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Febrile ulceronecrotic Mucha-Habermann disease is a rare and severe variant of pityriasis lichenoides, characterized by sudden onset of generalized ulceronecrotic papules that rapidly coalesce into ulcers associated with high fever. Systemic manifestations such as intravascular disseminated coagulation and pulmonary, cardiac, gastrointestinal, and central nervous system involvement are common. Treatment is based on oral corticosteroids, immunosuppressive drugs such as methotrexate, and general supportive treatment. The present case describes a stepwise approach to a patient with Mucha-Habermann disease with insufficient response to methotrexate. [ABSTRACT FROM AUTHOR]

Background: Pityriasis lichenoides is an uncommon papulosquamous disorder of an unknown etiology. The clinical spectrum consists of an acute ulcerative variant, pityriasis lichenoides et varioliformis acuta (PLEVA), and a chronic, non-ulcerative variant, pityriasis lichenoides chronica (PLC). A third, much more rare and aggressive form, febrile ulceronecrotic Mucha– Habermann disease (FUMHD), also occurs. Pityriasis Lichenoides is often benign, with a chronic course and with eventual spontaneous resolution over months to years. Objectives: The current study aims to evaluate the pityriasis lichenoides among patients attending Al-Sader medical city, Najaf, in the last five years, clinically and histologically. Patients and method: This is a case series performed retrospectively over the period from January 2017 through November 2021, in Najaf. Sixteen patients with clinical and histological PL were evaluated according to their medical records and online archives. A histopathological revision of their paraffin-embedded sections was also performed and statistically analyzed. Results: Sixteen patients with pityriasis lichenoides were evaluated; PLC was more common than PLEVA (14:2). PL mainly affects people in the second decade of life (37.5%). The age at the time of diagnosis ranged from 5 to 41 years, with a mean ±SD of 20.1± 9.9 years, which was higher for PLC (21.4±9.7) years than for PLEVA (11±7) years. Females outnumber males in PLC (9:5) as the only two reported cases of PLEVA were males. The skin phototype III was double that of type IV (11:5). More urban patients than rural patients were presented. The cases peak was in 2020 (31.25%), followed by 2021 (18.75). However, the clinical and histopathological features were classic and comparable to the published literature. Conclusion: PL is a disease predominant among young adults; more females were affected by PLC, while males were predominantly affected by PLEVA. More patients, who were more urban than rural, with skin phototype III were affected. [ABSTRACT FROM AUTHOR]

Pityriasis lichenoides is an acute and/or chronic skin disease associated with recurrent erythematous papules that self-resolve. While its etiology is unknown, preceding viral infection may play a role. We present an atypical case of a 40-year-old woman with pityriasis lichenoides et varioliformis acuta as a complication of a COVID-19 infection.

Background: Pityriasis lichenoides is an uncommon papulosquamous disorder of an unknown etiology. The clinical spectrum consists of an acute ulcerative variant, pityriasis lichenoides et varioliformis acuta (PLEVA), and a chronic, non-ulcerative variant, pityriasis lichenoides chronica (PLC). A third, much more rare and aggressive form, febrile ulceronecrotic Mucha–Habermann disease (FUMHD), also occurs. Pityriasis Lichenoides is often benign, with a chronic course and with eventual spontaneous resolution over months to years. Objectives: The current study aims to evaluate the pityriasis lichenoides among patients attending Al-Sader medical city, Najaf, in the last five years, clinically and histologically. Patients and method: This is a case series performed retrospectively over the period from January 2017 through November 2021, in Najaf. Sixteen patients with clinical and histological PL were evaluated according to their medical records and online archives. A histopathological revision of their paraffin-embedded sections was also performed and statistically analyzed. Results: Sixteen patients with pityriasis lichenoides were evaluated; PLC was more common than PLEVA (14:2). PL mainly affects people in the second decade of life (37.5%). The age at the time of diagnosis ranged from 5 to 41 years, with a mean ±SD of 20.1± 9.9 years, which was higher for PLC (21.4±9.7) years than for PLEVA (11±7) years. Females outnumber males in PLC (9:5) as the only two reported cases of PLEVA were males. The skin phototype III was double that of type IV (11:5). More urban patients than rural patients were presented. The cases peak was in 2020 (31.25%), followed by 2021 (18.75). However, the clinical and histopathological features were classic and comparable to the published literature. Conclusion: PL is a disease predominant among young adults; more females were affected by PLC, while males were predominantly affected by PLEVA. More patients, who were more urban than rural, with skin phototype III were affected.

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) that is characterized by a large ulceronecrotic appearance with high fever and a variety of systemic symptoms. We report here a case of FUMHD in a 17-year-old male Chinese patient who was treated successfully with a combination therapy of methotrexate, methylprednisolone, and intravenous immunoglobulin. In addition, a literature review was conducted to summarize the key characteristics of paediatric FUMHD cases.

Pityriasis lichenoides is an acute and/or chronic skin disease associated with recurrent erythematous papules that self-resolve. While its etiology is unknown, preceding viral infection may play a role. We present an atypical case of a 40-year-old woman with pityriasis lichenoides et varioliformis acuta as a complication of a COVID-19 infection. [ABSTRACT FROM AUTHOR]

Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare, potentially fatal subtype of pityriasis lichenoides et varioliformis acuta (PLEVA). Herein, we present a rare case of a 14-year-old male without significant past medical history who was diagnosed with FUMHD without a clear inciting factor. He was effectively treated with systemic corticosteroids with complete resolution of symptoms. [ABSTRACT FROM AUTHOR]

We observed ten children with a papular eruption with purpuric features during the SARS‐CoV‐2 pandemic in Northern Italy (May‐December 2020). Histological examination showed signs of SARS‐CoV‐2‐related dermatosis. Evidence of nucleocapsid viral proteins using SARS‐CoV‐2 (2019‐nCoV) nucleocapsid antibody revealed cuticular staining of the deep portion of the eccrine glands in all cases. [ABSTRACT FROM AUTHOR]

Objective Pityriasis ichenoides consists of Pityriasis Lichenoides et Varioliformis Acuta and Pityriasis Lichenoides Chronica. It might resolve spontaneously and without important sequelae such as lymphoma. This study aims to evaluate the demographic and clinical pictures of both types of pityriasis lichenoides. Methods This is a clinical descriptive study on a long-term basis, in which patients with a clinical picture of pityriasis lichenoides were collected during the period between 2012 and 2020. Any triggering factors before the onset of the disease were noted and biopsies for histopathological evaluation were carried out. Results Fifty-six patients with pityriasis lichenoides were evaluated; no obvious triggering factors were elucidated in both types. The acute form consisted of 16 (80%) males and 4 (20%) females. Their age range was from 5 to30 years with a median of around 17years. All presented with acute generalized erythematous necrotic lesions with burning and itching, simulating chicken pox that left hyperpigmentation after recovery. The chronic form consisted of 36 cases. Their age range was from 3 to 12 years with a median of 7 years; 31 (86%) were males and 5 (13.8%) were females. All cases had a slow course of progression over months and years. Fourteen patients (38.8%) were seen with generalized non-itchy erythematous papules with mica-like scales whereas 24 (66.66%) presented with hypopigmented lesions. Conclusion Both acute and chronic forms are self-limiting conditions that stay for weeks to years and remit spontaneously. They are considered as an immune reaction to specific triggering factors such as an infection. [ABSTRACT FROM AUTHOR]

Competing Interests: None disclosed.

Dermatologists make their clinical diagnosis mostly through skin reaction patterns. This study was done to assess the correlation between the clinical diagnoses of papulosquamous lesions made at dermatological clinics and the diagnosis of these lesions at biopsy. Our study lends insight into the list of most common to least common lesions of papulosquamous lesions. This is a cross-sectional study conducted at a dermatological clinic, on those patients who consulted to a dermatologist. This presumptive investigation on papulosquamous lesion was implied on 83 patients as lichen planus, lichen nitidus, lichen striata, lichenoides dermatitis, psoriasis, pityriasis rubra pilaris, pityriasis rosea, pityriasis lichenoides, pityriasis lichenoides et varioliformis acuta (PLEVA) and Reiter's disease and then the biopsy was performed on these patients for the confirmation of the clinical diagnosis to assess that diagnosis given by biopsy in these patients matched to the clinical diagnosis and whether it showed any deviation from the clinical diagnosis made by dermatologist. The histopathology report confirmed the clinical diagnosis in 67.5 % and gave the diagnosis in 32.5 % of the total number of cases, which means that 32.5 % cases were those in which the diagnosis provided by the biopsy did not match the diagnosis provided by the clinical diagnosis. The total number of cases was 83: lichen planus occurred most frequently, i.e. 32.5 %, biopsy confirmed diagnosis in 21 patients and gave correct diagnosis in six patients, followed by psoriasis 24.1 %. In the case of psoriasis, seven patients were misdiagnosed at clinics, and in these patients, biopsy gave the correct diagnosis of psoriasis. The frequency of pityriasis rubra pilaris and lichenoides dermatitis was the same, 14.5 %. About six patients with pityriasis rubra pilaris and six cases with lichenoides dermatitis were given wrong diagnosis at clinics, and the correct diagnosis was provided at biopsy; PLEVA was diagnosed in 6 % of the cases and pityriasis rosea in 3.6 %. Reiter's disease occurred in about 2.4 % of the cases and lichen nitidus and lichen striata in 1.2 % of the cases. Biopsy gave the correct diagnosis of one patient with pityriasis rubra pilaris, one with Reiter's disease and one with PLEVA. This research investigation, postulated and enquired on the basis of histopathology reports, confirmed the clinical hypothesis in 67.5 % of cases and gave the diagnosis in 32.5 % of the total number of cases. These results verified the aforementioned hypothesis that the patients who are diagnosed with the papulosquamous lesion must undergo biopsy for the confirmation of the disease. [ABSTRACT FROM AUTHOR]

ABSTRACT Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare, idiopathic, acquired dermatosis that can affect all ages and ethnic groups. We present a 10-year-old patient with FUMHD associated with arthritis and chronic fatigue, managed with methotrexate. Through our literature review, we also explore treatment protocols for a disease for which internationally standardized management is yet to be formulated. [ABSTRACT FROM AUTHOR]

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology. Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously described. This report may support the involvement of viral infection in the etiopathogeny of this disease., (Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.)

Objective: Pityriasis lichenoides et varioliformis acuta (PLEVA) is characterized by 2-3 mm erythematous papules that became vesiculopustular with hemorrhagic necrosis. Methode&Material: A 45-year-old lady, a known case of parathyroid adenoma, presented with a generalized itchy skin rash starting four days after radiocontrast iodide injection. Result: There are some reports of provocation of PLEVA by tegafur and astemizole. Conclusion: We report for the first time the triggering of PLEVA by radiocontrast iodide injection. [ABSTRACT FROM AUTHOR]