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International audience; We present experimental observations of the spatial distribution of large inertial particles suspended in a turbulent swirling flow at high Reynolds number. The plastic particles, which are tracked using several high speed cameras, are heavier than the working fluid so that their dynamics results from a competition between gravitational effects and turbulent agitation. We observe two different regimes of suspension. At low rotation rate, particles are strongly confined close to the bottom and are not able to reach the upper region of the tank whatever their size or density. At high rotation rate, particles are loosely confined: small particles become nearly homogeneously distributed while very large objects are preferentially found near the top as if gravity was reversed. We discuss these observations in light of a minimal model of random walk accounting for particle inertia and show that large particles have a stronger probability to remain in the upper part of the flow because they are too large to reach descending flow regions. As a consequence particles exhibit random horizontal motions near the top until they reach the central region where the mean flow vanishes, or until a turbulent fluctuation gets them down.

Purpose: TAVR has emerged as a standard approach for treating severe aortic stenosis patients. However, it is associated with several clinical complications, including subclinical leaflet thrombosis characterized by Hypoattenuated Leaflet Thickening (HALT). A rigorous analysis of TAVR device thrombogenicity considering anatomical variations is essential for estimating this risk. Clinicians use the Sinotubular Junction (STJ) diameter for TAVR sizing, but there is a paucity of research on its influence on TAVR devices thrombogenicity., Methods: A Medtronic Evolut® TAVR device was deployed in three patient models with varying STJ diameters (26, 30, and 34mm) to evaluate its impact on post-deployment hemodynamics and thrombogenicity, employing a novel computational framework combining prosthesis deployment and fluid- structure interaction analysis., Results: The 30 mm STJ patient case exhibited the best hemodynamic performance: 5.94 mmHg mean transvalvular pressure gradient (TPG), 2.64 cm 2 mean geometric orifice area (GOA), and the lowest mean residence time (T R ) - indicating a reduced thrombogenic risk; 26 mm STJ exhibited a 10 % reduction in GOA and a 35% increase in mean TPG compared to the 30 mm STJ; 34 mm STJ depicted hemodynamics comparable to the 30 mm STJ, but with a 6% increase in T R and elevated platelet stress accumulation., Conclusion: A smaller STJ size impairs adequate expansion of the TAVR stent, which may lead to suboptimal hemodynamic performance. Conversely, a larger STJ size marginally enhances the hemodynamic performance but increases the risk of TAVR leaflet thrombosis. Such analysis can aid pre- procedural planning and minimize the risk of TAVR leaflet thrombosis.