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Continuous deep brain stimulation (cDBS) of the subthalamic nucleus (STN) or globus pallidus is an effective treatment for the motor symptoms of Parkinson's disease. The relative benefit of one region over the other is of great interest but cannot usually be compared in the same patient. Simultaneous DBS of both regions may synergistically increase the therapeutic benefit. Continuous DBS is limited by a lack of responsiveness to dynamic, fluctuating symptoms intrinsic to the disease. Adaptive DBS (aDBS) adjusts stimulation in response to biomarkers to improve efficacy, side effects, and efficiency. We combined bilateral DBS of both STN and globus pallidus (dual target DBS) in a prospective within-participant, clinical trial in six patients with Parkinson's disease (n = 6, 55–65 years, n = 2 females). Dual target cDBS was tested for Parkinson's disease symptom control annually over 2 years, measured by motor rating scales, on time without dyskinesia, and medication reduction. Random amplitude experiments probed system dynamics to estimate parameters for aDBS. We then implemented proportional-plus-integral aDBS using a novel distributed (off-implant) architecture. In the home setting, we collected tremor and dyskinesia scores as well as individualized β and DBS amplitudes. Dual target cDBS reduced motor symptoms as measured by Unified Parkinson's Disease Rating Scale (UPDRS) to a greater degree than either region alone (P < 0.05, linear mixed model) in the cohort. The amplitude of β-oscillations in the STN correlated to the speed of hand grasp movements for five of six participants (P < 0.05, Pearson correlation). Random amplitude experiments provided insight into temporal windowing to avoid stimulation artefacts and demonstrated a correlation between STN β amplitude and DBS amplitude. Proportional plus integral control of aDBS reduced average power, while preserving UPDRS III scores in the clinic (P = 0.28, Wilcoxon signed rank), and tremor and dyskinesia scores during blinded testing at home (n = 3 , P > 0.05, Wilcoxon ranked sum). In the home setting, DBS power reductions were slight but significant. Dual target cDBS may offer an improvement in treatment of motor symptoms of Parkinson's disease over DBS of either the STN or globus pallidus alone. When combined with proportional plus integral aDBS, stimulation power may be reduced, while preserving the increased benefit of dual target DBS. [ABSTRACT FROM AUTHOR]

The National Science Foundation (NSF) Artificial Intelligence (AI) Institute for Edge Computing Leveraging Next Generation Networks (Athena) seeks to foment a transformation in modern edge computing by advancing AI foundations, computing paradigms, networked computing systems, and edge services and applications from a completely new computing perspective. Led by Duke University, Athena leverages revolutionary developments in computer systems, machine learning, networked computing systems, cyber‐physical systems, and sensing. Members of Athena form a multidisciplinary team from eight universities. Athena organizes its research activities under four interrelated thrusts supporting edge computing: Foundational AI, Computer Systems, Networked Computing Systems, and Services and Applications, which constitute an ambitious and comprehensive research agenda. The research tasks of Athena will focus on developing AI‐driven next‐generation technologies for edge computing and new algorithmic and practical foundations of AI and evaluating the research outcomes through a combination of analytical, experimental, and empirical instruments, especially with target use‐inspired research. The researchers of Athena demonstrate a cohesive effort by synergistically integrating the research outcomes from the four thrusts into three pillars: Edge Computing AI Systems, Collaborative Extended Reality (XR), and Situational Awareness and Autonomy. Athena is committed to a robust and comprehensive suite of educational and workforce development endeavors alongside its domestic and international collaboration and knowledge transfer efforts with external stakeholders that include both industry and community partnerships. [ABSTRACT FROM AUTHOR]

Internet of Things (IoT) technologies enable development of reconfigurable manufacturing systems—a new generation of modularized industrial equipment suitable for highly customized manufacturing. Sequential control in these systems is largely based on discrete events, whereas their formal execution semantics is specified as control interpreted Petri nets (CIPN). Despite industry-wide use of programming languages based on the CIPN formalism, formal verification of such control applications in the presence of adversarial activity is not supported. Consequently, in this article, we introduce security-aware modeling and verification techniques for CIPN-based sequential control applications. Specifically, we show how CIPN models of networked industrial IoT controllers can be transformed into time Petri net (TPN)-based models and composed with plant and security-aware channel models in order to enable system-level verification of safety properties in the presence of network-based attacks. Additionally, we introduce realistic channel-specific attack models that capture adversarial behavior using nondeterminism. Moreover, we show how verification results can be utilized to introduce security patches and facilitate design of attack detectors that improve system resiliency and enable satisfaction of critical safety properties. Finally, we evaluate our framework on an industrial case study. Note to Practitioners—Our main goal is to provide formal security guarantees for distributed sequential controllers. Specifically, we target smart automation controllers geared toward Industrial IoT applications that are typically programed in C/C++ and are running applications originally designed in, for example, GRAFCET (IEC 60848)/SFC (IEC 61131-3) automation programming languages. Since existing tools for the design of distributed automation do not support system-level verification of relevant safety properties, we show how security-aware transceiver and communication models can be developed and composed with distributed controller models. Then, we show how existing tools for verification of time Petri nets can be used to verify relevant properties including safety and liveness of the distributed automation system in the presence of network-based attacks. To provide an end-to-end analysis as well as security patching, results of our analysis can be used to deploy suitable firmware updates during the stage when executable code for target controllers (e.g., in C/C++) is generated based on GRAFCET/SFC control models. We also show that security guarantees can be improved as the relevant safety/liveness properties can be verified after corresponding security patches are deployed. Finally, we show applicability of our framework on a realistic distributed pneumatic manipulator. [ABSTRACT FROM AUTHOR]

A digital microfluidic biochip (DMFB) enables the miniaturization of immunoassays, point-of-care clinical diagnostics, and DNA sequencing. A recent generation of DMFBs uses a microelectrode-dot-array (MEDA) architecture, which provides fine-grained control of droplets and real-time droplet sensing using CMOS technology. However, microelectrodes in a MEDA biochip can degrade due to charge trapping when they are repeatedly charged and discharged during bioassay execution; such degradation leads to the failure of microelectrodes and erroneous bioassay outcomes. To address this problem, we first introduce a new microelectrode-cell design such that we can obtain the health status of all the microelectrodes in a MEDA biochip by employing the inherent sensing mechanism. Next, we present a stochastic game-based model for droplet manipulation, and a formal synthesis method for droplet routing that can dynamically change droplet transportation routes. This adaptation is based on the real-time health information obtained from microelectrodes. Comprehensive simulation results for four real-life bioassays show that our method increases the likelihood of successful bioassay completion with negligible impact on time-to-results. [ABSTRACT FROM AUTHOR]

A digital microfluidic biochip (DMFB) enables miniaturization of immunoassays, point-of-care clinical diagnostics, and DNA sequencing. A recent generation of DMFBs uses a micro-electrode-dot-array (MEDA) architecture, which provides fine-grained control of droplets and real-time droplet sensing using the CMOS technology. However, microelectrodes in a MEDA biochip degrade when they are charged and discharged frequently during bioassay execution. In this article, we first make the key observation that the droplet-sensing operations contribute up to 94% of all microelectrode actuation in MEDA. Consequently, to reduce the number of droplet-sensing operations, we present a new microelectrode cell (MC) design as well as a selective-sensing method such that only a small fraction of microelectrodes perform droplet sensing during bioassay execution. The selection of microelectrodes that need to perform the droplet sensing is based on an analysis of experimental data. A comprehensive set of simulation results show that the total number of droplet-sensing operations is reduced to only 0.7%, which prolongs the lifespan of a MEDA biochip by $11\times $ without any impact on bioassay time-to-response. [ABSTRACT FROM AUTHOR]

Recent trends in manufacturing require the use of reconfigurable equipment that facilitates rapid and cost-effective change of functionality through modular design, which supports fast integration. Intelligent devices (e.g., sensors, actuators) with integrated computation and communication capabilities enable high-level modularity, not only with the respect to hardware components but also in terms of control functionality; this can be achieved by distributing control to different network-connected devices. Thus, to enable fast and reliable system reconfigurations, in this brief, we introduce a method for distribution of control tasks and generation of control code for the devices in the control network. Our approach is based on the control interpreted Petri nets (CIPNs) formalism. We start from a CIPN capturing the centralized (overall) control system, and the mapping of input and output signals to local controllers (LCs) (i.e., smart devices) that have direct physical access to system sensors and actuators. From these, our method automatically designs distributed control tasks for LCs in the network, as well as generates control code for each LC. The applicability of the proposed method is experimentally verified on two real-world case studies. [ABSTRACT FROM AUTHOR]

Many important properties of cyber-physical systems (CPS) are defined upon the relationship between multiple executions simultaneously in continuous time. Examples include probabilistic fairness and sensitivity to modeling errors (i.e., parameters changes) for real-valued signals. These requirements can only be specified by hyperproperties. In this article, we focus on verifying probabilistic hyperproperties for CPS. To cover a wide range of modeling formalisms, we first propose a general model of probabilistic uncertain systems (PUSs) that unify commonly studied CPS models such as continuous-time Markov chains (CTMCs) and probabilistically parametrized Hybrid I/O Automata (P²HIOA). To formally specify hyperproperties, we propose a new temporal logic, hyper probabilistic signal temporal logic (HyperPSTL) that serves as a hyper and probabilistic version of the conventional signal temporal logic (STL). Considering the complexity of real-world systems that can be captured as PUSs, we adopt a statistical model checking (SMC) approach for their verification. We develop a new SMC technique based on the direct computation of significance levels of statistical assertions for HyperPSTL specifications, which requires no a priori knowledge on the indifference margin. Then, we introduce SMC algorithms for HyperPSTL specifications on the joint probabilistic distribution of multiple paths, as well as specifications with nested probabilistic operators quantifying different paths, which cannot be handled by existing SMC algorithms. Finally, we show the effectiveness of our SMC algorithms on CPS benchmarks with varying levels of complexity, including the Toyota Powertrain Control System. [ABSTRACT FROM AUTHOR]

A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a micro-electrode-dot-array (MEDA) architecture have been proposed. MEDA biochips can provide advantages of better capability of droplet manipulation and real-time sensing ability. However, errors are likely to occur due to defects, chip degradation, and the lack of precision inherent in biochemical experiments. Therefore, an efficient error-recovery strategy is essential to ensure the correctness of assays executed on MEDA biochips. By exploiting MEDA-specific advances in droplet sensing, we present a novel error-recovery technique to dynamically reconfigure the biochip using real-time data provided by on-chip sensors. Local recovery strategies based on probabilistic-timed-automata are presented for various types of errors. An online synthesis technique and a control flow are also proposed to connect local-recovery procedures with global error recovery for the complete bioassay. Moreover, an integer linear programming-based method is also proposed to select the optimal local-recovery time for each operation. Laboratory experiments using a fabricated MEDA chip are used to characterize the outcomes of key droplet operations. The PRISM model checker and three benchmarks are used for an extensive set of simulations. Our results highlight the effectiveness of the proposed error-recovery strategy. [ABSTRACT FROM PUBLISHER]

In this work, we focus on securing cyber-physical systems (CPS) in the presence of network-based attacks, such as Man-in-the-Middle (MitM) attacks, where a stealthy attacker is able to compromise communication between system sensors and controllers. Standard methods for this type of attacks rely on the use of cryptographic mechanisms, such as Message Authentication Codes (MACs) to ensure data integrity. However, this approach incurs significant computation overhead, limiting its use in resource constrained systems. Consequently, we consider the problem of scheduling multiple control tasks on a shared processor while providing a suitable level of security guarantees. Specifically, by security guarantees we refer to control performance, i.e., Quality-of-Control (QoC), in the presence of attacks. We start by mapping requirements for QoC under attack into constraints for security-aware control tasks that, besides standard control operations, intermittently perform data authentication. This allows for the analysis of the impact that security-related computation overhead has on both schedulability of control tasks and QoC. Building on this analysis, we introduce a mixed-integer linear programming-based technique to obtain a schedulable task set with predefined QoC requirements. Also, to facilitate optimal resource allocation, we provide a method to analyze interplay between available computational resources and the overall QoC under attack, and show how to obtain a schedulable task set that maximizes the overall QoC guarantees. Finally, we prove usability of our approach on a case study with multiple automotive control components. [ABSTRACT FROM AUTHOR]

A digital microfluidic biochip (DMFB) is an attractive technology platform for various biomedical applications. However, a conventional DMFB is limited by: (i) the number of electrical connections that can be practically realized, (ii) constraints on droplet size and volume, and (iii) the need for special fabrication processes and the associated reliability/yield concerns. To overcome the above challenges, DMFBs based on a microelectrode- dot-array (MEDA) architecture have been proposed and fabricated recently. Error recovery is of key interest for MEDA biochips due to the need for system reliability. Errors are likely to occur during droplet manipulation due to defects, chip degradation, and the uncertainty inherent in biochemical experiments. In this paper, we first formalize error-recovery objectives, and then synthesize optimal error-recovery protocols using a model based on Stochastic Multiplayer Games (SMGs). We also present a global error-recovery technique that can update the schedule of fluidic operations in an adaptive manner. Using three representative real-life bioassays, we show that the proposed approach can effectively reduce the bioassay completion time and increase the probability of success for error recovery. [ABSTRACT FROM AUTHOR]

Within industrial automation systems, three-dimensional (3-D) vision provides very useful feedback information in autonomous operation of various manufacturing equipment (e.g., industrial robots, material handling devices, assembly systems, and machine tools). The hardware performance in contemporary 3-D scanning devices is suitable for online utilization. However, the bottleneck is the lack of real-time algorithms for recognition of geometric primitives (e.g., planes and natural quadrics) from a scanned point cloud. One of the most important and the most frequent geometric primitive in various engineering tasks is plane. In this paper, we propose a new fast one-pass algorithm for recognition (segmentation and fitting) of planar segments from a point cloud. To effectively segment planar regions, we exploit the orthonormality of certain wavelets to polynomial function, as well as their sensitivity to abrupt changes. After segmentation of planar regions, we estimate the parameters of corresponding planes using standard fitting procedures. For point cloud structuring, a z-buffer algorithm with mesh triangles representation in barycentric coordinates is employed. The proposed recognition method is tested and experimentally validated in several real-world case studies. [ABSTRACT FROM PUBLISHER]

Purpose – The purpose of this paper is to provide a method for the generation of information machines for part mating process diagnosis. Recognition of contact states between parts during robotized part mating represents a significant element of the system for active compliant robot motion. All proposed information machines for contact states recognition will recognize one of the possible contact states even when irregular events in the process occur, and the active motion planner will continue to send commands to robot controller according to the planned trajectory. Design/methodology/approach – The presented framework is based on the general theory of automata and formal languages. Starting from possible regular contact states transitions in part mating, the authors create an automaton for diagnostics, which, besides regular, accepts all irregular (observable and unobservable) process sequences. Findings – Contact states do not appear arbitrarily during regular processes, but in certain context. Theory of automata represents a solid basis for contextual recognition and diagnosis of irregularities in part mating. Research limitations/implications – The proposed methodology is elaborated and experimentally verified using an example of cylindrical part mating, and stick-slip effect as an observable irregularity. The future work will address the generation of diagnosers for other types of part mating tasks and extension of the set of observable irregularities. Practical implications – The process diagnosis increases the robustness of active compliant motion system. Originality/value – Although very important feedback information provider for active motion planner, part mating process monitoring was not frequently addressed in the past. In this paper, the authors propose a methodology for generation of part mating process diagnoser that is based on general automata theory. [ABSTRACT FROM AUTHOR]