40 results on '"Perez, Marina"'
Search Results
2. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study
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Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert
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- 2023
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3. Urgent care and suicidal behavior in the child and adolescent population in a psychiatric emergency department in a Spanish province during the two COVID-19 states of alarm
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Llorca-Bofí, Vicent, Adrados-Pérez, Marina, Sánchez-Cazalilla, Marta, Torterolo, Giovanni, Arenas-Pijoan, Laura, Buil-Reiné, Esther, Nicolau-Subires, Eugènia, Albert-Porcar, Carla, Ibarra-Pertusa, Lucía, Puigdevall-Ruestes, Margarita, and Irigoyen-Otiñano, María
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- 2023
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4. Characteristics of patients treated for suicidal behavior during the pandemic in a psychiatric emergency department in a Spanish province
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Irigoyen-Otiñano, María, Nicolau-Subires, Eugènia, González-Pinto, Ana, Adrados-Pérez, Marina, Buil-Reiné, Esther, Ibarra-Pertusa, Lucía, Albert-Porcar, Carla, Arenas-Pijoan, Laura, Sánchez-Cazalilla, Marta, Torterolo, Giovanni, Puigdevall-Ruestes, Margarita, and Llorca-Bofí, Vicent
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- 2023
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5. The gut microbiota as a versatile immunomodulator in obesity and associated metabolic disorders
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Liébana-García, Rebeca, Olivares, Marta, Bullich-Vilarrubias, Clara, López-Almela, Inmaculada, Romaní-Pérez, Marina, and Sanz, Yolanda
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- 2021
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6. High prevalence of SARS-CoV-2 antibodies in care homes affected by COVID-19: Prospective cohort study, England
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Ladhani, Shamez N, Jeffery-Smith, Anna, Patel, Monika, Janarthanan, Roshni, Fok, Jonathan, Crawley-Boevey, Emma, Vusirikala, Amoolya, Fernandez Ruiz De Olano, Elena, Perez, Marina Sanchez, Tang, Suzanne, Dun-Campbell, Kate, Evans, Edward Wynne, Bell, Anita, Patel, Bharat, Amin-Chowdhury, Zahin, Aiano, Felicity, Paranthaman, Karthik, Ma, Thomas, Saavedra-Campos, Maria, Ellis, Joanna, Chand, Meera, Brown, Kevin, Ramsay, Mary E., Hopkins, Susan, Shetty, Nandini, Chow, J. Yimmy, Gopal, Robin, and Zambon, Maria
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- 2020
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7. Mechanical Complications of Proximal Femur Fractures Treated with Intramedullary Nailing: A Retrospective Study.
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Lopez-Hualda, Alvaro, García-Cabrera, Esperanza Marin, Lobato-Perez, Marina, Martinez-Martin, Javier, Rossettini, Giacomo, Leigheb, Massimiliano, and Villafañe, Jorge Hugo
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PROXIMAL femoral fractures ,HIP fractures ,MUSCULOSKELETAL system injuries ,INTRAMEDULLARY fracture fixation ,HIP surgery ,INTRAMEDULLARY rods ,RETROSPECTIVE studies - Abstract
Background and Objectives: This retrospective cohort study analyzes mechanical complications in hip fracture surgery using the Trochanteric Fixation Nail-Advanced (TFNA) implant. It investigates the correlation of these complications with demographic, intraoperative, and radiological factors, aiming to identify associated risk factors and suggest improvements in clinical surveillance and treatment strategies. Materials and Methods: We enrolled 253 patients diagnosed with pertrochanteric hip fractures treated between 2017 and 2021, with 126 meeting the criteria for a minimum 6-month follow-up. Data on demographics, American Anesthesia Association Classification (ASA), comorbidities, AO/OTA [AO (Arbeitsgemeinschaft für Osteosynthesefragen)/OTA (Orthopedic Trauma Association)] fracture classification, procedural details, and time to failure were collected. Radiographs were evaluated for reduction quality, the tip–apex distance (TAD), progressive varus deviation, and identification of mechanical complications. Statistical analysis was performed using SPSS software. Results: The predominant AO/OTA fracture classification was 31A2 in 67 cases (52.7%). Reduction quality was deemed good or acceptable in 123 cases (97.6%). The mean time to failure was 4.5 months (range: 2.2–6). The average TAD was 18 mm (range: 1.2–36), with a mean progressive varus deviation of 2.44° (range: 1.30–4.14). A good or acceptable reduction quality was observed in 97.6% of cases. Mechanical complications occurred in 21.4% of patients, with significant associations found with the lateral cortex fracture, use of a TFNA implant with a 130° angle, open reduction, and absence of prior osteoporosis treatment. Conclusions: The study provides insights into mechanical complications in proximal femur fractures treated with the TFNA nail, emphasizing the need for enhanced clinical and radiographic surveillance, especially in patients without osteoporosis treatment. Our findings support the necessity for further clinical studies comparing these outcomes with other implant designs and underscore the importance of personalized treatment strategies to reduce complication rates. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020
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Ladhani, Shamez N, Chow, J.Yimmy, Janarthanan, Roshni, Fok, Jonathan, Crawley-Boevey, Emma, Vusirikala, Amoolya, Fernandez, Elena, Perez, Marina Sanchez, Tang, Suzanne, Dun-Campbell, Kate, Evans, Edward Wynne, Bell, Anita, Patel, Bharat, Amin-Chowdhury, Zahin, Aiano, Felicity, Paranthaman, Karthik, Ma, Thomas, Saavedra-Campos, Maria, Myers, Richard, Ellis, Joanna, Lackenby, Angie, Gopal, Robin, Patel, Monika, Brown, Colin, Chand, Meera, Brown, Kevin, Ramsay, Mary E, Hopkins, Susan, Shetty, Nandini, and Zambon, Maria
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- 2020
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9. Hemophagocytic syndrome in patients living with HIV: a retrospective study
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Telles, João Paulo, de Andrade Perez, Marina, Marcusso, Rosa, Correa, Karina, Teixeira, Ralcyon Francis Azevedo, and Tobias, Walter Moises
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- 2019
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10. IMPLEMENTATION OF A MOBILE ECMO TEAM FOR NORMOTHERMIC REGIONAL PERFUSION AS DONOR PRESERVATION METHOD IN CONTROLLED DONATION AFTER CIRCULATORY DEATH (CDAC) IN THE COMMUNITY OF MADRID
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Rodriguez, Alonso Mateos, Davila, Fatima, Segade, Ma Jesus, Garcia, Carlina, Rubio, Juan Jose, Perez, Marina, Torres, Juan Ignacio, Casado, Esther, and Rio-Gallego, Francisco Jose Del
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- 2020
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11. Preparation of an ultra-cold sample of ammonia molecules for precision measurements
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Quintero-Pérez, Marina, Wall, Thomas E., Hoekstra, Steven, and Bethlem, Hendrick L.
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- 2014
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12. Taurine–nitrite interaction as a precursor of alkylation mechanisms
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Arenas-Valgañón, Jorge, Gómez-Bombarelli, Rafael, González-Pérez, Marina, González-Jiménez, Mario, Calle, Emilio, and Casado, Julio
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- 2012
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13. Reactivity of mucohalic acids in water
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Gómez-Bombarelli, Rafael, González-Pérez, Marina, Calle, Emilio, and Casado, Julio
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- 2011
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14. High neutrophil-lymphocyte ratio upon admission is associated with better response in psychotic depression
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Llorca-Bofí, Vicent, Palacios-Garrán, Roberto, Rey Routo, Diana, Buil-Reiné, Esther, Adrados-Pérez, Marina, Gich, Ignasi, Bioque, Miquel, and Mur, Maria
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- 2021
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15. Why keep an ECT unit open during a COVID-19 lockdown period
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Llorca-Bofí, Vicent, Batalla, Iolanda, Adrados-Pérez, Marina, Buil-Reiné, Esther, Pifarré, Josep, and Torrent, Aurora
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- 2021
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16. Using a Deep Learning Algorithm to Improve the Results Obtained in the Recognition of Vessels Size and Trajectory Patterns in Shallow Areas Based on Magnetic Field Measurements Using Fluxgate Sensors.
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Perez, Marina, Parras, Juan, Zazo, Santiago, Perez Alvarez, Ivan A., and Lluch, Maria del Mar Sanz
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Safety in coastal areas such as beaches, ports, pontoons, etc., is a current problem with a difficult solution and on which many organizations are putting efforts in terms of technological innovation. In this work the design of a possible solution based on magnetic sensors is presented. First, a study has been made of the type of sensors that best suit the application based on parameters such as sensitivity, the allowed bandwidth of excitation, price or physical construction. Then the system of excitation of the sensors and signal measurement is presented. To justify the design, a series of simulations of magnetic field variations have been carried out in the presence of large objects of conductive material, in the vicinity of the measuring points. With these data a mathematical model has been established that allows the identification of the dimensions and position of the object through triangulation and knowing only the data of the magnetic field. It was found that although this method seems quite effective, it has a significant error, so another method based on neural networks was developed also using data from the simulations. This method seems to yield much better and more reliable results. [ABSTRACT FROM AUTHOR]
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- 2022
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17. The OTELO survey II. The faint-end of the H alpha luminosity function at z similar to 0.40
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Ramon-Perez, Marina, Bongiovanni, Angel, Perez Garcia, Ana Maria, Cepa, Jordi, Lara-Lopez, Maritza A., de Diego, Jose A., Alfaro, Emilio, Castaneda, Hector O., Cervino, Miguel, Fernandez-Lorenzo, Mirian, Gallego, Jesus, Jesus Gonzalez, J., Ignacio Gonzalez-Serrano, J., Nadolny, Jakub, Oteo Gomez, Ivan, Perez Martinez, Ricardo, Pintos-Castro, Irene, Povi, Mirjana, and Sanchez-Portal, Miguel
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surveys ,active [galaxies] ,star formation [galaxies] ,luminosity function, mass function [galaxies] - Published
- 2019
18. The Personality of American Nations: An Exploratory Study.
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Lanning, Kevin, Warfel, Evan A., Wetherell, Geoffrey, Perez, Marina, Boyd, Ryan, and Condon, David M.
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PERSONALITY ,SCHOLARS ,DATA analysis - Abstract
Some scholars have presented models of the United States as a set of "nations" with distinct settlement histories and contemporary cultures. We examined personality differences in one such model, that of Colin Woodard, using data from over 75,000 respondents. Four nations were particularly distinct: The Deep South, Left Coast, New Netherland, and the Spanish Caribbean. Differences between nations at the level of the individual person were typically small, but were larger at the level of community, revealing how aggregation can contribute to differences in the lived experience of places in nations such as Yankeedom or Greater Appalachia. We represented effects in a three-dimensional model defined by Authoritarian conventionalism (which differentiated 'Red' and 'Blue' nations) as well as Cognitive resilience and Competitiveness (which differentiated among the Blue nations). Finally, we adjusted Woodard's model to better fit the data, and found that nations largely maintained their boundaries, with the most drastic changes occurring on the East Coast. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Increase in urgent care for patients with an eating disorder during the COVID-19 pandemic in a Spanish province
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Irigoyen-Otiñano, María, González-Pinto, Ana, Llorca-Bofí, Vicent, Adrados-Pérez, Marina, Arenas-Pijoan, Laura, Torterolo, Giovanni, Sánchez-Cazalilla, Marta, Buil, Esther, Nicolau-Subires, Eugènia, Albert-Porcar, Carla, Ibarra-Pertusa, Lucía, and Puigdevall-Ruestes, Margarita
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- 2022
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20. Mass testing after a single suspected or confirmed case of COVID-19 in London care homes, April–May 2020: implications for policy and practice.
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Tang, Suzanne, Perez, Marina Sanchez, Saavedra-Campos, Maria, Paranthaman, Karthik, Myers, Richard, Fok, Jonathan, Crawley-Boevey, Emma, Dun-Campbell, Kate, Janarthanan, Roshni, Fernandez, Elena, Vusirikala, Amoolya, Patel, Bharat, Ma, Thomas, Amin-Chowdhury, Zahin, Shetty, Nandini, Zambon, Maria, Bell, Anita, Wynne-Evans, Edward, Chow, Yimmy, and Ladhani, Shamez
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PREVENTION of infectious disease transmission , *REVERSE transcriptase polymerase chain reaction , *COVID-19 , *SEQUENCE analysis , *SARS-CoV-2 , *PREVENTION of communicable diseases , *MEDICAL screening , *NURSING care facilities , *DESCRIPTIVE statistics , *COVID-19 testing , *POLYMERASE chain reaction , *CLUSTER analysis (Statistics) , *COVID-19 pandemic , *EARLY diagnosis - Abstract
Introduction Previous investigations have identified high rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents and staff in care homes reporting an outbreak of coronavirus disease 2019 (COVID-19). We investigated care homes reporting a single suspected or confirmed case to assess whether early mass testing might reduce risk of transmission during the peak of the pandemic in London. Methods Between 18 and 27 April 2020, residents and staff in care homes reporting a single case of COVID-19 to Public Health England had a nasal swab to test for SARS-CoV-2 infection by reverse transcription polymerase chain reaction and subsequent whole-genome sequencing. Residents and staff in two care homes were re-tested 8 days later. Results Four care homes were investigated. SARS-CoV-2 positivity was 20% (65/333) overall, ranging between 3 and 59%. Among residents, positivity ranged between 3 and 76% compared with 3 and 40% in staff. Half of the SARS-CoV-2-positive residents (23/46, 50%) and 63% of staff (12/19) reported symptoms within 14 days before or after testing. Repeat testing 8 days later in two care homes with the highest infection rates identified only two new cases. Genomic analysis demonstrated a small number of introduction of the virus into care homes, and distinct clusters within three of the care homes. Conclusions We found extensive but variable rates of SARS-CoV-2 infection among residents and staff in care homes reporting a single case of COVID-19. Although routine whole-home testing has now been adopted into practice, care homes must remain vigilant and should be encouraged to report a single suspected case, which should trigger appropriate outbreak control measures. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes.
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Ladhani, Shamez N, Chow, J. Yimmy, Janarthanan, Roshni, Fok, Jonathan, Crawley-Boevey, Emma, Vusirikala, Amoolya, Fernandez, Elena, Perez, Marina Sanchez, Tang, Suzanne, Dun-Campbell, Kate, Wynne-Evans, Edward, Bell, Anita, Patel, Bharat, Amin-Chowdhury, Zahin, Aiano, Felicity, Paranthaman, Karthik, Ma, Thomas, Saavedra-Campos, Maria, Myers, Richard, and Ellis, Joanna
- Abstract
Background: Care homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among staff in six care homes experiencing a COVID-19 outbreak during the peak of the pandemic in London, England.Methods: Care home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. Whole genome sequencing (WGS) was performed on RT-PCR positive samples.Results: In total, 53 (21%) of 254 staff were SARS-CoV-2 positive but only 12/53 (23%) were symptomatic. Among staff working in a single care home, SARS-CoV-2 positivity was 15% (2/13), 16% (7/45) and 18% (30/169) in those reporting no, occasional and regular contact with residents. In contrast, staff working across different care homes (14/27, 52%) had a 3.0-fold (95% CI, 1.9-4.8; P<0.001) higher risk of SARS-CoV-2 positivity than staff working in single care homes (39/227, 17%). WGS identified SARS-CoV-2 clusters involving staff only, including some that included staff working across different care homes.Conclusions: SARS-CoV-2 positivity was significantly higher among staff working across different care homes than those who were working in the same care home. We found local clusters of SARS-CoV-2 infection between staff only, including those with minimal resident contact. Infection control should be extended for all contact, including those between staff, whilst on care home premises. [ABSTRACT FROM AUTHOR]- Published
- 2020
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22. Reactivity of the mutagen 1,4-dinitro-2-methylpyrrole as an alkylating agent
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Perez-Prior, M. Teresa, Gomez-Bombarelli, Rafael, Gonzalez-Perez, Marina, Manso, Jose A., Garcia-Santos, M. Pilar, Calle, Emilio, and Casado, Julio
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Sorbic acid -- Chemical properties ,Methyl groups -- Chemical properties ,Mutagenesis -- Analysis ,Pyrrole -- Chemical properties ,Pyrrole -- Structure ,Biological sciences ,Chemistry - Abstract
1,4-Dinitro-2-methylpyrrole (NMP), resulting from the reaction between sorbic acid and nitrite, has mutagenic properties and its alkylating capacity is examined. The calculated energy barrier for the alkylation of 4-(p-nitrobenzyl)pyridine (NBP) for NMP and the value of the fraction of alkylating agent forming the adduct are consistent with mutagenicity of NMP.
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- 2010
23. Computational calculation of equilibrium constants: addition to carbonyl compounds
- Author
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Gomez-Bombarelli, Rafael, Gonzalez-Perez, Marina, Perez-Prior, Mara Teresa, Calle, Emilio, and Casado, Julio
- Subjects
Aldehydes -- Chemical properties ,Carbonyl compounds -- Chemical properties ,Carbonyl compounds -- Thermal properties ,Gibbs' free energy -- Analysis ,Hydration (Chemistry) -- Analysis ,Chemicals, plastics and rubber industries - Published
- 2009
24. Computational study of the acid dissociation of esters and lactones. A case study of diketene
- Author
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Gomez-Bombarelli, Rafael, Gonzalez-Perez, Marina, Perez-Prior, Maria Teresa, Casado, Julio, and Calle, Emilio
- Subjects
Dissociation -- Usage ,Esters -- Chemical properties ,Esters -- Structure ,Hydrolysis -- Usage ,Ketones -- Chemical properties ,Ketones -- Structure ,Biological sciences ,Chemistry - Abstract
A computational study is carried out on the aqueous p[K.sub.a] of some saturated and unsaturated cyclic and linear esters and ketones, with the integral equation formalism polarizable continuum model for solvation by using a proton exchange mechanism. The low p[K.sub.a] value has shown that deprotonated diketene has not interconverted to a more stable, less acidic [alpha]-[beta] unsaturated isomer.
- Published
- 2009
25. Maternal high fat diet and early life stress induce metabolic disturbances and enhance motivation for palatable food in offspring
- Author
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Romaní-Perez, Marina, LEPINAY, Amandine, Alonso, Lucille, Rincel, Marion, Xia, Lin, Fanet, Hortense, Caille, Stéphanie, Cador, M., Layé, Sophie, Vancassel, Sylvie, DARNAUDERY, Muriel, Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), and Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2015
26. Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: Opinion papers of the MyNewGut project.
- Author
-
Sanz, Yolanda, Romaní-Perez, Marina, Benítez-Páez, Alfonso, Portune, Kevin J., Brigidi, Patrizia, Rampelli, Simone, Dinan, Ted, Stanton, Catherine, Delzenne, Nathalie, Blachier, François, Neyrinck, Audrey M., Beaumont, Martin, Olivares, Marta, Holzer, Peter, Günther, Kathrin, Wolters, Maike, Ahrens, Wolfgang, Claus, Sandrine P., Campoy, Cristina, and Murphy, Rinki
- Abstract
Summary The gut microbiota coexists in partnership with the human host through adaptations to environmental and physiological changes that help maintain dynamic homeostatic healthy states. Break-down of this delicate balance under sustained exposure to stressors (e.g. unhealthy diets) can, however, contribute to the onset of disease. Diet is a key modifiable environmental factor that modulates the gut microbiota and its metabolic capacities that, in turn, could impact human physiology. On this basis, the diet and the gut microbiota could act as synergistic forces that provide resilience against disease or that speed the progress from health to disease states. Associations between unhealthy dietary patterns, non-communicable diseases and intestinal dysbiosis can be explained by this hypothesis. Translational studies showing that dietary-induced alterations in microbial communities recapitulate some of the pathological features of the original host further support this notion. In this introductory paper by the European project MyNewGut, we briefly summarize the investigations conducted to better understand the role of dietary patterns and food components in metabolic and mental health and the specificities of the microbiome-mediating mechanisms. We also discuss how advances in the understanding of the microbiome's role in dietary health effects can help to provide acceptable scientific grounds on which to base dietary advice for promoting healthy living. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
27. Elderly inpatients with prediction of hospital discharge: Caregivers prepared for providing care?
- Author
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Forattore,Fernanda de Sousa, Miccas,Fernanda Luppino, Perez,Marina Picazzo, and Couto,Tatiana Vieira
- Subjects
Caregivers, preparation for the care, aged - Abstract
INTRODUCTION: The main caregiver is the one in charge of tasks, among others, of helping the dependent elderly person with his daily activities and is, in general, a member of his family nucleus. The role of the caregiver falls into his hands, without him being prepared for that. OBJECTIVE: Verify the caregivers preparation regarding the basic care of the elderly inpatients prone to hospital discharge. METHODS: The study was carried out at the Geriatric Ward of Hospital do Servidor Público Estadual Francisco Morato de Oliveira in September and October 2007. It is a descriptive transversal study, with quantitative approach. Identification questionnaires were applied to the caregivers and elderly patients and a semi-structured questionnaire to the caregivers. RESULTS: The study sample was composed of 17 caregivers, being 94% female and 76% daughters. In relation to the preparation to carry out the elderly persons' Daily Living Basic Activities, 65% of the caregivers stated that they feel prepared. It was observed that 59% of the caregivers didn't have doubts before the admission and all the research's participants mentioned they didn't need to receive further orientations. CONCLUSION: It was observed that, in agreement with previous studies, the majority of the caregiver was female and daughters, who did not report doubts with regard to the basic cares before the admission and also affirmed they were prepared for providing care of hospital discharge. This can be a pointer of positive impact of the work of orientation exerted by the interdisciplinary team throughout hospitalization, being objectified one better care of the elderly person in the domicile.
- Published
- 2008
28. Non-obese type 2 diabetes impairs emotional behavior and leads to medial prefrontal cortex alterations
- Author
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Darnaudéry, Muriel, Romaní-Pérez, Marina, Lépinay, Amandine, Rincel, Marion, Bailbé, Danielle, Rande, Marine, Layé, Sophie, Capuron, Lucile, Portha, Bernard, and Movassat, Jamileh
- Published
- 2017
- Full Text
- View/download PDF
29. Optimization of fluorescence in situ hybridization technique for analyzing microorganisms involved in bioprocesses
- Author
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González-Pérez, Marina, Vieira, Ricardo, Nunes, Patrícia, Pereira, António, Candeias, António, and Caldeira, Ana T.
- Published
- 2016
- Full Text
- View/download PDF
30. Development of a Fluorescence In Situ Hybridization protocol for analysis of Gram-positive and Gram-negative bacteria
- Author
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González-Pérez, Marina, Fernandes, Rafaela, Vieira, Ricardo, Pereira, António, Candeias, António, and Caldeira, Ana T.
- Published
- 2016
- Full Text
- View/download PDF
31. Rapid approaches for yeast cells analysis enabling detection/identification/quantification and/or viability assessment
- Author
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González-Pérez, Marina, Fernandes, Rafaela, Vieira, Ricardo, Candeias, António, and Caldeira, Ana T.
- Published
- 2016
- Full Text
- View/download PDF
32. Non-deterministic Local Search Methods for Feature Selection: An Experimental Study.
- Author
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Fernandez-Perez, Marina P. and Gonzalez-Navarro, Felix F.
- Published
- 2014
- Full Text
- View/download PDF
33. PP-28 MORPHOKINETIC FACTORS AS EMBRYO QUALITY PREDICTORS
- Author
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Ramirez, Jose Muñoz, Bueno, Ana Silvan, Papoff, Carlotta Zonza, Perez, Marina Toledano, Brandt, Matias, Fernandez, Jose Angel Garcia, Lopez, Enriqueta Garijo, and Fernandez, Federico Galera
- Published
- 2012
- Full Text
- View/download PDF
34. PP-27 EMBRYO CLEAVAGE RATE IN ZYGOTES WITH ONE, TWO AND THREE PRONUCLEI
- Author
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Ramirez, Jose Muñoz, Bueno, Ana Silvan, Papoff, Carlotta Zonza, Perez, Marina Toledano, Brandt, Matias, Fernandez, Jose Angel Garcia, Lopez, Enriqueta Garijo, and Fernandez, Federico Galera
- Published
- 2012
- Full Text
- View/download PDF
35. Letters.
- Author
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Randall, Margaret, S. F., DeMarco, Darcy, Lefkovitz, Karen, Ficklen, Martha S., Gillem, Angela R., Garcia, Nora, Guerrero, Rosa Maria, De Palacios, Amparo L., Mejia, Corina, Perez, Marina, Escoba, Reina, Quijada, Zoila Beatriz, Saenz, Rosa Dina, Masin, Celia, Alfaro, Cecilia, Quijada, Matilde, Martinez, Lorena, De Rivas, Coralia, and Ramos, M.
- Abstract
Presents letters to the editor referencing articles and topics discussed in previous issues of "Sojourner." Discussion on lesbian parenting of male children; "Legalized Prostitution : For Whose Benefit?," which focused on female prostitutes; Views on the June 1989 Massachusetts court decision in the LaLonde case, the case of ten-year Nicole LaLonde claimed to have been abused by her father.
- Published
- 1989
36. Mild deprotection of steroid esters by Bis(tributyltin)oxide
- Author
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Pérez, Marina G. and Maier, Marta S.
- Published
- 1995
- Full Text
- View/download PDF
37. Independent parental contributions initiate zygote polarization in Arabidopsis thaliana.
- Author
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Wang, Kai, Chen, Houming, Ortega-Perez, Marina, Miao, Yingjing, Ma, Yanfei, Henschen, Agnes, Lohmann, Jan U., Laubinger, Sascha, and Bayer, Martin
- Subjects
- *
ZYGOTES , *ARABIDOPSIS thaliana , *MITOGEN-activated protein kinases , *CELLULAR signal transduction , *FLOWERING of plants , *CELL division - Abstract
Embryogenesis of flowering plants is initiated by polarization of the zygote, a prerequisite for correct axis formation in the embryo. The daughter cells of the asymmetric zygote division form the pro-embryo and the mostly extra-embryonic suspensor. 1 The suspensor plays a pivotal role in nutrient and hormone transport and rapid growth of the embryo. 2,3 Zygote polarization is controlled by a MITOGEN-ACTIVATING PROTEIN (MAP) kinase signaling pathway including the MAPKK kinase (MAP3K) YODA (YDA) 4 and the upstream membrane-associated proteins BRASINOSTEROID SIGNALING KINASE 1 (BSK1) and BSK2. 5,6 Furthermore, suspensor development is controlled by cysteine-rich peptides of the EMBRYO SURROUNDING FACTOR 1 (ESF1) family. 7 While they act genetically upstream of YDA, the corresponding receptor to perceive these potential ligands is unknown. In other developmental processes, such as stomata development, YDA activity is controlled by receptor kinases of the ERECTA family (ERf). 8–12 While the receptor kinases upstream of BSK1/2 in the embryo have so far not been identified, 1 YDA is in part activated by the sperm cell-derived BSK family member SHORT SUSPENSOR (SSP) that represents a naturally occurring, constitutively active variant of BSK1. 5,13 It has been speculated that SSP might be a paternal component of a parental tug-of-war controlling resource allocation toward the embryo. 2,13 Here, we show that in addition to SSP, the receptor kinase ERECTA plays a crucial role in zygote polarization as a maternally contributed part of the embryonic YDA pathway. We conclude that two independent parental contributions initiate zygote polarization and control embryo development. [Display omitted] • Independent maternal and paternal factors influence Arabidopsis zygote polarity • Maternal ERECTA family receptor kinases activate the MAP3K YODA in the zygote • Paternal SHORT SUSPENSOR protein activates YODA independently of maternal ERECTA Cell polarization and asymmetric division of the zygote initiate axis formation of the embryo in the model plant Arabidopsis. Wang et al. show in this context that a maternal receptor complex and a paternally provided constitutively active signaling protein independently contribute to MAP kinase signaling controlling zygote polarization. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
38. Towards microbiome-informed dietary recommendations for promoting metabolic and mental health: opinion papers of the MyNewGut project
- Author
-
Yolanda Sanz, Wolfgang Ahrens, Timothy G. Dinan, Audrey M. Neyrinck, Nathalie M. Delzenne, Laura Fernández, Maike Wolters, Simone Rampelli, Catherine Stanton, Sandrine P. Claus, Alfonso Benítez-Páez, Martin Beaumont, Christina Sadler, Patrizia Brigidi, Marina Romaní-Pérez, Kevin J. Portune, Peter Holzer, Marta Olivares, Kathrin Günther, François Blachier, Jan Willem van der Kamp, Cristina Campoy, Rinki Murphy, Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Pharmacy and Biotechnology, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University College Cork (UCC), Teagasc Agriculture and Food Development Authority (Teagasc), Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain = Catholic University of Louvain (UCL), Physiologie de la Nutrition et du Comportement Alimentaire (PNCA), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Medical University Graz, University of Bremen, Department of Food and Nutritional Sciences, University of Reading (UOR), Universidad de Granada = University of Granada (UGR), Instituto de Salud Carlos III [Madrid] (ISC), University of Auckland [Auckland], EUFIC—European Food Information Council, Netherlands Organisation for Applied Scientific Research, European Project: 613979,EC:FP7:KBBE,FP7-KBBE-2013-7-single-stage,MYNEWGUT(2013), European Commission, University of Granada, Sanz, Yolanda, Romaní-Perez, Marina, Benítez-Páez, Alfonso, Portune, Kevin J., Brigidi, Patrizia, Rampelli, Simone, Dinan, Ted, Stanton, Catherine, Delzenne, Nathalie, Blachier, Françoi, Neyrinck, Audrey M., Beaumont, Martin, Olivares, Marta, Holzer, Peter, Günther, Kathrin, Wolters, Maike, Ahrens, Wolfgang, Claus, Sandrine P., Campoy, Cristina, Murphy, Rinki, Sadler, Christina, Fernández, Laura, and Kamp, Jan-Willem van der
- Subjects
0301 basic medicine ,Gerontology ,[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,media_common.quotation_subject ,Nutrition Education ,Metabolic health ,microbiome ,Disease ,Gut flora ,Critical Care and Intensive Care Medicine ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Nutrition and Dietetic ,microbiota ,Animals ,Humans ,Medicine ,Dietary recommendations ,030212 general & internal medicine ,Food components ,Microbiome ,media_common ,2. Zero hunger ,metabolic health ,Nutrition and Dietetics ,biology ,business.industry ,Microbiota ,Stressor ,biology.organism_classification ,Mental health ,Diet ,Gastrointestinal Microbiome ,3. Good health ,Metabolism ,030104 developmental biology ,dietary recommendation ,Psychological resilience ,business ,mental health - Abstract
The gut microbiota coexists in partnership with the human host through adaptations to environmental and physiological changes that help maintain dynamic homeostatic healthy states. Break-down of this delicate balance under sustained exposure to stressors (e.g. unhealthy diets) can, however, contribute to the onset of disease. Diet is a key modifiable environmental factor that modulates the gut microbiota and its metabolic capacities that, in turn, could impact human physiology. On this basis, the diet and the gut microbiota could act as synergistic forces that provide resilience against disease or that speed the progress from health to disease states. Associations between unhealthy dietary patterns, non-communicable diseases and intestinal dysbiosis can be explained by this hypothesis. Translational studies showing that dietary-induced alterations in microbial communities recapitulate some of the pathological features of the original host further support this notion. In this introductory paper by the European project MyNewGut, we briefly summarize the investigations conducted to better understand the role of dietary patterns and food components in metabolic and mental health and the specificities of the microbiome-mediating mechanisms. We also discuss how advances in the understanding of the microbiome's role in dietary health effects can help to provide acceptable scientific grounds on which to base dietary advice for promoting healthy living., The MyNewGut project is financially supported by a grant within the EU 7th Framework Programme under Grant Agreement 613979. The EU is not liable for the content presented in this publication. MO is a beneficiary of a >MOVE-IN Louvain> (incoming Post-Doctoral Fellowship co-funded by the Marie Curie Actions of the European).
- Published
- 2018
39. Breastfeeding Practices and Problems Among Obese Women Compared with Nonobese Women in a Brazilian Hospital.
- Author
-
Perez MR, de Castro LS, Chang YS, Sañudo A, Marcacine KO, Amir LH, Ross MG, and Coca KP
- Abstract
Background: Women who are obese have lower rates of breastfeeding initiation and duration and are less likely to breastfeed exclusively compared with women who are not obese. To develop programs to improve breastfeeding practices among this group of women, we investigated the association between maternal obesity and breastfeeding practices and problems in the first days postpartum. Methods: We analyzed medical records from postpartum women at a rooming-in maternity ward in State of São Paulo, Brazil, between 2016 and 2018. We included those who had intended to exclusively breastfeed, had given birth to a singleton and were admitted to rooming-in. We analyzed exclusive breastfeeding and nonexclusive breastfeeding each day of hospitalization and the presence of breastfeeding problems, comparing women in the obese category (body mass index [BMI] ≥30 kg/m
2 ) to normal and overweight women (≥18.6 to ≤29.9 kg/m2 ). Results: Two hundred and twenty-four postpartum women participated, including 86 women in the obese category. More than 50% of women with obesity reported a breastfeeding problem in the first and second postpartum days ( p = 0.026 and p = 0.017, respectively) compared with the 41% and 38% nonobese group. Children of obese women were 2.8 times more likely to have poor latch during breastfeeding (95% confidence interval [CI]: 1.29-6.10) compared with the nonobese group on the third day. Conclusion: Maternal obesity increased the probability of breastfeeding difficulties and nonexclusive breastfeeding at discharge. Professionals need to support breastfeeding techniques in the days immediate after delivery to improve breastfeeding outcomes for mothers with obesity., Competing Interests: No competing financial interests exist., (© Marina Rico Perezet al., 2021; Published by Mary Ann Liebert, Inc.)- Published
- 2021
- Full Text
- View/download PDF
40. Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020.
- Author
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Jeffery-Smith A, Dun-Campbell K, Janarthanan R, Fok J, Crawley-Boevey E, Vusirikala A, Fernandez Ruiz De Olano E, Sanchez Perez M, Tang S, Rowland TA, Wynne-Evans E, Bell A, Patel B, Amin-Chowdhury Z, Aiano F, Paranthaman K, Ma T, Saavedra-Campos M, Ellis J, Lackenby A, Whitaker H, Myers R, Höschler K, Brown K, Ramsay ME, Shetty N, Chow JY, Ladhani S, and Zambon M
- Abstract
Background: Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic., Methods: Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks., Findings: Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case.Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (r
s 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home., Interpretation: We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak., Funding: PHE., Competing Interests: The authors have nothing to disclose., (Crown Copyright © 2021 Published by Elsevier Ltd.)- Published
- 2021
- Full Text
- View/download PDF
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