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6. Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act

Author

Motter, Jennifer D., Hussain, Sarah, Brown, Diane M., Florman, Sander, Rana, Meenakshi M., Friedman-Moraco, Rachel, Gilbert, Alexander J., Stock, Peter, Mehta, Shikha, Mehta, Sapna A., Stosor, Valentina, Elias, Nahel, Pereira, Marcus R., Haidar, Ghady, Malinis, Maricar, Morris, Michele I., Hand, Jonathan, Aslam, Saima, Schaenman, Joanna M., Baddley, John, Small, Catherine B., Wojciechowski, David, Santos, Carlos A.Q., Blumberg, Emily A., Odim, Jonah, Apewokin, Senu K., Giorgakis, Emmanouil, Bowring, Mary Grace, Werbel, William A., Desai, Niraj M., Tobian, Aaron A.R., Segev, Dorry L., Massie, Allan B., Durand, Christine M., Kusemiju, Oyinkansola, Barnaba, Brittany, Prizzi, Michelle, Liang, Tao, Barnes, Grace Link, Chahoud, Margaret, Wiles, James, Cochran, Willa, Morrison, Michelle, Storm, Kaitlyn, Apte, Anuj, Paredes, Linda, Kuffar, Bahati, Stearns, Quinten, Brown, Nadine, Chang, Amy, Haydel, Brandy M., Pearson, Thomas, Mehta, Aneesh K., Lyon, G. Marshall, Kitchens, William, Huckaby, Jeryl, Elbein, Rivka, Roberson, April, Ferry, Elizabeth, Coakley, Margaret, Akhran, Aleya, Timpone, Joseph, Stucke, Alyssa, Mompoint-Williams, Darnell, Locke, Jayme E., Weldon, Elaina P., Dieter, Rebecca, Klein, Elizabeth, Goudy, Leah, Callegari, Michelle, Gallon, Lorenzo, Hughes, Kailey, Pakstis, Diana Lynn, Silveira, Fernanda, Tomlin, Ricarda, Smith, Angela, Shah, Mita, Mekeel, Kristin, Nguyen, Phirum, Mills, Jeff, Bunnapradist, Suphamai, Gritsch, H. Albin, Moe, Ardis A., Silva, Rosemary, Marrazzo, Ilise D., Muthukumar, Thangamani, Chang, Amy, Hoz, Ricardo La, Hubbard, Jarrett, Mall, Mark, Santos, Carlos, Dunn, Ty, Sawinski, Deirdre, Najdzinowicz, Maryann, Chen, Jeanne M., Nagy, Jamie, and Brigle, Nathaniel

Published
2024
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8. Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation

Author

Ajaimy, Maria, Al Azzi, Yorg, Annambhotla, Pallavi, Backenson, Bryon, Belden, Katherine, Colovai, Adriana, Coppock, Dagan, Du, Lydia, Estetter, Lindsey, Le, Marie, Martines, Roosecelis B., Pettengill, Matthew, Szymczak, Wendy, Vareechon, Chairut, Gould, Carolyn V, Free, Rebecca J, Bhatnagar, Julu, Soto, Raymond A, Royer, Tricia L, Maley, Warren R, Moss, Sean, Berk, Matthew A, Craig-Schapiro, Rebecca, Kodiyanplakkal, Rosy Priya L, Westblade, Lars F, Muthukumar, Thangamani, Puius, Yoram A, Raina, Amresh, Hadi, Azam, Gyure, Kymberly A, Trief, Danielle, Pereira, Marcus, Kuehnert, Matthew J, Ballen, Vennus, Kessler, Debra A, Dailey, Kimberly, Omura, Charles, Doan, Thuy, Miller, Steve, Wilson, Michael R, Lehman, Jennifer A, Ritter, Jana M, Lee, Elizabeth, Silva-Flannery, Luciana, Reagan-Steiner, Sarah, Velez, Jason O, Laven, Janeen J, Fitzpatrick, Kelly A, Panella, Amanda, Davis, Emily H, Hughes, Holly R, Brault, Aaron C, St George, Kirsten, Dean, Amy B, Ackelsberg, Joel, Basavaraju, Sridhar V, Chiu, Charles Y, and Staples, J Erin

Published
2023
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9. Living kidney donors with HIV: experience and outcomes from a case series by the HOPE in Action Consortium

Author

Agrawal, Neerja, Pereira, Marcus, Ranganna, Karthik, Wolfe, Cameron, Friedman-Moraco, Rachel, Kitchens, William, Adebiyi, Oluwafisayo, Kubal, Chandrashekhar, Cameron, Andrew, Desai, Niraj, Durand, Christine, Ottmann, Shane, Elias, Nahel, Gilbert, Alexander, Smith, Coleman, Castillo-Lugo, Jose A., Florman, Sander, Segev, Dorry L., Massie, Allan, Mehta, Sapna, Stosor, Valentina, Hand, Jonathan, Blumberg, Emily, Santos, Carlos A.Q., Goldberg, Ryan, Mehta, Shikha, Cannon, Robert, Giorgakis, Emmanouil, Schaenman, Joanna, Aslam, Saima, Stock, Peter, Price, Jennifer, Apewokin, Senu, Benamu, Esther, Spaggiari, Mario, Baddley, John, Morris, Michele I., Simkins, Jacques, Pruett, Timothy, Haidar, Ghady, Wojciechowski, David, Agarwal, Avinash, Balaraman, Vasanthi, Gupta, Gaurav, Chapman, Will, Muthukumar, Thangamani, Small, Catherine B., Malinis, Maricar, Durand, Christine M., Martinez, Nina, Neumann, Karl, Benedict, Reed C., Baker, Arthur W., Wolfe, Cameron R., Shetty, Aneesha, Dietch, Zachary C., Goudy, Leah, Callegari, Michelle A., Massie, Allan B., Brown, Diane, Cochran, Willa, Muzaale, Abimereki, Fine, Derek, Tobian, Aaron A.R., Winkler, Cheryl A., and Al Ammary, Fawaz

Published
2023
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13. COVID-19 in solid organ transplant recipients: Initial report from the US epicenter

Author

Pereira, Marcus R., Mohan, Sumit, Cohen, David J., Husain, Syed A., Dube, Geoffrey K., Ratner, Lloyd E., Arcasoy, Selim, Aversa, Meghan M., Benvenuto, Luke J., Dadhania, Darshana M., Kapur, Sandip, Dove, Lorna M., Brown, Robert S., Jr., Rosenblatt, Russell E., Samstein, Benjamin, Uriel, Nir, Farr, Maryjane A., Satlin, Michael, Small, Catherine B., Walsh, Thomas J., Kodiyanplakkal, Rosy P., Miko, Benjamin A., Aaron, Justin G., Tsapepas, Demetra S., Emond, Jean C., and Verna, Elizabeth C.

Published
2020
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18. H2S adsorption on NaY zeolite

Author

de Oliveira, Leonardo Hadlich, Meneguin, Joziane Gimenes, Pereira, Marcus Vinicius, da Silva, Edson Antonio, Grava, Wilson Mantovani, do Nascimento, Jailton Ferreira, and Arroyo, Pedro Augusto

Published
2019
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20. Genomic Surveillance Reveals Diversity of Multidrug-Resistant Organism Colonization and Infection : A Prospective Cohort Study in Liver Transplant Recipients

Author

Macesic, Nenad, Gomez-Simmonds, Angela, Sullivan, Sean B., Giddins, Marla J., Ferguson, Samantha A., Korakavi, Gautam, Leeds, David, Park, Sarah, Shim, Kevin, Sowash, Madeleine G., Hofbauer, Melanie, Finkel, Ryan, Hu, Yue, West, Jared, Toussaint, Nora C., Greendyke, William G., Miko, Benjamin A., Pereira, Marcus R., Whittier, Susan, Verna, Elizabeth C., and Uhlemann, Anne-Catrin

Published
2018

22. Incidence and Outcomes of COVID-19 in Kidney and Liver Transplant Recipients With HIV: Report From the National HOPE in Action Consortium

Author

Mehta, Sapna A., Rana, Meenakshi M., Motter, Jennifer D., Small, Catherine B., Pereira, Marcus R., Stosor, Valentina, Elias, Nahel, Haydel, Brandy, Florman, Sander, Odim, Jonah, Morsheimer, Megan, Robien, Mark, Massie, Allan B., Brown, Diane, Boyarsky, Brian, Garonzik Wang, Jacqueline, Tobian, Aaron A.R., Werbel, William A., Segev, Dorry L., and Durand, Christine M.

Published
2020
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24. Imagining Becoming Coalition: resisting academic ecosystems from within and beyond through coalition building and reversed research.

Author

Berbary, Lisbeth A., Alexander, R., Pereira, Marcus T., and Lopez, Kimberly J.

Abstract

Copyright of Leisure/Loisir: Journal of the Canadian Association for Leisure Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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27. Impact of CMV Reactivation, Treatment Approaches, and Immune Reconstitution in a Nonmyeloablative Tolerance Induction Protocol in Cynomolgus Macaques

Author

Alonso-Guallart, Paula, Duran-Struuck, Raimon, Zitsman, Jonah S., Sameroff, Stephen, Pereira, Marcus, Stern, Jeffrey, Berglund, Erik, Llore, Nathaly, Pierre, Genevieve, Lopes, Emily, Kofman, Sigal B., Danton, Makenzie, Sondermeijer, Hugo P., Woodland, David, Kato, Yojiro, Ekanayake-Alper, Dilrukshi K., Iuga, Alina C., Wuu, Cheng-Shie, Wu, Anette, Lipkin, W. Ian, Tokarz, Rafal, Sykes, Megan, and Griesemer, Adam

Published
2020
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28. Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients.

Author

Chou, Sunwen, Alain, Sophie, Cervera, Carlos, Chemaly, Roy F, Kotton, Camille N, Lundgren, Jens, Papanicolaou, Genovefa A, Pereira, Marcus R, Wu, Jingyang J, Murray, Rose Ann, Buss, Neil E, and Fournier, Martha

Subjects
CLINICAL trials, DRUG resistance, CYTOMEGALOVIRUS diseases, CLINICAL trial registries, VIRAL genes
Abstract

Background This drug resistance analysis of a randomized trial includes 234 patients receiving maribavir and 116 receiving investigator-assigned standard therapy (IAT), where 56% and 24%, respectively, cleared cytomegalovirus DNA at week 8 (treatment responders). Methods Baseline and posttreatment plasma samples were tested for mutations conferring drug resistance in viral genes UL97 , UL54, and UL27. Results At baseline, genotypic testing revealed resistance to ganciclovir, foscarnet, or cidofovir in 56% of patients receiving maribavir and 68% receiving IAT, including 9 newly phenotyped mutations. Among them, 63% (maribavir) and 21% (IAT) were treatment responders. Detected baseline maribavir resistance mutations were UL27 L193F (n = 1) and UL97 F342Y (n = 3). Posttreatment, emergent maribavir resistance mutations were detected in 60 (26%) of those randomized to maribavir, including 49 (48%) of 103 nonresponders and 25 (86%) of the 29 nonresponders where viral DNA initially cleared then rebounded while on maribavir. The most common maribavir resistance mutations were UL97 T409M (n = 34), H411Y (n = 26), and C480F (n = 21), first detected 26 to 130 (median 56) days after starting maribavir. Conclusions Baseline maribavir resistance was rare. Drug resistance to standard cytomegalovirus antivirals did not preclude treatment response to maribavir. Rebound in plasma cytomegalovirus DNA while on maribavir strongly suggests emerging drug resistance. Clinical Trials Registration NCT02931539. [ABSTRACT FROM AUTHOR]

Published
2024
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34. HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV.

Author

Benner, Sarah E, Zhu, Xianming, Hussain, Sarah, Florman, Sander, Eby, Yolanda, Fernandez, Reinaldo E, Ostrander, Darin, Rana, Meenakshi, Ottmann, Shane, Hand, Jonathan, Price, Jennifer C, Pereira, Marcus R, Wojciechowski, David, Simkins, Jacques, Stosor, Valentina, Mehta, Sapna A, Aslam, Saima, Malinis, Maricar, Haidar, Ghady, and Massie, Allan

Subjects
LIVER transplantation, CLINICAL trial registries, HIV, HIV-positive persons
Abstract

The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393. [ABSTRACT FROM AUTHOR]

Published
2023
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35. The prospect of universal coronavirus immunity: characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses.

Author

Soni, Mithil K., Migliori, Edoardo, Jianing Fu, Assal, Amer, Hei Ton Chan, Jian Pan, Khatiwada, Prabesh, Ciubotariu, Rodica, May, Michael S., Pereira, Marcus R., Giorgi, Valeria De, Sykes, Megan, Mapara, Markus Y., and Muranski, Pawel J.

Subjects
T cells, CORONAVIRUSES, SARS-CoV-2 Omicron variant, COVID-19, SARS-CoV-2
Abstract

T cell immunity plays a central role in clinical outcomes of Coronavirus Infectious Disease 2019 (COVID-19) and T cell-focused vaccination or cellular immunotherapy might provide enhanced protection for some immunocompromised patients. Preexisting T cell memory recognizing SARS-CoV-2 antigens antedating COVID-19 infection or vaccination, may have developed as an imprint of prior infections with endemic non-SARS human coronaviruses (hCoVs) OC43, HKU1, 229E, NL63, pathogens of “common cold”. In turn, SARS-CoV-2-primed T cells may recognize emerging variants or other hCoV viruses and modulate the course of subsequent hCoV infections. Cross-immunity between hCoVs and SARS-CoV-2 has not been well characterized. Here, we systematically investigated T cell responses against the immunodominant SARS-CoV-2 spike, nucleocapsid and membrane proteins and corresponding antigens from a- and b-hCoVs among vaccinated, convalescent, and unexposed subjects. Broad T cell immunity against all tested SARS-CoV-2 antigens emerged in COVID-19 survivors. In convalescent and in vaccinated individuals, SARS-CoV-2 spike-specific T cells reliably recognized most SARS-CoV-2 variants, however cross-reactivity against the omicron variant was reduced by approximately 47%. Responses against spike, nucleocapsid and membrane antigens from endemic hCoVs were significantly more extensive in COVID-19 survivors than in unexposed subjects and displayed cross-reactivity between a- and b-hCoVs. In some, nonSARS hCoV-specific T cells demonstrated a prominent non-reciprocal crossreactivity with SARS-CoV-2 antigens, whereas a distinct anti-SARS-CoV-2 immunological repertoire emerged post-COVID-19, with relatively limited crossrecognition of non-SARS hCoVs. Based on this cross-reactivity pattern, we established a strategy for in-vitro expansion of universal anti-hCoV T cells for adoptive immunotherapy. Overall, these results have implications for the future design of universal vaccines and cell-based immune therapies against SARS- and non-SARS-CoVs. [ABSTRACT FROM AUTHOR]

Published
2023
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36. When you need to dive in the deep end—Transplanting SARS‐CoV‐2 PCR+ recipients.

Author

Zavala, Sofia, DeLaurentis, Clare, Aaron, Justin G., Miko, Benjamin A., Fox, Alyson N., Bergelson, Michael, DeVore, Adam, Segovia, Maria Cristina, Wolfe, Cameron R., and Pereira, Marcus R.

Subjects
KIDNEY transplantation, SARS-CoV-2, COVID-19, DEEP diving, HEART transplant recipients, POLYMERASE chain reaction
Abstract

There is an ongoing need to understand whether transplantation during acute Coronavirus disease 2019 (COVID‐19) can be performed safely, especially when urgent transplant is required. We collected retrospective data of all consecutive non‐lung transplant recipients who had a positive SARS‐CoV‐2 polymerase chain reaction (PCR) on the day of planned deceased donor organ implantation. Data were collected from two large transplant centers from 01/01/2022 to 02/01/2023. Demographics, details regarding COVID‐19 infection, waitlist priority, and details regarding transplantation were obtained. A descriptive analysis was performed. A total of 12 patients were identified: 7 renal, 4 liver, and 1 heart transplant recipient. All 12 patients were vaccinated for COVID‐19. Ten were asymptomatic outpatients found positive on admission and transplanted immediately. Two were in‐patients with mild COVID‐19 symptoms and were reactivated on the waitlist following 3 days of remdesivir when no progression to severe COVID‐19 occurred. Most patients (10/12) received remdesivir posttransplant. No complications attributed to COVID‐19 were noted nor were any secondary family or healthcare worker infections observed. All recipients were managed with special isolation precautions befitting their potentially infectious state. Standard induction therapy was used in all recipients. After a median follow up period of 143 days (interquartile range: 96–201 days), 3 episodes of rejection were documented, 2/7 renal recipients experienced delayed graft function, and 2/4 liver recipients required renal replacement therapy. Graft and patient survival were 100%. Transplantation can safely proceed in select, minimally symptomatic, non‐lung recipients with a positive SARS‐CoV‐2 PCR at the time of transplant. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Audiovisual Physics Reports: Students' Video Production as a Strategy for the Didactic Laboratory

Author

Pereira, Marcus Vinicius, de Souza Barros, Susana, de Rezende Filho, Luiz Augusto C., and de A. Fauth, Leduc Hermeto

Abstract

Constant technological advancement has facilitated access to digital cameras and cell phones. Involving students in a video production project can work as a motivating aspect to make them active and reflective in their learning, intellectually engaged in a recursive process. This project was implemented in high school level physics laboratory classes resulting in 22 videos which are considered as audiovisual reports and analysed under two components: theoretical and experimental. This kind of project allows the students to spontaneously use features such as music, pictures, dramatization, animations, etc, even when the didactic laboratory may not be the place where aesthetic and cultural dimensions are generally developed. This could be due to the fact that digital media are more legitimately used as cultural tools than as teaching strategies. (Contains 3 tables and 2 figures.)

Published
2012
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47. Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

Author

Duran-Struuck, Raimon, Sondermeijer, Hugo P., Bühler, Leo, Alonso-Guallart, Paula, Zitsman, Jonah, Kato, Yojiro, Wu, Anette, McMurchy, Alicia N., Woodland, David, Griesemer, Adam, Martinez, Mercedes, Boskovic, Svetlan, Kawai, Tatsuo, Cosimi, A. Benedict, Wuu, Cheng-Shie, Slate, Andrea, Mapara, Markus Y., Baker, Sam, Tokarz, Rafal, DʼAgati, Vivette, Hammer, Scott, Pereira, Marcus, Lipkin, W. Ian, Wekerle, Thomas, Levings, Megan K., and Sykes, Megan

Published
2017
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50. Kidney allograft biopsy findings after COVID-19

Author

Daniel, Emily, Sekulic, Miroslav, Kudose, Satoru, Kubin, Christine, Ye, Xiaoyi, Shayan, Katayoon, Patel, Ankita, Cohen, David J., E. Ratner, Lloyd, Santoriello, Dominick, Barry Stokes, M., Markowitz, Glen S., Pereira, Marcus R., D’Agati, Vivette D., and Batal, Ibrahim

Published
2021
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