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The paper introduces a geometrically unfitted finite element method for the numerical solution of the tangential Navier–Stokes equations posed on a passively evolving smooth closed surface embedded in \mathbb {R}^3. The discrete formulation employs finite difference and finite elements methods to handle evolution in time and variation in space, respectively. A complete numerical analysis of the method is presented, including stability, optimal order convergence, and quantification of the geometric errors. Results of numerical experiments are also provided. [ABSTRACT FROM AUTHOR]

For a nonlinear dynamical system that depends on parameters, this paper introduces a novel tensorial reduced-order model (TROM). The reduced model is projection-based, and for systems with no parameters involved, it resembles proper orthogonal decomposition (POD) combined with the discrete empirical interpolation method (DEIM). For parametric systems, TROM employs low-rank tensor approximations in place of truncated SVD, a key dimension-reduction technique in POD with DEIM. Three popular low-rank tensor compression formats are considered for this purpose: canonical polyadic, Tucker, and tensor train. The use of multilinear algebra tools allows the incorporation of information about the parameter dependence of the system into the reduced model and leads to a POD-DEIM type ROM that (i) is parameter-specific (localized) and predicts the system dynamics for out-of-training set (unseen) parameter values, (ii) mitigates the adverse effects of high parameter space dimension, (iii) has online computational costs that depend only on tensor compression ranks but not on the full-order model size, and (iv) achieves lower reduced space dimensions compared to the conventional POD-DEIM ROM. This paper explains the method, analyzes its prediction power, and assesses its performance for two specific parameter-dependent nonlinear dynamical systems. [ABSTRACT FROM AUTHOR]

This paper studies the fusogenicity of cationic liposomes in relation to their surface distribution of cationic lipids and utilizes membrane phase separation to control this surface distribution. It is found that concentrating the cationic lipids into small surface patches on liposomes, through phase-separation, can enhance liposome's fusogenicity. Further concentrating these lipids into smaller patches on the surface of liposomes led to an increased level of fusogenicity. These experimental findings are supported by numerical simulations using a mathematical model for phase-separated charged liposomes. Findings of this study may be used for design and development of highly fusogenic liposomes with minimal level of toxicity. [ABSTRACT FROM AUTHOR]

We construct and analyze a CutFEM discretization for the Stokes problem based on the Scott–Vogelius pair. The discrete piecewise polynomial spaces are defined on macro-element triangulations which are not fitted to the smooth physical domain. Boundary conditions are imposed via penalization through the help of a Nitsche-type discretization, whereas stability with respect to small and anisotropic cuts of the bulk elements is ensured by adding local ghost penalty stabilization terms. We show stability of the scheme as well as a divergence–free property of the discrete velocity outside an O(h) neighborhood of the boundary. To mitigate the error caused by the violation of the divergence–free condition, we introduce local grad–div stabilization. The error analysis shows that the grad–div parameter can scale like O(h−1), allowing a rather heavy penalty for the violation of mass conservation, while still ensuring optimal order error estimates. [ABSTRACT FROM AUTHOR]