24 results on '"Oboh, Mary Aigbiremo"'
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2. Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa
- Author
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Wotodjo, Amélé Nyedzie, Oboh, Mary Aigbiremo, Doucoure, Souleymane, Diagne, Nafissatou, Diène-Sarr, Fatoumata, Niang, Makhtar, Trape, Jean-François, Sokhna, Cheikh, Amambua-Ngwa, Alfred, and D’Alessandro, Umberto
- Published
- 2023
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3. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Naghavi, Mohsen, Ong, Kanyin Liane, Aali, Amirali, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abtahi, Dariush, Abu Rumeileh, Samir, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Accrombessi, Manfred Mario Kokou, Adal, Tadele Girum, Adamu, Abdu A, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adekanmbi, Victor, Adepoju, Abiola Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adeyinka, Daniel Adedayo, Adeyomoye, Olorunsola Israel, Admass, Biruk Adie Adie, Adnani, Qorinah Estiningtyas Sakilah, Adra, Saryia, Afolabi, Aanuoluwapo Adeyimika, Afzal, Muhammad Sohail, Afzal, Saira, Agampodi, Suneth Buddhika, Agasthi, Pradyumna, Aggarwal, Manik, Aghamiri, Shahin, Agide, Feleke Doyore, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahmad, Aqeel, Ahmad, Danish, Ahmad, Firdos, Ahmad, Muayyad M, Ahmad, Sajjad, Ahmad, Shahzaib, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadzade, Amir Mahmoud, Ahmed, Ali, Ahmed, Ayman, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Mehrunnisha Sharif, Ahmed, Meqdad Saleh, Ahmed, Muktar Beshir, Ahmed, Syed Anees, Ajami, Marjan, Aji, Budi, Akara, Essona Matatom, Akbarialiabad, Hossein, Akinosoglou, Karolina, Akinyemiju, Tomi, Akkaif, Mohammed Ahmed, Akyirem, Samuel, Al Hamad, Hanadi, Al Hasan, Syed Mahfuz, Alahdab, Fares, Alalalmeh, Samer O, Alalwan, Tariq A, Al-Aly, Ziyad, Alam, Khurshid, Alam, Manjurul, Alam, Noore, Al-amer, Rasmieh Mustafa, Alanezi, Fahad Mashhour, Alanzi, Turki M, Al-Azzam, Sayer, Albakri, Almaza, Albashtawy, Mohammed, AlBataineh, Mohammad T, Alcalde-Rabanal, Jacqueline Elizabeth, Aldawsari, Khalifah A, Aldhaleei, Wafa A, Aldridge, Robert W, Alema, Haileselasie Berhane, Alemayohu, Mulubirhan Assefa, Alemi, Sharifullah, Alemu, Yihun Mulugeta, Al-Gheethi, Adel Ali Saeed, Alhabib, Khalid F, Alhalaiqa, Fadwa Alhalaiqa Naji, Al-Hanawi, Mohammed Khaled, Ali, Abid, Ali, Amjad, Ali, Liaqat, Ali, Mohammed Usman, Ali, Rafat, Ali, Shahid, Ali, Syed Shujait Shujait, Alicandro, Gianfranco, Alif, Sheikh Mohammad, Alikhani, Reyhaneh, Alimohamadi, Yousef, Aliyi, Ahmednur Adem, Aljasir, Mohammad A M, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Al-Marwani, Sabah, Al-Maweri, Sadeq Ali Ali, Almazan, Joseph Uy, Al-Mekhlafi, Hesham M, Almidani, Louay, Almidani, Omar, Alomari, Mahmoud A, Al-Omari, Basem, Alonso, Jordi, Alqahtani, Jaber S, Alqalyoobi, Shehabaldin, Alqutaibi, Ahmed Yaseen, Al-Sabah, Salman Khalifah, Altaany, Zaid, Altaf, Awais, Al-Tawfiq, Jaffar A, Altirkawi, Khalid A, Aluh, Deborah Oyine, Alvis-Guzman, Nelson, Alwafi, Hassan, Al-Worafi, Yaser Mohammed, Aly, Hany, Aly, Safwat, Alzoubi, Karem H, Amani, Reza, Amare, Azmeraw T, Amegbor, Prince M, Ameyaw, Edward Kwabena, Amin, Tarek Tawfik, Amindarolzarbi, Alireza, Amiri, Sohrab, Amirzade-Iranaq, Mohammad Hosein, Amu, Hubert, Amugsi, Dickson A, Amusa, Ganiyu Adeniyi, Ancuceanu, Robert, Anderlini, Deanna, Anderson, David B, Andrade, Pedro Prata, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anil, Abhishek, Anil, Sneha, Anoushiravani, Amir, Ansari, Hossein, Ansariadi, Ansariadi, Ansari-Moghaddam, Alireza, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anvari, Saeid, Anwar, Saleha, Anwar, Sumadi Lukman, Anwer, Razique, Anyasodor, Anayochukwu Edward, Aqeel, Muhammad, Arab, Juan Pablo, Arabloo, Jalal, Arafat, Mosab, Aravkin, Aleksandr Y, Areda, Demelash, Aremu, Abdulfatai, Aremu, Olatunde, Ariffin, Hany, Arkew, Mesay, Armocida, Benedetta, Arndt, Michael Benjamin, Ärnlöv, Johan, Arooj, Mahwish, Artamonov, Anton A, Arulappan, Judie, Aruleba, Raphael Taiwo, Arumugam, Ashokan, Asaad, Malke, Asadi-Lari, Mohsen, Asgedom, Akeza Awealom, Asghariahmadabad, Mona, Asghari-Jafarabadi, Mohammad, Ashraf, Muhammad, Aslani, Armin, Astell-Burt, Thomas, Athar, Mohammad, Athari, Seyyed Shamsadin, Atinafu, Bantalem Tilaye Tilaye, Atlaw, Habtamu Wondmagegn, Atorkey, Prince, Atout, Maha Moh'd Wahbi, Atreya, Alok, Aujayeb, Avinash, Ausloos, Marcel, Avan, Abolfazl, Awedew, Atalel Fentahun, Aweke, Amlaku Mulat, Ayala Quintanilla, Beatriz Paulina, Ayatollahi, Haleh, Ayuso-Mateos, Jose L, Ayyoubzadeh, Seyed Mohammad, Azadnajafabad, Sina, Azevedo, Rui M S, Azzam, Ahmed Y, B, Darshan B, Babu, Abraham Samuel, Badar, Muhammad, Badiye, Ashish D, Baghdadi, Soroush, Bagheri, Nasser, Bagherieh, Sara, Bah, Sulaiman, Bahadorikhalili, Saeed, Bahmanziari, Najmeh, Bai, Ruhai, Baig, Atif Amin, Baker, Jennifer L, Bako, Abdulaziz T, Bakshi, Ravleen Kaur, Balakrishnan, Senthilkumar, Balasubramanian, Madhan, Baltatu, Ovidiu Constantin, Bam, Kiran, Banach, Maciej, Bandyopadhyay, Soham, Banik, Palash Chandra, Bansal, Hansi, Bansal, Kannu, Barbic, Franca, Barchitta, Martina, Bardhan, Mainak, Bardideh, Erfan, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barone-Adesi, Francesco, Barqawi, Hiba Jawdat, Barrero, Lope H, Barrow, Amadou, Barteit, Sandra, Barua, Lingkan, Basharat, Zarrin, Bashiri, Azadeh, Basiru, Afisu, Baskaran, Pritish, Basnyat, Buddha, Bassat, Quique, Basso, João Diogo, Basting, Ann V L, Basu, Sanjay, Batra, Kavita, Baune, Bernhard T, Bayati, Mohsen, Bayileyegn, Nebiyou Simegnew, Beaney, Thomas, Bedi, Neeraj, Beghi, Massimiliano, Behboudi, Emad, Behera, Priyamadhaba, Behnoush, Amir Hossein, Behzadifar, Masoud, Beiranvand, Maryam, Bejarano Ramirez, Diana Fernanda, Béjot, Yannick, Belay, Sefealem Assefa, Belete, Chalie Mulu, Bell, Michelle L, Bello, Muhammad Bashir, Bello, Olorunjuwon Omolaja, Belo, Luis, Beloukas, Apostolos, Bender, Rose Grace, Bensenor, Isabela M, Beran, Azizullah, Berezvai, Zombor, Berhie, Alemshet Yirga, Berice, Betyna N, Bernstein, Robert S, Bertolacci, Gregory J, Bettencourt, Paulo J G, Beyene, Kebede A, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhalla, Ashish, Bhandari, Dinesh, Bhangdia, Kayleigh, Bhardwaj, Nikha, Bhardwaj, Pankaj, Bhardwaj, Prarthna V, Bhargava, Ashish, Bhaskar, Sonu, Bhat, Vivek, Bhatti, Gurjit Kaur, Bhatti, Jasvinder Singh, Bhatti, Manpreet S, Bhatti, Rajbir, Bhutta, Zulfiqar A, Bikbov, Boris, Bishai, Jessica Devin, Bisignano, Catherine, Bisulli, Francesca, Biswas, Atanu, Biswas, Bijit, Bitaraf, Saeid, Bitew, Bikes Destaw, Bitra, Veera R, Bjørge, Tone, Boachie, Micheal Kofi, Boampong, Mary Sefa, Bobirca, Anca Vasilica, Bodolica, Virginia, Bodunrin, Aadam Olalekan, Bogale, Eyob Ketema, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolarinwa, Obasanjo Afolabi, Boloor, Archith, Bonakdar Hashemi, Milad, Bonny, Aime, Bora, Kaustubh, Bora Basara, Berrak, Borhany, Hamed, Borzutzky, Arturo, Bouaoud, Souad, Boustany, Antoine, Boxe, Christopher, Boyko, Edward J, Brady, Oliver J, Braithwaite, Dejana, Brant, Luisa C, Brauer, Michael, Brazinova, Alexandra, Brazo-Sayavera, Javier, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle, Brown, Julie, Brugha, Traolach, Bulamu, Norma B, Bulto, Lemma N, Buonsenso, Danilo, Burns, Richard A, Busse, Reinhard, Bustanji, Yasser, Butt, Nadeem Shafique, Butt, Zahid A, Caetano dos Santos, Florentino Luciano, Calina, Daniela, Cámera, Luis Alberto, Campos, Luciana Aparecida, Campos-Nonato, Ismael R, Cao, Chao, Cao, Yin, Capodici, Angelo, Cárdenas, Rosario, Carr, Sinclair, Carreras, Giulia, Carrero, Juan J, Carugno, Andrea, Carvalheiro, Cristina G, Carvalho, Felix, Carvalho, Márcia, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A, Castelpietra, Giulio, Catalá-López, Ferrán, Catapano, Alberico L, Cattaruzza, Maria Sofia, Cederroth, Christopher R, Cegolon, Luca, Cembranel, Francieli, Cenderadewi, Muthia, Cercy, Kelly M, Cerin, Ester, Cevik, Muge, Chadwick, Joshua, Chahine, Yaacoub, Chakraborty, Chiranjib, Chakraborty, Promit Ananyo, Chan, Jeffrey Shi Kai, Chan, Raymond N C, Chandika, Rama Mohan, Chandrasekar, Eeshwar K, Chang, Chin-Kuo, Chang, Jung-Chen, Chanie, Gashaw Sisay, Charalampous, Periklis, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chatzimavridou-Grigoriadou, Victoria, Chaurasia, Akhilanand, Chen, Angela W, Chen, An-Tian, Chen, Catherine S, Chen, Haowei, Chen, Meng Xuan, Chen, Simiao, Cheng, Ching-Yu, Cheng, Esther T W, Cherbuin, Nicolas, Cheru, Wondimye Ashenafi, Chien, Ju-Huei, Chimed-Ochir, Odgerel, Chimoriya, Ritesh, Ching, Patrick R, Chirinos-Caceres, Jesus Lorenzo, Chitheer, Abdulaal, Cho, William C S, Chong, Bryan, Chopra, Hitesh, Choudhari, Sonali Gajanan, Chowdhury, Rajiv, Christopher, Devasahayam J, Chukwu, Isaac Sunday, Chung, Eric, Chung, Erin, Chung, Eunice, Chung, Sheng-Chia, Chutiyami, Muhammad, Cindi, Zinhle, Cioffi, Iolanda, Claassens, Mareli M, Claro, Rafael M, Coberly, Kaleb, Cogen, Rebecca M, Columbus, Alyssa, Comfort, Haley, Conde, Joao, Cortese, Samuele, Cortesi, Paolo Angelo, Costa, Vera Marisa, Costanzo, Simona, Cousin, Ewerton, Couto, Rosa A S, Cowden, Richard G, Cramer, Kenneth Michael, Criqui, Michael H, Cruz-Martins, Natália, Cuadra-Hernández, Silvia Magali, Culbreth, Garland T, Cullen, Patricia, Cunningham, Matthew, Curado, Maria paula, Dadana, Sriharsha, Dadras, Omid, Dai, Siyu, Dai, Xiaochen, Dai, Zhaoli, Dalli, Lachlan L, Damiani, Giovanni, Darega Gela, Jiregna, Das, Jai K, Das, Saswati, Das, Subasish, Dascalu, Ana Maria, Dash, Nihar Ranjan, Dashti, Mohsen, Dastiridou, Anna, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davis Weaver, Nicole, Davletov, Kairat, De Leo, Diego, de Luca, Katie, Debele, Aklilu Tamire, Debopadhaya, Shayom, Degenhardt, Louisa, Dehghan, Azizallah, Deitesfeld, Lee, Del Bo', Cristian, Delgado-Enciso, Ivan, Demessa, Berecha Hundessa, Demetriades, Andreas K, Deng, Ke, Deng, Xinlei, Denova-Gutiérrez, Edgar, Deravi, Niloofar, Dereje, Nebiyu, Dervenis, Nikolaos, Dervišević, Emina, Des Jarlais, Don C, Desai, Hardik Dineshbhai, Desai, Rupak, Devanbu, Vinoth Gnana Chellaiyan, Dewan, Syed Masudur Rahman, Dhali, Arkadeep, Dhama, Kuldeep, Dhimal, Meghnath, Dhingra, Sameer, Dhulipala, Vishal R, Dias da Silva, Diana, Diaz, Daniel, Diaz, Michael J, Dima, Adriana, Ding, Delaney D, Ding, Huanghe, Dinis-Oliveira, Ricardo Jorge, Dirac, M Ashworth, Djalalinia, Shirin, Do, Thao Huynh Phuong, do Prado, Camila Bruneli, Doaei, Saeid, Dodangeh, Masoud, Dodangeh, Milad, Dohare, Sushil, Dokova, Klara Georgieva, Dolecek, Christiane, Dominguez, Regina-Mae Villanueva, Dong, Wanyue, Dongarwar, Deepa, D'Oria, Mario, Dorostkar, Fariba, Dorsey, E Ray, dos Santos, Wendel Mombaque, Doshi, Rajkumar, Doshmangir, Leila, Dowou, Robert Kokou, Driscoll, Tim Robert, Dsouza, Haneil Larson, Dsouza, Viola, Du, Mi, Dube, John, Duncan, Bruce B, Duraes, Andre Rodrigues, Duraisamy, Senbagam, Durojaiye, Oyewole Christopher, Dwyer-Lindgren, Laura, Dzianach, Paulina Agnieszka, Dziedzic, Arkadiusz Marian, E'mar, Abdel Rahman, Eboreime, Ejemai, Ebrahimi, Alireza, Echieh, Chidiebere Peter, Edinur, Hisham Atan, Edvardsson, David, Edvardsson, Kristina, Efendi, Defi, Efendi, Ferry, Effendi, Diyan Ermawan, Eikemo, Terje Andreas, Eini, Ebrahim, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elbarazi, Iffat, Elema, Teshome Bekele, Elemam, Noha Mousaad, Elgar, Frank J, Elgendy, Islam Y, ElGohary, Ghada Metwally Tawfik, Elhabashy, Hala Rashad, Elhadi, Muhammed, El-Huneidi, Waseem, Elilo, Legesse Tesfaye, Elmeligy, Omar Abdelsadek Abdou, Elmonem, Mohamed A, Elshaer, Mohammed, Elsohaby, Ibrahim, Emeto, Theophilus I, Engelbert Bain, Luchuo, Erkhembayar, Ryenchindorj, Esezobor, Christopher Imokhuede, Eshrati, Babak, Eskandarieh, Sharareh, Espinosa-Montero, Juan, Esubalew, Habtamu, Etaee, Farshid, Fabin, Natalia, Fadaka, Adewale Oluwaseun, Fagbamigbe, Adeniyi Francis, Fahim, Ayesha, Fahimi, Saman, Fakhri-Demeshghieh, Aliasghar, Falzone, Luca, Fareed, Mohammad, Farinha, Carla Sofia e Sá, Faris, MoezAlIslam Ezzat Mahmoud, Faris, Pawan Sirwan, Faro, Andre, Fasanmi, Abidemi Omolara, Fatehizadeh, Ali, Fattahi, Hamed, Fauk, Nelsensius Klau, Fazeli, Pooria, Feigin, Valery L, Feizkhah, Alireza, Fekadu, Ginenus, Feng, Xiaoru, Fereshtehnejad, Seyed-Mohammad, Feroze, Abdullah Hamid, Ferrante, Daniela, Ferrari, Alize J, Ferreira, Nuno, Fetensa, Getahun, Feyisa, Bikila Regassa, Filip, Irina, Fischer, Florian, Flavel, Joanne, Flood, David, Florin, Bobirca Teodor, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Behzad, Foroutan, Masoud, Forthun, Ingeborg, Fortuna, Daniela, Foschi, Matteo, Fowobaje, Kayode Raphael, Francis, Kate Louise, Franklin, Richard Charles, Freitas, Alberto, Friedman, Joseph, Friedman, Sara D, Fukumoto, Takeshi, Fuller, John E, Fux, Blima, Gaal, Peter Andras, Gadanya, Muktar A, Gaidhane, Abhay Motiramji, Gaihre, Santosh, Gakidou, Emmanuela, Galali, Yaseen, Galles, Natalie C, Gallus, Silvano, Ganbat, Mandukhai, Gandhi, Aravind P, Ganesan, Balasankar, Ganiyani, Mohammad Arfat, Garcia-Gordillo, MA, Gardner, William M, Garg, Jalaj, Garg, Naval, Gautam, Rupesh K, Gbadamosi, Semiu Olatunde, Gebi, Tilaye Gebru, Gebregergis, Miglas W, Gebrehiwot, Mesfin, Gebremeskel, Teferi Gebru, Georgescu, Simona Roxana, Getachew, Tamirat, Gething, Peter W, Getie, Molla, Ghadiri, Keyghobad, Ghahramani, Sulmaz, Ghailan, Khalid Yaser, Ghasemi, Mohammad-Reza, Ghasempour Dabaghi, Ghazal, Ghasemzadeh, Afsaneh, Ghashghaee, Ahmad, Ghassemi, Fariba, Ghazy, Ramy Mohamed, Ghimire, Ajnish, Ghoba, Sama, Gholamalizadeh, Maryam, Gholamian, Asadollah, Gholamrezanezhad, Ali, Gholizadeh, Nasim, Ghorbani, Mahsa, Ghorbani Vajargah, Pooyan, Ghoshal, Aloke Gopal, Gill, Paramjit Singh, Gill, Tiffany K, Gillum, Richard F, Ginindza, Themba G, Girmay, Alem, Glasbey, James C, Gnedovskaya, Elena V, Göbölös, Laszlo, Godinho, Myron Anthony, Goel, Amit, Golchin, Ali, Goldust, Mohamad, Golechha, Mahaveer, Goleij, Pouya, Gomes, Nelson G M, Gona, Philimon N, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C, Goulart, Bárbara Niegia Garcia, Goyal, Anmol, Grada, Ayman, Graham, Simon Matthew, Grivna, Michal, Grosso, Giuseppe, Guan, Shi-Yang, Guarducci, Giovanni, Gubari, Mohammed Ibrahim Mohialdeen, Gudeta, Mesay Dechasa, Guha, Avirup, Guicciardi, Stefano, Guimarães, Rafael Alves, Gulati, Snigdha, Gunawardane, Damitha Asanga, Gunturu, Sasidhar, Guo, Cui, Gupta, Anish Kumar, Gupta, Bhawna, Gupta, Manoj Kumar, Gupta, Mohak, Gupta, Rajat Das, Gupta, Rajeev, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vijai Kumar, Gupta, Vivek Kumar, Gurmessa, Lami, Gutiérrez, Reyna Alma, Habibzadeh, Farrokh, Habibzadeh, Parham, Haddadi, Rasool, Hadei, Mostafa, Hadi, Najah R, Haep, Nils, Hafezi-Nejad, Nima, Hailu, Alemayehu, Haj-Mirzaian, Arvin, Halboub, Esam S, Hall, Brian J, Haller, Sebastian, Halwani, Rabih, Hamadeh, Randah R, Hameed, Sajid, Hamidi, Samer, Hamilton, Erin B, Han, Chieh, Han, Qiuxia, Hanif, Asif, Hanifi, Nasrin, Hankey, Graeme J, Hanna, Fahad, Hannan, Md Abdul, Haque, Md Nuruzzaman, Harapan, Harapan, Hargono, Arief, Haro, Josep Maria, Hasaballah, Ahmed I, Hasan, Ikramul, Hasan, M Tasdik, Hasani, Hamidreza, Hasanian, Mohammad, Hashi, Abdiwahab, Hasnain, Md Saquib, Hassan, Ikrama, Hassanipour, Soheil, Hassankhani, Hadi, Haubold, Johannes, Havmoeller, Rasmus J, Hay, Simon I, He, Jiawei, Hebert, Jeffrey J, Hegazi, Omar E, Heidari, Golnaz, Heidari, Mohammad, Heidari-Foroozan, Mahsa, Helfer, Bartosz, Hendrie, Delia, Herrera-Serna, Brenda Yuliana, Herteliu, Claudiu, Hesami, Hamed, Hezam, Kamal, Hill, Catherine L, Hiraike, Yuta, Holla, Ramesh, Horita, Nobuyuki, Hossain, Md Mahbub, Hossain, Sahadat, Hosseini, Mohammad-Salar, Hosseinzadeh, Hassan, Hosseinzadeh, Mehdi, Hosseinzadeh Adli, Ahmad, Hostiuc, Mihaela, Hostiuc, Sorin, Hsairi, Mohamed, Hsieh, Vivian Chia-rong, Hsu, Rebecca L, Hu, Chengxi, Huang, Junjie, Hultström, Michael, Humayun, Ayesha, Hundie, Tsegaye Gebreyes, Hussain, Javid, Hussain, M Azhar, Hussein, Nawfal R, Hussien, Foziya Mohammed, Huynh, Hong-Han, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ibrahim, Khalid S, Iftikhar, Pulwasha Maria, Ijo, Desta, Ikiroma, Adalia I, Ikuta, Kevin S, Ikwegbue, Paul Chukwudi, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Imam, Mohammad Tarique, Immurana, Mustapha, Inamdar, Sumant, Indriasih, Endang, Iqhrammullah, Muhammad, Iradukunda, Arnaud, Iregbu, Kenneth Chukwuemeka, Islam, Md Rabiul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Ismail, Faisal, Ismail, Nahlah Elkudssiah, Iso, Hiroyasu, Isola, Gaetano, Iwagami, Masao, Iwu, Chidozie C D, Iyamu, Ihoghosa Osamuyi, Iyer, Mahalaxmi, J, Linda Merin, Jaafari, Jalil, Jacob, Louis, Jacobsen, Kathryn H, Jadidi-Niaragh, Farhad, Jafarinia, Morteza, Jafarzadeh, Abdollah, Jaggi, Khushleen, Jahankhani, Kasra, Jahanmehr, Nader, Jahrami, Haitham, Jain, Nityanand, Jairoun, Ammar Abdulrahman, Jaiswal, Abhishek, Jamshidi, Elham, Janko, Mark M, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayapal, Sathish Kumar, Jayaram, Shubha, Jebai, Rime, Jee, Sun Ha, Jeganathan, Jayakumar, Jha, Anil K, Jha, Ravi Prakash, Jiang, Heng, Jin, Yingzhao, Johnson, Olatunji, Jokar, Mohammad, Jonas, Jost B, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshua, Charity Ehimwenma, Joshy, Grace, Jozwiak, Jacek Jerzy, Jürisson, Mikk, K, Vaishali, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kadir, Dler Hussein, Kalani, Rizwan, Kalankesh, Laleh R, Kalankesh, Leila R, Kaliyadan, Feroze, Kalra, Sanjay, Kamal, Vineet Kumar, Kamarajah, Sivesh Kathir, Kamath, Rajesh, Kamiab, Zahra, Kamyari, Naser, Kanagasabai, Thanigaivelan, Kanchan, Tanuj, Kandel, Himal, Kanmanthareddy, Arun R, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kannan S, Suthanthira, Kansal, Sushil Kumar, Kantar, Rami S, Kapoor, Neeti, Karajizadeh, Mehrdad, Karanth, Shama D, Karasneh, Reema A, Karaye, Ibraheem M, Karch, André, Karim, Asima, Karimi, Salah Eddin, Karimi Behnagh, Arman, Kashoo, Faizan Zaffar, Kasnazani, Qalandar Hussein Abdulkarim, Kasraei, Hengameh, Kassebaum, Nicholas J, Kassel, Molly B, Kauppila, Joonas H, Kaur, Navjot, Kawakami, Norito, Kayode, Gbenga A, Kazemi, Foad, Kazemian, Sina, Kazmi, Tahseen Haider, Kebebew, Getu Mosisa, Kebede, Adera Debella, Kebede, Fassikaw, Keflie, Tibebeselassie S, Keiyoro, Peter Njenga, Keller, Cathleen, Kelly, Jaimon Terence, Kempen, John H, Kerr, Jessica A, Kesse-Guyot, Emmanuelle, Khajuria, Himanshu, Khalaji, Amirmohammad, Khalid, Nauman, Khalil, Anees Ahmed, Khalilian, Alireza, Khamesipour, Faham, Khan, Ajmal, Khan, Asaduzzaman, Khan, Gulfaraz, Khan, Ikramullah, Khan, Imteyaz 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Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabish, Mohammad, TADAKAMADLA, JYOTHI, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tang, Hong K, Tarigan, Ingan Ukur, Tariku, Mengistie Kassahun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Rishu, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Thomas, Nikhil Kenny, Thomson, Azalea M, Thrift, Amanda G, Thum, Chern Choong Chern, Thygesen, Lau Caspar, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L
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- 2024
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4. Plasmodium falciparum population structure and genetic diversity of cell traversal protein for ookinetes and sporozoites (CelTOS) during malaria resurgences in Dielmo, Senegal
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Wotodjo, Amélé Nyedzie, Oboh, Mary Aigbiremo, Sokhna, Cheikh, Diagne, Nafissatou, Diène-Sarr, Fatoumata, Trape, Jean-François, Doucouré, Souleymane, Amambua-Ngwa, Alfred, and D'Alessandro, Umberto
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- 2023
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5. Knowledge, attitude and perception of West Africans towards COVID-19: a survey to inform public health intervention
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Udoakang, Aniefiok John, Djomkam Zune, Alexandra Lindsey, Tapela, Kesego, Owoicho, Oloche, Fagbohun, Ifeoluwa Kayode, Anyigba, Claudia Adzo, Lowe, Mat, Nganyewo, Nora Nghochuzie, Keneme, Bineta, Olisaka, Frances Ngozi, Henry-Ajala, Agatha Nkem, Oboh, Mary Aigbiremo, Paemka, Lily, and Amenga-Etego, Lucas N
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- 2022
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6. Multiple Plasmodium falciparum drug resistance polymorphisms identified in a pregnant woman with severe malaria and a concomitant spontaneous abortion in Cross River, Nigeria, West Africa
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Oboh, Mary Aigbiremo, Faal, Fatou, Adeniji, Oluwagbemisola Elizabeth, Correa, Simon, Amawu, Anthony Uyimulam, Ogban, Ekon, Heinz, Eva, Hughes, Grant, Meremikwu, Martin M., and Amambua-Ngwa, Alfred
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- 2022
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7. Comparative analysis of four malaria diagnostic tools and implications for malaria treatment in southwestern Nigeria
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Oboh, Mary Aigbiremo, Oriero, Eniyou Cheryl, Ndiaye, Tolla, Badiane, Aida Sadikh, Ndiaye, Daouda, and Amambua-Ngwa, Alfred
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- 2021
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8. Rising report of Plasmodium vivax in sub-Saharan Africa: Implications for malaria elimination agenda
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Oboh, Mary Aigbiremo, Oyebola, Kolapo Muyiwa, Idowu, Emmanuel Taiwo, Badiane, Aida Sadikh, Otubanjo, Olubunmi Adetoro, and Ndiaye, Daouda
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- 2020
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9. Translation of genomic epidemiology of infectious pathogens: Enhancing African genomics hubs for outbreaks
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Oboh, Mary Aigbiremo, Omoleke, Semeeh Akinwale, Ajibola, Olumide, Manneh, Jarra, Kanteh, Abdoulie, Sesay, Abdul-Karim, and Amambua-Ngwa, Alfred
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- 2020
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10. Detection of novel Plasmodium falciparum coronin gene mutations in a recrudescent ACT-treated patient in South-Western Nigeria.
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Ajibaye, Olusola, Olukosi, Yetunde Adeola, Oriero, Eniyou C., Oboh, Mary Aigbiremo, Iwalokun, Bamidele, Nwankwo, Ikechukwu Chidiebere, Nnam, Chinaza Favour, Adaramoye, Olawunmi Victoria, Chukwemeka, Somadina, Okanazu, Judith, Gabriel, Eniafe, Balogun, Emmanuel Oluwadare, and Amambua-Ngwa, Alfred
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PLASMODIUM falciparum ,GENETIC mutation ,MICROFILAMENT proteins ,MONTE Carlo method ,TREATMENT failure - Abstract
Background: Routine surveillance for antimalarial drug resistance is critical to sustaining the efficacy of artemisinin-based Combination Therapies (ACTs). Plasmodium falciparum kelch-13 (Pfkelch-13) and non-Pfkelch-13 artemisinin (ART) resistance-associated mutations are uncommon in Africa. We investigated polymorphisms in Plasmodium falciparum actin-binding protein (Pfcoronin) associated with in vivo reduced sensitivity to ART in Nigeria. Methods: Fifty-two P. falciparum malaria subjects who met the inclusion criteria were followed up in a 28-day therapeutic efficacy study of artemetherlumefantrine in Lagos, Nigeria. Parasite detection was done by microscopy and molecular diagnostic approaches involving PCR amplification of genes for Pf18S rRNA, varATS, telomere-associated repetitive elements-2 (TARE-2). Pfcoronin and Pfkelch-13 genes were sequenced bi-directionally while clonality of infections was determined using 12 neutral P. falciparum microsatellite loci and msp2 analyses. Antimalarial drugs (sulfadoxine-pyrimethamine, amodiaquine, chloroquine and some quinolones) resistance variants (DHFR_51, DHFR_59, DHFR_108, DHFR_164, MDR1_86, MDR1_184, DHPS_581 and DHPS_613) were genotyped by high-resolution melting (HRM) analysis. Results: A total of 7 (26.92%) cases were identified either as early treatment failure, late parasitological failure or late clinical failure. Of the four posttreatment infections identified as recrudescence by msp2 genotypes, only one was classified as recrudescence by multilocus microsatellites genotyping. Microsatellite analysis revealed no significant difference in the mean allelic diversity, He, (P = 0.19, Mann-Whitney test). Allele sizes and frequency per locus implicated one isolate. Genetic analysis of this isolate identified two new Pfcoronin SNVs (I68G and L173F) in addition to the P76S earlier reported. Linkage-Disequilibrium as a standardized association index, IA S, between multiple P. falciparum loci revealed significant LD (IA S = 0.2865, P=0.02, Monte-Carlo simulation) around the neutral microsatellite loci. The pfdhfr/ pfdhps/pfmdr1 drug resistance-associated haplotypes combinations, (108T/N/ 51I/164L/59R/581G/86Y/184F), were observed in two samples. Conclusion: Pfcoronin mutations identified in this study, with potential to impact parasite clearance, may guide investigations on emerging ART tolerance in Nigeria, and West African endemic countries. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Presence of additional Plasmodium vivax malaria in Duffy negative individuals from Southwestern Nigeria
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Oboh, Mary Aigbiremo, Singh, Upasana Shyamsunder, Ndiaye, Daouda, Badiane, Aida Sadikh, Ali, Nazia Anwar, Bharti, Praveen Kumar, and Das, Aparup
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- 2020
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12. Prevalence of Malaria Infection in Pregnant Women Attending Antenatal Clinics in Southern Senegal.
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Diouf, Marie Pierre, Kande, Safietou, Oboh, Mary Aigbiremo, Manga, Isaac Akhenaton, Tairou, Fassiatou, Seck, Amadou, Diallo, Abdoulaye, Lo, Aminata Colle, Sow, Doudou, Sylla, Khadime, Ndiaye, Magatte, Tine, Roger Clement, Faye, Babacar, Merle, Corinne, Amambua-Ngwa, Alfred, Miligan, Paul, and Ndiaye, Jean-Louis Abdourahim
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- 2024
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13. Knowledge, attitude and perception towards COVID-19 among representative educated sub-Saharan Africans: A cross-sectional study during the exponential phase of the pandemic.
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Udoakang, Aniefiok John, Nganyewo, Nora Nghochuzie, Djomkam Zune, Alexandra Lindsey, Olwal, Charles Ochieng', Etim, Nsikak-Abasi Aniefiok, Oboh, Mary Aigbiremo, Tapela, Kesego, Dzabeng, Francis, Adadey, Samuel Mawuli, Udoh, Agnes, Koné, Mazo, Mutungi, Joe Kimanthi, Quashie, Peter Kojo, Awandare, Gordon Akanzuwine, and Paemka, Lily
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Coronavirus disease 2019 (COVID-19) pandemic, caused by the Severe Acute Coronavirus 2 (SARS-CoV-2), is a global health threat with extensive misinformation and conspiracy theories. Therefore, this study investigated the knowledge, attitude and perception of sub-Saharan Africans (SSA) on COVID-19 during the exponential phase of the pandemic. In this cross-sectional survey, self-administered web-based questionnaires were distributed through several online platforms. A total of 1046 respondents from 35 SSA countries completed the survey. The median age was 33 years (18–76 years) and about half (50.5%) of them were males. More than 40% across all socio-demographic categories except the Central African region (21.2%), vocational/secondary education (28.6%), student/unemployed (35.5%), had high COVID-19 knowledge score. Socio-demographic factors and access to information were associated with COVID-19 knowledge. Bivariate analysis revealed that independent variables, including the region of origin, age, gender, education and occupation, were significantly (p < 0.05) associated with COVID-19 knowledge. Multivariate analysis showed that residing in East (odds ratio [OR]: 7.9, 95% confidence interval (CI): 4.7–14, p<0.001), Southern (OR: 3.7, 95% CI: 2.1–6.5, p<0.001) and West (OR: 3.9, 95% CI: 2.9–5.2, p<0.001) Africa was associated with high COVID-19 knowledge level. Apart from East Africa (54.7%), willingness for vaccine acceptance across the other SSA regions was <40%. About 52%, across all socio-demographic categories, were undecided. Knowledge level, region of origin, age, gender, marital status and religion were significantly (p < 0.05) associated with COVID-19 vaccine acceptance. About 67.4% were worried about contracting SARS-CoV-2, while 65.9% indicated they would consult a health professional if exposed. More than one-third of the respondents reported that their governments had taken prompt measures to tackle the pandemic. Despite high COVID-19 knowledge in our study population, most participants were still undecided regarding vaccination, which is critical in eliminating the pandemic. Therefore, extensive, accurate, dynamic and timely education in this aspect is of ultimate priority. [ABSTRACT FROM AUTHOR]
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- 2024
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14. High genetic and haplotype diversity in vaccine candidate Pfceltos but not Pfrh5 among malaria-infected children in Ibadan, Nigeria.
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Oboh, Mary Aigbiremo, Asmorom, Naemy, Falade, Catherine, Ojurongbe, Olusola, and Thomas, Bolaji N.
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INSECTICIDE resistance ,GENETIC variation ,MOLECULAR evolution ,MALARIA vaccines ,DNA vaccines ,VACCINE effectiveness - Abstract
Malaria remains a global public health challenge. The disease has a great impact in sub-Saharan Africa among children under five years of age and pregnant women. Malaria control programs targeting the parasite and mosquitoes vectors with combinational therapy and insecticide-treated bednets are becoming obsolete due to the phenomenon of resistance, which is a challenge for reducing morbidity and mortality. Malaria vaccines would be effective alternative to the problem of parasite and insecticide resistance, but focal reports of polymorphisms in malaria candidate antigens have made it difficult to design an effective malaria vaccine. Therefore, studies geared towards elucidating the polymorphic pattern and how genes targeted for vaccine design evolve are imperative. We have carried out molecular and genetic analysis of two genes encoding vaccine candidates-the Plasmodium falciparum cell traversal ookinetes and sporozoites (Pfceltos) and P. falciparum reticulocyte binding protein 5 (Pfrh5) in parasite isolates from malaria-infected children in Ibadan, Nigeria to evaluate their genetic diversity, relatedness and pattern of molecular evolution. Pfceltos and Pfrh5 genes were amplified from P. falciparum positive samples. Amplified fragments were purified and sequenced using the chain termination method. Post-sequence edit of fragments and application of various population genetic analyses was done. We observed a higher number of segregating sites and haplotypes in the Pfceltos than in Pfrh5 gene, the former also presenting higher haplotype (0.942) and nucleotide diversity (θ = 0:01219 and π = 0:01148). In contrast, a lower haplotype (0.426) and nucleotide diversity (θ = 0:00125; π = 0:00095) was observed in the Pfrh5 gene. Neutrality tests do not show deviation from neutral expectations for Pfceltos, with the circulation of multiple low frequency haplotypes (Tajima's D=0.21637; Fu and Li's D=0.08164; Fu and Li's F = -0.14051). Strong linkage disequilibrium was observed between variable sites, in each of the genes studied. We postulate that the high diversity and circulation of multiple haplotypes has the potential of making a Pfceltos-subunit vaccine ineffective, while the low genetic diversity of Pfrh5 gene substantiates its evolutionary conservation and potential as a malaria vaccine candidate. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Evolution of the Ace-1 and Gste2 Mutations and Their Potential Impact on the Use of Carbamate and Organophosphates in IRS for Controlling Anopheles gambiae s.l. , the Major Malaria Mosquito in Senegal.
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Diallo, Moussa, Kolley, Ebrima SM, Dia, Abdoulaye Kane, Oboh, Mary Aigbiremo, Seck, Fatoumata, Manneh, Jarra, Sesay, Abdul Karim, Diédhiou, Seynabou Macote, Sarr, Pape Cheikh, Sy, Ousmane, Samb, Badara, Gaye, Oumar, Faye, Ousmane, Konaté, Lassana, Assogba, Benoit Sessinou, and Niang, El Hadji Amadou
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Widespread of insecticide resistance amongst the species of the Anopheles gambiae complex continues to threaten vector control in Senegal. In this study, we investigated the presence and evolution of the Ace-1 and Gste2 resistance genes in natural populations of Anopheles gambiae s.l., the main malaria vector in Senegal. Using historical samples collected from ten sentinel health districts, this study focused on three different years (2013, 2017, and 2018) marking the periods of shift between the main public health insecticides families (pyrethroids, carbamates, organophosphates) used in IRS to track back the evolutionary history of the resistance mutations on the Ace-1 and Gste2 loci. The results revealed the presence of four members of the Anopheles gambiae complex, with the predominance of An. arabiensis followed by An. gambiae, An. coluzzii, and An. gambiae–coluzzii hybrids. The Ace-1 mutation was only detected in An. gambiae and An. gambiae–coluzzii hybrids at low frequencies varying between 0.006 and 0.02, while the Gste2 mutation was found in all the species with a frequency ranging between 0.02 and 0.25. The Ace-1 and Gste2 genes were highly diversified with twenty-two and thirty-one different haplotypes, respectively. The neutrality tests on each gene indicated a negative Tajima's D, suggesting the abundance of rare alleles. The presence and spread of the Ace-1 and Gste2 resistance mutations represent a serious threat to of the effectiveness and the sustainability of IRS-based interventions using carbamates or organophosphates to manage the widespread pyrethroids resistance in Senegal. These data are of the highest importance to support the NMCP for evidence-based vector control interventions selection and targeting. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Evaluation of decreased haematocrit and haemoglobin levels in Plasmodium falciparum infected individuals from South-western Nigeria
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Oboh, Mary Aigbiremo, Diongue, Khadim, Diallo, Mamadou Alpha, Badiane, Aida S., and Ndiaye, Daouda
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malaria burden, Plasmodium falciparum, vulnerable, parasite density, haemoglobin, haematocrit, anaemia - Abstract
Objective: Plasmodium parasite is responsible for the breakdown of red blood cells, resulting into life threatening situation. Thus, an observational study of the parasitaemic impact of P. falciparum on some haematological parameters in comparison to non-infected individuals was carried out in two endemic state of Nigeria (Edo and Lagos).Methodology and Results: Blood samples collected from individuals (from September 2016-March, 2017) aged 2 years and above, were subjected to rapid diagnostic test (RDT) and microscopy assay to determine the presence of P. falciparum. Further, auto-haematology analyser and/or microcentrifuge where available were employed to acquire information on the haematocrit and haemoglobin levels. Of the 2376 collected samples, three hundred (12.6%) were positive by RDT, out of which Plasmodium falciparum was detected microscopically in 137. The mean haematocrit (PCV) level (37.36±0.37) of the negative samples was significantly higher (p
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- 2020
17. High and persistent circulation of Plasmodium falciparum drug resistant isolates in Nigeria
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Oboh, Mary Aigbiremo, Diongue, Khadim, and Ndiaye, Daouda
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- 2019
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18. EFFICACY OF PIPERONYL BUTOXIDE (PBO) SYNERGIST ON PYRETHROID AND DICHLORODIPHENYL TRICHLOROETHANE (DDT) RESISTANT MOSQUITOES IN LEKKI, LAGOS STATE, NIGERIA.
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OLUSEGUN-JOSEPH, Taiye Shade, OBOH, Mary Aigbiremo, AWONIYI, Adedayo Michael, ADEBOWALE, Afolabi, AGBASO, Martins, and FAGBOHUN, Ifeoluwa Kayode
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PIPERONYL butoxide ,PYRETHROIDS ,DDT (Insecticide) ,INSECTICIDE resistance - Abstract
Vector control using insecticide is an integral part of the global strategy for management of mosquito-borne diseases.. The development of insecticides resistance is a major concern in mosquito control. We evaluated the effect of piperonyl butoxide (PBO) synergist on dichlorodiphenyl trichloroethane (DDT) and pyrethroids resistant Anopheles gambiae s.l., Culex quinquefasciatus and Aedes aegypti in Lekki peninsula area of Lagos State, Nigeria. Mosquito larval collected from breeding sites in Lekki peninsula were allowed to emerge in the insectary and identified using appropriate morphological keys. Two-three days old female adults were subjected to susceptibility assays using WHO kits and insecticides impregnated test papers. Twenty (20) female adult mosquitoes of each genus were exposed to DDT (4%) and permethrin (0.75%) alone. Subsequently, another set of 20 of each genus were pre-exposed to PBO (4%) for 1 hour before exposing them to permethrin and DDT, all assays were carried out in four biological replicates. The knockdown time was recorded as the time intervals for 60 minutes and mortality at 24 hour. Resistance to DDT was detected with percentages mortality of 55, 60 and 87.5% for An. gambiae, Cx. quinquefasciatus and Ae. aegypti species respectively. Pre-exposure of mosquitoes to PBO significantly suppressed (p<0.05) resistance to both DDT and permethrin in all the mosquito species indicating the activities of P450 monooxygenase as a detoxifying enzymes mediating resistance to DDT and pyrethroids. Therefore, PBO should be incorporated in insecticide resistance management strategies in this area and others with similar mosquitos' resistance profile. [ABSTRACT FROM AUTHOR]
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- 2020
19. Beyond SARS-CoV-2: Lessons That African Governments Can Apply in Preparation for Possible Future Epidemics.
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Oboh, Mary Aigbiremo, Omoleke, Semeeh Akinwale, Imafidon, Christian Eseigbe, Ajibola, Olumide, Oriero, Eniyou Cheryll, and Amambua-Ngwa, Alfred
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- 2020
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20. Molecular epidemiology and evolution of drug-resistant genes in the malaria parasite Plasmodium falciparum in southwestern Nigeria.
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Oboh, Mary Aigbiremo, Singh, Upasana Shyamsunder, Antony, Hiasindh Ashmi, Ndiaye, Daouda, Badiane, Aida Sadikh, Ali, Nazia Anwar, Bharti, Praveen Kumar, and Das, Aparup
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MOLECULAR epidemiology , *PLASMODIUM falciparum , *MALARIA prevention , *DISEASE incidence , *ANTIMALARIALS - Abstract
Abstract Malaria is an age-old disease of human kind living in the tropical and sub-tropical regions of the globe, with Africa contributing the highest incidence of morbidity and mortality. Among many hurdles, evolution and spread of drug-resistant Plasmodium falciparum parasites constitute major challenges to malaria control and elimination. Information on molecular epidemiology and pattern of evolution of genes conferring resistance to different antimalarials are needed to track the route of the spread of resistant parasites and also to inform if the drug-resistant genes are adapted in the population following the Darwinian model of evolution. In the present study, we have followed molecular methods to detect both the known and emerging mutations in three genes (Pfcrt , Pfdhfr and Pfdhps) of P. falciparum conferring resistance to chloroquine and sulfadoxine-pyrimethamine from two different states (Edo: meso-endemic and Lagos: hypo-endemic) in southwestern Nigeria. High diversities in haplotypes and nucleotides in genes responsible for chloroquine (Pfcrt) and sulfadoxine (Pfdhps) resistance are recorded. About 96% of Pfdhfr and Pfdhps gene in both the meso- and hypo- endemic areas were mutant type, followed by 61% in Pfcrt gene. Many unique haplotypes of Pfdhps and Pfcrt were found to be segregated in these two populations. One particular mutant haplotype of Pfdhfr (AIRNI) was found to be in very high frequency in both Lagos and Edo. While the net haplotype diversity was highest in Pfdhps (0.81 in Lagos, 0.87 in Edo), followed by Pfcrt (0.69 in Lagos, 0.65 in Edo); highest number of haplotype was found in Pfdhps with 13 distinct haplotypes, followed by seven in Pfcrt and four in Pfdhfr gene. Moreover, detection of strong linkage among mutations of Pfcrt and Pfdhfr and feeble evidence for balancing selection in Pfdhps are indicative of evolutionary potential of mutation in genes responsible for drug resistance in Nigerian populations of P. falciparum. Highlights •We studied molecular epidemiology of three drug-resistant genes of Plasmodium falciparum in two populations in Nigeria. • Evolutionary patterns of the three drug-resistant genes were also inferred. • High haplotype and nucleotide diversities in both the populations were detected. • Some of the single nucleotide polymorphisms (SNPs) were found to be linked. • Preliminary evidences for balancing selection in Pfdhfr gene was ascertained in the study areas. [ABSTRACT FROM AUTHOR]
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- 2018
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21. Status of Artemisinin Resistance in Malaria Parasite Plasmodium falciparum from Molecular Analyses of the Kelch13 Gene in Southwestern Nigeria.
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Oboh, Mary Aigbiremo, Ndiaye, Daouda, Antony, Hiasindh Ashmi, Badiane, Aida Sadikh, Singh, Upasana Shyamsunder, Ali, Nazia Anwar, Bharti, Praveen Kumar, and Das, Aparup
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DRUG therapy for malaria , *MALARIA , *ANTIMALARIALS , *DRUG resistance in microorganisms , *MICROBIAL genetics , *GENETIC mutation , *POLYMERASE chain reaction , *PROTOZOA , *PUBLIC health , *SEQUENCE analysis , *GENETICS , *THERAPEUTICS - Abstract
Evolution and spread of malaria parasite Plasmodium falciparum capable of evading antimalarials are the prime concern to malaria control. The currently effective drug, artemisinin (ART), is under threat due to detection of ART-resistant P. falciparum parasites in the Southeast Asian countries. It has been shown that amino acid (AA) mutations at the P. falciparum Kelch13 (Pfk13) gene provide resistance to ART. Nigeria, a part of the Sub-Saharan Africa, is highly endemic to malaria, contributing quite significantly to malaria, and resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) combination drugs has already been reported. Since artemisinin combined therapy (ACT) is the first-line drug for treatment of uncomplicated malaria in Nigeria and five amino acid mutations have been validated in the Pfk13 gene alongside with candidate mutations for ART resistance, we performed molecular surveillance for mutations (following PCR and DNA sequence analyses) in this gene from two southwestern states of Nigeria. Statistical analyses of DNA sequences were also performed following different evolutionary models. None of the different validated and candidate AA mutations of Pfk13 gene conferring resistance to ART could be detected in P. falciparum sampled in the two southwestern states of Nigeria. In addition, DNA sequencing and sequence analyses indicated neither evolutionary selection pressure on the Pfk13 gene nor association of mutations in Pfk13 gene with mutations of other three genes conferring resistance to CQ and SP. Therefore, based on the monomorphism at the Pfk13 gene and nonassociation of mutations of this gene with mutations in three other drug-resistant genes in malaria parasite P. falciparum, it can be proposed that malaria public health is not under immediate threat in southwestern Nigeria concerning ART resistance. [ABSTRACT FROM AUTHOR]
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- 2018
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22. Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria.
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Oboh, Mary Aigbiremo, Badiane, Aida Sadikh, Ntadom, Godwin, Ndiaye, Yaye Die, Diongue, Khadim, Diallo, Mamadou Alpha, and Ndiaye, Daouda
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- *
PLASMODIUM , *MALARIA , *PLASMODIUM vivax , *RIBOSOMAL RNA , *DUFFY blood group system , *NUCLEOTIDE sequencing , *RNA sequencing , *BLOOD testing - Abstract
Background: Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. Plasmodium vivax is thought to be absent in Nigeria in particular and sub-Saharan Africa in general, due to the near fixation of the Duffy negative gene in this population. Nevertheless, there are frequent reports of P. vivax infection in Duffy negative individuals in the sub-region, including reports from two countries sharing border with Nigeria to the west (Republic of Benin) and east (Cameroon). Additionally, there were two cases of microscopic vivax-like malaria from Nigerian indigenous population. Hence molecular surveillance of the circulating Plasmodium species in two states (Lagos and Edo) of southwestern Nigeria was carried out. Methods: A cross-sectional survey between September 2016 and March 2017 was conducted. 436 febrile patients were included for the present work. Venous blood of these patients was subjected to RDT as well as microscopy. Further, parasite DNA was isolated from positive samples and PCR diagnostic was employed followed by direct sequencing of the 18S rRNA of Plasmodium species as well as sequencing of a portion of the promoter region of the Duffy antigen receptor for chemokines. Samples positive for P. vivax were re-amplified several times and finally using the High Fidelity Taq to rule out any bias introduced. Results: Of the 256 (58.7%) amplifiable malaria parasite DNA, P. falciparum was, as expected, the major cause of infection, either alone 85.5% (219/256; 97 from Edo and 122 from Lagos), or mixed with P. malariae 6.3% (16/256) or with P. vivax 1.6% (4/256). Only one of the five P. vivax isolates was found to be a single infection. DNA sequencing and subsequent alignment of the 18S rRNA of P. vivax with the reference strains displayed very high similarities (100%). Remarkably, the T-33C was identified in all P. vivax samples, thus confirming that all vivax-infected patients in the current study are Duffy negative. Conclusion: The present study gave the first molecular evidence of P. vivax in Nigeria in Duffy negative individuals. Though restricted to two states; Edo in South–South and Lagos in South-west Nigeria, the real burden of this species in Nigeria and sub-Saharan Africa might have been underestimated, hence there is need to put in place a country-wide, as well as a sub-Saharan Africa-wide surveillance and appropriate control measures. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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23. Complexity of Plasmodium falciparum infection and genetic variations associated with differences in parasite clearance time in two Malian villages.
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Sissoko S, Kone A, Dara A, Oboh MA, Fofana B, Sangare CO, Dembele D, Haidara AS, Diallo N, Toure S, Haidara K, Sanogo K, Doumbo OK, Ouattar A, Amambua-Ngwa A, and Djimde AA
- Abstract
Background: Effective approaches to fight against malaria include disease prevention, an early diagnosis of malaria cases, and rapid management of confirmed cases by treatment with effective antimalarials. Artemisinin-based combination therapies are first-line treatments for uncomplicated malaria in endemic areas. However, cases of resistance to artemisinin have already been described in South-East Asia resulting in prolonged parasite clearance time after treatment. In Mali, though mutations in the K13 gene associated with delayed clearance in Asia are absent, a significant difference in parasite clearance time following treatment with artesunate was observed between two malaria endemic sites, Bougoula-Hameau and Faladje. Hypothetically, differences in complexity of Plasmodium falciparum infections may be accounted for this difference. Hence, the aims of this study were to assess the complexity of infection (COI) and genetic diversity of P. falciparum parasites during malaria treatment in Bougoula-Hameau and Faladje in Mali., Methods: Thirty (30) patients per village were randomly selected from 221 patients enrolled in a prospective artesunate monotherapy study conducted in Faladje and Bougoula-Hameau in 2016. All parasitemic blood samples of patients from enrollment to last positive slide were retained to assess malaria parasite COI and polymorphisms. DNA were extracted with a Qiagen kit and Pfcsp and Pfama1 encoding gene were amplified by nested PCR and sequenced using the Illumina platform. The parasite clearance time (PCT) was determined using the parasite clearance estimator of Worldwide Antimarial Resistance Network (WWARN). Data were analyzed with R
® ., Results: The median number of genetically distinct parasite clones was similar at enrollment, 7 (IQR of 5-9) in Faladje and 6 (IQR of 4-10) in Bougoula-Hameau (p-value = 0.1). On the first day after treatment initiation, the COI was higher in Faladje (6; CI:4-8) than in Bougoula-Hameau (4; CI:4-6) with a p-value =0. 02. Overall, COI was high with higher PCT. Finally, there was a low genetic diversity between Faladje and Bougoula-Hameau., Conclusion: This study demonstrated that the difference in PCT observed between the two villages could be due to differences in the complexity of infection of these two villages., Competing Interests: Potential conflicts of interest The authors declare no competing interests.- Published
- 2023
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24. Adopting an heterologous prime-boost strategy in COVID-19 vaccination: the need for locally generated evidence in Africa.
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Oboh MA, Omoleke S, and Salami K
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- ChAdOx1 nCoV-19, Humans, Immunogenicity, Vaccine, SARS-CoV-2, Vaccination, COVID-19 prevention & control, COVID-19 Vaccines
- Abstract
The reduction in the severity and prevalence of COVID-19 has been largely due to the rapid development and deployment of COVID-19 vaccines. Consequently, WHO, in partnership with the Coalition for Epidemic Preparedness Innovation, GAVI, the Vaccine Alliance, set up the COVID-19 Vaccines Global Access (COVAX) Initiative. The goal of this initiative is to prevent discrimination between high and low-income/middle-income countries and ensure equitable vaccine distribution. The first COVID-19 vaccine sent to most countries in the region through the COVAX initiative was the Oxford AstraZeneca (ChAdOx1 nCoV-19) vaccine. Due to the reduced protection against variants of concern, safety issues, and supply challenges of the AstraZeneca vaccine in some countries, heterologous booster dose with alternative vaccines for individuals who have received a prime dose of AstraZeneca. Moreover, vaccine mixing (heterologous vaccination) due to its superior immunogenicity and enhanced protection is being recommended even for individuals who are yet to be vaccinated. However, it is important that prior adoption, empirical data on immunogenicity, safety, and reactogenicity be locally generated in populations where such heterologous vaccine is to be implemented. Regrettably, such data from our search in all clinical trial databases is not ongoing in Africa as at the time of writing this manuscript. Therefore, this treatise advocates an experimental arm to generate such robust evidence. This will provide empirical evidence to guide this innovative approach aimed at ensuring equity and access to COVID-19 vaccines in LMICs, particularly countries within the African region., Competing Interests: The authors declare no competing interests., (Copyright: Mary Aigbiremo Oboh et al.)
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- 2022
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