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Simple Summary: Inflammasomes are intricate protein complexes initiating caspase-1 activation, resulting in the release of inflammatory cytokines and pyroptosis. In canines, the conserved NLRP3 gene and observed caspase-1/4 activity implicate the NLRP3 inflammasome in specific inflammatory ailments. Andrographolide, sourced from Andrographis paniculate, exhibits diverse biological effects, notably antioxidant and anti-inflammatory properties, with clinical studies hinting at its therapeutic potential across various diseases. This study seeks to explore andrographolide's impact on gene expression linked to the NLRP3 inflammasome and cytokines in canine blood cells. The findings indicate that andrographolide diminishes the expression of NLRP3, caspase-1/4, IL-1β, IL-18, and proinflammatory cytokines, alongside reducing IL-1β secretion. This underscores andrographolide's ability to impede inflammasome activation, thereby mitigating inflammation. Nonetheless, further research is imperative to comprehensively unravel its mechanisms and therapeutic efficacy concerning canine inflammatory conditions. Inflammasomes are multiprotein complexes that trigger processes through caspase-1 activation, leading to the maturation of proinflammatory cytokines, such as IL-1β and IL-18. The gene encoding the inflammasome stimulatory protein NLRP3 is conserved in canines. Caspase-1/4 homologues have been identified in multiple carnivores, including canines, and caspase-1 activity has been shown in humans. The NLRP3 inflammasome has also been described in some canine inflammatory diseases. Andrographolide, a labdane diterpene, is the principal active ingredient in the herb Andrographis paniculate. The objective of this study was to determine the effect of andrographolide on the gene expression of the components of the NLRP3 inflammasome, proinflammatory cytokines, and IL-1β secretion in canine peripheral blood mononuclear cells. For this, MTT assays and real-time PCR were employed to assess the cytotoxicity and gene expression. Further, an ELISA test was performed to measure the IL-1β concentration. The findings reveal that andrographolide significantly reduces the expression of NLRP3, caspase-1/4, IL-1β, and IL-18. Additionally, it decreases the secretion of IL-1β and other proinflammatory cytokines, including IL-6, IL-8, and TNF-α. The results show that andrographolide decreases the expression of NLRP3, caspase-1/4, IL-1β, and IL-18. Andrographolide also reduces proinflammatory cytokines expression, and decreases IL-1β secretion. This indicates that andrographolide can interfere with the activation and function of the inflammasome, resulting in a decrease in the inflammatory response in canines. Research in this area is still budding, and more studies are necessary to fully understand andrographolide's mechanisms of action and its therapeutic potential in relation to the NLRP3 inflammasome in dogs. [ABSTRACT FROM AUTHOR]

In a multi-source permanent magnet synchronous motor (PMSM) drive, three distinct winding structures can be implemented: multi-sector, multi-three-phase, and highly coupled. However, due to variations in the magnetic coupling between windings, their low-frequency DC-link current ripple components differ. This paper presents a method to identify the phenomena associated with each low-frequency harmonic content. Three analytical models are developed for the DC current ripple induced by unbalanced winding, counter-electromotive force (back-EMF) harmonics and aliasing effects, respectively, with the results validated through simulations. Experimental validation is conducted for highly coupled winding drives, demonstrating agreement with the analytical models and simulations. The maximum DC current ripple ratio found in the analytical model, the simulation and the experiments is less than 15 % , which is deemed acceptable for motor drive applications. [ABSTRACT FROM AUTHOR]

On 3 March 2020, the first case of COVID-19 was confirmed in Chile. Since then, the Ministry of Health has imposed mobility restrictions, a global policy implemented to mitigate the propagation of the virus. The national seismic network operating throughout Chile provides an opportunity to monitor the ambient seismic noise (ASN) and determine the effectiveness of public policies imposed to reduce urban mobility in the major cities. Herein, we analyse temporal variations in high-frequency ASN recorded by broadband and strong-motion instruments deployed throughout the main cities of Chile. We focus on the capital, Santiago, a city with more than 7 million inhabitants because it is seismically well instrumented and has high levels of urban mobility due to worker commutes inside the region. We observed strong similarities between anthropogenic seismic noise and human mobility indicators, as shown in the difference between urban and rural amplitudes, long-term variations, and variability due to the COVID-19 outbreak. The same results are observed in other cities such as Iquique, La Serena, and Concepción. Our findings suggest that the initially implemented public health policies and the early end to confinement in mid-April 2020 in the metropolitan region caused an increase in mobility and virus transmission, where the peak in anthropogenic seismic noise coincides with the peak of the effective reproductive number from confirmed positive cases of COVID-19. These results confirm that seismic networks are capable of recording the urban mobility of population within cities, and we show that continuous monitoring of ASN can quantify urban mobility. Finally, we suggest that real-time changes in ASN amplitudes should be considered part of public health policy in further protocols in Santiago and other high-density cities of the world, as has been useful during the recent pandemic. [ABSTRACT FROM AUTHOR]

Enterohepatic Helicobacter (EHH) species have been increasingly associated with acute gastroenteritis, inflammatory bowel disease and hepatobiliary diseases in humans. However, their host range and transmission routes are poorly understood. Therefore, the aim of this study was to determine the presence of EHH in healthy dogs using both cultivation‐dependent and ‐independent methods. Three hundred and ninety faecal samples from domestic dogs without gastrointestinal symptoms were analysed between June 2018 and July 2019 in Valdivia (South of Chile). Samples were inoculated on selective medium and in parallel were filtrated over an antibiotic‐free blood agar. Both media were incubated in a microaerobic atmosphere at 37°C for 7 days. Colonies were identified by PCR and phylogenetic analysis. A subset of 50 samples (half of them positive for EHH by cultivation and the remaining half negative) was analysed by PCR‐Denaturing Gradient Gel Electrophoresis (PCR‐DGGE) for direct detection. Cultivation method detected EHH in 15.4% (60/390) of the samples, being the most prevalent species H. canis (5.8%, 23/390) and H. canicola (5.1%, 20/390), followed by H. bilis (3.6%, 14/390) and 'H. winghamensis' (1.3%, 5/390). In contrast, PCR‐DGGE method detected Helicobacter DNA in almost all (96%, 48/50) tested samples. On the other hand, the method used also allowed to isolate other Campylobacterales, in fact 44.3% (173/390) of the samples were positive for Campylobacter upsaliensis (43.3%, 169/390) followed by C. jejuni (2.0%, 8/390). Moreover, two strains that presented Campylobacter‐like morphology were finally identified as Anaerobiospirillum succiniciproducens. Our results indicate that healthy domestic dogs commonly carry EHH and other Campylobacter species. However, further studies are needed to determine whether and how these Helicobacter and Campylobacter species can be transmitted to humans. [ABSTRACT FROM AUTHOR]

On 3 March 2020, the first case of COVID-19 was confirmed in Chile. Since then, the Ministry of Health has imposed mobility restrictions, a global policy implemented to mitigate the propagation of the virus. The national seismic network operating throughout Chile provides an opportunity to monitor the ambient seismic noise (ASN) and determine the effectiveness of public policies imposed to reduce urban mobility in the major cities. Herein, we analyse temporal variations in high-frequency ASN recorded by broadband and strong-motion instruments deployed throughout the main cities of Chile. We focus on the capital, Santiago, a city with more than 7 million inhabitants, because it is seismically well-instrumented, and has high levels of urban mobility due to work commutes inside the region. We observed strong similarities between anthropogenic seismic noise and human mobility indicators, as shown in the difference between urban and rural amplitudes, long-term variations, and variability due to the COVID-19 outbreak. Our findings suggest that the initially implemented public health policies and the early deconfinement in mid-April 2020 in the metropolitan region caused an increase in mobility and virus transmission, where the peak in anthropogenic seismic noise coincides with the peak of the effective reproductive number from confirmed positive cases of COVID-19. These results confirm that seismic networks are capable of monitoring the urban mobility of population within cities, and we show that continuous monitoring of ASN can quantify urban mobility. Finally, we suggest to consider monitoring in real time the changes in ASN amplitudes to be included in the public policies about urban mobilities in Santiago as well as other high density cities of the world, as has been useful during the recent pandemic. [ABSTRACT FROM AUTHOR]

Shedding of DNA of pathogenic Leptospira spp. has been documented in naturally infected cats in several countries, but urinary shedding of infectious Leptospira spp. has only recently been proven. The climate in Southern Chile is temperate rainy with high annual precipitations which represents ideal preconditions for survival of Leptospira spp., especially during spring and summer. The aims of this study were to investigate shedding of pathogenic Leptospira spp. in outdoor cats in Southern Chile, to perform molecular characterization of isolates growing in culture, and to assess potential risk factors associated with shedding. Urine samples of 231 outdoor cats from rural and urban areas in southern Chile were collected. Urine samples were investigated for pathogenic Leptospira spp. by 4 techniques: qPCR targeting the lipL32 gene, immunomagnetic separation (IMS)-coupled qPCR (IMS-qPCR), direct culture and IMS-coupled culture. Positive urine cultures were additionally confirmed by PCR. Multilocus sequence typing (MLST) was used to molecularly characterize isolates obtained from positive cultures. Overall, 36 urine samples (15.6%, 95% confidence interval (CI) 11.4–20.9) showed positive results. Eighteen (7.8%, 95% CI 4.9–12.1), 30 (13%, 95% CI 9.2–18), 3 (1.3%, 0.3–3.9) and 4 cats (1.7%; 95% CI 0.5–4.5) were positive in qPCR, IMS-qPCR, conventional culture, and IMS-coupled culture, respectively. MLST results of 7 culture-positive cats revealed sequences that could be assigned to sequence type 17 (6 cats) and sequence type 27 (1 cat) corresponding to L. interrogans (Pathogenic Leptospira Subgroup 1). Shedding of pathogenic Leptospira spp. by cats might be an underestimated source of infection for other species including humans. The present study is the first one reporting growth of leptospires from feline urine in culture in naturally infected cats in South-America and characterisation of culture-derived isolates. So far, very few cases of successful attempts to culture leptospires from naturally infected cats are described worldwide. [ABSTRACT FROM AUTHOR]

The 2011 Tohoku-Oki megathrust earthquake and its aftershocks were well recorded by the KiK-net network in accelerographs placed inside boreholes and on the surface. These data allow comparing strong-motion records with synthetic acceleration time histories for this large magnitude earthquake that caused extensive damage in Japan. Generating synthetic accelerograms at high frequencies can be approached using different techniques. We use the stochastic method to simulate horizontal and vertical strong-motion accelerograms in hard-rock boreholes; additionally, we incorporate P, SV, and SH soil amplification transfer functions to generate surface accelerograms. We reproduce the three components of the strong motion for 18 stations of the Mw 9.0 mainshock event; additionally, we simulated 8 stations for an Mw 6.9 aftershock. Our simulated acceleration time histories show similarity in time and frequency with the acceleration records for the period band between 0.05 and 1 s. [ABSTRACT FROM AUTHOR]

Abstract: In this study, highly neutralized, highly porous, and ultralight polymeric aerogels prepared from aqueous colloidal suspensions of chitosan (CS) and chondroitin sulfate (ChS) nanocomplexes, formulated as quasi‐equimolar amounts of both, are described. These aerogels were designed as healing agents under the inspiration of minimizing the amount of matter applied to wounds, reducing the electrostatic potential of the material and avoiding covalent cross‐linkers in order to decrease metabolic stress over wounds. Aerogels synthesized under these criteria are biocompatible and provide specific properties for the induction of wound healing. They do not affect neither the metabolic activity of cultured 3T3 fibroblasts nor the biochemical parameters of experimental animals, open wounds close significantly faster and, unlike control wounds, complete reepithelialization and scarring can be attained 14 days after surgery. Because of its hydration abilities, rapid adaptation to the wound bed and the early accelerator effect of wound closure, the CS/ChS aerogels appear to be functional inducers of the healing. Previous information show that CS/ChS aerogels improve wound bed quality, increase granulation tissue and have pain suppressive effect. CS/ChS aerogels are useful as safe, inexpensive and easy to handle materials for topical applications, such as skin chronic wounds. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2464–2471, 2018. [ABSTRACT FROM AUTHOR]

According to the literature, the risk of developing iliotibial band syndrome (ITBS) is related to the running technique of each runner. The purpose of this study was to investigate whether differences exist in the running technique of runners with ITBS and healthy runners. The sample was composed of 60 recreational runners (30 healthy runners and 30 with ITBS). A 3D kinematic analysis was performed to measure 3D joint angles of the lower limb. Reaction forces in the stance phase of running were also determined. Runners in the ITBS group exhibited significantly lower contact time, knee valgus, peak knee flexion and hip rotation. Of note, gender-based differences were observed. No differences were found between groups in hip adduction angle, tibial internal rotation and foot kinematics. The runners with current ITBS showed an altered kinematic profile. Male and female runners with ITBS showed different alterations in running kinematics. These results suggest that gender should be considered when investigating the biomechanical etiology of ITBS. [ABSTRACT FROM AUTHOR]

Primary nasal canine transmissible venereal tumor (CTVT) without genital affection is uncommon. The aim of this report was to describe the primary nasal CTVT findings and CT staging in 4 dogs with different cytological phenotypes. Three male dogs and 1 bitch were evaluated for their chronic histories of sneezing, snoring, mucopurulent nasal discharge and nasal deformation. Cytological examination of nasal secretions suggested CTVT, confirmed by histopathological examination and LINE-1/c-myc. Males had the plasmacytoid phenotype of CTVT, and the bitch had the lymphocytoid phenotype. CTVT were staged based on the CT findings using modified Adams staging system. The bitch was classified as stage 1, 2 males were classified as stage 3 and 1 male as stage 4. All dogs had a complete tumoral remission after chemotherapy. Plasmacytoid phenotype was identified in cases with most important damage of the nasal cavity. However, the cytological type did not affect the response to chemotherapy. [ABSTRACT FROM AUTHOR]

The irreversible magnet demagnetisation phenomena are investigated, under both healthy and short‐circuit conditions for a switched flux permanent magnet (SFPM) machine. The temperature effects on permanent magnet material are taken into account and the influence of short‐circuit current over demagnetisation is evaluated. To calculate the short‐circuit current (mainly inter‐turn short circuit), the MATLAB/Simulink model has been employed. The aforementioned short‐circuit current is then fed to the finite‐element model, so the demagnetisation analysis can be carried out. Various fault scenarios are investigated, including a high speed and high fault severity. It is found that the short‐circuit current has limited effect on the magnet demagnetisation due to particular features of the SFPM machines. The mechanism of demagnetisation has been revealed and found out to be mainly due to temperature rise and poor PM materials utilisation. Experiments have been carried out to validate the MATLAB/Simulink model for short‐circuit current predictions. [ABSTRACT FROM AUTHOR]

This paper focuses on external volume and power consumption optimization of an electromagnetic actuator used to move pins in a two-stage variable valve lift component within an automotive engine. This system is designed to change the valve lift at each engine cycle. To achieve this optimization, three models were developed: a magnetic, an electric, and a dynamic model. They evaluate the performances of a given actuator, check if it fulfills its role, and define the springs needed for the displacement of the pins. The optimization is made using a particle swarm method and can reduce the volume up to 20% with the same electric consumption. [ABSTRACT FROM PUBLISHER]

Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim of this study is to explore the contribution of candidate genetic factors to HD AO in order to gain insight into the pathogenic mechanisms underlying this disorder. For that purpose, two AO definitions were used: the earliest age with unequivocal signs of HD (earliest AO or eAO), and the first motor symptoms age (motor AO or mAO). Multiple linear regression analyses were performed between genetic variation within 20 candidate genes and eAO or mAO, using DNA and clinical information of 253 HD patients from REGISTRY project. Gene expression analyses were carried out by RT-qPCR with an independent sample of 35 HD patients from Basque Country Hospitals. We found suggestive association signals between HD eAO and/or mAO and genetic variation within the E2F2, ATF7IP, GRIN2A, GRIN2B, LINC01559, HIP1 and GRIK2 genes. Among them, the most significant was the association between eAO and rs2742976, mapping to the promoter region of E2F2 transcription factor. Furthermore, rs2742976 T allele patient carriers exhibited significantly lower lymphocyte E2F2 gene expression, suggesting a possible implication of E2F2-dependent transcriptional activity in HD pathogenesis. Thus, E2F2 emerges as a new potential HD AO modifier factor. [ABSTRACT FROM AUTHOR]

This paper presents the numerical modeling of a classical switched reluctance motor (SRM) and a mutually coupled SRM (MCSRM); both have three phases with 12 slots and 8 poles. The multiphysics models have been developed, which can take into account the electromagnetic characteristics, mechanical vibration, and acoustic noise of the foregoing machines. A 2-D electromagnetic model has been used to calculate the magnetic force which is the main source of vibration of the entire motor system. The vibration of the motor is calculated by a mode superposition method, while the acoustic noise is predicted by a 3-D finite-element acoustic model. In order to validate the numerical models, experiments have been carried out. A good agreement between measured and numerical results has been observed, and it is found that the vibration and the noise levels of MCSRM are considerably lower than those of classical SRM. [ABSTRACT FROM PUBLISHER]

This paper presents an analytical approach for the determination of the mechanical eigenfrequencies of an electrical machine stator. This model is based on the calculation and the minimization of Rayleigh's quotient. It uses an energetic approach from beam theory applied to stators with a Timoshenko kinematic model. This model is very specially adapted for stators with a thick yoke as the high-speed machines. This approach is validated by finite-element simulations and experimental measurements. [ABSTRACT FROM AUTHOR]

We describe a 46-year-old woman who presented with a 2-year history of aprosodic speech together with apathy and disinhibition. Brain magnetic resonance imaging showed subcortical hyperintensities over both insular regions that later extended to both frontal and temporal cortices. The post-mortem exam showed a massive tau protein deposition throughout the brain. No mutation in the gene MAPT was detected. This case illustrates an atypical clinical-radiological presentation of a frontotemporal dementia with an unusual speech and abnormal signal of both insulae. Furthermore, it reinforces the crucial role of the insula in the development of symptoms in frontotemporal dementia. [ABSTRACT FROM AUTHOR]

We describe a 46-year-old woman who presented with a 2-year history of aprosodic speech together with apa-thy and disinhibition. Brain magnetic resonance imaging showed subcortical hyperintensities over both insular regions that later extended to both frontal and temporal cortices. The post-mortem exam showed a massive tau protein deposition throughout the brain. No mutation in the gene MAPT was detected. This case illustrates an atypical clinical-radiological presentation of a frontotemporal dementia with an unusual speech and abnormal signal of both insulae. Furthermore, it reinforces the crucial role of the insula in the development of symptoms in frontotemporal dementia. [ABSTRACT FROM AUTHOR]

This paper proposes a parametric optimization of a flux-switching electrical machine customized for a wind turbine application with a typical operating range for average and low-power wind energy sites. Statistics of wind resources are taken into consideration for the machine design for definition of the turbine power envelope. Both copper and iron losses for three different machine designs are evaluated. A very important consideration taken in this design is the elimination of gearbox requirements for coupling to the turbine. Although the developed approach makes the machine somewhat voluminous, the overall performance is highly improved because a direct-drive flux-switching electrical generator becomes very competitive for small-scale wind turbines. The design methodology presented in this paper will support widespread application of small-scale wind turbines for rural systems, farms, and villages. This paper concludes by demonstrating that a very cost-effective distributed wind system can be approached with this design. [ABSTRACT FROM AUTHOR]

This paper presents a new method to minimize the torque ripple of a 3-phase, 6-slot, and 4-pole mutually coupled switched reluctance motor (MCSRM 6/4). The difference between a MCSRM and a classical SRM is their winding configuration. In a MCSRM, the mutual inductances are no longer neglectable when compared to self inductance. On the contrary, due to mutual inductances, the MCSRM can produce higher average torque than a classical SRM. A literature review is firstly performed to identify the source of high torque ripple level of a MCSRM. Then, the method using punching holes in rotor poles to modify the waveforms of flux as well as derivatives of inductances with respect to rotor position (dL/d\theta and dM/d\theta) is proposed. Using the 2-D finite-element method (FEM), the influence of dimensions of punching hole on the electromagnetic performances (average torque and torque ripple) is analyzed. The two MCSRM are supplied by three-phase sine wave currents, and comparisons in terms of average torque and torque ripple versus RMS current density are also carried out. In order to make sure that the presence of punching holes does not cause mechanical problems, some mechanical studies are performed. Finally, experimental tests are also realized to validate numerical results obtained by 2-D FEM. [ABSTRACT FROM PUBLISHER]

This paper presents a fast and precise electromagnetic–thermal model of a redundant dual-star flux-switching permanent-magnet (FSPM) motor for embedded applications with driving cycles, e.g., hybrid electrical vehicle (HEV) and aerospace. This model is based on a prior steady characterization by finite-element method (FEM) 2-D of the FSPM motor via calculating the instantaneous torque and the normal and tangential components of the magnetic flux density (Br and B\theta) of each element of the stator and the rotor for different root-mean-square (RMS) current densities and different rotor positions. These results are then used in the analytical copper and iron loss models for calculating the instantaneous copper and rotor and stator iron losses during one driving cycle. The lumped-parameter (LP) and finite-element 2-D transient thermal models are then carried out, in which the previously obtained instantaneous power losses are used as heat sources for calculating the temperatures of different motor parts during driving cycles. In the thermal studies, a transformation of an irregular slot structure into a regular (rectangular) one is applied to simplify the calculation of the winding thermal resistance. The thermal–electromagnetic analysis method in this paper can also be extended for all the other applications with driving cycles. The experimental tests are carried out to validate the analytical and numerical results. [ABSTRACT FROM PUBLISHER]

An analytical method has been developed that can be used to determine the potential dermal exposure (PDE) of workers to the pesticide captan in small-scale horticultural production units. The methodology is based on the whole body dosimetry technique, using a cotton coverall and cotton gloves as sampling media, with protective clothing worn beneath the cotton media to protect the operator. The quantitative determination of captan was done by gas chromatography-electron capture detector (GC-ECD), with the analytical method validated by measuring limits of detection and quantification, linear ranges, sample recovery and precision. Special emphasis is placed on factors that affected the stability of captan during chromatographic determination. The data generated for potential dermal exposure are presented separately for mixing/loading and application activities. These data are compared with values obtained with visible tracers using a similar field technique. Margin of safety (MOS) values are also calculated for the agricultural procedures studied. [ABSTRACT FROM AUTHOR]

Simple Summary: The present study was carried out in order to determine the effect of type of pregnancy on the mammary gland development, evaluated through the transcriptional expression of genes that are associated to angiogenesis and cell turnover/lactogenesis and the metabolic response of the animals. For this, six twin and seven single-bearing ewes were fed with naturalized pasture from day −45 pre-partum until day +70 post-partum, taking samples of mammary tissue and plasma at different times from the birth until weaning. The results showed the type of pregnancy could only explain a few differences in the transcriptional expression of in some genes that are involved in angiogenesis and cell turnover/lactogenesis in the mammary gland tissue, which had no impact on the metabolic status of ewes or the metabolic response in plasma, performance, and muscle transcriptional expression of the lambs. The following study was performed in order to determine the effect of type of pregnancy on the transcriptional expression of genes that are engaged in angiogenesis and cell turnover/lactogenesis in the ewe mammary gland, evaluating its impact on the plasma metabolic response. In addition, an assessment of its further influence on plasma metabolic response, performance, and muscle transcriptional expression of lipogenic enzymes in progeny lambs was made. Thirteen Ile de France sheep (six twin- and seven single-bearing ewes) were allocated to graze ad libitum naturalized pasture from d 45 pre-partum to day 70 post-partum, while keeping their lambs on the same diet until day 60 after weaning. The samples were collected at different times and analyzed by qRT-PCR and plasma metabolic indicators. The data were processed using SPSS package. The results showed that twin-bearing ewes overexpressed VEGFR1 at birth, and BCL2 at birth and day 35 post-partum; however, single-bearing ewes overexpressed CAIV and IGF1 at day 35 post-partum. Similar metabolite concentrations in blood plasma were found between groups of ewes. The plasma metabolic response in lambs was similar between groups and it did not influence their performance, where a similar transcriptional expression of lipogenic enzymes in muscle was observed. Therefore, the type of pregnancy can explain the slight differences in mRNA expression that were found in angiogenesis and cell turnover/lactogenesis in mammary gland, although these differences not only did not affect the plasma metabolic response in ewes, but they also had no influence on plasma metabolic response, performance, and muscle transcriptional expression of their lambs. [ABSTRACT FROM AUTHOR]

Subdividing stator winding is a way to lower the DC link voltage value in electric drives and reduce the stress on motor insulation. Coupled windings sharing the same stator teeth are modelled in order to evaluate the link between voltages disparities and current ripple. This paper provides an assessment of current ripple rise in the subdivided windings compared to ordinary topologies through the use of a basic inductive model. A method for PWM-Induced current ripple and high-frequency loss estimation based on admittance measurements is developed and experimentally validated. The use of this subdivided structure does not induce more than a 10% rise of the PWM-induced current ripple compared to a standard winding structure. [ABSTRACT FROM AUTHOR]