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Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights the gut microbiome as a putative biological mechanism underlying such generational risks. In a sample of 450 mother–child dyads living in Singapore, we examined associations between three distinct adversity exposures experienced across two generations—maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children’s exposure to stressful life events—and the gut microbiome composition of second-generation children at 2 y of age. We found distinct differences in gut microbiome profiles linked to each adversity exposure, as well as some nonaffected microbiome features (e.g., beta diversity). Remarkably, some of the microbial taxa associated with concurrent and prospective child socioemotional functioning shared overlapping putative functions with those affected by adversity, suggesting that the intergenerational transmission of adversity may have a lasting impact on children’s mental health via alterations to gut microbiome functions. Our findings open up a new avenue of research into the underlying mechanisms of intergenerational transmission of mental health risks and the potential of the gut microbiome as a target for intervention. [ABSTRACT FROM AUTHOR]

The quality of the early environment influences the development of psychopathology. Children who are deprived of sufficient environmental enrichment in infancy may be at higher risk for developing symptoms of psychopathology in toddlerhood. In this study, we investigated the prospective association between naturalistic measures of adult language input obtained through passive monitoring of infants' daily environments and emerging psychopathology in toddlerhood. In a sample of 100 mothers and their infants recruited from the community (mean age [range] = 6.73 [5–9] months), we used the Language ENvironment Analysis (LENA) system to measure multiple dimensions of infants' language environments, including both the quantity and consistency of adult speech and conversational turns in infants' daily lives as well as the quantity of infant vocalizations. Subsequently, during toddlerhood (mean age [range] = 18.29 [17–21] months), mothers reported on their children's symptoms of psychopathology. Infants who experienced more consistent adult speech and conversational turns had lower symptoms of psychopathology in toddlerhood, independent of negative emotionality in infancy, maternal depressive symptoms, and laboratory‐based measures of maternal sensitivity. These findings have implications for the measurement of environmental factors that may confer risk and resilience to emerging psychopathology. [ABSTRACT FROM AUTHOR]

This study utilized attachment theory as a framework for understanding how fathers' reflective functioning (RF) and social emotional (SE) and autonomy (AU) supportive behaviors relate to children's emotion regulation (ER) beyond effects of mothers' RF. Moreover, the study explored how fathers' RF may be a protective factor against risks associated with low income. Fathers (n = 77) and their toddlers participated. Fathers' RF was coded from narrative accounts of parenting and mothers' RF was assessed by questionnaire. Fathers' SE and AU supportive behaviors were coded from observations of father-child interactions; toddlers' ER was assessed as distress on a challenging task. Results show that, after accounting for mothers' RF, fathers' RF was directly associated with SE supportive behaviors; RF moderated the association between income and AU supportive behaviors. Fathers' SE and AU supportive behaviors were associated with children's distress. Fathers' RF plays a central role in parenting and in children's ER. [ABSTRACT FROM AUTHOR]