023 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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39. Effects of Preoperative Abnormality of Posterior Tibial Tendon on the Surgical Outcomes of Medial Osteochondral Lesion of the Talus.
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Kawabata S, Nakasa T, Ikuta Y, Sakurai S, Moriwaki D, Ishibashi S, and Adachi N
- Abstract
Background: Although surgical treatment for osteochondral lesion of the talus (OLT) can obtain good clinical outcomes, the rate of return to sports is variable. It is reported that medial OLT unrelated to trauma has abnormal structures in the medial aspect, which may induce the medial OLT due to the medial instability. The posterior tibial tendon (PTT) plays an important role in the stabilization of the foot, and high mechanical stress may be added to the PTT to compensate for medial instability in medial OLT. We investigated whether abnormal PTT findings on preoperative magnetic resonance imaging (MRI) in patients with OLT affect clinical outcomes after surgery. Methods: Eighty-one ankles in 74 patients who were treated surgically for OLT were included in this study (41 men and 33 women; mean age, 26.0 years). Abnormalities of the PTT were evaluated using preoperative MRI. The Japanese Society for Surgery of the Foot (JSSF) scale, arch height, and ankle activity score (AAS) on standing plain radiogram were compared between patients with and those without preoperative PTT abnormalities., Results: Twenty-five ankles (30.9%) had PTT abnormalities on preoperative MRI. All patients with preoperative PTT abnormalities were medial OLT. There were no significant differences in the preoperative JSSF scale in the procedures for OLT. The postoperative JSSF scale and arch height were significantly lower in patients with preoperative PTT abnormalities than those without them. AAS in patients with preoperative abnormalities significantly decreased at the final follow-up. Conclusion: PTT abnormalities on preoperative MRI may affect clinical outcomes even in preoperative asymptomatic patients in the medial OLT unrelated to trauma., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Ethical Committee of Hiroshima University issued approval E-879. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Kawabata et al.)
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- 2024
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40. Osteophyte Cartilage as a Potential Source for Minced Cartilage Implantation: A Novel Approach for Articular Cartilage Repair in Osteoarthritis.
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Kawabata S, Nakasa T, Nekomoto A, Yimiti D, Miyaki S, and Adachi N
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- Humans, Male, Female, Aged, Middle Aged, Collagen Type II metabolism, Collagen Type II genetics, SOX9 Transcription Factor metabolism, SOX9 Transcription Factor genetics, Cells, Cultured, Cell Movement, Cartilage, Articular metabolism, Cartilage, Articular pathology, Cartilage, Articular surgery, Chondrocytes metabolism, Chondrocytes pathology, Osteophyte metabolism, Osteophyte pathology, Cell Proliferation, Osteoarthritis metabolism, Osteoarthritis pathology, Osteoarthritis surgery
- Abstract
Osteoarthritis (OA) is a common joint disorder characterized by cartilage degeneration, often leading to pain and functional impairment. Minced cartilage implantation (MCI) has emerged as a promising one-step alternative for large cartilage defects. However, the source of chondrocytes for MCI remains a challenge, particularly in advanced OA, as normal cartilage is scarce. We performed in vitro studies to evaluate the feasibility of MCI using osteophyte cartilage, which is present in patients with advanced OA. Osteophyte and articular cartilage samples were obtained from 22 patients who underwent total knee arthroplasty. Chondrocyte migration and proliferation were assessed using cartilage fragment/atelocollagen composites to compare the characteristics and regenerative potential of osteophytes and articular cartilage. Histological analysis revealed differences in cartilage composition between osteophytes and articular cartilage, with higher expression of type X collagen and increased chondrocyte proliferation in the osteophyte cartilage. Gene expression analysis identified distinct gene expression profiles between osteophytes and articular cartilage; the expression levels of COL2A1, ACAN, and SOX9 were not significantly different. Chondrocytes derived from osteophyte cartilage exhibit enhanced proliferation, and glycosaminoglycan production is increased in both osteophytes and articular cartilage. Osteophyte cartilage may serve as a viable alternative source of MCI for treating large cartilage defects in OA.
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- 2024
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41. Nonunion of Isolated Medial Cuneiform Fracture Fixed With a Compression Screw and Compression Staple: A Case Report.
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Kanemitsu M, Nakasa T, Shiraishi K, Ikuta Y, and Adachi N
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Isolated cuneiform fractures are rare and account for only 1.7% of all midfoot fractures. Medial cuneiform fractures can be treated conservatively or surgically, with good clinical outcomes. However, nonunion is a rare complication of medial cuneiform fractures, and only a few cases have been reported in the literature. We report a case of a medial cuneiform fracture requiring surgical treatment that had a good clinical outcome. A 15-year-old boy presented to an orthopedic clinic with a complaint of pain in his right foot. The patient had landed on the foot during a handball game and was treated conservatively for several months. However, his symptoms persisted, and he was referred to our clinic for further evaluation, where he was diagnosed with medial cuneiform nonunion of the right foot. Open reduction and internal fixation surgery using a compression screw and staple and autologous bone grafting were performed. Postoperatively, bone union was observed, and the patient returned to full competition with no complaints of pain during exercise. The Self-Administered Foot Evaluation Questionnaire (SAFE-Q) score at 21 months after surgery was 100.0 for the following subscales: Pain & Pain-Related; Physical Functioning & Daily Living; Social Functioning; Shoe-Related; General Health & Well-Being; and Sport (handball). We encountered a case of an isolated medial cuneiform fracture that required surgical treatment. During the surgical treatment, fixation with a combination of compression staples and screws may be considered simple and useful for achieving strong fixation because the medial cuneiform fracture has a small bone fragment., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Kanemitsu et al.)
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- 2024
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42. First tarsometatarsal joint mobility in hallux valgus during gait: A synchronized ultrasound and three-dimensional motion capture analysis.
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Tashiro T, Ikuta Y, Maeda N, Arima S, Morikawa M, Kaneda K, Ishihara H, Tsutsumi S, Kawai M, Brand A, Nakasa T, Adachi N, Komiya M, and Urabe Y
- Subjects
- Humans, Female, Male, Cross-Sectional Studies, Young Adult, Adult, Metatarsal Bones diagnostic imaging, Metatarsal Bones physiopathology, Range of Motion, Articular, Imaging, Three-Dimensional methods, Tarsal Joints diagnostic imaging, Tarsal Joints physiopathology, Motion Capture, Hallux Valgus diagnostic imaging, Hallux Valgus physiopathology, Ultrasonography methods, Gait physiology
- Abstract
Purpose: To quantify the vertical translation between the first metatarsal and medial cuneiform during the stance phase of gait in young individuals with and without hallux valgus., Design: This cross-sectional observational study included 34 young adults (male, n = 4; female, n = 30) who were divided into three groups according to the hallux valgus angle: control (< 20°, n = 13), mild hallux valgus (≥ 20° to < 30°, n = 12), and moderate hallux valgus (≥ 30°, n = 9). The mobility of the first tarsometatarsal joint was evaluated during the stance phase using B-mode ultrasound synchronized with a motion analysis system., Results: The medial cuneiform shifted more plantar during the early phase in mild hallux valgus and during the middle and terminal phases in moderate hallux valgus than in control. The severity of the hallux valgus was correlated with a trend toward plantar shift of the medial cuneiform. The first metatarsal was located more dorsal than the medial cuneiform; however, there was no significant variation. No significant differences in the peak ankle plantarflexion angle and moment were noted between the groups., Conclusion: The hypermobility of the first tarsometatarsal joint, especially plantar displacement of the medial cuneiform in the sagittal plane, was found in young individuals with hallux valgus during the stance phase of gait, and the mobility increased with the severity of hallux valgus. Our findings suggest the significance of preventing hallux valgus deformity early in life., (© 2024. The Author(s).)
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- 2024
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43. Effect of a compression staple on correction of varus deformity during arthroscopic ankle arthrodesis.
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Nakasa T, Ikuta Y, Kawabata S, Sakurai S, Moriwaki D, and Adachi N
- Abstract
Background: Arthroscopic ankle arthrodesis (AAA) has become popular because of its higher rate of bone union, lower invasiveness, and shorter hospital stays compared to those of open arthrodesis. However, postoperative malalignment is often observed for severe varus deformity, which can cause nonunion, pain, and adjacent joint arthrosis. A compression staple can provide a persistent, strong compressive force on the bone surface. This study aimed to clarify the difference in alignment correction in AAA by comparing a compression staple and screws fixation with screws-only fixation pre- and postoperatively., Methods: Seventy ankles in 67 patients undergoing AAA were retrospectively reviewed. AAA with three screws through the distal tibia was performed in 53 ankles, and 17 ankles underwent AAA with a compression staple and two screws. After the preparation of the joint surface arthroscopically, patients in the S group had three canulated cancellous screws inserted through the medial tibia. Patients in the CS group had a compression staple placed at the lateral aspect of the tibiotalar joint and two screws inserted through the medial side. Clinical scores and pre-and postoperative alignment on plain radiographs were compared between the two procedures., Results: There were no significant differences in the pre-and postoperative Japanese Society for Surgery of the Foot scale. One ankle in the S group exhibited nonunion. There were no significant differences in talar tilt and tibiotalar angles between the groups. The tibial plafond angle in the CS group was significantly lower than that in the S group (p < 0.05). Postoperatively, talar tilt and tibiotalar angles on the coronal image, and the lateral tibiotalar angle in the CS group were significantly lower than those in the S group (p < 0.05)., Conclusion: AAA with a compression staple and two-screw fixations could obtain more optimal alignments than AAA with screw-only fixation, even in cases with severe varus deformity., Competing Interests: Declaration of competing interest The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)
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- 2024
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44. Comparison of Clinical Outcomes With Arthroscopic ATFL Repair With the CFL Repair and Open ATFL and CFL Repair in Chronic Lateral Ankle Instability.
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Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, and Adachi N
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- Humans, Ankle Joint diagnostic imaging, Ankle Joint surgery, Ankle, Arthroscopy methods, Retrospective Studies, Lateral Ligament, Ankle surgery, Orthopedics, Joint Instability diagnostic imaging, Joint Instability surgery
- Abstract
It is important to eliminate instability related to chronic lateral ankle instability (CLAI) to prevent osteoarthritis progression. We performed arthroscopic anterior talofibular ligament (ATFL) repair and performed calcaneofibular ligament (CFL) repair if instability remained. This study aimed to assess the clinical outcomes of our arthroscopic procedure compared to that of open surgery. Forty ankles underwent arthroscopic surgery and 23 ankles underwent open surgery to repair the lateral ankle ligaments for CLAI. In the arthroscopic surgery, varus stress was applied under fluoroscopy after ATFL repair, and CFL repair was performed if instability remained. Open surgery was performed using the Broström procedure with ATFL and CFL repair. To assess clinical outcomes, American Orthopaedic Foot & Ankle Society (AOFAS) and Karlsson-Peterson (KP) scores were collected preoperatively and at the final follow-up. The talar tilt angle (TTA) was measured preoperatively and 1 year postoperatively. The arthroscopic group showed significantly higher AOFAS and KP scores at the final follow-up compared to the open surgery group. There was no significant difference in TTA at 1 year between the groups. In open surgery, 2 patients required revision surgery. There were no major complications, but scar-related pain in 2 cases of open surgery was reported. Arthroscopic ATFL repair with the CFL repair gave satisfactory clinical outcomes compared to open surgery in CLAI because of low invasive to soft tissue including the joint capsule. It is important to minimize soft tissue dissection in repairing the lateral ankle ligament in patients with CLAI., (Copyright © 2023 the American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.)
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- 2024
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45. Relationship between pain and intra-articular pathology in patients with chronic lateral ankle instability.
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Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, and Adachi N
- Subjects
- Humans, Ankle Joint surgery, Ankle, Retrospective Studies, Arthroscopy methods, Arthralgia complications, Lateral Ligament, Ankle surgery, Joint Instability complications, Joint Instability pathology, Cartilage Diseases complications, Synovitis complications, Bone Diseases pathology, Ankle Injuries complications, Ankle Injuries surgery
- Abstract
Purpose: Repeated ankle sprains can lead to chronic lateral ankle instability (CLAI). It is unclear whether CLAI causes pain unless complicated by intra-articular lesions. This study aimed to analyze the characteristics of pain and the relationship between pain and intra-articular pathology in patients with CLAI., Materials and Methods: Fifty-three ankles in 46 patients with CLAI who had undergone surgery were retrospectively reviewed. The self-administered foot evaluation questionnaire (SAFE-Q) was given to patients the day before surgery. Intra-articular lesions were assessed using arthroscopy and magnetic resonance imaging (MRI). In addition, the Hounsfield Unit (HU) on computed tomography (CT) of the medial gutter was measured. The relationship between pain and intra-articular findings was also analyzed., Results: The pain and pain-related scores in the SAFE-Q were significantly correlated with synovitis in 96.3% (rs = - 0.532). HU ratios in the tibia and talus were also significantly correlated with pain (rs = - 0.603, - 0.534, respectively). The arthroscopic synovitis score and HU ratios in patients with high pain scores were significantly higher than those in patients with low pain scores. Forty ankles (75.5%) had synovitis and articular cartilage injuries were observed in 22 ankles (41.5%). Patients with fluid collection or bone marrow lesions (BML) scored significantly lower in pain than those without, but there was no significant difference between patients with and without cartilage injury. Multiple regression analysis revealed that a high synovitis score and HU ratio of the talus were significantly associated with high pain., Conclusions: Intra-articular lesions such as synovitis and BML were associated with pain in patients with CLAI. Osteosclerotic changes in the medial gutter also induced ankle pain, indicating that osteoarthritic changes had already begun. Therefore, lateral ankle ligament injuries after ankle sprain should be appropriately treated to avoid secondary degenerative changes., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2024
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46. Arthroscopic Fixation Using Bioabsorbable Pins With Bone Grafting via a Medial Malleolus Approach to Treat Osteochondral Lesion of the Talus.
- Author
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Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, and Adachi N
- Subjects
- Humans, Adolescent, Bone Transplantation methods, Absorbable Implants, Tibia surgery, Bone Nails, Treatment Outcome, Talus diagnostic imaging, Talus surgery, Intra-Articular Fractures
- Abstract
Fixation of the osteochondral fragment has the advantage to restore the naturally congruent morphology of the talar dome with native hyaline cartilage in the treatment of the osteochondral lesion of the talus (OLT). Surgical treatment of medial talar osteochondral lesions is commonly done through a medial malleolar osteotomy. However, a medial malleolar osteotomy is an invasive procedure and gives negative impacts on clinical outcomes. Fixation for the posteromedial lesion of the OLT without the medial malleolar osteotomy may provide good clinical outcomes. We showed arthroscopic fixation for medial OLT without the medial malleolar osteotomy. Curettage and bone grafting between the fragment and its bed were performed, and then 2-mm bone tunnel in the medial malleolus was created. Bioabsorbable pins were inserted through the tunnel to fix the osteochondral fragment. Three cases (mean age 18.6 years) were treated using this technique for medial OLT and followed at 16 months (range, 12-24 months). The Japanese Society for Surgery of the Foot scale improved from 73.3 ± 1.2 points before surgery to 95.7 ± 7.5 points at the final follow-up. Bone union of the osteochondral fragment was confirmed on magnetic resonance imaging (MRI). Arthroscopic fixation for medial OLT is less invasive and yields good clinical outcomes. Levels of Evidence: Level V., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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47. High incidence of osteoarthritic changes in patients with osteochondral lesions of the talus without chronic lateral ankle instability.
- Author
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Kawabata S, Nakasa T, Ikuta Y, Sumii J, Nekomoto A, and Adachi N
- Subjects
- Humans, Adult, Middle Aged, Ankle, Retrospective Studies, Incidence, Ankle Joint diagnostic imaging, Ankle Joint surgery, Magnetic Resonance Imaging, Treatment Outcome, Talus diagnostic imaging, Talus surgery, Osteophyte diagnostic imaging, Joint Instability diagnostic imaging, Joint Instability etiology, Joint Instability pathology, Osteoarthritis diagnostic imaging, Osteoarthritis epidemiology
- Abstract
Background: It is unclear whether osteochondral lesions of the talus (OLTs) without chronic lateral ankle instability (CLAI) progress to osteoarthritis, which affects the therapeutic strategy. Especially, the efficacy of conservative treatment for OLT remains controversial. Since various anatomical abnormalities have been reported, there may be abnormal movement of the talus in the mortise, causing ankle instability. We hypothesized that OLTs have frequent osteoarthritic changes even without CLAI. This study aimed to evaluate the incidence of osteoarthritic changes and stress distribution on the talus in OLT., Methods: Fifty-eight ankles with medial OLT without CLAI were retrospectively reviewed. Osteophytes and joint space narrowing on radiographs were scored using Kraus's classification and compared to ankles without OLTs. OA scores were compared between over 18 years and less than 17 years in OLTs. On computed tomography images, the area of OLTs was measured. Besides, Hounsfield Units (HU) of the talus in patients with and without OLTs were measured and compared., Results: Osteoarthritic changes were observed in 54 of the 58 ankles (94.8%) in the OLT patients. Osteophytes were frequently observed at the medial gutter and anterior tibial plafond. The OA score in patients aged over 18 years was significantly higher than that in patients aged less than 17 years (P < 0.05). HU values in the talus were significantly higher than those in non-OLT patients. OLTs more than 100 mm
2 had a significantly higher osteoarthritic score than those less than 100 mm2 ., Conclusion: Medial OLT without CLAI has frequently osteoarthritic changes, especially large lesions. Osteoarthritic changes in OLTs will progress over time, which needs to be considered when deciding whether to perform the surgical or non-surgical treatment., Competing Interests: Declaration of competing interest No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article., (Copyright © 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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48. Loosening of the anterolateral capsule affects the stability after arthroscopic lateral ankle ligament repair of chronic ankle instability.
- Author
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Nakasa T, Ikuta Y, Sumii J, Nekomoto A, Kawabata S, Luthfi APWY, and Adachi N
- Subjects
- Humans, Ankle Joint diagnostic imaging, Ankle Joint surgery, Ankle, Arthroscopy methods, Magnetic Resonance Imaging, Retrospective Studies, Lateral Ligament, Ankle surgery, Joint Instability diagnostic imaging, Joint Instability surgery
- Abstract
Purpose: Arthroscopic anterior talofibular ligament (ATFL) repair for chronic lateral ankle instability (CLAI) has been widely performed. The recurrence of the instability after the surgery sometimes occurs, which may cause the development of osteoarthritis. Therefore, it is important to elucidate the factors of the recurrence. This study aimed to evaluate the loosening of the capsule in the MRI and whether it affected clinical outcomes or not in arthroscopic ATFL repair., Materials and Methods: Thirty-eight ankles in 35 patients with CLAI treated by arthroscopic lateral ligament repair were included. The capsule protrusion area defined as the area that protruded ATFL laterally from the line connecting the fibula and talus attachment on MRI was measured. Capsule protrusion area in ankles with or without CLAI was compared and the relationships between it and clinical outcomes were assessed., Results: The capsule protrusion area in the CLAI group (74.2 ± 36.4 mm
2 ) was significantly larger than that in the control (25.5 ± 14.3 mm2 ) (p < 0.01). The capsule protrusion area in the poor remnant group (93.8 ± 36.4 mm2 ) was significantly larger than that in the excellent (53.2 ± 40.3 mm2 ) (p < 0.05). The capsule protrusion area in the patients with recurrent instability (99.8 ± 35.2 mm2 ) was significantly larger than that without recurrent instability (62.4 ± 30.9 mm2 ) (p < 0.01). Clinical scores in the recurrent group were significantly lower than those in the non-recurrent group (p < 0.05)., Conclusions: Capsule loosening would be one of the causes of the recurrence of instability after arthroscopic lateral ankle ligament repair. Evaluation of the capsule protrusion area on MRI is helpful to choose appropriate surgical procedures for CLAI patients., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)- Published
- 2024
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49. Relationship between foot morphologic characteristic and postural control after jump-landing in youth competitive athletes.
- Author
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Maeda N, Tsutsumi S, Arima S, Ikuta Y, Ushio K, Komiya M, Tashiro T, Nishikawa Y, Kobayashi T, Nakasa T, Adachi N, and Urabe Y
- Subjects
- Humans, Adolescent, Leg physiology, Athletes, Postural Balance physiology, Biomechanical Phenomena, Foot physiology, Lower Extremity
- Abstract
Background: Foot arch dynamics play an important role in dynamic postural control. Association between foot arch dynamics and postural control among adolescent athletes remains poorly explored., Objective: To examine the relationship between foot arch dynamics, intrinsic foot muscle (IFM) morphology, and toe flexor strength and dynamic postural stability after jump landing and repetitive rebound jump performance in competitive adolescent athletes., Methods: Based on foot arch dynamics, evaluated from relative change in the foot arch height in sitting and standing positions, 50 adolescent athletes were classified as stiff, normal, or flexible. IFM morphology was evaluated by ultrasonography. Dynamic postural stability index (DPSI) was measured as participants jumped and landed with the right leg onto a force plate, whereas repetitive rebound jumping performance was assessed using the jump height and reactive jump index., Results: The stiff group had a significantly worse DPSI and vertical stability index than the normal group (p= 0.26, p= 0.44, respectively), and worse anteroposterior stability index (APSI) values than the flexible group (p= 0.005). Multivariate regression models of the relationship between the APSI and foot arch dynamics showed adequate power (probability of error = 0.912)., Conclusions: Increased foot arch stiffness negatively affects dynamic balance during jump-landing, which may deteriorate their performance.
- Published
- 2024
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50. Decreased Joint Position Sense of the Ankle Joint Is a Risk Factor for Falls in the Elderly.
- Author
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Kanemitsu M, Nakasa T, Ikuta Y, and Adachi N
- Abstract
Background: Falls in the elderly are common causes of morbidity, mortality, loss of independence, and poor quality of life. We hypothesized that decreased ankle position sense is one among several risk factors that might lead to falls., Methods: A total of 54 feet from 28 patients over 65 years of age and 10 feet from five healthy volunteers were included. Measurements of ankle position sense, medical history, and fall history within a year were obtained, which were compared between the groups., Results: The mean replication error angle of internal and external rotation was significantly higher in the elderly, and the mean replication error angle of internal rotation was significantly higher in the group with a history of falls., Conclusion: The mean replication error angle of internal rotation and a history of fractures were significant risk factors for falls. Hence, an increase in the mean replication error angle of internal rotation may increase the risk of falls in the elderly population., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Kanemitsu et al.)
- Published
- 2023
- Full Text
- View/download PDF
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