48 results on '"Obeng, Esther A."'
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2. Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
3. Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
4. Venetoclax-based therapy as a bridge to allogeneic hematopoietic cell transplantation in children with relapsed/refractory AML
5. An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
6. Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors
7. SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation
8. Engineering naturally occurring CD7− T cells for the immunotherapy of hematological malignancies
9. Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition
10. Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL
11. Murine fetal bone marrow does not support functional hematopoietic stem and progenitor cells until birth
12. Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia
13. Clones assemble! The clonal complexity of blood during ontogeny and disease
14. The development of therapy related myeloid neoplasms in childhood cancer survivors
15. Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice
16. Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia
17. A Prospective Cohort Quality Improvement Study to Reduce the Time to Antibiotics for New Fever in Neutropenic Pediatric Oncology Inpatients
18. Pediatric Heparin-Induced Thrombocytopenia: Prevalence, Thrombotic Risk, and Application of the 4Ts Scoring System
19. 3211 – SF3B1/DNMT3A CO-MUTATIONS MITIGATES DNMT3A PHENOTYPE IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
20. 3138 – EPIGENETIC REGULATORS TET2 AND POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) COORDINATE GENE EXPRESSION IN MYELODYSPLASTIC SYNDROME (MDS)
21. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
22. A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome
23. 148 - Venetoclax-Based Combination Therapy As a Bridge to Allogeneic Hematopoietic Stem Cell Transplant in Children with Relapsed/Refractory AML
24. 128 - CD45RA-Depleted Haploidentical Transplantation Combined with NK Cell Addback Results in Promising Long-Term Outcomes in Pediatric Patients with High-Risk Hematologic Malignancies
25. 41 - CD45RA Depleted T-Cell Addback and Prophylactic Blinatumomab Administration Following Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
26. 3220 – SF3B1/DNMT3A CO-MUTATION MIMICS FEATURES OF SOLE SF3B1 OR DNMT3A MUTATION DEPENDING ON STRESS CONDITIONS
27. 3137 – A MODIFIED ACTIVIN RECEPTOR TYPE IIB LIGAND TRAP (RAP-536) IMPROVES ANEMIA IN SF3B1K700E MICE BY PROMOTING EARLY-STAGE ERYTHROPOIESIS AND IMPROVING ALTERNATIVE SPLICING
28. 3116 – SELECTIVE TARGETING OF SPLICING FACTOR MUTANT HEMATOPOIETIC STEM AND PROGENITOR CELLS VIA STAT3 INHIBITION
29. 3123 – STAT3 INHIBITION IS A SYNTHETIC LETHAL VULNERABILITY FOR SPLICING FACTOR-MUTATED HEMATOPOIETIC STEM CELLS
30. STAT3 INHIBITION IS A SYNTHETIC LETHAL VULNERABILITY FOR SF3B1-MUTATED HEMATOPOIETIC STEM CELLS
31. Mutant SF3B1 splices a more leukemogenic EVI1
32. 3000 - A Cryptic Intronic GATA1 Splicing Mutation Provides Insights Into Human Hematopoietic Differentiation
33. Congenital Thrombocytopenia and Myelofibrosis Due to Germline Mutations in G6b-B— a Megakaryocyte-Specific Immunoreceptor Tyrosine-Based Inhibitory Motif (ITIM) Receptor
34. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.
35. Physiologic Expression of Sf3b1K700E Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.
36. Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells
37. Expressionof Sf3b1- K700Ein Murine B Cells Causes Pre-mRNA Splicing and Altered B Cell Differentiation and Function
38. Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation
39. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability
40. Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis.
41. Charting the “Splice” Routes to MDS.
42. A Murine Model of Chronic Lymphocytic Leukemia Based on B Cell-Restricted Expression of Sf3b1 Mutation and Atm Deletion.
43. Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis.
44. Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.
45. Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations.
46. Altered RNA Processing in Cancer Pathogenesis and Therapy.
47. Impaired human hematopoiesis due to a cryptic intronic GATA1 splicing mutation.
48. R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways.
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