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418 results on '"Okuda, Takashi"'

2. Solidified magma reservoir derived from active source seismic experiments in the Aira caldera, southern Kyushu, Japan

Author

Miyamachi, Hiroki, Yakiwara, Hiroshi, Kobayashi, Reiji, Hirano, Shuichiro, Kubo, Takeshi, Souda, Masakazu, Sakao, Kenyu, Unno, Naohiro, Matsushima, Takeshi, Uchida, Kazunari, Miyamachi, Rintaro, Isoda, Kenshin, Teguri, Yoshiko, Kamiya, Yoshinosuke, Triahadini, Agnis, Shimizu, Hiroshi, Katao, Hiroshi, Shibutani, Takuo, Tameguri, Takeshi, Yamashita, Yusuke, Miura, Tsutomu, Nakagawa, Jun, Yoneda, Itaru, Kato, Shinya, Takishita, Kosei, Nakai, Kazuho, Maeda, Yuta, Watanabe, Toshiki, Horikawa, Shinichiro, Matsushiro, Kenjiro, Okuda, Takashi, Tsuji, Shuhei, Sogawa, Naoki, Hasegawa, Daima, Nakahigashi, Kazuo, Kurashimo, Eiji, Yamada, Tomoaki, Abe, Hideji, Ando, Miwako, Tanaka, Shinichi, Ikezawa, Satoshi, Iwasaki, Takaya, Shinohara, Masanao, Sato, Toshinori, Yamamoto, Mare, Azuma, Ryosuke, Hirahara, Satoshi, Nakayama, Takashi, Suzuki, Syuichi, Otomo, Shuhei, Hino, Ryota, Tsutsui, Tomoki, Inoue, Yusuke, Takei, Ryuichi, Tada, Yuya, Takahashi, Hiroaki, Murai, Yoshio, Aoyama, Hiroshi, Ohzono, Mako, Shiina, Takahiro, Takada, Masamitsu, Ichiyanagi, Masayoshi, Yamaguchi, Teruhiro, Ono, Natsuki, Saito, Kazuma, Ito, Chihiro, Susukida, Yuuki, Nakagaki, Tatsuya, Tanaka, Yasuhisa, and Akinaga, Yasuhiko

Published
2023
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18. Population Genomics of Two Closely Related Anhydrobiotic Midges Reveals Differences in Adaptation to Extreme Desiccation.

Author

Shaikhutdinov, Nurislam M, Klink, Galya V, Garushyants, Sofya K, Kozlova, Olga S, Cherkasov, Alexander V, Kikawada, Takahiro, Okuda, Takashi, Pemba, Dylo, Shagimardanova, Elena I, Penin, Aleksey A, Deviatiiarov, Ruslan M, Gazizova, Guzel R, Cornette, Richard, Gusev, Oleg A, and Bazykin, Georgii A

Subjects
GENE families, GENOMICS, DIPTERA, BIOLOGICAL evolution
Abstract

The sleeping chironomid Polypedilum vanderplanki is capable of anhydrobiosis, a striking example of adaptation to extreme desiccation. Tolerance to complete desiccation in this species is associated with emergence of multiple paralogs of protective genes. One of the gene families highly expressed under anhydrobiosis and involved in this process is protein-L-isoaspartate (D-aspartate) O-methyltransferases (PIMTs). Recently, another closely related midge was discovered, Polypedilum pembai , which is able not only to tolerate desiccation but also to survive multiple desiccation–rehydration cycles. To investigate the evolution of anhydrobiosis in these species, we sequenced and assembled the genome of P. pembai and compared it with P. vanderplanki and also performed a population genomics analysis of several populations of P. vanderplanki and one population of P. pembai. We observe positive selection and radical changes in the genetic architecture of the PIMT locus between the two species, including its amplification in the P. pembai lineage. In particular, PIMT-4 , the most highly expressed of these PIMTs , is present in six copies in the P. pembai ; these copies differ in expression profiles, suggesting possible sub- or neofunctionalization. The nucleotide diversity of the genomic region carrying these new genes is decreased in P. pembai, but not in the orthologous region carrying the ancestral gene in P. vanderplanki , providing evidence for a selective sweep associated with postduplication adaptation in the former. Overall, our results suggest an extensive relatively recent and likely ongoing adaptation of the mechanisms of anhydrobiosis. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy

Author

Hara, Tasuku, Ohara, Tomoya, Taniguchi, Masashi, Sakai, Toshiaki, Oka, Kohei, Iwai, Naoto, Tsuji, Toshifumi, Okuda, Takashi, Komaki, Toshiyuki, Sakagami, Junichi, and Kagawa, Keizo

Subjects
Article Subject, virus diseases, digestive system diseases
Abstract

A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR.

Published
2020
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41. 834 ASSOCIATION BETWEEN THE COOL TEMPERATURE-DEPENDENT SUPPRESSION OF GASTROINTESTINAL PERISTALSIS AND TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 ACTIVATION

Author

Sugino, Satoshi, Inoue, Ken, Kobayashi, Reo, Hirose, Ryohei, Doi, Toshifumi, Harusato, Akihito, Dohi, Osamu, Yoshida, Naohisa, Uchiyama, Kazuhiko, Ishikawa, Takeshi, Takagi, Tomohisa, Konishi, Hideyuki, Hirai, Yasuko, Mizushima, Katsura, Naito, Yuji, Tsuji, Toshifumi, Okuda, Takashi, kagawa, Keizo, Tominaga, Makoto, Yagi, Nobuaki, and Itoh, Yoshito

Published
2023
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42. [beta]-Catenin regulates excitatory postsynaptic strength at hippocampal synapses

Author

Okuda, Takashi, Yu, Lily M.Y., Cingolani, Lorenzo A., Kemler, Rolf, and Goda, Yukiko

Subjects
Synapses -- Chemical properties, Neural transmission -- Evaluation, Cell adhesion -- Evaluation, Spine -- Evaluation, Cytoskeleton -- Chemical properties, Cytoskeletal proteins -- Chemical properties, Science and technology
Abstract

The precise contribution of the cadherin-[beta]-catenin synapse adhesion complex in the functional and structural changes associated with the pre- and postsynaptic terminals remains unclear. Here we report a requirement for endogenous [beta]-catenin in regulating synaptic strength and dendritic spine morphology in cultured hippocampal pyramidal neurons. Ablating [beta]-catenin after the initiation of synaptogenesis in the postsynaptic neuron reduces the amplitude of spontaneous excitatory synaptic responses without a concurrent change in their frequency and synapse density. The normal glutamatergic synaptic response is maintained by post-synaptic [beta]-catenin in a cadherin-dependent manner and requires the C-terminal PDZ-binding motif of [beta]-catenin but not the link to the actin cytoskeleton. In addition, ablating [beta]-catenin in post-synaptic neurons accompanies a block of bidirectional quantal scaling of glutamatergic responses induced by chronic activity manipulation. In older cultures at a time when neurons have abundant dendritic spines, neurons ablated for [beta]-catenin show thin, elongated spines and reduced proportion of mushroom spines without a change in spine density. Collectively, these findings suggest that the cadherin-[beta]-catenin complex is an integral component of synaptic strength regulation and plays a basic role in coupling synapse function and spine morphology. [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors | spine morphology | synapse adhesion proteins | quantal scaling

Published
2007

44. Factors inducing successful anhydrobiosis in the African chironomid Polypedilum vanderplanki: significance of the larval tubular nest

Author

Kikawada, Takahiro, Minakawa, Noboru, Watanabe, Masahiko, and Okuda, Takashi

Subjects
Aquatic biology -- Research, Dehydration (Physiology) -- Research, Larvae -- Research, Zoology and wildlife conservation
Abstract

The African chironomid Polypedilum vanderplanki exhibits anhydrobiosis, i.e., the larvae can survive complete desiccation. Recovery rate and trehalose content were investigated in larvae desiccated slowly or at a rate more than 3 times faster. Upon slow desiccation (evaporation rate 0.22 ml [day.sup.-1) larvae synthesized 38 [micro]g trehalose/individual before complete desiccation, and all of there recovered after rehydration, whereas larvae that were dehydrated quickly (evaporation rate 0.75 ml [day.sup.-1) accumulated only 6.8 [micro]g trehalose/individual and none of there revived after rehydration. In the pools that are their natural habitat P. vanderplanki larvae make tubes by incorporating detritus or soil with their sticky saliva. This tubular structure is a physical barrier not only to protect the larva from natural enemies but also induces successful anhydrobiosis by reducing the dehydration rate. When larvae were dehydrated with 100 [micro]l distilled water (DW) in soil tubes, they accumulated 37 [micro]g trehalose/individual and more than half of them could revive after rehydration, whereas larvae without tubes accumulated lower level of trehalose and none recovered after rehydration.

Published
2005

48. Phenolic Compounds in Food and Their Effects on Health II

Author

MOU-TUAN HUANG, CHI-TANG HO, CHANG Y. LEE, Chi-Tang Ho, Mou-Tuan Huang, Thomas Ferraro, John H. Weisburger, Harold L. Newmark, D. E. Pratt, Nobuji Nakatani, Takuo Okuda, Takashi Yoshida, Tsutomu Hatano, Y. Fleury, D. H. Welti, G. Philippossian, D. Magnolato, T. L. Lunder, T. Osawa, N. Ramarathnam, S

Published
1992

50. Interstitial Lung Disease Associated with Agaricus blazei Murill in a Patient with Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine-Based Therapy.

Author

Iwai, Naoto, Okuda, Takashi, Sawada, Ryo, Ohara, Tomoya, Hattori, Chie, Taniguchi, Masashi, Sakai, Hiroaki, Oka, Kohei, Hara, Tasuku, Tsuji, Toshifumi, Komaki, Toshiyuki, Sakagami, Junichi, Kagawa, Keizo, Dohi, Osamu, Yasuda, Hiroaki, and Itoh, Yoshito

Subjects
*INTERSTITIAL lung diseases, *PANCREATIC duct, *INTERFERON gamma release tests, *PULMONARY fibrosis, *DIETARY supplements
Abstract

A male in his sixties with locally advanced pancreatic ductal adenocarcinoma (PDAC) was administered gemcitabine plus nab-paclitaxel therapy. Computed tomography (CT) scans after five courses revealed nonspecific interstitial pneumonitis in addition to PDAC aggravation. No evidence of respiratory infection was detected, and his condition was stable and asymptomatic at diagnosis. Sputum test and interferon-gamma release assay revealed no evidence of tuberculosis. Through careful history taking, the patient was found to be taking dietary supplementation with Agaricus blazei Murill extract for approximately 1 month. Drug-induced lymphocyte stimulation tests for gemcitabine and nab-paclitaxel were negative, whereas those for Agaricus blazei Murill were positive. CT scans after withdrawal showed improved pneumonitis. These findings suggest a possibility that the dietary supplementation may lead to drug-induced interstitial lung disease (ILD). This patient indicates that pertinent diagnostic interviews are essential for the identification of drug-induced ILD. [ABSTRACT FROM AUTHOR]

Published
2022
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