44 results on '"Pengqian Wang"'
Search Results
2. Identification of the susceptible genes and mechanism underlying the comorbid presence of coronary artery disease and rheumatoid arthritis: a network modularization analysis
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Siqi Zhang, Qikai Niu, Lin Tong, Sihong Liu, Pengqian Wang, Haiyu Xu, Bing Li, and Huamin Zhang
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Coronary artery disease ,Rheumatoid arthritis ,Comorbidity mechanism ,Network module ,Susceptibility gene ,Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Objective The comorbidities of coronary artery disease (CAD) and rheumatoid arthritis (RA) are mutual risk factors, which lead to higher mortality, but the biological mechanisms connecting the two remain unclear. Here, we aimed to identify the risk genes for the comorbid presence of these two complex diseases using a network modularization approach, to offer insights into clinical therapy and drug development for these diseases. Method The expression profile data of patients CAD with and without RA were obtained from the GEO database (GSE110008). Based on the differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA) was used to construct a gene network, detect co-expression modules, and explore their relation to clinical traits. The Zsummary index, gene significance (GS), and module membership (MM) were utilized to screen the important differentiated modules and hub genes. The GO and KEGG pathway enrichment analysis were applied to analyze potential mechanisms. Result Based on the 278 DEGs obtained, 41 modules were identified, of which 17 and 24 modules were positively and negatively correlated with the comorbid occurrence of CAD and RA (CAD&RA), respectively. Thirteen modules with Zsummary < 2 were found to be the underlying modules, which may be related to CAD&RA. With GS ≥ 0.5 and MM ≥ 0.8, 49 hub genes were identified, such as ADO, ABCA11P, POT1, ZNF141, GPATCH8, ATF6 and MIA3, etc. The area under the curve values of the representative seven hub genes under the three models (LR, KNN, SVM) were greater than 0.88. Enrichment analysis revealed that the biological functions of the targeted modules were mainly involved in cAMP-dependent protein kinase activity, demethylase activity, regulation of calcium ion import, positive regulation of tyrosine, phosphorylation of STAT protein, and tissue migration, etc. Conclusion Thirteen characteristic modules and 49 susceptibility hub genes were identified, and their corresponding molecular functions may reflect the underlying mechanism of CAD&RA, hence providing insights into the development of clinical therapies against these diseases.
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- 2023
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3. A molecular classification of gastric cancer associated with distinct clinical outcomes and validated by an XGBoost-based prediction model
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Bing Li, Fengbin Zhang, Qikai Niu, Jun Liu, Yanan Yu, Pengqian Wang, Siqi Zhang, Huamin Zhang, and Zhong Wang
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MT: Bioinformatics ,gastric cancer ,molecular classification ,precision oncology ,prognostic marker ,prediction model ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Gastric cancer (GC) is a heterogeneous disease and a leading cause of cancer-related deaths. Discovering robust, clinically relevant molecular classifications is critical for guiding personalized therapies for GC. Here, we propose a refined molecular classification scheme for GC using integrated optimal algorithms and multi-omics data. Based on the important features of mRNA, microRNA, and DNA methylation data selected by the multivariate Cox regression model, three subtypes linked to distinct clinical outcomes were identified by combining similarity network fusion and consensus clustering methods. Three subtypes were validated by an extreme gradient boosting machine learning prediction model with 125 differentially expressed genes in multiple independent cohorts. The molecular characteristics of mutation signatures, characteristic gene sets, driver genes, and chemotherapy sensitivity for each subtype were also identified: subtype 1 was associated with favorable prognosis and characterized by high ARID1A and PIK3CA mutations, subtype 2 was associated with a poor prognosis and harbored high recurrent TP53 mutations, and subtype 3 was associated with high CHD1, APOA1 mutations, and a poor prognosis. The proposed three-subtype scheme achieved a better clinical prediction performance (area under the curve value = 0.71) than The Cancer Genome Atlas classification, which may provide a practical subtyping framework to improve the treatment of GC.
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- 2023
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4. Modular Screening Reveals Driver Induced Additive Mechanisms of Baicalin and Jasminoidin on Cerebral Ischemia Therapy
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Bing Li, Ying Wang, Hao Gu, Yanan Yu, Pengqian Wang, Jun Liu, Yingying Zhang, Yinying Chen, Qikai Niu, Bo Wang, Qiong Liu, Shuang Guan, Yanda Li, Huamin Zhang, and Zhong Wang
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combination therapy ,synergistic effect ,cerebral ischemia ,network driver ,modular pharmacology ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Combination therapy with increased efficacy and reduced toxicity plays a crucial role in treating complex diseases, such as stroke, but it remains an insurmountable barrier to elucidate the mechanisms of synergistic effects. Here, we present a Driver-induced Modular Screening (DiMS) strategy integrated synergistic module and driver gene identification to elucidate the additive mechanisms of Baicalin (BA) and Jasminoidin (JA) on cerebral ischemia (CI) therapy. Based on anti-ischemia genomic networks BA, JA, and their combination (BJ), we obtained 4, 3, and 9 On-modules of BA, JA, and BJ by modular similarity analysis. Compared with the monotherapy groups, four additive modules (Add-module, BJ_Mod-4, 7, 9, and 13), 15 driver genes of BJ were identified by modular similarity and network control methods, and seven driver proteins (PAQR8, RhoA, EMC10, GGA2, VIPR1, FAM120A, and SEMA3F) were validated by animal experiments. The functional analysis found neuroprotective roles of the Add-modules and driver genes, such as the Neurotrophin signaling pathway and FoxO signaling pathway, which may reflect the additive mechanisms of BJ. Moreover, such a DiMS paradigm provides a new angle to explore the synergistic mechanisms of combination therapy and screen multi-targeted drugs for complex diseases.
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- 2022
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5. Potential Gene Association Studies of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis
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Xinyu Yang, Guoping Li, Manke Guan, Aneesh Bapat, Qianqian Dai, Changming Zhong, Tao Yang, Changyong Luo, Na An, Wenjing Liu, Fan Yang, Haie Pan, Pengqian Wang, Yonghong Gao, Ye Gong, Saumya Das, Hongcai Shang, and Yanwei Xing
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chemotherapy ,cardiotoxicity ,gene ,SNPs ,meta-analysis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Chemotherapy is widely used in the treatment of cancer patients, but the cardiotoxicity induced by chemotherapy is still a major concern to most clinicians. Currently, genetic methods have been used to detect patients with high risk of chemotherapy-induced cardiotoxicity (CIC), and our study evaluated the correlation between genomic variants and CIC. The systematic literature search was performed in the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), China Biology Medicine disc (CBMdisc), the Embase database, China National Knowledge Internet (CNKI) and Wanfang database from inception until June 2020. Forty-one studies were identified that examined the relationship between genetic variations and CIC. And these studies examined 88 different genes and 154 single nucleotide polymorphisms (SNPs). Our study indicated 6 variants obviously associated with the increased risk for CIC, including CYBA rs4673 (pooled odds ratio, 1.93; 95% CI, 1.13–3.30), RAC2 rs13058338 (2.05; 1.11–3.78), CYP3A5 rs776746 (2.15; 1.00–4.62) ABCC1 rs45511401 (1.46; 1.05–2.01), ABCC2 rs8187710 (2.19; 1.38–3.48), and HER2-Ile655Val rs1136201 (2.48; 1.53–4.02). Although further studies are required to validate the diagnostic and prognostic roles of these 6 variants in predicting CIC, our study emphasizes the promising benefits of pharmacogenomic screening before chemotherapy to minimize the CIC.
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- 2021
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6. Development of a Core Outcome Set for the Benefits and Adverse Events of Acute Heart Failure in Clinical Trials of Traditional Chinese Medicine and Western Medicine: A Study Protocol
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Ruijin Qiu, Songjie Han, Xuxu Wei, Changming Zhong, Min Li, Jiayuan Hu, Pengqian Wang, Chen Zhao, Jing Chen, and Hongcai Shang
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acute heart failure ,core outcome set ,integrative medicine ,methodology ,safety and efficacy ,study protocol ,Medicine (General) ,R5-920 - Abstract
Aims: To identify a minimum set of efficacy and adverse events for patients with acute heart failure (AHF) among different stakeholders in clinical trials of traditional Chinese medicine and Western medicine.Methods and Analysis: First, we will develop a preliminary long list of outcomes that includes efficacy and adverse events/reactions via three steps: (i) systematic reviews of efficacy and safety outcomes for clinical trials of AHF; (ii) drugs included in the National Medical Insurance Catalog, the National Essential Medicines Catalog, and the WHO Essential Medicines List will be collected and safety outcomes extracted from the package inserts; and (iii) patients' or caregivers' semi-structured interviews will be carried out to add new viewpoints to the list. Second, after merging outcomes and grouping them under different outcome domains, questionnaires for health professionals and patients will be separately developed. Further, two rounds of Delphi survey for health professionals and a survey for patients and the public will be carried out. Third, different stakeholders will discuss and determine the final core outcome set (COS) for AHF in a consensus meeting.Ethics and Dissemination: The entire project has been approved by the Ethics Committee of the main institution. After the final COS is developed, it will be published and discussed widely in conferences.Clinical Trial Registration: This study is registered with the Core Outcome Measures in Effectiveness Trials database as study 1566 (available at: https://www.cometinitiative.org/Studies/Details/1566).
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- 2021
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7. Deciphering the scalene association among type‐2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease‐gene network
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Qiong Liu, Yingying Zhang, Pengqian Wang, Jun Liu, Bing Li, Yanan Yu, Hongli Wu, Ruixia Kang, Xiaoxu Zhang, and Zhong Wang
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chronic myeloid leukemia ,overlapping gene and module ,prostate cancer ,therapeutic prediction ,type 2 diabetes mellitus ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract The potential biological relationship between type‐2 diabetes mellitus (T2DM) has been focused in numerous studies. To investigate the molecular associations among T2DM, prostate cancer (PCa), and chronic myeloid leukemia (CML), using a biomolecular network enrichment analysis. We obtained a list of disease‐related genes and constructed disease networks. Then, GO enrichment analysis was performed to identify the significant functions and pathways of overlapping modules in the Database for Annotation, Visualization and Integrated Discovery (DAVID) database. More than 75% of these overlapping genes were found to be consistent with the findings of previous studies. In the three diseases, we found that Sarcoglycan delta (SGCD) and Rho family GTPase 3 (RND3) were the overlapping genes and identified negative regulation of apoptotic process and negative regulation of transcription from RNA polymerase II promoter RNA as the two overlapping biological functions. CML and PCa were the most closely related, with 34 overlapping genes, five overlapping modules, 27 overlapping biological functions, and nine overlapping pathways. There were 13 overlapping genes, one overlapping modules, four overlapping biological functions and one overlapping pathway (FoxO signaling pathway) were found in T2DM and CML.And T2DM and PCa were the least related pair in our study, with only six overlapping genes, five overlapping modules, and one overlapping biological function. SGCD and RND3 were the main gene‐to‐gene relationship among T2DM, CML, and PCa; apoptosis, development, and transcription from RNA polymerase II promote processes were the main functional connections among T2DM, CML, and PCa by network enrichment analysis. There is a “scalene” relationship among T2DM, CML, and PCa at gene, pathway, biological process, and module levels: CML and PCa were the most closely related, the second were T2DM and PCa, and T2DM and PCa were the least related pair in our study. Our study provides a new avenue for further studies on T2DM and cancers, which may promote the discovery and development of novel therapeutic and can be used to treat multiple diseases.
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- 2019
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8. IMCC: A Novel Quantitative Approach Revealing Variation of Global Modular Map and Local Inter-Module Coordination Among Differential Drug’s Targeted Cerebral Ischemic Networks
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Pengqian Wang, Yanan Yu, Jun Liu, Bing Li, Yingying Zhang, Dongfeng Li, Wenjuan Xu, Qiong Liu, and Zhong Wang
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IMCC ,modular map rewiring ,inter-module coordination ,multiple-target drug ,cerebral ischemia ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Stroke is a common disease characterized by multiple genetic dysfunctions. In this complex disease, detecting the strength of inter-module coordination (genetic community interaction) and subsequent modular rewiring is essential to characterize the reactive biosystematic variation (biosystematic perturbation) brought by multiple-target drugs, whose effects are achieved by hitting on a series of targets (target profile) jointly. Here, a quantitative approach for inter-module coordination and its transition, named as IMCC, was developed. Applying IMCC to mouse cerebral ischemia–related gene microarray, we investigated a holistic view of modular map and its rewiring from ischemic stroke to drugs (baicalin, BA; ursodeoxycholic acid, UA; and jasminoidin, JA) perturbation states and locally identified the cooperative pathological module pair and its dissection. Our result suggested the global modular map in cerebral ischemia exhibited a characteristic “core–periphery” architecture, and this architecture was rewired by the effective drugs heterogeneously: BA and UA converged modules into an intensively connected integrity, whereas JA diverged partial modules and widened the remaining inter-module paths. Locally, the PMP dissociation brought by drugs contributed to the reversion of the pathological condition: the focus of the cellular function shift from survival after nervous system injury into development and repair, including neurotrophin regulation, hormone releasing, and chemokine signaling activation. The core targets and mechanisms were validated by in vivo experiments. Overall, our result highlights the holistic inter-module coordination rearrangement rather than a target or a single module that brings phenotype alteration. This strategy may lead to systematically explore detailed variation of inter-module pharmacological action mode of multiple-target drugs, which is the principal problem of module pharmacology for network-based drug discovery.
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- 2021
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9. Divergence and Convergence of Cerebral Ischemia Pathways Profile Deciphers Differential Pure Additive and Synergistic Mechanisms
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Penglu Wei, Pengqian Wang, Bing Li, Hao Gu, Jun Liu, and Zhong Wang
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additive effect ,synergistic effect ,signaling pathway ,cerebral ischemia ,pure mechanism ,Therapeutics. Pharmacology ,RM1-950 - Abstract
AimThe variable mechanisms on additive and synergistic effects of jasminoidin (JA)-Baicalin (BA) combination and JA-ursodeoxycholic acid (UA) combination in treating cerebral ischemia are not completely understood. In this study, we explored the differential pure mechanisms of additive and synergistic effects based on pathway analysis that excluded ineffective interference.MethodsThe MCAO mice were divided into eight groups: sham, vehicle, BA, JA, UA, Concha Margaritifera (CM), BA-JA combination (BJ), and JA-UA combination (JU). The additive and synergistic effects of combination groups were identified by cerebral infarct volume calculation. The differentially expressed genes based on a microarray chip containing 16,463 oligoclones were uploaded to GeneGo MetaCore software for pathway analyses and function catalogue. The comparison of specific pathways and functions crosstalk between different groups were analyzed to reveal the underlying additive and synergistic pharmacological variations.ResultsAdditive BJ and synergistic JU were more effective than monotherapies of BA, JA, and UA, while CM was ineffective. Compared with monotherapies, 43 pathways and six functions were found uniquely in BJ group, with 33 pathways and three functions in JU group. We found six overlapping pathways and six overlapping functions between BJ and JU groups, which mainly involved central nervous system development. Thirty-seven specific pathways and 10 functions were activated by additive BJ, which were mainly related to cell adhesion and G-protein signaling; and 27 specific pathways and three functions of synergistic JU were associated with regulation of metabolism, DNA damage, and translation. The overlapping and distinct pathways and functions may contribute to different additive and synergistic effects.ConclusionThe divergence pathways of pure additive effect of BJ were mainly related to cell adhesion and G-protein signaling, while the pure synergistic mechanism of JU depended on metabolism, translation and DNA damage. Such a systematic analysis of pathways may provide an important paradigm to reveal the pharmacological mechanisms underlying drug combinations.
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- 2020
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10. Genome Analysis Reveals a Synergistic Mechanism of Ursodeoxycholic Acid and Jasminoidin in Mice Brain Repair After Ischemia/Reperfusion: Crosstalk Among Muti-Pathways
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Yingying Zhang, Haixia Li, Huan Guo, Bing Li, Zide Zhao, Pengqian Wang, Hongli Wu, Jun Liu, Yinying Chen, Xiaoxu Zhang, Ping Wu, Zhong Wang, and Jie Wang
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cerebral ischemia ,synergistic mechanism ,GeneGo MetaCore™ software ,signaling pathway ,network analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Studies have shown that combination drug therapy which corresponding treatment involves multiple genes and targets is more effective against cerebral ischemia. To identify the synergistic mechanism of ursodeoxycholic acid and jasminoidin based on differential pathway network, which protect against brain ischemia-reperfusion injury. Totally 115 mice with focal cerebral ischemia-reperfusion injury were allocated into five groups: sham, vehicle, ursodeoxycholic acid (UA), jasminoidin (JA), and JA and UA combination group (JU). The differentially expressed genes identified by microarray which consisted of 11,644 complementary DNAs were loaded to the GeneGo MetaCore™ software to analyze the enriched pathways and processes among different groups. Of the top 10 pathways and process networks, 5, 6, and 3 overlapping pathways as well as 5, 3, and 4 overlapping process networks were observed between UA and JA, UA and JU, and JA and JU, respectively. Of these, three pathways and three process networks overlapped across the three groups. Interestingly, four representative pathways and six process networks were only noted in the JU group. Gene Ontology process analysis showed 2 processes were shared by all three treatment groups in the top 10 processes. The UA and JA combination resulted in synergistic effects through affecting multi-signal transduction pathways, different locations in the same pathway, and the new signaling pathway emerged in drug combination group, those together may enhance the treatment of cerebral ischemia-reperfusion injury through promoting neural cell apoptosis, decreasing calcium levels, inhibiting inflammation, and protecting neurons.
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- 2019
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11. Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke
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Pengqian Wang, Li Dai, Weiwei Zhou, Jing Meng, Miao Zhang, Yin Wu, Hairu Huo, Xingjiang Xiong, and Feng Sui
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Huang-Lian-Jie-Du decoction ,stroke ,inter-module analysis ,pharmacological mechanism ,network pharmacology ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Huang-Lian-Jie-Du Decoction (HLJDD) is a "Fangji" made up of well-designed Chinese herb array and widely used to treat ischemic stroke. Here we aimed to investigate pharmacological mechanism by introducing an inter-module analysis to identify an overarching view of target profile and action mode of HLJDD. Stroke-related genes were obtained from OMIM (Online Mendelian Inheritance in Man). And the potential target proteins of HLJDD were identified according to TCMsp (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform). The two sets of molecules related to stroke and HLJDD were respectively imported into STRING database to construct the stroke network and HLJDD network, which were dissected into modules through MCODE, respectively. We analyzed the inter-module connectivity by quantify "coupling score" (CS) between HLJDD-modules (H-modules) and stroke-modules (S-module) to explore the pharmacological acting pattern of HLJDD on stroke. A total of 267 stroke-related proteins and 15 S-modules, 335 HLJDD putative targeting proteins, and 13 H-modules were identified, respectively. HLJDD directly targeted 28 proteins in stroke network, majority (16, 57.14%) of which were in S-modules 1 and 4. According to the modular map based on inter-module CS analysis, H-modules 1, 2, and 8 densely connected with S-modules 1, 3, and 4 to constitute a module-to-module bridgeness, and the enriched pathways of this bridgeness with top significance were TNF signaling pathway, HIF signaling pathway, and PI3K-Akt signaling pathway. Furthermore, through this bridgeness, H-modules 2 and 4 cooperatively work together to regulate mitochondrial apoptosis against the ischemia injury. Finally, the core protein in H-module 4 account for mitochondrial apoptosis was validated by an in vivo experiment. This study has developed an integrative approach by inter-modular analysis for elucidating the "shotgun-like" pharmacological mechanism of HLJDD for stroke.
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- 2019
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12. Mining the Synergistic Core Allosteric Modules Variation and Sequencing Pharmacological Module Drivers in a Preclinical Model of Ischemia
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Yingying Zhang, Zide Zhao, Yanan Yu, Jun Liu, Pengqian Wang, Bing Li, Xiaoxu Zhang, Yinying Chen, and Zhong Wang
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Identifying the variation of core modules and hubs seems to be critical for characterizing variable pharmacological mechanisms based on topological alteration of disease networks. We first identified a total of eight core modules by using an approach of multiple modular characteristic fusing (MMCF) from different targeted networks in ischemic mice. Interestingly, the value of module disturbance intensity (MDI) increased in drug combination group. Second, we redefined a weak allosteric module and a strong allosteric module. Then, we identified 15 pharmacological module drivers (PMDs) by leave‐one‐out screening with a cutoff of two folds, which were at least, in part, validated by expression and variation of topological contribution. Finally, we revealed the fusional and emergent variation of PMD in core modules contributing to multidimensional synergistic mechanism in ischemic mice and rats. Our findings provide a new set of drivers that might promote the pharmacological modular flexibility and offer a potential avenue for disease treatment.
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- 2018
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13. Numerical Investigation on Co-firing Characteristics of Semi-Coke and Lean Coal in a 600 MW Supercritical Wall-Fired Boiler
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Chang’an Wang, Qinqin Feng, Qiang Lv, Lin Zhao, Yongbo Du, Pengqian Wang, Jingwen Zhang, and Defu Che
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semi-coke ,supercritical wall-fired boiler ,combustion efficiency ,NOx emission ,co-combustion ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Semi-coke is one of the principal by-products of coal pyrolysis and gasification, which features the disadvantages of ignition difficulty, low burnout rate, and high nitrogen oxides (NOx) emission during combustion process. Co-firing semi-coke with coal is a potential approach to achieve clean and efficient utilization of such low-volatile fuel. In this paper, the co-firing performance of semi-coke and lean coal in a 600 MW supercritical wall-fired boiler was numerically investigated which has been seldom done previously. The influences of semi-coke blending ratio, injection position of semi-coke, excess air ratio in the main combustion zone, the co-firing method, and over fire air (OFA) arrangement on the combustion efficiency and NOx generation characteristics of the utility boiler were extensively analyzed. The simulation results indicated that as the blending ratio of semi-coke increased, the NOx emission at furnace outlet decreased. The blending methods (in-furnace versus out-furnace) had certain impacts on the NOx emission and carbon content in fly ash, while the in-furnace blending method showed more flexibility in co-firing adjustment. The injection of semi-coke from the upper burners could significantly abate NOx emission at the furnace outlet, but also brought about the rise of carbon content in fly ash and the increase of outlet temperature. Compared with the condition that semi-coke and lean coal were injected from different burners, the burnout ratio of the blend premixed outside the furnace was higher at the same blending ratio of semi-coke. With the excess air ratio in the main combustion zone increased, NOx concentration at the furnace outlet was increased. The excess air ratio of 0.75 in the main combustion zone was recommended for co-firing 45% semi-coke with lean coal. The operational performance of the boiler co-firing semi-coke was greatly affected by the arrangement of OFA as well. The amount of NOx generated from the supercritical wall-fired boiler could be reduced with an increase of the OFA height.
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- 2019
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14. Experimental Study on NOx Reduction in Oxy-fuel Combustion Using Synthetic Coals with Pyridinic or Pyrrolic Nitrogen
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Chang’an Wang, Pengqian Wang, Lin Zhao, Yongbo Du, and Defu Che
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oxy-fuel combustion ,NOx reduction ,pyridinic nitrogen ,pyrrolic nitrogen ,synthetic coal ,mineral effect ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Oxy-fuel combustion technology can capture carbon dioxide (CO2) in the large-scale and greatly lower nitrogen oxides (NOx) emission in coal-fired power plants. However, the influence of inherent minerals on NOx reduction still remains unclear and the impact of oxy-fuel combustion on the transformation of different nitrogen functional groups has yet to be fully understood. The present work aims to obtain a further understanding of the NOx reduction during oxy-fuel combustion using synthetic coals with pyrrolic or pyridinic nitrogen. Compared to pyridinic nitrogen, more of the pyrrolic nitrogen in synthetic coal was converted to NOx. The conversion ratio of nitric oxide (NO) first increased significantly with the rising oxygen content and then trended to an asymptotically constant as the oxygen (O2) content varied between 10⁻50%. The nitrogen dioxide (NO2) formation was roughly proportional to the oxygen content. The NO2 conversion was increased with particle size but the case of NO showed a non-monotonic variation. The catalytic effects of sodium carbonate (Na2CO3), calcium carbonate (CaCO3), and ferric oxide (Fe2O3) on the transformation of pyridinic nitrogen to NO were independent of the combustion atmosphere, while the alteration from air to the oxy-fuel combustion led to a change of mineral catalytic effect on the oxidation of pyrrolic nitrogen within the coal matrix.
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- 2018
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15. Pharmacodynamics, metabolomics and pathological studies on mechanisms of traditional benefits of Angelica sinensis in blood circulation.
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Xiujuan Yang, Yunxiang Hai, Zhijun Yang, Pengqian Wang, Jiameng Li, Danli Hao, Miao Zhang, Yi Deng, and Feng Sui
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DONG quai ,PHARMACODYNAMICS ,BLOOD circulation ,TRADITIONAL knowledge ,BLOOD viscosity - Abstract
Angelica sinensis is a rich source of medically important active molecules that need in-depth understanding on its action mechanisms. Therefore, through pharmacodynamics, metabolomics, and network pharmacology, the traditional benefits of A. sinensis in blood circulation was studied using 24 randomly selected Sprague-Dawley (SD) rats. Measurement of the blood rheological parameters for whole blood viscosity (WBV) and plasma viscosity (PV), and inspection of the heart and lung tissues pathological changes were undertaken using molecular and bioinformatic techniques. Multivariate statistical analysis and establishment of the model of the relationship between metabolite expression and sample categories to test the prediction of sample categories were performed. Screening was undertaken to find the potential metabolites for A. sinensis to treat blood stasis syndrome and find related metabolic pathways. Active ingredients of A. sinensis and targets and building of an "effect component-target" network was undertaken, A. sinensis was confirmed to improve blood stasis syndrome in rats and improve heart and lung pathology to varying degrees. Compared with the blood stasis model group, A. sinensis significantly reduced WBV and PV in hemorheology (p<0.05, p<0.01) and regulated blood stasis-induced changes in 22 metabolites including alpha-D-glucose, L-isoleucine, creatine and acetylcarnitine, which are involved in the metabolism of linoleic acid, linolenic acid, phenylalanine, ascorbic acid and uronic acid. Using the network pharmacology to build a "component-target-pathway" network of A. sinensis, 62 active ingredients, 169 active proteins and 18 metabolic pathways were obtained, among which linoleic acid metabolism, ascorbic acid and uronic acid metabolism were consistent with the metabolic pathways obtained by metabolomics. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Development of a Core Outcome Set for the Benefits and Adverse Events of Acute Heart Failure in Clinical Trials of Traditional Chinese Medicine and Western Medicine: A Study Protocol
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Jing Chen, Hongcai Shang, Min Li, Pengqian Wang, Songjie Han, Jiayuan Hu, Ruijin Qiu, Chen Zhao, Xuxu Wei, and Changming Zhong
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Protocol (science) ,integrative medicine ,medicine.medical_specialty ,Medicine (General) ,Package insert ,business.industry ,acute heart failure ,Delphi method ,methodology ,General Medicine ,core outcome set ,Essential medicines ,Clinical trial ,Systematic review ,R5-920 ,safety and efficacy ,Family medicine ,medicine ,Medicine ,Integrative medicine ,Adverse effect ,business ,study protocol - Abstract
Aims: To identify a minimum set of efficacy and adverse events for patients with acute heart failure (AHF) among different stakeholders in clinical trials of traditional Chinese medicine and Western medicine.Methods and Analysis: First, we will develop a preliminary long list of outcomes that includes efficacy and adverse events/reactions via three steps: (i) systematic reviews of efficacy and safety outcomes for clinical trials of AHF; (ii) drugs included in the National Medical Insurance Catalog, the National Essential Medicines Catalog, and the WHO Essential Medicines List will be collected and safety outcomes extracted from the package inserts; and (iii) patients' or caregivers' semi-structured interviews will be carried out to add new viewpoints to the list. Second, after merging outcomes and grouping them under different outcome domains, questionnaires for health professionals and patients will be separately developed. Further, two rounds of Delphi survey for health professionals and a survey for patients and the public will be carried out. Third, different stakeholders will discuss and determine the final core outcome set (COS) for AHF in a consensus meeting.Ethics and Dissemination: The entire project has been approved by the Ethics Committee of the main institution. After the final COS is developed, it will be published and discussed widely in conferences.Clinical Trial Registration: This study is registered with the Core Outcome Measures in Effectiveness Trials database as study 1566 (available at: https://www.cometinitiative.org/Studies/Details/1566).
- Published
- 2021
17. Deciphering the scalene association among type‐2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease‐gene network
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Jun Liu, Yingying Zhang, Pengqian Wang, Qiong Liu, Xiaoxu Zhang, Yanan Yu, Hongli Wu, Ruixia Kang, Bing Li, and Zhong Wang
- Subjects
0301 basic medicine ,Male ,Cancer Research ,endocrine system diseases ,type 2 diabetes mellitus ,RNA polymerase II ,Disease ,Computational biology ,Biology ,lcsh:RC254-282 ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Transcription (biology) ,chronic myeloid leukemia ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Genetic Predisposition to Disease ,Gene ,therapeutic prediction ,Original Research ,Cancer Biology ,overlapping gene and module ,Rnd3 ,Myeloid leukemia ,RNA ,Prostatic Neoplasms ,medicine.disease ,prostate cancer ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,030104 developmental biology ,Gene Ontology ,Oncology ,Diabetes Mellitus, Type 2 ,030220 oncology & carcinogenesis ,biology.protein - Abstract
The potential biological relationship between type‐2 diabetes mellitus (T2DM) has been focused in numerous studies. To investigate the molecular associations among T2DM, prostate cancer (PCa), and chronic myeloid leukemia (CML), using a biomolecular network enrichment analysis. We obtained a list of disease‐related genes and constructed disease networks. Then, GO enrichment analysis was performed to identify the significant functions and pathways of overlapping modules in the Database for Annotation, Visualization and Integrated Discovery (DAVID) database. More than 75% of these overlapping genes were found to be consistent with the findings of previous studies. In the three diseases, we found that Sarcoglycan delta (SGCD) and Rho family GTPase 3 (RND3) were the overlapping genes and identified negative regulation of apoptotic process and negative regulation of transcription from RNA polymerase II promoter RNA as the two overlapping biological functions. CML and PCa were the most closely related, with 34 overlapping genes, five overlapping modules, 27 overlapping biological functions, and nine overlapping pathways. There were 13 overlapping genes, one overlapping modules, four overlapping biological functions and one overlapping pathway (FoxO signaling pathway) were found in T2DM and CML.And T2DM and PCa were the least related pair in our study, with only six overlapping genes, five overlapping modules, and one overlapping biological function. SGCD and RND3 were the main gene‐to‐gene relationship among T2DM, CML, and PCa; apoptosis, development, and transcription from RNA polymerase II promote processes were the main functional connections among T2DM, CML, and PCa by network enrichment analysis. There is a “scalene” relationship among T2DM, CML, and PCa at gene, pathway, biological process, and module levels: CML and PCa were the most closely related, the second were T2DM and PCa, and T2DM and PCa were the least related pair in our study. Our study provides a new avenue for further studies on T2DM and cancers, which may promote the discovery and development of novel therapeutic and can be used to treat multiple diseases.
- Published
- 2019
18. Intermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke
- Author
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Li Dai, Jing Meng, Xingjiang Xiong, Yin Wu, Pengqian Wang, Miao Zhang, Hai-Ru Huo, Weiwei Zhou, and Feng Sui
- Subjects
0301 basic medicine ,Traditional Chinese medicine ,Computational biology ,Biology ,03 medical and health sciences ,0302 clinical medicine ,inter-module analysis ,medicine ,OMIM : Online Mendelian Inheritance in Man ,pharmacological mechanism ,network pharmacology ,Pharmacology (medical) ,Stroke ,Original Research ,Pharmacology ,Huang lian jie du decoction ,Mechanism (biology) ,lcsh:RM1-950 ,Core protein ,Huang-Lian-Jie-Du decoction ,medicine.disease ,stroke ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,030220 oncology & carcinogenesis ,Signal transduction ,Systems pharmacology - Abstract
Huang-Lian-Jie-Du Decoction (HLJDD) is a "Fangji" made up of well-designed Chinese herb array and widely used to treat ischemic stroke. Here we aimed to investigate pharmacological mechanism by introducing an inter-module analysis to identify an overarching view of target profile and action mode of HLJDD. Stroke-related genes were obtained from OMIM (Online Mendelian Inheritance in Man). And the potential target proteins of HLJDD were identified according to TCMsp (Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform). The two sets of molecules related to stroke and HLJDD were respectively imported into STRING database to construct the stroke network and HLJDD network, which were dissected into modules through MCODE, respectively. We analyzed the inter-module connectivity by quantify "coupling score" (CS) between HLJDD-modules (H-modules) and stroke-modules (S-module) to explore the pharmacological acting pattern of HLJDD on stroke. A total of 267 stroke-related proteins and 15 S-modules, 335 HLJDD putative targeting proteins, and 13 H-modules were identified, respectively. HLJDD directly targeted 28 proteins in stroke network, majority (16, 57.14%) of which were in S-modules 1 and 4. According to the modular map based on inter-module CS analysis, H-modules 1, 2, and 8 densely connected with S-modules 1, 3, and 4 to constitute a module-to-module bridgeness, and the enriched pathways of this bridgeness with top significance were TNF signaling pathway, HIF signaling pathway, and PI3K-Akt signaling pathway. Furthermore, through this bridgeness, H-modules 2 and 4 cooperatively work together to regulate mitochondrial apoptosis against the ischemia injury. Finally, the core protein in H-module 4 account for mitochondrial apoptosis was validated by an in vivo experiment. This study has developed an integrative approach by inter-modular analysis for elucidating the "shotgun-like" pharmacological mechanism of HLJDD for stroke.
- Published
- 2019
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19. Numerical Investigation on Co-firing Characteristics of Semi-Coke and Lean Coal in a 600 MW Supercritical Wall-Fired Boiler
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Pengqian Wang, Defu Che, Yongbo Du, Qinqin Feng, Chang’an Wang, Qiang Lv, Jingwen Zhang, and Lin Zhao
- Subjects
supercritical wall-fired boiler ,020209 energy ,02 engineering and technology ,Combustion ,lcsh:Technology ,law.invention ,lcsh:Chemistry ,020401 chemical engineering ,law ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Coal ,0204 chemical engineering ,lcsh:QH301-705.5 ,Instrumentation ,NOx ,Fluid Flow and Transfer Processes ,co-combustion ,Waste management ,lcsh:T ,business.industry ,Process Chemistry and Technology ,General Engineering ,Boiler (power generation) ,Coke ,lcsh:QC1-999 ,Supercritical fluid ,Computer Science Applications ,NOx emission ,Ignition system ,lcsh:Biology (General) ,lcsh:QD1-999 ,lcsh:TA1-2040 ,Fly ash ,Environmental science ,semi-coke ,lcsh:Engineering (General). Civil engineering (General) ,business ,combustion efficiency ,lcsh:Physics - Abstract
Semi-coke is one of the principal by-products of coal pyrolysis and gasification, which features the disadvantages of ignition difficulty, low burnout rate, and high nitrogen oxides (NOx) emission during combustion process. Co-firing semi-coke with coal is a potential approach to achieve clean and efficient utilization of such low-volatile fuel. In this paper, the co-firing performance of semi-coke and lean coal in a 600 MW supercritical wall-fired boiler was numerically investigated which has been seldom done previously. The influences of semi-coke blending ratio, injection position of semi-coke, excess air ratio in the main combustion zone, the co-firing method, and over fire air (OFA) arrangement on the combustion efficiency and NOx generation characteristics of the utility boiler were extensively analyzed. The simulation results indicated that as the blending ratio of semi-coke increased, the NOx emission at furnace outlet decreased. The blending methods (in-furnace versus out-furnace) had certain impacts on the NOx emission and carbon content in fly ash, while the in-furnace blending method showed more flexibility in co-firing adjustment. The injection of semi-coke from the upper burners could significantly abate NOx emission at the furnace outlet, but also brought about the rise of carbon content in fly ash and the increase of outlet temperature. Compared with the condition that semi-coke and lean coal were injected from different burners, the burnout ratio of the blend premixed outside the furnace was higher at the same blending ratio of semi-coke. With the excess air ratio in the main combustion zone increased, NOx concentration at the furnace outlet was increased. The excess air ratio of 0.75 in the main combustion zone was recommended for co-firing 45% semi-coke with lean coal. The operational performance of the boiler co-firing semi-coke was greatly affected by the arrangement of OFA as well. The amount of NOx generated from the supercritical wall-fired boiler could be reduced with an increase of the OFA height.
- Published
- 2019
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20. IMCC: Quantitative Analysis of the Inter-module Connectivity for Bio-network
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Qiong Liu, Pengqian Wang, Wenjuan Xu, Bing Li, Yanan Yu, Dongfeng Li, Yingying Zhang, Jun Liu, and Zhong Wang
- Subjects
Structure (mathematical logic) ,Quantitative analysis (finance) ,Computer science ,business.industry ,Connection (vector bundle) ,Construct (python library) ,Variation (game tree) ,Data mining ,Modular design ,computer.software_genre ,business ,computer - Abstract
Inter-module connectivity, which tend to connect different communities and maintain network architectural integrity, is contributing to functional coordination and information flow between modules in perturbations. Detecting the strength of inter-module connection is essential to characterize the reactive bio-systematical variation. A quantitative evaluation method for inter-module connections is needed. Here, based on the high-throughput microarray data from mouse, an evaluation approach (named as IMCC) for inter-module connectivity was developed. The IMCC model, which is an integration of direct and indirect inter-module connections, successfully excluded inter-module connections without statistical significance or below the cutoff value, and provided a more comprehensive landscape of inter-module relationships. We showed that the IMCC method reflected a more precise functional coordination between modules according to KEGG database, were validated by topological parameter. Application of IMCC in genome-scale stroke networks deciphered characteristic pathological “core-periphery” structure of modular map and functional coordination module pair.Author summeryInter-module connectivity, which tend to connect different communities and maintain network architectural integrity, is contributing to functional coordination and information flow between modules in perturbations. Moreover, modular rearrangements provide more efficient ways for phenotype alteration, inter-module connections have been considered to be ‘‘evolutionary interaction switches”. Such modular map rewiring can be used as a network biomarker to characterize the dynamics of drug responses. Detecting the strength of inter-module connection is essential to characterize the reactive bio-systematical variation response to disease or drug. We aim to construct a quantitative evaluation method for inter-module connections. Thus, this study has implications in systematical exploration detailed variation of inter-module pharmacological action mode of drugs.
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- 2019
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21. Experimental Study on NOx Reduction in Oxy-fuel Combustion Using Synthetic Coals with Pyridinic or Pyrrolic Nitrogen
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Yongbo Du, Lin Zhao, Defu Che, Chang’an Wang, and Pengqian Wang
- Subjects
020209 energy ,Inorganic chemistry ,Oxide ,chemistry.chemical_element ,02 engineering and technology ,Combustion ,Oxygen ,oxy-fuel combustion ,mineral effect ,lcsh:Technology ,lcsh:Chemistry ,chemistry.chemical_compound ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,Coal ,Nitrogen dioxide ,NOx reduction ,Instrumentation ,lcsh:QH301-705.5 ,NOx ,synthetic coal ,Fluid Flow and Transfer Processes ,business.industry ,lcsh:T ,Process Chemistry and Technology ,General Engineering ,respiratory system ,Nitrogen ,lcsh:QC1-999 ,Computer Science Applications ,chemistry ,lcsh:Biology (General) ,lcsh:QD1-999 ,lcsh:TA1-2040 ,Carbon dioxide ,pyrrolic nitrogen ,business ,lcsh:Engineering (General). Civil engineering (General) ,pyridinic nitrogen ,lcsh:Physics - Abstract
Oxy-fuel combustion technology can capture carbon dioxide (CO2) in the large-scale and greatly lower nitrogen oxides (NOx) emission in coal-fired power plants. However, the influence of inherent minerals on NOx reduction still remains unclear and the impact of oxy-fuel combustion on the transformation of different nitrogen functional groups has yet to be fully understood. The present work aims to obtain a further understanding of the NOx reduction during oxy-fuel combustion using synthetic coals with pyrrolic or pyridinic nitrogen. Compared to pyridinic nitrogen, more of the pyrrolic nitrogen in synthetic coal was converted to NOx. The conversion ratio of nitric oxide (NO) first increased significantly with the rising oxygen content and then trended to an asymptotically constant as the oxygen (O2) content varied between 10&ndash, 50%. The nitrogen dioxide (NO2) formation was roughly proportional to the oxygen content. The NO2 conversion was increased with particle size but the case of NO showed a non-monotonic variation. The catalytic effects of sodium carbonate (Na2CO3), calcium carbonate (CaCO3), and ferric oxide (Fe2O3) on the transformation of pyridinic nitrogen to NO were independent of the combustion atmosphere, while the alteration from air to the oxy-fuel combustion led to a change of mineral catalytic effect on the oxidation of pyrrolic nitrogen within the coal matrix.
- Published
- 2018
22. Dissociation of multiply ionized isocyanic acid through electron impact.
- Author
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Pengqian Wang, Ibrahim A., Vidal, C. R., Geith, Janna, Klapötke, Thomas M., and Fuβ, Werner
- Subjects
- *
ISOCYANIC acid , *ELECTRON impact ionization , *SPECTRUM analysis , *ELECTRONIC excitation , *ANALYSIS of covariance - Abstract
The dissociation of singly to triply ionized isocyanic acid (HNCO) has been investigated by two- and three-dimensional covariance mapping techniques through electron impact ionization at an electron energy of 200 eV. The absolute cross sections for the various dissociation channels of up to triply ionized HNCO have been measured. The HNCO dications dissociate mostly into ion pairs, while the HNCO trications dissociate mostly into ion triples, both through all the possible bond cleavages and charge allocations. Some major ion-pair dissociation channels of HNCO[sup 2+] are supposed to be sequential dissociation through initial charge separation. The metastable decay traces caused by HNCO[sup 2+]→H[sup +]+NCO[sup +] and HNCO[sup +]→HCO[sup +]+N have been observed on the covariance map. © 2004 American Institute of Physics. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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23. Quantitative assessment of gene expression network module-validation methods
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Yingying Zhang, Yanan Yu, Yongyan Wang, Yongcheng Wang, Pengqian Wang, Zhong Wang, and Bing Li
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Multidisciplinary ,Models, Statistical ,business.industry ,Computer science ,Systems biology ,Gene regulatory network ,Value (computer science) ,Computational Biology ,Gene Expression ,Modular design ,Validation Studies as Topic ,computer.software_genre ,Article ,Validation methods ,Gene expression ,Databases, Genetic ,Quantitative assessment ,Gene Regulatory Networks ,Data mining ,business ,computer - Abstract
Validation of pluripotent modules in diverse networks holds enormous potential for systems biology and network pharmacology. An arising challenge is how to assess the accuracy of discovering all potential modules from multi-omic networks and validating their architectural characteristics based on innovative computational methods beyond function enrichment and biological validation. To display the framework progress in this domain, we systematically divided the existing Computational Validation Approaches based on Modular Architecture (CVAMA) into topology-based approaches (TBA) and statistics-based approaches (SBA). We compared the available module validation methods based on 11 gene expression datasets and partially consistent results in the form of homogeneous models were obtained with each individual approach, whereas discrepant contradictory results were found between TBA and SBA. The TBA of the Zsummary value had a higher Validation Success Ratio (VSR) (51%) and a higher Fluctuation Ratio (FR) (80.92%), whereas the SBA of the approximately unbiased (AU) p-value had a lower VSR (12.3%) and a lower FR (45.84%). The Gray area simulated study revealed a consistent result for these two models and indicated a lower Variation Ratio (VR) (8.10%) of TBA at 6 simulated levels. Despite facing many novel challenges and evidence limitations, CVAMA may offer novel insights into modular networks.
- Published
- 2015
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24. Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice
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HaiNan Wang, Yanan Yu, KangNing Li, Pengqian Wang, Jun Liu, Zhong Wang, Haixia Dang, Yongyan Wang, Haixia Li, Bing Li, and Yingying Zhang
- Subjects
0301 basic medicine ,Male ,Middle Cerebral Artery ,Microarray ,Pharmacology ,Biology ,Neuroprotection ,General Biochemistry, Genetics and Molecular Biology ,Brain ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Ischemia ,medicine ,Animals ,Gene Regulatory Networks ,Iridoids ,Original Research ,Flavonoids ,Mechanism (biology) ,Gene Expression Profiling ,Ursodeoxycholic Acid ,Cell cycle ,medicine.disease ,Microarray Analysis ,Ursodeoxycholic acid ,030104 developmental biology ,Neuroprotective Agents ,chemistry ,Reperfusion Injury ,Baicalin ,030217 neurology & neurosurgery ,Metabolic Networks and Pathways ,medicine.drug ,Systems pharmacology - Abstract
Using a system pharmacology strategy, this study evaluated the unique pharmacological characteristics of three different neuroprotective compounds for the treatment of cerebral ischemia-reperfusion. A microarray including 374 brain ischemia-related genes was used to identify the differentially expressed genes among five treatment groups: baicalin, jasminoidin, ursodeoxycholic acid, sham, and vehicle, and MetaCore analysis software was applied to identify the significantly altered pathways, processes and interaction network parameters. At pathway level, 46, 25, and 31 pathways were activated in the baicalin, jasminoidin, and ursodeoxycholic acid groups, respectively. Thirteen pathways mainly related with apoptosis and development were commonly altered in the three groups. Additionally, baicalin also targeted pathways related with development, neurophysiologic process and cytoskeleton remodeling, while jasminoidin targeted pathways related with cell cycle and ursodeoxycholic acid targeted those related with apoptosis and development. At process level, three processes were commonly regulated by the three groups in the top 10 processes. Further interaction network analysis revealed that baicalin, jasminoidin, and ursodeoxycholic acid displayed unique features either on network topological parameters or network structure. Additional overlapping analysis demonstrated that compared with ursodeoxycholic acid, the pharmacological mechanism of baicalin was more similar with that of jasminoidin in treating brain ischemia. The data presented in this study may contribute toward the understanding of the common and differential pharmacological mechanisms of these three compounds.
- Published
- 2015
25. Computational fluid dynamics investigation on the effect of co-firing semi-coke and bituminous coal in a 300MW tangentially fired boiler.
- Author
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Yongbo Du, Chang'an Wang, Pengqian Wang, Yi Meng, Zhichao Wang, Wei Yao, and Defu Che
- Subjects
COMPUTATIONAL fluid dynamics ,BITUMINOUS coal ,HEAT of combustion ,COMBUSTION efficiency ,THERMAL efficiency ,RADIAL distribution function - Abstract
In this paper, the effect of co-firing semi-coke in a 300MW tangentially fired boiler was numerically investigated. The results indicate that the incomplete combustion heat loss and NO
x emission both increase with semi-coke co-fired ratio. Semi-coke may be injected into the furnace at a different height, which can lead to different thermal efficiency and NOx emission. It is suggested that semi-coke should not be fed from the top or bottom layer burners, since this could give rise to high carbon content respectively in fly ash and bottom slag. In addition, injecting semi-coke from the top burners could significantly increase the NOx emission. Under 1/2 co-firing ratio, the optimal fuel allocation is that feeding semi-coke from the B, D, and E layer burners. The growth in semi-coke particle size could increase the unburned carbon loss and NOx emission. It is highly recommended to reduce the unburned carbon loss under semi-coke co-fired condition by increasing the stoichiometric ratio of primary air for semi-coke. As it is increased from 0.25 to 0.3, the combustion efficiency of the co-fired condition is 99.47%, the same as when only firing bituminous coal, and the NOx emission is about 30% higher. [ABSTRACT FROM AUTHOR]- Published
- 2019
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26. Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine
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Wei Liu, Pengqian Wang, Fuyong Chu, Xiaochen Yang, Jie Wang, and Xingjiang Xiong
- Subjects
medicine.medical_specialty ,Traditional medicine ,business.industry ,media_common.quotation_subject ,Perspective (graphical) ,Alternative medicine ,MEDLINE ,Review Article ,Traditional Chinese medicine ,lcsh:Other systems of medicine ,lcsh:RZ201-999 ,Elevated blood ,Blood pressure ,Complementary and alternative medicine ,Medicine ,business ,Intensive care medicine ,Seriousness ,media_common - Abstract
Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine.
- Published
- 2013
27. Geometrical ray tracing in uniaxial crystals: direct formulas and the equivalence between the electromagnetic wave method and Huygens' principle.
- Author
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Pengqian Wang
- Published
- 2018
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28. Chinese Patent Medicine Liu Wei Di Huang Wan Combined with Antihypertensive Drugs, a New Integrative Medicine Therapy, for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials
- Author
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Xingjiang Xiong, Jie Wang, Jizheng Ma, Xiaochen Yang, Wei-Wei Liu, Kui-Wu Yao, Xinliang Du, Pengqian Wang, and Bo Feng
- Subjects
medicine.medical_specialty ,Chinese patent medicine ,Article Subject ,business.industry ,lcsh:Other systems of medicine ,Pharmacology ,lcsh:RZ201-999 ,Essential hypertension ,medicine.disease ,Jadad scale ,law.invention ,Blood pressure ,Complementary and alternative medicine ,Randomized controlled trial ,law ,Medicine ,Integrative medicine ,Adverse effect ,Liu-wei-di-huang wan ,business ,Intensive care medicine ,Research Article - Abstract
Objectives. To assess the beneficial and adverse effects of Liu Wei Di Huang Wan (LWDHW), combined with antihypertensive drugs, for essential hypertension.Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of LWDHW combined with antihypertensive drugs for essential hypertension reported in any language, with main outcome measures as blood pressure. The quality of the included studies was assessed with the Jadad scale and a customized standard quality assessment scale.Results. 6 randomized trials were included. The methodological quality of the trials was evaluated as generally low. The pooled results showed that LWDHW combined with antihypertensive drugs was more effective in blood pressure and the scale for TCM syndrome and symptom differentiation scores compared with antihypertensive drugs alone. Most of the trials did not report adverse events, and the safety is still uncertain.Conclusions. LWDHW combined with antihypertensive drugs appears to be effective in improving blood pressure and symptoms in patients with essential hypertension. However, the evidence remains weak due to the poor methodological quality of the included studies.
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- 2012
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29. Deciphering the genetic and modular connections between coronary heart disease, idiopathic pulmonary arterial hypertension and pulmonary heart disease.
- Author
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YE YUAN, YINGYING ZHANG, XIAOXU ZHANG, YANAN YU, BING LI, PENGQIAN WANG, HAIXIA LI, YIJUN ZHAO, CHUNTI SHEN, and ZHONG WANG
- Subjects
CORONARY disease ,ESSENTIAL hypertension ,ARTERIAL diseases ,PULMONARY heart disease ,CARDIOVASCULAR diseases ,GENETICS - Abstract
Coronary heart disease (CHD), idiopathic pulmonary arterial hypertension (IPAH) and pulmonary heart disease (PHD) are circulatory system diseases that may simultaneously emerge in a patient and they are often treated together in clinical practice. However, the molecular mechanisms connecting these three diseases remain unclear. In order to determine the multidimensional characteristic correlations between these three diseases based on genomic networks to aid in medical decision-making, genes from the Online Mendelian Inheritance in Man database were obtained, and applied network construction and modularized analysis were conducted. Functional enrichment analysis was conducted to explore the associations between overlapping genes, modules and pathways. A total of 29 overlapping genes and 3 common modules were identifed for the 3 diseases. Glycosphingolipid biosynthesis and the arachidonic acid metabolism are common pathways, and the biosynthetic process is suggested to be the major function involved in the three diseases. The current study reported, to the best of our knowledge for the first time, the role of glycosphingolipid biosynthesis in IPAH and PHD. The present study provided an improved understanding of the pathological mechanisms underlying CHD, IPAH and PHD. The overlapping genes, modules and pathways suggest novel areas for further research, and drug targets. The observations of the current study additionally suggest that drug indications can be broadened because of the presence of common targets. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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30. Evaluating the effects of Danhong injection in treatment of acute ischemic stroke: study protocol for a multicenter randomized controlled trial.
- Author
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Bing Li, Yilong Wang, Jingjing Lu, Jun Liu, Ye Yuan, Yanan Yu, Pengqian Wang, Xingquan Zhao, Zhong Wang, Li, Bing, Wang, Yilong, Lu, Jingjing, Liu, Jun, Yuan, Ye, Yu, Yanan, Wang, Pengqian, Zhao, Xingquan, and Wang, Zhong
- Subjects
CHINESE medicine ,STROKE treatment ,RANDOMIZED controlled trials ,MESSENGER RNA ,MICRORNA ,STROKE diagnosis ,CARDIOVASCULAR agents ,CEREBRAL ischemia ,COMPARATIVE studies ,FUNCTIONAL assessment ,EXPERIMENTAL design ,HERBAL medicine ,INJECTIONS ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH protocols ,QUALITY of life ,QUESTIONNAIRES ,RESEARCH ,RNA ,STATISTICAL sampling ,STROKE ,TIME ,GENETIC markers ,EVALUATION research ,TREATMENT effectiveness ,BLIND experiment ,GENE expression profiling ,BARTHEL Index ,NIH Stroke Scale ,DRUG administration ,DRUG dosage ,DIAGNOSIS - Abstract
Background: Danhong injection (DHI) has been widely prescribed to patients with acute ischemic stroke (AIS). However, due to methodological deficiencies, previous research has not yet provided rigorous evidence to support the use of DHI in the treatment of AIS. Therefore, we designed this multicenter, randomized, controlled, and double-blind trial to evaluate the efficacy and safety of DHI for AIS.Methods/design: It is a randomized, multicenter, double-blind, placebo-controlled, adaptive clinical trial. A total of 864 eligible patients will be randomized into either the DHI or placebo group in a 2:1 ratio. All patients will be given the standard medical care as recommended by guidelines. Participants will undergo a 2-week treatment regimen and 76-day follow-up period. The primary outcome is the proportion of patients with a favorable outcome, defined as a score of 0-1 on the modified Rankin scale at day 90. Secondary outcomes include a change in the total score of the Chinese medicine symptom scales of "Xueyu Zheng" (blood stasis syndrome), the proportion of patients with a Barthel Index score of ≥90, the proportion of patients with an improvement in NIHSS score of ≥4 or NIHSS score of 0-1, quality of life measured by the EQ-5D scale, etc. Safety outcomes such as global disability (mRS ≥3) at day 90 will also be assessed. The changes in mRNA and microRNA profiles in 96 patients selected from certain centers will also be assessed. As this is an adaptive design, two interim analyses are prospectively planned, which will be carried out after one-third and two-thirds of patients have completed the trial, respectively. Based on the results of the interim analyses, the Data Monitoring Committee (DMC) will decide how to modify the study.Discussion: This trial will provide high-quality evidence for DHI in treatment of AIS.Trial Registration: Clinical Trials.gov NCT01677208 (Date of registration 22 December 2012). [ABSTRACT FROM AUTHOR]- Published
- 2015
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31. Efficacy and Safety of a Traditional Chinese Herbal Formula Xuefu Zhuyu Decoction for Hypertension: A Systematic Review and Meta-Analysis.
- Author
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Pengqian Wang, Xingjiang Xiong, Shengjie Li, Wang, Pengqian, Xiong, Xingjiang, and Li, Shengjie
- Published
- 2015
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32. Effects of Traditional Chinese Patent Medicine on Essential Hypertension.
- Author
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Xingjiang Xiong, Pengqian Wang, Yuqing Zhang, and Xiaoke Li
- Published
- 2015
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33. The effect of Chinese herbal medicine Jian Ling Decoction for the treatment of essential hypertension: a systematic review.
- Author
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Xingjiang Xiong, Pengqian Wang, Xiaoke Li, and Yuqing Zhang
- Abstract
Objectives: Jian Ling Decoction (JLD) is often prescribed to improve hypertension-related symptoms in China. However, this treatment has not been systematically reviewed for its efficacy against essential hypertension (EH). This review aims to assess the current clinical evidence of JLD in the treatment of EH. Design: Seven electronic databases, including the Cochrane Central Register of Controlled Trials, PubMed, EMBASE, the Chinese National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database (VIP), the Chinese Biomedical Literature Database (CBM) and the Wanfang Database, were searched up to March 2014. Randomised control trials (RCTs) comparing JLD or combined with antihypertensive drugs versus antihypertensive drugs were included. We assessed the methodological quality, extracted the valid data and conducted the meta-analysis according to criteria from the Cochrane group. The primary outcome was categorical or continuous blood pressure (BP), and the secondary outcome was quality of life (QOL). Results: Ten trials (655 patients) with unclear-to-high risk of bias were identified. Meta-analysis showed that JLD used alone showed no BP reduction effect; however, improvement on QOL was found in the JLD group compared to antihypertensive drugs. A significant reduction in systolic and diastolic BP was observed for JLD plus antihypertensive drugs when compared with antihypertensive drugs alone. No serious adverse effects were reported. Conclusions: Owing to insufficient clinical data, it is difficult to draw a definite conclusion regarding the effectiveness and safety of JLD for EH, and better trials are needed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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34. Qigong for Hypertension.
- Author
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Xingjiang Xiong, Pengqian Wang, Xiaoke Li, and Yuqing Zhang
- Published
- 2015
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35. Trends in the Treatment of Hypertension from the Perspective of Traditional Chinese Medicine.
- Author
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Xingjiang Xiong, Xiaochen Yang, Wei Liu, Fuyong Chu, Pengqian Wang, and Jie Wang
- Subjects
THERAPEUTICS ,ALTERNATIVE medicine ,HYPERTENSION ,ANTIHYPERTENSIVE agents ,MEDICAL care costs ,BOTANIC medicine ,CHINESE medicine ,DISEASE complications - Abstract
Hypertension is a major public-health issue. Much consensus has been reached in the treatment, and considerable progress has been made in the field of antihypertensive drugs. However, the standard-reaching rate of blood pressure is far from satisfaction. Considering these data and the seriousness of the effects of hypertension on the individual and society as a whole, both economically and socially, physicians must look for more effective and alternative ways to achieve the target blood pressure. Could treatment of hypertension be improved by insights from traditional Chinese medicine? As one of the most important parts in complementary and alternative therapies, TCM is regularly advocated for lowering elevated blood pressure. Due to the different understanding of the pathogenesis of hypertension between ancient and modern times, new understanding and treatment of hypertension need to be reexplored. Aiming to improve the efficacy of Chinese herbal medicine in treating hypertension, the basis of treatment is explored through systematically analyzing the literature available in both English and Chinese search engines. This paper systematically reviews the trends in emerging therapeutic strategies for hypertension from the perspective of traditional Chinese medicine. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
36. Zhen Gan Xi Feng Decoction, a Traditional Chinese Herbal Formula, for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials.
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Xingjiang Xiong, Xiaochen Yang, Bo Feng, Wei Liu, Lian Duan, Ao Gao, Haixia Li, Jizheng Ma, Xinliang Du, Nan Li, Pengqian Wang, Kelei Su, Fuyong Chu, Guohao Zhang, Xiaoke Li, and Jie Wang
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HYPERTENSION ,INFORMATION storage & retrieval systems ,MEDICAL databases ,CHINESE medicine ,MEDLINE ,ONLINE information services ,RESEARCH funding ,SYSTEMATIC reviews ,PLANT extracts ,DATA analysis software - Abstract
Objectives. To assess the clinical effectiveness and adverse effects of Zhen Gan Xi Feng Decoction (ZGXFD) for essential hypertension (EH). Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of ZGXFD for EH reported in any language, with main outcome measure as blood pressure (BP). Results. Six randomized trials were included. Methodological quality of the trials was evaluated as generally low. Four trials compared prescriptions based on ZGXFD with antihypertensive drugs. Meta-analysis showed that ZGXFD was more effective in BP control and TCM syndrome and symptom differentiation (TCM-SSD) scores than antihypertensive drugs. Two trials compared the combination of modified ZGXFD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed that there is significant beneficial effect on TCM-SSD scores. However, no significant effect on BP was found. The safety of ZGXFD is still uncertain. Conclusions. ZGXFD appears to be effective in improving blood pressure and hypertension-related symptoms for EH. However, the evidence remains weak due to poor methodological quality of the included studies. More rigorous trials are warranted to support their clinical use. [ABSTRACT FROM AUTHOR]
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- 2013
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37. Chinese Patent Medicine Liu Wei Di Huang Wan Combined with Antihypertensive Drugs, a New Integrative Medicine Therapy, for the Treatment of Essential Hypertension: A Systematic Review of Randomized Controlled Trials.
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Jie Wang, Kuiwu Yao, Xiaochen Yang, Wei Liu, Bo Feng, Jizheng Ma, Xinliang Du, Pengqian Wang, and Xingjiang Xiong
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Objectives. To assess the beneficial and adverse effects of Liu Wei Di Huang Wan (LWDHW), combined with antihypertensive drugs, for essential hypertension. Methods. Five major electronic databases were searched up to August 2012 to retrieve any potential randomized controlled trials designed to evaluate the clinical effectiveness of LWDHW combined with antihypertensive drugs for essential hypertension reported in any language, with main outcome measures as blood pressure. The quality of the included studies was assessed with the Jadad scale and a customized standard quality assessment scale. Results. 6 randomized trials were included. The methodological quality of the trials was evaluated as generally low. The pooled results showed that LWDHW combined with antihypertensive drugs was more effective in blood pressure and the scale for TCM syndrome and symptom differentiation scores compared with antihypertensive drugs alone. Most of the trials did not report adverse events, and the safety is still uncertain. Conclusions. LWDHW combined with antihypertensive drugs appears to be effective in improving blood pressure and symptoms in patients with essential hypertension. However, the evidence remains weak due to the poor methodological quality of the included studies. [ABSTRACT FROM AUTHOR]
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- 2012
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38. Banxia Baizhu Tianma Decoction for Essential Hypertension: A Systematic Review of Randomized Controlled Trials.
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Xingjiang Xiong, Xiaochen Yang, Wei Liu, Bo Feng, Jizheng Ma, Xinliang Du, Pengqian Wang, Fuyong Chu, Jun Li, and Jie Wang
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Objectives. To assess the current clinical evidence of Banxia Baizhu Tianma Decoction (BBTD) for essential hypertension (EH). Search Strategy. Electronic databases were searched until July 2012. Inclusion Criteria. We included randomized clinical trials testing BBTD against placebo, antihypertensive drugs, or combined with antihypertensive drugs against antihypertensive drugs. Data Extraction and Analyses. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Results. 16 randomized trials were included. Methodological quality of the included trials was evaluated as generally low. 2 trials compared prescriptions based on BBTD using alone with antihypertensive drugs. Meta-analysis showed no significant effect of modified BBTD compared with captopril in systolic blood pressure ( MD: -0.75 (-5.77, 4.27); P = 0.77) and diastolic blood pressure ( MD: -0.75 (-2.89, 1.39); P = 0.49). 14 trials compared the combination of BBTD or modified BBTD plus antihypertensive drugs with antihypertensive drugs. Meta-analysis showed there are significant beneficial effect on systolic blood pressure in the combination group compare to the antihypertensive drugs ( MD: -4.33 (-8.44, -0.22); P = 0.04). The safety of BBTD is uncertain. Conclusions. There is encouraging evidence of BBTD for lowering SBP, but evidence remains weak. Rigorously designed trials are warranted to confirm these results. [ABSTRACT FROM AUTHOR]
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- 2012
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39. Generation of a completely dense femtosecond optical supercontinuum.
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I G Koprinkov, Akira Suda, Pengqian Wang, and Katsumi Midorikawa
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- 2006
40. Visualizing the conoscopic isochromatic interference fringes in anisotropic crystals by spinning polarizer and analyzer.
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Pengqian Wang
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- 2012
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41. Disentangling the volume effect through intensity-difference spectra: application to laser-induced dissociation of H2+.
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Pengqian Wang, Sayler, A. Max, Carnes, Kevin D., Esry, Brett D., and Itzik Ben-Itzhak
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- 2005
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42. Evaluating the effects of Danhong injection in treatment of acute ischemic stroke: study protocol for a multicenter randomized controlled trial
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Ye Yuan, Jun Liu, Yilong Wang, Pengqian Wang, Jingjing Lu, Zhong Wang, Yanan Yu, Xingquan Zhao, and Bing Li
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Research design ,Male ,Time Factors ,Medicine (miscellaneous) ,Traditional Chinese medicine ,law.invention ,Brain Ischemia ,Brain ischemia ,Disability Evaluation ,Study Protocol ,Randomized controlled trial ,Quality of life ,Clinical Protocols ,law ,Surveys and Questionnaires ,Pharmacology (medical) ,Stroke ,Middle Aged ,humanities ,Treatment Outcome ,Research Design ,Female ,Adult ,Genetic Markers ,medicine.medical_specialty ,China ,Adolescent ,Acute ischemic stroke ,Danhong injection ,Injections ,Young Adult ,Double-Blind Method ,medicine ,Humans ,RNA, Messenger ,Aged ,Protocol (science) ,Chinese medicine ,business.industry ,Gene Expression Profiling ,Cardiovascular Agents ,medicine.disease ,MicroRNAs ,Cardiovascular agent ,Emergency medicine ,Physical therapy ,Quality of Life ,business ,Drugs, Chinese Herbal - Abstract
Background Danhong injection (DHI) has been widely prescribed to patients with acute ischemic stroke (AIS). However, due to methodological deficiencies, previous research has not yet provided rigorous evidence to support the use of DHI in the treatment of AIS. Therefore, we designed this multicenter, randomized, controlled, and double-blind trial to evaluate the efficacy and safety of DHI for AIS. Methods/Design It is a randomized, multicenter, double-blind, placebo-controlled, adaptive clinical trial. A total of 864 eligible patients will be randomized into either the DHI or placebo group in a 2:1 ratio. All patients will be given the standard medical care as recommended by guidelines. Participants will undergo a 2-week treatment regimen and 76-day follow-up period. The primary outcome is the proportion of patients with a favorable outcome, defined as a score of 0–1 on the modified Rankin scale at day 90. Secondary outcomes include a change in the total score of the Chinese medicine symptom scales of “Xueyu Zheng” (blood stasis syndrome), the proportion of patients with a Barthel Index score of ≥90, the proportion of patients with an improvement in NIHSS score of ≥4 or NIHSS score of 0–1, quality of life measured by the EQ-5D scale, etc. Safety outcomes such as global disability (mRS ≥3) at day 90 will also be assessed. The changes in mRNA and microRNA profiles in 96 patients selected from certain centers will also be assessed. As this is an adaptive design, two interim analyses are prospectively planned, which will be carried out after one-third and two-thirds of patients have completed the trial, respectively. Based on the results of the interim analyses, the Data Monitoring Committee (DMC) will decide how to modify the study. Discussion This trial will provide high-quality evidence for DHI in treatment of AIS. Trial registration Clinical Trials.gov NCT01677208 (Date of registration 22 December 2012). Electronic supplementary material The online version of this article (doi:10.1186/s13063-015-1076-4) contains supplementary material, which is available to authorized users.
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43. Feedback control of intense femtosecond laser pulses using a novel spatial light modulator.
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Suda, A., Oishi, Y., Pengqian Wang, Nagasaka, K., and Midorikawa, K.
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- 2000
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44. Self-compression of femtosecond laser pulses and full-dimensional spatiotemporal optical soliton formation.
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Koprinkov, I.G., Suda, A., Pengqian Wang, and Midorikawa, K.
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- 1999
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