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1,070 results on '"Prigerson, Holly G"'

7. EMPOWER: A Multi-Site Pilot Trial to Reduce Distress in Surrogate Decision-Makers in the ICU

Author

Lichtenthal, Wendy G., Lief, Lindsay, Rogers, Madeline, Russell, David, Viola, Martin, Winoker, Hillary, Kakarala, Sophia, Traube, Chani, Coats, Taylor, Fadalla, Carol, Roberts, Kailey E., Pavao, Madison, Osso, Francesco, Brewin, Chris R., Pan, Cynthia X., Maciejewski, Paul K., Berlin, David, Pastores, Stephen, Halpern, Neil, Vaughan, Susan C., Cox, Christopher E., and Prigerson, Holly G.

Published
2024
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12. Illness understanding and religiousness in patients with recurrent glioblastoma.

Author

Fortunato, John T, Walsh, Leah E, Polacek, Laura C, Reiner, Anne S, Walbert, Tobias, Thomas, Alissa A, Buthorn, Justin, Sigler, Allison, Prigerson, Holly G, Applebaum, Allison J, and Diamond, Eli L

Subjects
CANCER patients, FISHER exact test, RELIGIOUSNESS, GLIOBLASTOMA multiforme, PATIENT surveys
Abstract

Background Patients with glioblastoma (GBM) often have inaccurate perceptions of prognosis. Strong religious beliefs have been associated with limited illness understanding (IU) in patients with advanced cancer, but IU and religiousness have not been investigated in patients with GBM. The aim of this study was to evaluate the association between religiousness and spirituality and IU in patients with GBM. Methods Patients enrolled in a prospective multicenter study of recurrent GBM (Coping with Glioblastoma, NCT02375841). Within one month of medical visits discussing MRI scans showing GBM progression, patients completed study surveys containing published measures of IU and religiousness. IU was compared between participants with moderate or high versus slight or no religiousness based on several patient-reported prompts using Fisher's exact tests. Results Twenty-four patients completed surveys of religiousness and IU. IU was partial within our cohort. Fifteen participants (62.5%) acknowledged that their illness was terminal. Only 6 (25%) correctly acknowledged their prognosis (months). Eleven patients (46%) were moderately or very religious, while 9 (38%) were either slightly religious or not at all religious. High religiousness and spirituality were each associated with partial IU (P  = .06 and P  = .01, respectively). A belief that God could perform a miracle to cure them of cancer and a belief in sanctity through suffering were also each associated with partial IU. Conclusions This prospective study that suggests religiousness, including the belief in miracles and a belief in sanctification through suffering, might influence patients' IU. Further research is warranted to study this association. [ABSTRACT FROM AUTHOR]

Published
2025
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22. Predictors of ICU Surrogates' States of Concurrent Prolonged Grief, Posttraumatic Stress, and Depression Symptoms*.

Author

Wen, Fur-Hsing, Prigerson, Holly G., Chuang, Li-Pang, Chou, Wen-Chi, Huang, Chung-Chi, Hu, Tsung-Hui, and Tang, Siew Tzuh

Subjects
*EMERGENCY room visits, *POST-traumatic stress disorder, *POST-traumatic stress, *DO-not-resuscitate orders, *INTENSIVE care units, *COMPLICATED grief
Abstract

OBJECTIVES: Scarce research explores factors of concurrent psychologic distress (prolonged grief disorder [PGD], posttraumatic stress disorder [PTSD], and depression). This study models surrogates' longitudinal, heterogenous grief-related reactions and multidimensional risk factors drawing from the integrative framework of predictors for bereavement outcomes (intrapersonal, interpersonal, bereavement-related, and death-circumstance factors), emphasizing clinical modifiability. DESIGN: Prospective cohort study. SETTING: Medical ICUs of two Taiwanese medical centers. SUBJECTS: Two hundred eighty-eight family surrogates. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Factors associated with four previously identified PGD-PTSD-depressive-symptom states (resilient, subthreshold depression-dominant, PGD-dominant, and PGD-PTSD-depression concurrent) were examined by multinomial logistic regression modeling (resilient state as reference). Intrapersonal: Prior use of mood medications correlated with the subthreshold depression-dominant state. Financial hardship and emergency department visits correlated with the PGD-PTSD-depression concurrent state. Higher anxiety symptoms correlated with the three more profound psychologic-distress states (adjusted odds ratio [95% CI] = 1.781 [1.562–2.031] to 2.768 [2.288–3.347]). Interpersonal: Better perceived social support was associated with the subthreshold depression-dominant state. Bereavement-related: Spousal loss correlated with the PGD-dominant state. Death circumstances: Provision of palliative care (8.750 [1.603–47.768]) was associated with the PGD-PTSD-depression concurrent state. Surrogate-perceived quality of patient dying and death as poor-to-uncertain (4.063 [1.531–10.784]) correlated with the subthreshold depression-dominant state, poor-to-uncertain (12.833 [1.231–133.775]), and worst (12.820 [1.806–91.013]) correlated with the PGD-PTSD-depression concurrent state. Modifiable social-worker involvement (0.004 [0.001–0.097]) and a do-not-resuscitate order issued before death (0.177 [0.032–0.978]) were negatively associated with the PGD-PTSD-depression concurrent and the subthreshold depression-dominant state, respectively. Apparent unmodifiable buffering factors included surrogates' higher educational attainment, married status, and longer time since loss. CONCLUSIONS: Surrogates' concurrent bereavement distress was positively associated with clinically modifiable factors: poor quality dying and death, higher surrogate anxiety, and palliative care—commonly provided late in the terminal-illness trajectory worldwide. Social-worker involvement and a do-not-resuscitate order appeared to mitigate risk. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Transitional objects of grief

Author

Goldstein, Richard D., Petty, Carter R., Morris, Sue E., Human, Melanie, Odendaal, Hein, Elliott, Amy J., Tobacco, Deborah, Angal, Jyoti, Brink, Lucy, and Prigerson, Holly G.

Published
2020
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41. Associations Between Family-Assessed Quality-of-Dying-and-Death Latent Classes and Bereavement Outcomes for Family Surrogates of ICU Decedents.

Author

Fur-Hsing Wen, Prigerson, Holly G., Tsung-Hui Hu, Chung-Chi Huang, Wen-Chi Chou, Li-Pang Chuang, Ming Chu Chiang, and Siew Tzuh Tang

Subjects
*COMPLICATED grief, *POST-traumatic stress disorder, *BEREAVEMENT, *APACHE (Disease classification system), *QUALITY of life, *MENTAL depression
Abstract

OBJECTIVES: To examine associations between family surrogates' bereavement outcomes and four previously determined quality of dying and death (QODD) latent classes (high, moderate, poor-to-uncertain, and worst). DESIGN: Prospective, longitudinal, observational study. SETTING: Medical ICUs at two academically affiliated medical centers in Taiwan. PATIENTS/PARTICIPANTS: Three hundred nine family surrogates responsible for decision-making for critically ill patients at high risk of death (Acute Physiology and Chronic Health Evaluation II scores > 20) from a disease. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Participants were assessed by the depression and anxiety subscales of the Hospital Anxiety and Depression Scale, the Impact of Event Scale-Revised, 11 items of the Prolonged Grief Disorder (PGD) scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey at 1, 3, 6, 13, 18, and 24 months post-loss. We simultaneously examined associations of four QODD latent classes with physical and mental health-related quality of life (HRQOL) and symptoms of anxiety, depression, post-traumatic stress disorder (PTSD), and PGD assessed over 24 bereavement months using multivariate hierarchical linear modeling. Surrogates' distinct QODD latent classes assessed at 1-month post-loss were significantly associated with bereavement outcomes, except for physical HRQOL and PGD symptoms. Significantly more depressive symptoms and worse mental HRQOL (β [95% CI]) were reported by bereaved surrogates in the moderate (1.958 [1.144-2.772], -2.245 [-3.961 to -0.529]), poor-to-uncertain (2.224 [1.438-3.010], -7.026 [-8.683 to -5.369]), and worst (2.081 [1.215-2.964], -4.268 [-6.096 to -2.440]) QODD classes than those in the high QODD class. Bereaved surrogates in the moderate (2.095 [1.392-2.798]) and poor-to-uncertain (0.801 [0.123-1.480]) QODD classes reported more anxiety symptoms, whereas those in the poor-to-uncertain QODD class suffered more PTSD symptoms (2.889 [1.005-4.774]) than those in the high QODD class. CONCLUSIONS: The four distinct QODD latent classes were significantly associated with ICU family surrogates' bereavement outcomes, suggesting targets to improve end-of-life care quality in ICUs. [ABSTRACT FROM AUTHOR]

Published
2024
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