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5. In vitro activities of furoquinoline and acridone alkaloids against Plasmodium falciparum.

Author

Basco LK, Mitaku S, Skaltsounis AL, Ravelomanantsoa N, Tillequin F, Koch M, and Le Bras J

Subjects
Acridines isolation & purification, Alkaloids isolation & purification, Animals, Antimalarials isolation & purification, Chloroquine pharmacology, Drug Resistance, Plants, Medicinal chemistry, Quinolones isolation & purification, Acridines pharmacology, Alkaloids pharmacology, Antimalarials pharmacology, Plasmodium falciparum drug effects, Quinolones pharmacology
Abstract

The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.

Published
1994
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