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Your search keyword '"Nasu, Kaei"' showing total 466 results
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466 results on '"Nasu, Kaei"'

10. Extragonadal recurrence of benign mature teratoma in the pouch of Douglas.

Author

Sato, Miho, Nasu, Kaei, Matsumoto, Harunobu, Konishi, Kota, Yasumi, Shunsuke, Sato, Yusuke, Yano, Mitsutake, and Kobayashi, Eiji

Subjects
*TERATOMA, *TRANSVAGINAL ultrasonography, *RESTORATIVE proctocolectomy, *GONADAL dysgenesis, *MAGNETIC resonance imaging, *BENIGN tumors, *JAPANESE women, *ANTI-NMDA receptor encephalitis
Abstract

Laparoscopic cystectomy for mature teratomas is associated with a high incidence of intraperitoneal spillage and tumor spread; however, extragonadal recurrence of this benign tumor is rare. We hereby present an additional case of extragonadal mature teratoma that recurred in the pouch of Douglas after ovarian cystectomy. A 43‐year‐old Japanese woman presented with atypical genital bleeding. A 7 cm mature teratoma was detected using transvaginal ultrasonography and magnetic resonance imaging. At 26 years old, she underwent bilateral cystectomy for bilateral mature teratoma of the ovary. During laparoscopic surgery, a cystic tumor appeared in the pouch of Douglas and was firmly adhered to the surrounding tissues. Both ovaries were normal. The resected tumor was diagnosed as extragonadal, benign, mature teratoma. To avoid the extragonadal recurrence of mature teratoma, removal of tumor contents from intraperitoneal spillage by lavage should be performed at the end of surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Efficacy and safety of olanzapine combined with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy in gynecological cancer: KCOG-G1301 phase II trial

Author

Abe, Masakazu, Hirashima, Yasuyuki, Kasamatsu, Yuka, Kado, Nobuhiro, Komeda, Satomi, Kuji, Shiho, Tanaka, Aki, Takahashi, Nobutaka, Takekuma, Munetaka, Hihara, Hanako, Ichikawa, Yoshikazu, Itonaga, Yui, Hirakawa, Tomoko, Nasu, Kaei, Miyagi, Kanoko, Murakami, Junko, and Ito, Kimihiko

Published
2016
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18. Metastasis from follicular lymphoma to an ovarian mature teratoma: a case report of tumor-to-tumor metastasis.

Author

Sato, Yusuke, Yano, Mitsutake, Eto, Satoshi, Takano, Kuniko, and Nasu, Kaei

Subjects
FOLLICULAR lymphoma, TERATOMA, OVARIAN follicle, LYMPHATIC metastasis, LYMPH node cancer, FLUORESCENCE in situ hybridization
Abstract

Background: Tumor-to-tumor metastasis (TTM) is a rare but well-established phenomenon where histologically distinct tumors metastasize within each other. Here we report the first "known" case of follicular lymphoma that metastasized and extended to a mature ovarian teratoma. Case presentation: A 59-year-old Japanese postmenopausal woman visited our hospital for a detailed examination of an ovarian tumor. Clinical imaging suggested it to be either teratoma-associated ovarian cancer with multiple lymph node metastases, or tumor-to-tumor metastasis from malignant lymphoma to ovarian teratoma. A bilateral adnexectomy and retroperitoneal lymph node biopsy were performed. Lined with squamous epithelium, the cyst constituted a mature ovarian teratoma, and the solid part showed diffuse proliferation of abnormal lymphoid cells. Immunohistochemically, the abnormal lymphoid cells were negative for CD5, MUM1, and CyclinD1, and positive for CD10, CD20, CD21, BCL2, and BCL6. Genetic analysis using G-banding and fluorescence in situ hybridization identified a translocation of t(14;18) (q32;q21), and we diagnosed tumor-to-tumor metastasis from nodal follicular lymphoma to mature ovarian teratoma. Twelve months after surgery, the patient showed no progression without adjuvant therapy. Conclusions: The present case suggests that molecular approaches are useful in the diagnosis of TTM in mature ovarian teratomas when morphologic and immunohistochemical findings alone are insufficient for diagnoses. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Efficacy and safety of triple therapy with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy for gynecological cancer: KCOG-G1003 phase II trial

Author

Takeshima, Nobuhiro, Matoda, Maki, Abe, Masakazu, Hirashima, Yasuyuki, Kai, Kentaro, Nasu, Kaei, Takano, Masashi, Furuya, Kenichi, Sato, Seiya, Itamochi, Hiroaki, Tsubamoto, Hiroshi, Hasegawa, Kosei, Terao, Kiminari, Otsuki, Takeo, Kuritani, Keiko, and Ito, Kimihiko

Published
2014
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37. Clinicopathological features and programmed death-ligand 1 immunohistochemical expression in a multicenter cohort of uterine and ovarian melanomas: a retrospective study in Japan (KCOG-G1701s).

Author

Yano, Mitsutake, Nasu, Kaei, Yasuda, Masanori, Katoh, Tomomi, Kagabu, Masahiro, Kobara, Hisanori, Matsuura, Motoki, Tokuyama, Osamu, Yamawaki, Takaharu, Wakahashi, Senn, Noguchi, Tomoko, Mizuno, Kaoruko, Shitsukawa, Keiji, Onohara, Yoshimasa, Nakabori, Takashi, Miyasaka, Aki, Nakao, Takehiro, Matsunaga, Tatsuya, Kunimi, Yusuke, and Sakurai, Manabu

Published
2022
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40. Application of the nuclear factor-[kappa]B inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study

Author

Nasu, Kaei, Nishida, Masakazu, Ueda, Tami, Yuge, Akitoshi, Takai, Noriyuki, and Narahara, Hisashi

Subjects
Endometriosis -- Research, Cellular control mechanisms -- Research, Apoptosis -- Research, Genetic regulation -- Research, Enzyme inhibitors -- Research, Cell research, Biological sciences
Abstract

Most of the current medical treatments for endometriosis aim to downregulate estrogen activity. However, a high recurrence rate after medical treatment has been the most significant problem. BAY 11-7085, a soluble inhibitor of NK-[kappa]B activation, has been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. To examine the potential application of BAY 11-7085 in the treatment of endometriosis, we investigated the effects of this agent on the cell proliferation and apoptosis of cultured ovarian endometriotic cyst stromal cells (ECSCs) by a modified methylthiazole tetrazolium assay, a 5-bromo-2'-deoxyuridine incorporation assay, and internucleosomal DNA fragmentation assays. The effect of BAY 11-7085 on the cell cycle of ECSCs was also determined by flow cytometry. The expression of apoptosis-related molecules was examined in ECSCs with Western blot analysis. BAY 11-7085 significantly inhibited the cell proliferation and DNA synthesis of ECSCs and induced apoptosis and the G0/G1 phase cell cycle arrest of these cells. Additionally, downregulation of the B-cell lymphoma/leukemia-2 (Bcl-2) and Bcl-[X.sub.L] expression with simultaneous activation of caspase-3, -8, and -9 was observed in ECSCs after treatment with BAY 11-7085. These results suggest that BAY 11-7085 induces apoptosis of ECSCs by suppressing antiapoptotic proteins, and that caspase-3-, -8-, and -9-mediated cascades are involved in this mechanism. Therefore, BAY 11-7085 could be used as a therapeutic agent for the treatment of endometriosis. apoptosis; cell cycle arrest; Bcl-2; Bcl-[X.sub.L] doi:10.1152/ajpendo.00135.2006

Published
2007

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