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4. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome

Author

Horiuchi, Yu, Wettersten, Nicholas, Patel, Mitul P., Mueller, Christian, Neath, Sean-Xavier, Christenson, Robert H., Morgenthaler, Nils G., McCord, James, Nowak, Richard M., Vilke, Gary M., Daniels, Lori B., Hollander, Judd E., Apple, Fred S., Cannon, Chad M., Nagurney, John T., Schreiber, Donald, deFilippi, Christopher, Hogan, Christopher, Diercks, Deborah B., Headden, Gary, Limkakeng, Alexander T., Jr., Anand, Inder, Wu, Alan H.B., Ebmeyer, Stefan, Jaffe, Allan S., Peacock, W. Frank, and Maisel, Alan

Published
2022
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7. CLUE: a randomized Comparative effectiveness trial of IV nicardipine versus Labetalol Use in the Emergency department

Author

Peacock, W, Varon, Joseph, Baumann, Brigitte M, Borczuk, Pierre, Cannon, Chad M, Chandra, Abhinav, Cline, David M, Diercks, Deborah, Hiestand, Brian, Hsu, A, Jois-Bilowich, Preeti, Kaminski, Brian, Levy, Philip, Nowak, Richard M, and Schrock, Jon W

Abstract

Abstract Introduction Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension. Methods Multicenter randomized clinical trial. Eligible patients had 2 systolic blood pressure (SBP) measures ≥180 mmHg and no contraindications to nicardipine or labetalol. Before randomization, the physician specified a target SBP ± 20 mmHg (the target range: TR). The primary endpoint was the percent of subjects meeting TR during the initial 30 minutes of treatment. Results Of 226 randomized patients, 110 received nicardipine and 116 labetalol. End organ damage preceded treatment in 143 (63.3%); 71 nicardipine and 72 labetalol patients. Median initial SBP was 212.5 (IQR 197, 230) and 212 mmHg (IQR 200,225) for nicardipine and labetalol patients (P = 0.68), respectively. Within 30 minutes, nicardipine patients more often reached TR than labetalol (91.7 vs. 82.5%, P = 0.039). Of 6 BP measures (taken every 5 minutes) during the study period, nicardipine patients had higher rates of five and six instances within TR than labetalol (47.3% vs. 32.8%, P = 0.026). Rescue medication need did not differ between nicardipine and labetalol (15.5 vs. 22.4%, P = 0.183). Labetalol patients had slower heart rates at all time points (P < 0.01). Multivariable modeling showed nicardipine patients were more likely in TR than labetalol patients at 30 minutes (OR 2.73, P = 0.028; C stat for model = 0.72) Conclusions Patients treated with nicardipine are more likely to reach the physician-specified SBP target range within 30 minutes than those treated with labetalol. Trial registration ClinicalTrials.gov: NCT00765648

Published
2011

8. Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction

Author

Horiuchi, Yu, Wettersten, Nicholas, Patel, Mitul P., Mueller, Christian, Neath, Sean-Xavier, Christenson, Robert H., Morgenthaler, Nils G., McCord, James, Nowak, Richard M., Vilke, Gary M., Daniels, Lori B., Hollander, Judd E., Apple, Fred S., Cannon, Chad M., Nagurney, John T., Schreiber, Donald, deFilippi, Christopher, Hogan, Christopher, Diercks, Deborah B., Headden, Gary, Limkakeng, Alexander T., Jr, Anand, Inder, Wu, Alan H.B., Ebmeyer, Stefan, Jaffe, Allan S., Peacock, W. Frank, and Maisel, Alan

Published
2020
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9. Absolute and relative changes (delta) in troponin I for early diagnosis of myocardial infarction: Results of a prospective multicenter trial

Author

Storrow, Alan B., Nowak, Richard M., Diercks, Deborah B., Singer, Adam J., Wu, Alan H.B., Kulstad, Erik, LoVecchio, Frank, Fromm, Christian, Headden, Gary, Potis, Tracie, Hogan, Christopher J., Schrock, Jon W., Zelinski, Daniel P., Greenberg, Marna R., Christenson, Robert H., Ritchie, James C., Chamberlin, Janna S., Bray, Kurtis R., Rhodes, Daniel W., Trainor, Deirdre, and Southwick, Paula C.

Published
2015
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10. Diagnostic performance of cardiac Troponin I for early rule-in and rule-out of acute myocardial infarction: Results of a prospective multicenter trial

Author

Storrow, Alan B., Christenson, Robert H., Nowak, Richard M., Diercks, Deborah B., Singer, Adam J., Wu, Alan H.B., Kulstad, Erik, LoVecchio, Frank, Fromm, Christian, Headden, Gary, Potis, Tracie, Hogan, Christopher J., Schrock, Jon W., Zelinski, Daniel P., Greenberg, Marna R., Ritchie, James C., Chamberlin, Janna S., Bray, Kurtis R., Rhodes, Daniel W., Trainor, Deirdre, Holmes, Dawn, and Southwick, Paula C.

Published
2015
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15. Copeptin Helps in the Early Detection of Patients With Acute Myocardial Infarction: Primary Results of the CHOPIN Trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction)

Author

Maisel, Alan, Mueller, Christian, Neath, Sean-Xavier, Christenson, Robert H., Morgenthaler, Nils G., McCord, James, Nowak, Richard M., Vilke, Gary, Daniels, Lori B., Hollander, Judd E., Apple, Fred S., Cannon, Chad, Nagurney, John T., Schreiber, Donald, deFilippi, Christopher, Hogan, Christopher, Diercks, Deborah B., Stein, John C., Headden, Gary, Limkakeng, Alexander T., Jr., Anand, Inder, Wu, Alan H.B., Papassotiriou, Jana, Hartmann, Oliver, Ebmeyer, Stefan, Clopton, Paul, Jaffe, Allan S., and Peacock, W. Frank

Published
2013
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16. Necessity of hospitalization and stress testing in low risk chest pain patients

Author

Beri, Neil, Marston, Nicholas A., Daniels, Lori B., Nowak, Richard M., Schreiber, Donald, Mueller, Christian, Jaffe, Allan, Diercks, Deborah B., Wettersten, Nicholas, DeFilippi, Christopher, Peacock, Frank W., Limkakeng, Alexander T., Anand, Inder, McCord, James, Hollander, Judd E., Wu, Alan H.B., Apple, Fred S., Nagurney, John T., Berardi, Cecilia, Cannon, Chad M., Clopton, Paul, Neath, Sean-Xavier, Christenson, Robert H., Hogan, Christopher, Vilke, Gary, and Maisel, Alan

Published
2017
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19. Midregion Prohormone Adrenomedullin and Prognosis in Patients Presenting With Acute Dyspnea: Results From the BACH (Biomarkers in Acute Heart Failure) Trial

Author

Maisel, Alan, Mueller, Christian, Nowak, Richard M., Peacock, W. Frank, Ponikowski, Piotr, Mockel, Martin, Hogan, Christopher, Wu, Alan H.B., Richards, Mark, Clopton, Paul, Filippatos, Gerasimos S., Di Somma, Salvatore, Anand, Inder, Ng, Leong L., Daniels, Lori B., Neath, Sean-Xavier, Christenson, Robert, Potocki, Mihael, McCord, James, Hartmann, Oliver, Morgenthaler, Nils G., and Anker, Stefan D.

Published
2011
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23. Serial sampling of copeptin levels improves diagnosis and risk stratification in patients presenting with chest pain: results from the CHOPIN trial

Author

Marston, Nicholas A, Shah, Kevin S, Mueller, Christian, Neath, Sean-Xavier, Christenson, Robert H, McCord, James, Nowak, Richard M, Daniels, Lori B, Hollander, Judd E, Apple, Fred, Nagurney, John, Schreiber, Donald, deFilippi, Christopher, Diercks, Deborah, Limkakeng, Alexander, Anand, Inder S, Wu, Alan HB, Jaffe, Allan S, Peacock, W Frank, Maisel, Alan S, Cannon, Chad, Vilke, Gary, Hogan, Christopher, and Clopton, Paul

Published
2016
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24. Midregional Proadrenomedullin Predicts Mortality and Major Adverse Cardiac Events in Patients Presenting With Chest Pain: Results From the CHOPIN Trial

Author

Shah, Kevin S., Marston, Nicholas A., Mueller, Christian, Neath, Sean-Xavier, Christenson, Robert H., McCord, James, Nowak, Richard M., Vilke, Gary M., Daniels, Lori B., Hollander, Judd E., Apple, Fred S., Cannon, Chad M., Nagurney, John, Schreiber, Donald, deFilippi, Christopher, Hogan, Christopher J., Diercks, Deborah B., Limkakeng, Alexander, Anand, Inder S., Wu, Alan H. B., Clopton, Paul, Jaffe, Allan S., Peacock, Frank W., Maisel, Alan S., and Hiestand, Brian

Published
2015
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28. Contributors

Author

Aaronson, Emily L., Abbott, Ethan E., Abraham, Gallane, Abraham, Michael K., Agrait-Gonzalez, Miguel, Akhtar, Saadia, Aks, Steven E., Atchinson, Patricia Ruth, Auerbach, Marc, Aufderheide, Tom P., Banks, Laura L., Barksdale, Aaron N., Barrett, Whitney, Becker, Bruce M., Ben Ma, Zheng, Biese, Kevin, Biros, Michelle H., Bitterman, Robert A., Blackwell, Thomas H., Blum, Frederick C., Blumen, Ira J., Bolgiano, Edward B., Bond, Michael C., Bookman, Kelly, Borhart, Joelle, Boswell, Brittany, Brady, William J., Braithwaite, Sabina A., Brody, Aaron, Brown, Calvin A., III, Brown, David F.M., Brown, James E., Buchanan, Jennie Alison, Bukhman, Alice Kidder, Bullard-Berent, Jeffrey, Bunney, E. Bradshaw, Burton, John H., Caglar, Derya, Cahill, John D., Carlberg, David J., Chang, Andrew K., Chary, Michael A., Chen, Paul, Chumpitazi, Corrie E., Cico, Stephen John, Claudius, Ilene, Coates, Wendy C., Cole, Jon B., Colwell, Christopher B., Corbin, Theodore, Cooper, Robert, Corwell, Brian Niall, Curtis, Amelia M., D’Andrea, Shawn, Danzl, Daniel F., Davenport, Moira, Davis, Alysa S., Davis, Jonathan, Davis, Natalie L., Daya, Mohamud R., DeGeorge, Lindsey M., Derlet, Robert W., Dobiesz, Valerie A., Dupré, Alan A., Duran-Gehring, Petra, Easter, Joshua S., Edwards, Christopher J., Eilbert, Wesley P., Eiting, Erick, Elie-Turenne, Marie-Carmelle, Erickson, Timothy B., Eyre, Andrew J., Fairley, Romeo, Farrell, Susan E., Fath, John J., Fernandez-Frackelton, Madonna, Finnell, John T., Franco, Vanessa, Frazee, Bradley W., Friedman, Benjamin W., Gaddy, Jeremiah D., Ganetsky, Michael, Gausche-Hill, Marianne, Geiderman, Joel M., Germann, Carl A., Glass, George F., III, Glauser, Jonathan M., Godwin, Steven A., Goldberg, Scott A., Goodloe, Jeffrey M., Gorgas, Diane L., Green, Thomas J., Grossman, Shamai A., Guluma, Kama, Guttman, Joshua, Haas, Nathan L., Haines, Elizabeth J., Hajicharalambous, Christina, Hall, Matthew M., Halmo, Laurie Seidel, Hansoti, Bhakti, Harris, N. Stuart, Harrison, Nicholas, Hart, Danielle, Hatten, Benjamin W., Heine, Carlton E., Heiner, Jason D., Henn, Megan C., Hern, H. Gene, Jr., Hess, Jamie M., Hill, Adam D., Himelfarb, Nadine T., Hockberger, Robert S., Hogrefe, Christopher, Holland, Carolyn Kluwe, Holmes, James F., Hoppe, Jason A., Horeczko, Timothy, Hoyte, Christopher, Hsieh, Dennis, Hudson, Korin, Huesgen, Karl, Hwang, Ula, Iserson, Kenneth V., Iwanicki, Janetta L., Jagoda, Andy, James, Thea, Jewell, Corlin, Johnson, Nicholas J., Jones, Alan E., Jones, Emily M., Jouriles, Nicholas J., Kabrhel, Christopher, Kaide, Colin G., Kaji, Amy H., Kaplan, Julius (Jay) A., Kayden, Stephanie, Kearney, Ryan D., Kelly, Matthew P., Kim, Hyung T., Kivlehan, Sean M., Koenig, Kristi L., Kosowsky, Joshua M., Koval, Christine E., Koyfman, Alex, Kurz, Michael C., Lall, Michelle D., Lang, Spenser C., Lee, Jeffrey E., Lei, Charles, Levine, Michael D., Levy, Matthew J., Levy, Phillip D., Lim, Christopher S., Lindberg, Daniel, Lipsky, Ari M., Liu, J. Marc, Long, Brit, Macias-Konstantopoulos, Wendy, Maciel, Carolina Barbosa, Maher, Patrick J., Maloney, Gerald E., Jr, Maloney, Patrick J., Marco, Catherine Anna, Marill, Keith A., Martinez, Joseph P., Matlock, Aaron G., Mayersak, Ryanne J., May, Larissa S., McCoin, Nicole S., McCurdy, Michael T., McKinzie, Jeffry, Meaden, Christopher W., Meehan, Timothy J., Mehta, Niyati, Meurer, William J., Mick, Nathan W., Miloslavsky, Eli M., Miner, James R., Mohr, Nicholas M., Moll, Joel, Monas, Jessica, Monte, Andrew A., Montgomery, Martha M., Moore, Malia J., Moran, Gregory J., Mycyk, Mark B., Nable, Jose V., Nagler, Joshua, Nassisi, Denise, Nathan, Joshua B., Nelson, Lewis S., Nelson, Michael E., Newton, Kim, Nguyen, Thomas, Nicholson, Adam M., Nickels, L. Connor, Nikolaides, Jenna Karagianis, Nite, Micah J., Nitzberg, Michael, Norman, Marquita S., Norse, Ashley Booth, Nowak, Richard M., Ogunniyi, Adedamola A., Overbeek, Daniel L., Padlipsky, Patricia, Palmer, Jessica, Papa, Linda, Peak, David A., Pedigo, Ryan Anthony, Perkins, Jack, Jr, Pfaff, James A., Pfennig, Camiron L., Phelan, Michael P., Pierce, Ava E., Platt, Melissa A., Pontius, Elizabeth P.D., Pour, Trevor R., Preston-Suni, Kian, Price, Timothy G., Prince, William B., Probst, Marc, Pulia, Michael, Puskarich, Michael A., Quest, Tammie E., Raja, Ali S., Raukar, Neha P., Reardon, Robert F., Reed, Kevin C., Richards, David B., Rischall, Megan L., Robinson, Daniel W., Rodenberg, Howard, Roginski, Matthew A., Roline, Chad E., Rose, Emily, Rose, Jeremy, Rose, Nicholas G.W., Rosen, Tony, Ross, Weston, Rudy, C. Craig, Ruha, Anne-Michelle, Rybarczyk, Megan M., Sachs, Carolyn Joy, Salzberg, Matthew, Sánchez, León D., Sanders, Arthur B., San Miguel, Christopher E., Scarfone, Richard J., Schmidt, Andrew, Schmitt, Eric R., Schnapp, Benjamin H., Schoener, Benjamin, Schultz, Carl H., Seethala, Raghu, Seiden, Jeffrey A., Seigel, Todd A., Selby, Sarah Tolford, Self, Wesley H., Sexton, Joseph, Shaikh, Huma, Shapiro, Michael A., Shapiro, Nathan I., Shappell, Eric, Shapshak, Dag, Sharp, Andrea C., She, Trent, Shetty, Pranav, Shewakramani, Sanjay N., Shreves, Ashley, Simon, Barry C., Simon, Leslie V., Singh, Manpreet, Singh, Sonia, Skolnik, Aaron B., Slovis, Corey M., Smereck, Janet, Smith, Clay, Sokolove, Peter E., Soskin, Philippa, Soulek, Jaron, Southerland, Lauren T., Springer, Brian L., Stenson, Bryan A., Stoklosa, Hanni, Tainter, Christopher R., Takhar, Sukhjit S., Tang, Nelson, Taylor, Todd Andrew, Theobald, Jillian L., Thiessen, Molly E.W., Thomas, Anita A., Thomas, Natasha, Thompson, Holly, Thompson, Trevonne M., Thornton, Joseph E., Tyndall, J. Adrian, VanRooyen, Michael, Verbillion, Meagan B., Vohra, Taher T., Vojta, Leslie R., Waasdorp, Christopher P., Jr, Wacker, David A., Wagner, Mary Jo, Walker, Laura E., Wallenstein, Joshua, Walls, Ron M., Wang, George Sam, Wardi, Gabriel, Waxman, Matthew A., Weichenthal, Lori, Welker, Katherine Louise, Wessel, Amanda L., White, Benjamin, White, William, Wilcox, Susan R., Williamson, Craig A., Wolfson, Allan B., Wu, Andrea W., Yealy, Donald M., Young, Henry W., II, Zafren, Ken, Zdradzinski, Michael J., Zink, Brian J., and Zun, Leslie S.

Published
2023
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29. How obesity affects the cut-points for B-type natriuretic peptide in the diagnosis of acute heart failure: Results from the Breathing Not Properly Multinational Study

Author

Daniels, Lori B., Clopton, Paul, Bhalla, Vikas, Krishnaswamy, Padma, Nowak, Richard M., McCord, James, Hollander, Judd E., Duc, Philippe, Omland, Torbjørn, Storrow, Alan B., Abraham, William T., Wu, Alan H.B., Steg, Philippe G., Westheim, Arne, Knudsen, Cathrine Wold, Perez, Alberto, Kazanegra, Radmila, Herrmann, Howard C., McCullough, Peter A., and Maisel, Alan S.

Published
2006
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31. Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial

Author

Maisel, Alan, Neath, Sean-Xavier, Landsberg, Judd, Mueller, Christian, Nowak, Richard M., Peacock, W. Frank, Ponikowski, Piotr, Möckel, Martin, Hogan, Christopher, Wu, Alan H.B., Richards, Mark, Clopton, Paul, Filippatos, Gerasimos S., Di Somma, Salvatore, Anand, Inder, Ng, Leong L., Daniels, Lori B., Christenson, Robert H., Potocki, Mihael, McCord, James, Terracciano, Garret, Hartmann, Oliver, Bergmann, Andreas, Morgenthaler, Nils G., and Anker, Stefan D.

Published
2012
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33. Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.

Author

Limkakeng, Alexander T., Hertz, Julian, Lerebours, Reginald, Kuchibhatla, Maragatha, McCord, James, Singer, Adam J., Apple, Fred S., Peacock, William F., Christenson, Robert H., Nowak, Richard M., and Limkakeng, Alexander T Jr

Abstract

Objective: High-sensitivity cardiac troponin assays (hs-cTn) aid in diagnosis of myocardial infarction (MI). These assays have lower specificity for non-ST Elevation MI (NSTEMI) in patients with renal disease. Our objective was to determine an optimized cutoff for patients with renal disease.Methods: We conducted an a priori secondary analysis of a prospective FDA study in adults with suspected MI presenting to 29 academic urban EDs between 4/2015 and 4/2016. Blood was drawn 0, 1, 2-3, and 6-9 h after ED arrival. We recorded cTn and estimated glomerular filtrate rate (eGFR) by Chronic Kidney Disease Epidemiology Collaboration equation. The primary endpoint was NSTEMI (Third Universal Definition of MI), adjudicated by physicians blinded to hs-cTn results. We generated an adjusted hscTn rule-in cutoff to increase specificity.Results: 2505 subjects were enrolled; 234 were excluded. Patients were mostly male (55.7%) and white (57.2%), median age was 56 years 472 patients [20.8%] had an eGFR <60 mL/min/1.73 m2. In patients with eGFR <15 mL/min/1.73 m2, a baseline rule-in cutoff of 120 ng/L led to a specificity of 85.0% and Positive Predictive Value (PPV) of 62.5% with 774 patients requiring further observation. Increasing the cutoff to 600 ng/L increased specificity and PPV overall and in every eGFR subgroup (specificity and PPV 93.3% and 78.9%, respectively for eGFR <15 mL/min/1.73m2), while increasing the number (79) of patients requiring observation.Conclusions: An eGFR-adjusted baseline rule-in threshold for the Siemens Atellica hs-cTnI improves specificity with identical sensitivity. Further study in a prospective cohort with higher rates of renal disease is warranted. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Impact of age, race, and sex on the ability of B-type natriuretic peptide to aid in the emergency diagnosis of heart failure: results from the Breathing Not Properly (BNP) multinational study

Author

Maisel, Alan S, Clopton, Paul, Krishnaswamy, Padma, Nowak, Richard M, McCord, James, Hollander, Judd E, Duc, Philippe, Omland, Torbjørn, Storrow, Alan B, Abraham, William T, Wu, Alan H.B, Steg, Gabriel, Westheim, Arne, Knudsen, Catherine Wold, Perez, Alberto, Kazanegra, Radmila, Bhalla, Vikas, Herrmann, Howard C, Aumont, Marie Claude, and McCullough, Peter A

Published
2004
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49. B-type natriuretic peptide and renal function in the diagnosis of heart failure: An analysis from the breathing not properly multinational study

Author

McCullough, Peter A., Duc, Philippe, Omland, Torbjørn, McCord, James, Nowak, Richard M., Hollander, Judd E., Herrmann, Howard C., Steg, Philippe G., Westheim, Arne, Knudsen, Cathrine Wold, Storrow, Alan B., Abraham, William T., Lamba, Sumant, Wu, Alan H.B., Perez, Alberto, Clopton, Paul, Krishnaswamy, Padma, Kazanegra, Radmila, and Maisel, Alan S.

Published
2003
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