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4. Hepatitis C Virus as a Possible Helper Virus in Human Hepatitis Delta Virus Infection.

Author

Crobu, Maria Grazia, Ravanini, Paolo, Impaloni, Clotilde, Martello, Claudia, Bargiacchi, Olivia, Di Domenico, Christian, Faolotto, Giulia, Macaluso, Paola, Mercandino, Alessio, Riggi, Miriam, Quaglia, Vittorio, Andreoni, Stefano, Pirisi, Mario, and Smirne, Carlo

Subjects
HEPATITIS D virus, HEPATITIS C virus, HEPATITIS B virus, HEPATITIS B
Abstract

Previous studies reported that the hepatitis C virus (HCV) could help disseminate the hepatitis D virus (HDV) in vivo through the unrelated hepatitis B virus (HBV), but with essentially inconclusive results. To try to shed light on this still-debated topic, 146 anti-HCV-positive subjects (of whom 91 HCV/HIV co-infected, and 43 with prior HCV eradication) were screened for anti-HDV antibodies (anti-HD), after careful selection for negativity to any serologic or virologic marker of current or past HBV infection. One single HCV/HIV co-infected patient (0.7%) tested highly positive for anti-HD, but with no positive HDV-RNA. Her husband, in turn, was a HCV/HIV co-infected subject with a previous contact with HBV. While conducting a thorough review of the relevant literature, the authors attempted to exhaustively describe the medical history of both the anti-HD-positive patient and her partner, believing it to be the key to dissecting the possible complex mechanisms of HDV transmission from one subject to another, and speculating that in the present case, it may have been HCV itself that behaved as an HDV helper virus. In conclusion, this preliminary research, while needing further validation in large prospective studies, provided some further evidence of a role of HCV in HDV dissemination in humans. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Gas6/TAM system as potential biomarker for multiple sclerosis prognosis.

Author

D'Onghia, Davide, Colangelo, Donato, Bellan, Mattia, Tonello, Stelvio, Puricelli, Chiara, Virgilio, Eleonora, Apostolo, Daria, Minisini, Rosalba, Ferreira, Luciana L., Sozzi, Leonardo, Vincenzi, Federica, Cantello, Roberto, Comi, Cristoforo, Pirisi, Mario, Vecchio, Domizia, and Sainaghi, Pier Paolo

Subjects
CENTRAL nervous system viral diseases, MULTIPLE sclerosis, PROGNOSIS, CENTRAL nervous system diseases, DEMYELINATION, BIOMARKERS
Abstract

Introduction: The protein growth arrest-specific 6 (Gas6) and its tyrosine kinase receptors Tyro-3, Axl, and Mer (TAM) are ubiquitous proteins involved in regulating inflammation and apoptotic body clearance. Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system leading to progressive and irreversible disability if not diagnosed and treated promptly. Gas6 and TAM receptors have been associated with neuronal remyelination and stimulation of oligodendrocyte survival. However, few data are available regarding clinical correlation in MS patients. We aimed to evaluate soluble levels of these molecules in the cerebrospinal fluid (CSF) and serum at MS diagnosis and correlate them with short-term disease severity. Methods: In a prospective cohort study, we enrolled 64 patients with a diagnosis of clinical isolated syndrome (CIS), radiological isolated syndrome (RIS) and relapsing-remitting (RR) MS according to the McDonald 2017 Criteria. Before any treatment initiation, we sampled the serum and CSF, and collected clinical data: disease course, presence of gadolinium-enhancing lesions, and expanded disability status score (EDSS). At the last clinical follow-up, we assessed EDSS and calculated MS severity score (MSSS) and age-related MS severity (ARMSS). Gas6 and TAM receptors were determined using an ELISA kit (R&D Systems) and compared to neurofilament (NFLs) levels evaluated with SimplePlex™ fluorescence-based immunoassay. Results: At diagnosis, serum sAxl was higher in patients receiving none or lowefficacy disease-modifying treatments (DMTs) versus patients with high-efficacy DMTs (p = 0.04). Higher CSF Gas6 and serum sAXL were associated with an EDSS <3 at diagnosis (p = 0.04; p = 0.037). Serum Gas6 correlates to a lower MSSS (r² = -0.32,p = 0.01). Serumand CSF NFLs were confirmed as disability biomarkers in our cohort according to EDSS (p = 0.005; p = 0.002) and MSSS (r² = 0.27, p = 0.03; r² = 0.39, p = 0.001). Results were corroborated using multivariate analysis. Conclusions: Our data suggest a protective role of Gas6 and its receptors in patients with MS and suitable severity disease biomarkers. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Effectiveness and safety of glecaprevir/pibrentasvir in chronic hepatitis C patients: Results of the Italian cohort of a post-marketing observational study

Author

Aghemo, Alessio, Alberti, Alfredo, Andreone, Pietro, Angelico, Mario, Brunetto, Maurizia Rossana, Chessa, Luchino, Ciancio, Alessia, Craxì, Antonio, Gaeta, Giovanni Battista, Galli, Massimo, Gasbarrini, Antonio, Giorgini, Alessia, Grilli, Elisabetta, Lampertico, Pietro, Lichtner, Miriam, Milella, Michele, Morisco, Filomena, Persico, Marcello, Pirisi, Mario, Puoti, Massimo, Raimondo, Giovanni, Romano, Antonietta, Russello, Maurizio, Sangiovanni, Vincenzo, Schiavini, Monica, Serviddio, Gaetano, Villa, Erica, Vinci, Maria, De Michina, Antonella, Gallinaro, Valentina, Gualberti, Giuliana, Roscini, Antonio Saverio, and Zignego, Anna Linda

Published
2021
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10. Unveiling the Mystery of Adult-Onset Still's Disease: A Compelling Case Report.

Author

Sola, Daniele, Smirne, Carlo, Bruggi, Francesco, Bottino Sbaratta, Chiara, Tamen Njata, Aubin Cardin, Valente, Guido, Pavanelli, Maria Cristina, Vitetta, Rosetta, Bellan, Mattia, De Paoli, Lorenzo, and Pirisi, Mario

Subjects
STILL'S disease, MACROPHAGE activation syndrome, MEDICAL specialties & specialists, CRITICAL care medicine, CYTOKINE release syndrome, TRANSCRANIAL direct current stimulation, PUBERTY
Abstract

Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder. Diagnosis can take a long time, especially in the presence of confounding factors, and it is, to some extent, a process of exclusion. AOSD has life-threating complications ranging from asymptomatic to severe, such as macrophage activation syndrome (MAS), which is also referred to as hemophagocytic lymphohistocytosis (HLH). This condition is correlated with cytokine storm production and monocyte/macrophage overactivation and typically occurs with rash, pyrexia, pancytopenia, hepatosplenomegaly and systemic involvement. Exitus occurs in approximately 10% of cases. For the treatment of MAS-HLH, the Histiocyte Society currently suggests high-dose corticosteroids, with the possible addition of cyclosporine A, anti-interleukin (IL)-1, or IL-6 biological drugs; the inclusion of etoposide is recommended for the most severe conditions. In all cases, a multidisciplinary collaboration involving the resources and expertise of several specialists (e.g., rheumatologist, infectiologist, critical care medicine specialist) is advised. Herein, we provide a detailed description of the clinical case of a previously healthy young woman in which MAS developed as a dramatic onset manifestation of AOSD and whose diagnosis posed a real clinical challenge; the condition was finally resolved by applying the HLH-94 protocol (i.e., etoposide in combination with dexamethasone). [ABSTRACT FROM AUTHOR]

Published
2024
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11. The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.

Author

Sacchetti, Sara, Vidali, Matteo, Esposito, Teresa, Zorzi, Stefano, Burgener, Alessia, Ciccarello, Lorenzo, Cammarota, Gianmaria, Zanotti, Valentina, Giacomini, Luca, Bellan, Mattia, Pirisi, Mario, Lopez, Ramon Simon, Dianzani, Umberto, Vaschetto, Rosanna, and Rolla, Roberta

Subjects
SEPSIS, BLOOD cell count, EARLY diagnosis, INTENSIVE care units, CELL morphology
Abstract

Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis. Materials and Methods: A complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara's Hospital (Italy) and in 56 patients with localized infection. Results: In univariate logistic regression, age, Hb, RDW, MO#, NMR, NeuX, NeuY, NeuZ, LymX, MonX, MonY, MonZ were associated with sepsis (p < 0.005). In multivariate analysis, only RDW, NeuX, NeuY, NeuZ, MonX and MonZ were found to be independent predictors of sepsis (p < 0.005). Morphological research parameters are confirmed to be predictors of sepsis even when analyzing the group with localized infection. Conclusions: In addition to already established biomarkers and basic CBC parameters, new morphological cell parameters can be a valuable aid in the early diagnosis of sepsis at no additional cost. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Circadian control of hepatitis B virus replication

Author

Zhuang, Xiaodong, Forde, Donall, Tsukuda, Senko, D’Arienzo, Valentina, Mailly, Laurent, Harris, James M., Wing, Peter A. C., Borrmann, Helene, Schilling, Mirjam, Magri, Andrea, Rubio, Claudia Orbegozo, Maidstone, Robert J., Iqbal, Mudassar, Garzon, Miguel, Minisini, Rosalba, Pirisi, Mario, Butterworth, Sam, Balfe, Peter, Ray, David W., Watashi, Koichi, Baumert, Thomas F., and McKeating, Jane A.

Published
2021
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14. Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Author

Bellan, Mattia, Baricich, Alessio, Patrucco, Filippo, Zeppegno, Patrizia, Gramaglia, Carla, Balbo, Piero Emilio, Carriero, Alessandro, Amico, Chiara Santa, Avanzi, Gian Carlo, Barini, Michela, Battaglia, Marco, Bor, Simone, Cantaluppi, Vincenzo, Cappellano, Giuseppe, Ceruti, Federico, Chiocchetti, Annalisa, Clivati, Elisa, Giordano, Mara, Cuneo, Daria, Gambaro, Eleonora, Gattoni, Eleonora, Loro, Alberto, Manfredi, Marcello, Morosini, Umberto, Murano, Francesco, Paracchini, Elena, Patti, Giuseppe, Pinato, David James, Raineri, Davide, Rolla, Roberta, Sainaghi, Pier Paolo, Tricca, Stefano, and Pirisi, Mario

Published
2021
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18. Hospital Care of Older Patients With COPD: Adherence to International Guidelines for Use of Inhaled Bronchodilators and Corticosteroids

Author

Mannucci, Pier Mannuccio, Nobili, Alessandro, Tettamanti, Mauro, Pasina, Luca, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thomas, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Pontremoli, Roberto, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Colangelo, Lidia, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, Vecchio, Sara del, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, and Proietti, Marco

Published
2019
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19. Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author

Frigeni, Marco, Besson, Caroline, Visco, Carlo, Fontaine, Helene, Goldaniga, Maria, Visentini, Marcella, Pulsoni, Alessandro, Torres, Harrys A., Peveling-Oberhag, Jan, Rossotti, Roberto, Zaja, Francesco, Rigacci, Luigi, Merli, Michele, Dorival, Céline, Alric, Camille, Piazza, Francesco, Gentile, Massimo, Ferrari, Angela, Pirisi, Mario, Nassi, Luca, Rattotti, Sara, Frustaci, Annamaria, Milella, Michele, Cencini, Emanuele, Defrancesco, Irene, Ferretti, Virginia Valeria, Bruno, Raffaele, Hermine, Olivier, and Arcaini, Luca

Published
2020
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22. HepaDisk – A new quality of life questionnaire for HCV patients

Author

Fagiuoli, Stefano, Caporaso, Nicola, Morisco, Filomena, Buelli, Fabio, Gualberti, Giuliana, Saragaglia, Valeria, Chessa, Luchino, Corti, Giampaolo, Maida, Ivana, Mastroianni, Claudio M., Pirisi, Mario, Russo, Francesco P., Farina, Francesca, Giannitrapani, Lydia, Toniutto, Pierluigi, Tarquini, Pierluigi, Tundo, Paolo, Vecchiet, Jacopo, Vinci, Maria, and Taliani, Gloria

Published
2019
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24. From MASH to HCC: the role of Gas6/TAM receptors.

Author

Apostolo, Daria, Ferreira, Luciana L., Vincenzi, Federica, Vercellino, Nicole, Minisini, Rosalba, Latini, Federico, Ferrari, Barbara, Burlone, Michela E., Pirisi, Mario, and Bellan, Mattia

Subjects
METASTASIS, NON-alcoholic fatty liver disease, LIVER diseases, DISEASE progression, LIVER cancer, FIBROSIS, FATTY liver
Abstract

Metabolic dysfunction-associated steatohepatitis (MASH) is the replacement term for what used to be called nonalcoholic steatohepatitis (NASH). It is characterized by inflammation and injury of the liver in the presence of cardiometabolic risk factors and may eventually result in the development of hepatocellular carcinoma (HCC), the most common form of primary liver cancer. Several pathogenic mechanisms are involved in the transition from MASH to HCC, encompassing metabolic injury, inflammation, immune dysregulation and fibrosis. In this context, Gas6 (Growth Arrest-Specific 6) and TAM (Tyro3, Axl, and MerTK) receptors may play important roles. The Gas6/TAM family is involved in the modulation of inflammation, lipid metabolism, fibrosis, tumor progression and metastasis, processes which play an important role in the pathophysiology of acute and chronic liver diseases. In this review, we discuss MASH-associated HCC and the potential involvement of the Gas6/TAM system in disease development and progression. In addition, since therapeutic strategies for MASH and HCC are limited, we also speculate regarding possible future treatments involving the targeting of Gas6 or TAM receptors. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunctionassociated steatohepatitis.

Author

Provera, Alessia, Ramavath, Naresh Naik, Gadipudi, Laila Lavanya, Gigliotti, Casimiro Luca, Boggio, Elena, Vecchio, Cristina, Stoppa, Ian, Rolla, Roberta, Boldorini, Renzo, Pirisi, Mario, Smirne, Carlo, Albano, Emanuele, Dianzani, Umberto, and Sutti, Salvatore

Subjects
LECTINS, CELLULAR evolution, MYELOID cells, CHOLINE, FATTY liver, KUPFFER cells, HEPATIC fibrosis
Abstract

Background and aims: Inducible T-cell Co-Stimulator (ICOS) present on T-lymphocytes and its ligand ICOSL expressed by myeloid cells play multiple roles in regulating T-cell functions. However, recent evidence indicates that reverse signalling involving ICOSL is also important in directing the differentiation of monocyte-derived cells. In this study, we investigated the involvement of ICOS/ICOSL dyad in modulating macrophage functions during the evolution of metabolic dysfunction-associated steatohepatitis (MASH). Results: In animal models of MASH, ICOS was selectively up-regulated on CD8+ T-cells in parallel with an expansion of ICOSL-expressing macrophages. An increase in circulating soluble ICOSL was also evident in patients with MASH as compared to healthy individuals. ICOSL knockout (ICOSL-/-) mice receiving choline/methionine deficient (MCD) diet for 6 weeks had milder steatohepatitis than wild type mice. MASH improvement was confirmed in mice fed with cholesterol-enriched Western diet for 24 weeks in which ICOSL deficiency greatly reduced liver fibrosis along with the formation of crown-like macrophage aggregates producing the pro-fibrogenic mediators osteopontin (OPN) and galectin-3 (Gal-3). These effects associated with a selective shewing of F4-80+/CD11bhigh monocyte-derived macrophages (MoMFs) expressing the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) to CD11blow/F4-80+ cells positive for the Kupffer cell marker C-type lectin-like type 2 receptor (CLEC-2), thus indicating an increased MoMF maturation toward monocyte-derived Kupffer cells. Conclusions: These results suggest that CD8+ T-cells interaction with monocyte-derived macrophages through ICOS/ICOSL critically supports a specific subset of TREM2+-expressing cells contributing to the evolution of steatohepatitis. The data also point ICOS/ICOSL dyad as a possible target for therapeutic interventions in MASH. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Author

Bellan, Mattia, Patti, Giuseppe, Hayden, Eyal, Azzolina, Danila, Pirisi, Mario, Acquaviva, Antonio, Aimaretti, Gianluca, Aluffi Valletti, Paolo, Angilletta, Roberto, Arioli, Roberto, Avanzi, Gian Carlo, Avino, Gianluca, Balbo, Piero Emilio, Baldon, Giulia, Baorda, Francesca, Barbero, Emanuela, Baricich, Alessio, Barini, Michela, Barone-Adesi, Francesco, Battistini, Sofia, Beltrame, Michela, Bertoli, Matteo, Bertolin, Stephanie, Bertolotti, Marinella, Betti, Marta, Bobbio, Flavio, Boffano, Paolo, Boglione, Lucio, Borrè, Silvio, Brucoli, Matteo, Calzaducca, Elisa, Cammarata, Edoardo, Cantaluppi, Vincenzo, Cantello, Roberto, Capponi, Andrea, Carriero, Alessandro, Casciaro, Francesco Giuseppe, Castello, Luigi Mario, Ceruti, Federico, Chichino, Guido, Chirico, Emilio, Cisari, Carlo, Cittone, Micol Giulia, Colombo, Crizia, Comi, Cristoforo, Croce, Eleonora, Daffara, Tommaso, Danna, Pietro, Della Corte, Francesco, De Vecchi, Simona, Dianzani, Umberto, Di Benedetto, Davide, Esposto, Elia, Faggiano, Fabrizio, Falaschi, Zeno, Ferrante, Daniela, Ferrero, Alice, Gagliardi, Ileana, Gaidano, Gianluca, Galbiati, Alessandra, Gallo, Silvia, Garavelli, Pietro Luigi, Gardino, Clara Ada, Garzaro, Massimiliano, Gastaldello, Maria Luisa, Gavelli, Francesco, Gennari, Alessandra, Giacomini, Greta Maria, Giacone, Irene, Giai Via, Valentina, Giolitti, Francesca, Gironi, Laura Cristina, Gramaglia, Carla, Grisafi, Leonardo, Inserra, Ilaria, Invernizzi, Marco, Krengli, Marco, Labella, Emanuela, Landi, Irene Cecilia, Landi, Raffaella, Leone, Ilaria, Lio, Veronica, Lorenzini, Luca, Maconi, Antonio, Malerba, Mario, Manfredi, Giulia Francesca, Martelli, Maria, Marzari, Letizia, Marzullo, Paolo, Mennuni, Marco, Montabone, Claudia, Morosini, Umberto, Mussa, Marco, Nerici, Ilaria, Nuzzo, Alessandro, Olivieri, Carlo, Padelli, Samuel Alberto, Panella, Massimiliano, Parisini, Andrea, Paschè, Alessio, Pau, Alberto, Pedrinelli, Anita Rebecca, Percivale, Ilaria, Re, Roberta, Rigamonti, Cristina, Rizzi, Eleonora, Rognoni, Andrea, Roveta, Annalisa, Salamina, Luigia, Santagostino, Matteo, Saraceno, Massimo, Savoia, Paola, Sciarra, Marco, Schimmenti, Andrea, Scotti, Lorenza, Spinoni, Enrico, Smirne, Carlo, Tarantino, Vanessa, Tillio, Paolo Amedeo, Vaschetto, Rosanna, Vassia, Veronica, Zagaria, Domenico, Zavattaro, Elisa, Zeppegno, Patrizia, Zottarelli, Francesca, and Sainaghi, Pier Paolo

Published
2020
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29. Gender differences in chronic liver diseases in two cohorts of 2001 and 2014 in Italy

Author

Sagnelli, Evangelista, Stroffolini, Tommaso, Sagnelli, Caterina, Pirisi, Mario, Babudieri, Sergio, Colloredo, Guido, Russello, Maurizio, Coppola, Nicola, Gaeta, Giovanni Battista, Cacopardo, Bruno, De Luca, Massimo, Almasio, Piero Luigi, Andriulli, Angelo, Babudieri, Sergio, Brancaccio, Giuseppina, Cacopardo, Bruno, Colloredo, Guido, Coppola, Nicola, De Luca, Massimo, Furlan, Caterina, Licata, Anna, Morisco, Filomena, Pirisi, Mario, Pisaturo, Mariantonietta, Rosina, Floriano, Rusello, Maurizio, Sagnelli, Caterina, Santantonio, Teresa, Smedile, Antonina, and on behalf of EPACRON study group

Published
2017
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30. Characteristics of liver cirrhosis in Italy: Evidence for a decreasing role of HCV aetiology

Author

Almasio, Piero Luigi, Gaeta, Giovanni Battista, Sagnelli, Evangelista, Stroffolini, Tommaso, Andriulli, Angelo, Babudieri, Sergio, Brancaccio, Giuseppina, Cacopardo, Bruno, Colloredo, Guido, Coppola, Nicola, De Luca, Massimo, Furlan, Caterina, Licata, Anna, Morisco, Filomena, Pirisi, Mario, Pisaturo, Mariantonietta, Rosina, Floriano, Russello, Maurizio, Sagnelli, Caterina, Santantonio, Teresa, and Smedile, Antonina

Published
2017
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32. SARS-CoV-2 infection risk is higher in vaccinated patients with inflammatory autoimmune diseases or liver transplantation treated with mycophenolate due to an impaired antiviral immune response: results of the extended follow up of the RIVALSA prospective cohort

Author

Rizzi, Manuela, Tonello, Stelvio, Brinno, Cristiana, Zecca, Erika, Matino, Erica, Cittone, Micol, Rizzi, Eleonora, Casciaro, Giuseppe Francesco, D'Onghia, Davide, Colangelo, Donato, Minisini, Rosalba, Bellan, Mattia, Castello, Luigi Mario, Chiocchetti, Annalisa, Pirisi, Mario, Rigamonti, Cristina, Lilleri, Daniele, Zavaglio, Federica, Bergami, Federica, and Sola, Daniele

Subjects
LIVER transplantation, AUTOIMMUNE diseases, SARS-CoV-2, IMMUNOGLOBULIN producing cells, IMMUNE response, MYCOPHENOLIC acid
Abstract

Background: A relevant proportion of immunocompromised patients did not reach a detectable seroconversion after a full primary vaccination cycle against SARS-CoV-2. The effect of different immunosuppressants and the potential risks for SARS-CoV-2 infection in these subjects is largely unknown. Methods: Patients from the Rivalsa prospective, observational cohort study with planned anti SARS-CoV-2 third dose mRNA vaccination between October and December 2021 were asked to participate to this follow-up study. Patients were asked about eventual confirmed positivity to SARS-CoV-2 infection within 6 months from the third dose and to undergo a blood draw to evaluate seroconversion status after the additional vaccine shot. Results: 19 out of 114 patients taking part in the survey developed a confirmed SARS-CoV-2 infection; we identified mycophenolate treatment as an independent predictor of an increased risk of infection even after the third vaccine dose (OR: 5.20, 95% CI: 1.70-20.00, p=0.0053). This result is in agreement with the in vitro evidence that MMF impairs both B and T lymphocytes driven immune responses (reduction both in memory B cells producing anti-spike antibodies and in proliferating CD4+ and CD8+ T cells). Conclusions: Immunocompromised patients need an additional vaccine administration to reach a detectable seroconversion, thus fostering a more personalized approach to their clinical management. Moreover, patients undergoing mycophenolate treatment show a specific increased infection risk, with respect to other immunosuppressants thus supporting a closer monitoring of their health status. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Plasma Pattern of Extracellular Vesicles Isolated from Hepatitis C Virus Patients and Their Effects on Human Vascular Endothelial Cells.

Author

Grossini, Elena, Smirne, Carlo, Venkatesan, Sakthipriyan, Tonello, Stelvio, D'Onghia, Davide, Minisini, Rosalba, Cantaluppi, Vincenzo, Sainaghi, Pier Paolo, Comi, Cristoforo, Tanzi, Adele, Bussolati, Benedetta, and Pirisi, Mario

Subjects
VASCULAR endothelial cells, HEPATITIS C virus, EXTRACELLULAR vesicles, PROTEIN kinase B, ENDOTHELIUM diseases
Abstract

Hepatitis C virus (HCV) patients are at increased risk of cardiovascular disease (CVD). In this study, we aimed to evaluate the role of extracellular vesicles (EVs) as pathogenic factors for the onset of HCV-related endothelial dysfunction. Sixty-five patients with various stages of HCV-related chronic liver disease were enrolled in this case series. Plasma EVs were characterized and used to stimulate human vascular endothelial cells (HUVEC), which were examined for cell viability, mitochondrial membrane potential, and reactive oxygen species (ROS) release. The results showed that EVs from HCV patients were mainly of endothelial and lymphocyte origin. Moreover, EVs were able to reduce cell viability and mitochondrial membrane potential of HUVEC, while increasing ROS release. Those harmful effects were reduced by the pretreatment of HUVEC with the NLR family pyrin domain containing 3 (NLRP3)/AMP-activated protein kinase and protein kinase B blockers. In conclusion, in HCV patients, we could highlight a circulating pattern of EVs capable of inducing damage to the endothelium. These data represent a novel possible pathogenic mechanism underlying the reported increase of CVD occurrence in HCV infection and could be of clinical relevance also in relation to the widespread use of antiviral drugs. [ABSTRACT FROM AUTHOR]

Published
2023
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48. THU-486-YI A multi-center comparison of Atezolizumab plus Bevacizumab and Lenvatinib as primary systemic therapy for unresectable hepatocellar carcinoma: focus on thrombotic and hemorragic adverse events

Author

Tizzani, Marco, Mazzarelli, Chiara, Burlone, Michela Emma, Carucci, Patrizia, Caviglia, Gian Paolo, Lisi, Chiara, Canalis, Chiara, Cesarini, Lucia, Pirisi, Mario, Acquaviva, Antonio, Rolle, Emanuela, Pochettino, Paolo, Bencardino, Katia, Villa, Federica, Angiolillo, Martina, Castellana, Eleonora, Scaldaferri, Matilde, Cattel, Francesco, Airoldi, Mario, Saracco, Giorgio Maria, and Gaia, Silvia

Published
2024
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49. THU-471-YI From randomised clinical trials to clinical practice: a systematic reviewand meta-analysis of real-word data on atezolizumab plus bevacizumab for advanced hepatocellular carcinoma

Author

Manfredi, Giulia Francesca, Fulgenzi, Claudia, Celsa, Ciro, Stefanini, Bernardo, D'Alessio, Antonio, Pinter, Matthias, Scheiner, Bernhard, Awosika, Nichola, Huang, Yi-Hsiang, Lin, Chun-yen, Dalbeni, Andrea, Vogel, Arndt, Galle, Peter R., Kudo, Masatoshi, Rimassa, Lorenza, Chon, Hong Jae, Cabibbo, Giuseppe, Piscaglia, Fabio, Camma, Calogero, Pillai, Anjana, Pirisi, Mario, Singal, Amit, and Pinato, David J.

Published
2024
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