136 results on '"Ravitsky, V."'
Search Results
2. Non-invasive prenatal testing for fetal chromosome abnormalities: review of clinical and ethical issues
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Gekas J, Langlois S, Ravitsky V, Audibert F, van den Berg DG, Haidar H, and Rousseau F
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Prenatal diagnosis ,Down syndrome ,non-invasive prenatal testing ,cell-free fetal DNA ,informed consent ,reproductive autonomy. ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Jean Gekas,1,2 Sylvie Langlois,3 Vardit Ravitsky,4 François Audibert,5 David Gradus van den Berg,6 Hazar Haidar,4 François Rousseau2,7 1Prenatal Diagnosis Unit, Department of Medical Genetics and Pediatrics, Faculty of Medicine, Université Laval, Québec City, QC, Canada; 2Department of Medical Biology, CHU de Québec, Québec City, QC, Canada; 3Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada; 4Bioethics Program, Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada; 5Department of Obstetrics and Gynecology, Hospital Sainte-Justine, Montreal, QC, Canada; 6Department of Social and Preventive Medicine, Faculty of Medicine, Université Laval, Québec City, QC, Canada; 7Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Université Laval, Québec City, QC, Canada Abstract: Genomics-based non-invasive prenatal screening using cell-free DNA (cfDNA screening) was proposed to reduce the number of invasive procedures in current prenatal diagnosis for fetal aneuploidies. We review here the clinical and ethical issues of cfDNA screening. To date, it is not clear how cfDNA screening is going to impact the performances of clinical prenatal diagnosis and how it could be incorporated in real life. The direct marketing to users may have facilitated the early introduction of cfDNA screening into clinical practice despite limited evidence-based independent research data supporting this rapid shift. There is a need to address the most important ethical, legal, and social issues before its implementation in a mass setting. Its introduction might worsen current tendencies to neglect the reproductive autonomy of pregnant women. Keywords: prenatal diagnosis, Down syndrome, non-invasive prenatal testing, cell-free fetal DNA, informed consent, reproductive autonomy
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- 2016
3. Identification of trisomy 18, trisomy 13, and Down syndrome from maternal plasma
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Gekas J, Langlois S, Ravitsky V, Audibert F, van den Berg D, Haidar H, and Rousseau F
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Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Jean Gekas,1,2 Sylvie Langlois,3 Vardit Ravitsky,4 François Audibert,5 David-Gradus van den Berg,6 Hazar Haidar,4 François Rousseau2,71Prenatal Diagnosis Unit, Department of Medical Genetics and Pediatrics, Faculty of Medicine, Laval University, Québec City, Quebec, Canada; 2Department of Medical Biology, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; 3Department of Medical Genetics, University of British Columbia, Vancouver, Canada; 4Bioethics Program, Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Canada; 5Department of Obstetrics and Gynecology, Sainte Justine Hospital, Montreal, Canada; 6Department of Social and Preventive Medicine, 7Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine, Laval University, Québec City, Quebec, CanadaAbstract: Current prenatal diagnosis for fetal aneuploidies (including trisomy 21 [T21]) generally relies on an initial biochemical serum-based noninvasive prenatal testing (NIPT) after which women who are deemed to be at high risk are offered an invasive confirmatory test (amniocentesis or chorionic villi sampling for a fetal karyotype), which is associated with a risk of fetal miscarriage. Recently, genomics-based NIPT (gNIPT) was proposed for the analysis of fetal genomic DNA circulating in maternal blood. The diffusion of this technology in routine prenatal care could be a major breakthrough in prenatal diagnosis, since initial research studies suggest that this novel approach could be very effective and could reduce substantially the number of invasive procedures. However, the limitations of gNIPT may be underappreciated. In this review, we examine currently published literature on gNIPT to highlight advantages and limitations. At this time, the performance of gNIPT is relatively well-documented only in high-risk pregnancies for T21 and trisomy 18. This additional screening test may be an option for women classified as high-risk of aneuploidy who wish to avoid invasive diagnostic tests, but it is crucial that providers carefully counsel patients about the test's advantages and limitations. The gNIPT is currently not recommended as a first-tier prenatal screening test for T21. Since gNIPT is not considered as a diagnostic test, a positive gNIPT result should always be confirmed by an invasive test, such as amniocentesis or chorionic villus sampling. Validation studies are needed to optimally introduce this technology into the existing routine workflow of prenatal care.Keywords: prenatal diagnosis, Down syndrome, noninvasive prenatal testing, cell-free fetal DNA, informed consent, reproductive autonomy
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- 2014
4. Disclosing individual genetic results to research participants
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Ravitsky, V. and Wilfond, B.S.
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Health - Abstract
Ravitsky V, Wilfond BS. Disclosing individual genetic results to research participants. American Journal of Bioethics 2006;6(6):8-17. * Ravitsky and Wilfond propose a framework for investigators and IRBs to use in [...]
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- 2007
5. The epigenetic effects of assisted reproductive technologies: ethical considerations.
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Roy, M.-C., Dupras, C., and Ravitsky, V.
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The use of assisted reproductive technologies (ART) has increased significantly, allowing many coping with infertility to conceive. However, an emerging body of evidence suggests that ART could carry epigenetic risks for those conceived through the use of these technologies. In accordance with the Developmental Origins of Health and Disease hypothesis, ART could increase the risk of developing late-onset diseases through epigenetic mechanisms, as superovulation, fertilization methods and embryo culture could impair the embryo’s epigenetic reprogramming. Such epigenetic risks raise ethical issues for all stakeholders: prospective parents and children, health professionals and society. This paper focuses on ethical issues raised by the consideration of these risks when using ART. We apply two key ethical principles of North American bioethics (respect for autonomy and non-maleficence) and suggest that an ethical tension may emerge from conflicting duties to promote the reproductive autonomy of prospective parents on one hand, and to minimize risks to prospective children on the other. We argue that this tension is inherent to the entire enterprise of ART and thus cannot be addressed by individual clinicians in individual cases. We also consider the implications of the ‘non-identity problem’ in this context. We call for additional research that would allow a more robust evidence base for policy. We also call upon professional societies to provide clinicians with guidelines and educational resources to facilitate the communication of epigenetic risks associated with ART to patients, taking into consideration the challenges of communicating risk information whose validity is still uncertain. [ABSTRACT FROM PUBLISHER]
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- 2017
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6. O-29 An ethical argument in favor of introducing the discussion of preimplantation genetic diagnosis into consultations for hereditary cancer syndromes
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Côté, S., Hamet, P., Bouffard, C., and Ravitsky, V.
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- 2013
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7. “What's left in the dish?” Ethical aspects of preimplantation genetic diagnosis
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Boyle, K., Batzer, F., and Ravitsky, V.
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- 2008
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8. On the proliferation of bioethics sub-disciplines: do we really need 'genethics' and 'neuroethics'?
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Wilfond BS and Ravitsky V
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- 2005
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9. Early diagnosis of fibrodysplasia ossificans progressiva.
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Kaplan FS, Xu M, Glaser DL, Collins F, Connor M, Kitterman J, Sillence D, Zackai E, Ravitsky V, Zasloff M, Ganguly A, and Shore EM
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- 2008
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10. Beyond Consent: The MAMLS in the Room.
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Rhim J, Gallois H, Ravitsky V, and Bélisle-Pipon JC
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- Humans, Informed Consent ethics
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- 2024
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11. Stoking fears of AI X-Risk (while forgetting justice here and now).
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Jecker NS, Atuire CA, Bélisle-Pipon JC, Ravitsky V, and Ho A
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Competing Interests: Competing interests: None declared.
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- 2024
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12. Diversifying Bioethics: Taking Action, Making Progress, Sustaining Success.
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Ravitsky V, Berlinger N, Brown V, Fletcher FE, and Pacia DM
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- Humans, United States, Bioethics, Cultural Diversity
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- 2024
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13. Early AI Lifecycle Co-Reasoning: Ethics Through Integrated and Diverse Team Science.
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Pacia DM, Ravitsky V, Hansen JN, Lundberg E, Schulz W, and Bélisle-Pipon JC
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- Artificial Intelligence ethics
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- 2024
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14. Mapping ethical, legal, and social implications (ELSI) of fertility preservation.
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Alon I, Bussod I, Golan OC, and Ravitsky V
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- Humans, Female, Male, Transgender Persons, Reproductive Techniques, Assisted ethics, Reproductive Techniques, Assisted legislation & jurisprudence, Informed Consent ethics, Decision Making ethics, Counseling ethics, Cryopreservation ethics, Fertility Preservation ethics
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Research Question: The study examines the ethical, legal, and social implications of fertility preservation, highlighting its importance across oncofertility, elective egg freezing, and posthumous assisted reproduction, as well as its impact on transgender individuals undergoing gender-affirming surgeries., Design: A comprehensive analysis of 600 articles, focusing on a diverse range of disciplines, including bioethics, psychology, and sociology, to explore public and healthcare professionals' knowledge, patient experiences, and regulatory constraints., Results: The body of literature is growing, indicating increasing recognition of FP's significance. Key themes included the centrality of counseling and informed decision-making, especially in oncofertility and EEF, and ethical debates surrounding informed consent and the autonomy of involved individuals. The analysis underscored a western-centric bias in current research, emphasizing the need for more inclusive and culturally sensitive studies., Conclusions: The study calls for a nuanced understanding of FP, advocating for policies that consider ethical, cultural, and social dimensions. It suggests the necessity for interdisciplinary research to address identified gaps, particularly in understanding non-Western perspectives and ensuring equitable access to FP services globally. Moreover, the review emphasizes the importance of integrating patient-centric approaches and ethical frameworks to guide FP practices and policies, ensuring they respect diverse values and meet individuals' needs., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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15. Mapping Ethical, Legal, and Social Implications (ELSI) of gamete donation.
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Alon I, Cassou M, Golan OC, and Ravitsky V
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Research Question: This scoping review investigates the Ethical, Legal, and Social Implications (ELSI) of gamete donation, a critical facet of Assisted Reproductive Technologies, by analyzing the evolving research scope, methodological approaches, and the geographical skew in the literature. Despite the increased global uptake of donor gametes, current scholarship predominantly emanates from Western contexts and focuses on majoritized groups. This bias constrains the universality of research findings and limits their applicability across varied legal, cultural, and social contexts, underscoring a need for broader inclusivity., Design: We addressed 867 pivotal articles published between 1999 and 2019., Results: Our analysis reveals a discernible escalation in research volume, with 62% based on empirical research. The intellectual landscape unfolds into four dominant clusters: Regulatory Frameworks, Incentives, and Access; Family Dynamics and Genetic Linkages; Identity and Privacy in Donor Conception; and Cultural and Societal Attitudes towards GD. Each cluster highlights nuanced dimensions of gamete donation, from regulatory intricacies and psychological welfare to identity ethics and cultural perceptions., Conclusion: Our findings advocate for a shift towards more globally representative and methodologically inclusive research. By integrating diverse cultural narratives and expanding geographical breadth, future research can offer holistic understandings of gamete donation, fostering equitable and culturally resonant practices and policies worldwide., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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16. Unpacking the notion of "serious" genetic conditions: towards implementation in reproductive decision-making?
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Kleiderman E, Boardman F, Newson AJ, Laberge AM, Knoppers BM, and Ravitsky V
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The notion of a "serious" genetic condition is commonly used in clinical contexts, laws, and policies to define and delineate both the permissibility of and, access to, reproductive genomic technologies. Yet, the notion lacks conceptual and operational clarity, which can lead to its inconsistent appraisal and application. A common understanding of the relevant considerations of "serious" is lacking. This article addresses this conceptual gap. We begin by outlining existing distinctions around the notion of "serious" that will factor into its appraisal and need to be navigated, in the context of prenatal testing and the use of reproductive genomic technologies. These include tensions between clinical care and population health; the impact of categorizing a condition as "serious"; and the role of perception of quality of life. We then propose a set of four core dimensions and four procedural elements that can serve as a conceptual tool to prompt a mapping of the features of seriousness in any given context. Ultimately, consideration of these core dimensions and procedural elements may lead to improvements in the quality and consistency of decision-making where the seriousness of a genetic condition is a pivotal component at both a policy and practice level., (© 2024. The Author(s).)
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- 2024
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17. Stakeholder perspectives on ethical and trustworthy voice AI in health care.
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Bélisle-Pipon JC, Powell M, English R, Malo MF, Ravitsky V, and Bensoussan Y
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Objective: Voice as a health biomarker using artificial intelligence (AI) is gaining momentum in research. The noninvasiveness of voice data collection through accessible technology (such as smartphones, telehealth, and ambient recordings) or within clinical contexts means voice AI may help address health disparities and promote the inclusion of marginalized communities. However, the development of AI-ready voice datasets free from bias and discrimination is a complex task. The objective of this study is to better understand the perspectives of engaged and interested stakeholders regarding ethical and trustworthy voice AI, to inform both further ethical inquiry and technology innovation., Methods: A questionnaire was administered to voice AI experts, clinicians, scholars, patients, trainees, and policy-makers who participated at the 2023 Voice AI Symposium organized by the Bridge2AI-Voice AI Consortium. The survey used a mix of Likert scale, ranking and open-ended questions. A total of 27 stakeholders participated in the study., Results: The main results of the study are the identification of priorities in terms of ethical issues, an initial definition of ethically sourced data for voice AI, insights into the use of synthetic voice data, and proposals for acting on the trustworthiness of voice AI. The study shows a diversity of perspectives and adds nuance to the planning and development of ethical and trustworthy voice AI., Conclusions: This study represents the first stakeholder survey related to voice as a biomarker of health published to date. This study sheds light on the critical importance of ethics and trustworthiness in the development of voice AI technologies for health applications., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)
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- 2024
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18. War, Bioethics, and Public Health.
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Jecker NS, Atuire C, Ravitsky V, Behrens K, and Ghaly M
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This paper argues that bioethics as a field should broaden its scope to include the ethics of war, focusing on war's public health effects. The "Introduction" section describes the bioethics literature on war, which emphasizes clinical and research topics while omitting public health. The section, "War as a public health crisis" demonstrates the need for a public health ethics approach by framing war as a public health crisis. The section, "Bioethics principles for war and public health" proposes six bioethics principles for war that address its public health dimensions: health justice, accountability, dignified lives, public health sustainability, nonmaleficence, and public health maximization. The section, "Justifying and applying bioethical principles" shows how these principles inform ethical analysis, including just war theory and military ethics. The section, "From principles to practice" envisions ways in which bioethicists can promote these principles in practice through research, teaching, and service. The "Conclusion" section urges bioethicists to engage with war as a public health crisis, including calling attention to war's impact on civilians, especially women, children, and other vulnerable groups.
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- 2024
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19. Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines.
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Clark T, Mohan J, Schaffer L, Obernier K, Al Manir S, Churas CP, Dailamy A, Doctor Y, Forget A, Hansen JN, Hu M, Lenkiewicz J, Levinson MA, Marquez C, Nourreddine S, Niestroy J, Pratt D, Qian G, Thaker S, Bélisle-Pipon JC, Brandt C, Chen J, Ding Y, Fodeh S, Krogan N, Lundberg E, Mali P, Payne-Foster P, Ratcliffe S, Ravitsky V, Sali A, Schulz W, and Ideker T
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This article describes the Cell Maps for Artificial Intelligence (CM4AI) project and its goals, methods, standards, current datasets, software tools , status, and future directions. CM4AI is the Functional Genomics Data Generation Project in the U.S. National Institute of Health's (NIH) Bridge2AI program. Its overarching mission is to produce ethical, AI-ready datasets of cell architecture, inferred from multimodal data collected for human cell lines, to enable transformative biomedical AI research.
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- 2024
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20. Mapping ethical, legal, and social implications (ELSI) of preimplantation genetic testing (PGT).
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Alon I, Bussod I, and Ravitsky V
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- Humans, Female, Pregnancy, Preimplantation Diagnosis ethics, Genetic Testing ethics, Genetic Testing legislation & jurisprudence
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Purpose: Preimplantation Genetic Testing (PGT) has attracted considerable ethical, legal, and social scrutiny, but academic debate often fails to reflect clinical realities., Methods: Addressing this disconnect, a review of 506 articles from 1999 to 2019 across humanities and social sciences was conducted to synthesize the Ethical, Legal, and Social Implications (ELSI) of PGT. This review mined PubMed, WoS, and Scopus databases, using both MeSH terms and keywords to map out the research terrain., Results: The findings reveal a tenfold increase in global research output on PGT's ELSI from 1999 to 2019, signifying rising interest and concern. Despite heightened theoretical discourse on selecting "optimal" offspring, such practices were scarcely reported in clinical environments. Conversely, critical issues like PGT funding and familial impacts remain underexplored. Notably, 86% of the ELSI literature originates from just 12 countries, pointing to a research concentration., Conclusion: This review underscores an urgent need for ELSI research to align more closely with clinical practice, promoting collaborations among ethicists, clinicians, policymakers, and economists. Such efforts are essential for grounding debates in practical relevance, ultimately steering PGT towards ethical integrity, societal acceptance, and equitable access, aiming to harmonize PGT research with real-world clinical concerns, enhancing the relevance and impact of future ethical discussions., (© 2024. The Author(s).)
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- 2024
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21. AI and the falling sky: interrogating X-Risk.
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Jecker NS, Atuire CA, Bélisle-Pipon JC, Ravitsky V, and Ho A
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Competing Interests: Competing interests: None declared.
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- 2024
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22. Bioethics' Duty to Conference in Qatar: Reply to Magnus.
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Jecker NS, Savulescu J, Caplan A, Capron A, McMillan J, Ghaly M, Ortiz Millán G, Atuire C, McMahan J, Chuan VT, Bélisle-Pipon JC, Viswani V, and Ravitsky V
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- Humans, Qatar, Bioethics
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- 2024
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23. Proposed Principles for International Bioethics Conferencing: Anti-Discriminatory, Global, and Inclusive.
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Jecker NS, Ravitsky V, Ghaly M, Bélisle-Pipon JC, and Atuire C
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- Humans, Ethicists, Bioethics
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This paper opens a critical conversation about the ethics of international bioethics conferencing and proposes principles that commit to being anti-discriminatory, global, and inclusive. We launch this conversation in the Section, Case Study, with a case example involving the International Association of Bioethics' (IAB's) selection of Qatar to host the 2024 World Congress of Bioethics. IAB's choice of Qatar sparked controversy. We believe it also may reveal deeper issues of Islamophobia in bioethics. The Section, Principles for International Bioethics Conferencing, sets forth and defends proposed principles for international bioethics conferencing. The Section, Applying Principles to Site Selection applies the proposed principles to the case example. The Section, Applying Principles Beyond Site Selection addresses other applications of the proposed principles. The Section, Objections responds to objections. We close (in the Section, Conclusion) by calling for a wider discussion of our proposed principles. One-Sentence Capsule Summary: How should bioethicists navigate the ethics of global bioethics conferencing?
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- 2024
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24. The Ethics of International Bioethics Conferencing: Continuing the Conversation.
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Jecker NS, Atuire C, Ravitsky V, Ghaly M, and Bélisle-Pipon JC
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- Humans, Ethicists, Bioethics
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- 2024
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25. Ethical, legal, social, and policy issues of ovarian tissue cryopreservation in prepubertal girls: a critical interpretive review.
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Affdal AO, Salama M, and Ravitsky V
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- Humans, Female, Child, Cancer Survivors, Neoplasms, Cryopreservation ethics, Cryopreservation methods, Fertility Preservation ethics, Fertility Preservation methods, Ovary
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Purpose: Despite the increasing number of childhood cancer survivors, significant advances in ovarian tissue cryopreservation (OTC) technique and medical societies' recommendations, fertility preservation (FP) and FP discussions are not always offered as a standard of care in the pediatric context. The aim of this literature review is to understand what ethical, legal, social, and policy issues may influence the provision of FP by OTC in prepubertal girls with cancer., Methods: A critical interpretive review of peer-reviewed papers published between 2000 and January 2023 was conducted, guided by the McDougall's version of the critical interpretive synthesis (Dixon-Woods), to capture recurring concepts, principles, and arguments regarding FP by OTC for prepubertal girls., Results: Of 931 potentially relevant papers, 162 were included in our analysis. Data were grouped into seven thematic categories: (1) risks of the procedure, (2) unique decision-making issues in pediatric oncofertility, (3) counseling, (4) cultural and cost issues, and (5) disposition of cryopreserved reproductive tissue., Conclusion: This first literature review focusing on ethical, legal, social, and policy issues surrounding OTC in prepubertal girls highlights concerns in the oncofertility debate. Although OTC is no longer experimental as of December 2019, these issues could limit its availability and the child's future reproductive autonomy. This review concludes that specific actions must be provided to enable the offer of FP, such as supporting families' decision-making in this unique and complex context, and providing pediatric patients universal and full access to free or highly subsidized OTC., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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26. Pandemics, intellectual property and 'our economy': A worldview analysis of Canada's role in compromising global access to COVID-19 vaccines.
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Brisbois B, Plamondon K, Walugembe D, Pereira RC, Edet C, Dixon J, Habibi R, Karamouzian M, Labonté R, Murthy S, and Ravitsky V
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- Humans, Pandemics prevention & control, Canada epidemiology, Intellectual Property, Global Health, COVID-19 Vaccines, COVID-19 epidemiology, COVID-19 prevention & control
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Despite self-congratulatory rhetoric, Canada compromised COVID-19 vaccine equity with policies impeding a proposed global waiver of vaccine intellectual property (IP) rules. To learn from Canada's vaccine nationalism we explore the worldview - a coherent textual picture of the world - in a sample of Government of Canada communications regarding global COVID-19 vaccine sharing. Analysed documents portray risks and disparities as unrelated to the dynamics and power relations of the Canadian and international economies. Against this depoliticised backdrop, economic growth fueled by strict IP rules and free trade is advanced as the solution to inequities. Global vaccine access and distribution are pursued via a charity-focused public-private-partnership approach, with proposals to relax international IP rules dismissed as unhelpful. Rather than a puzzling lapse by a good faith 'middle power', Canada's obstruction of global COVID-19 vaccine equity is a logical and deliberate extension of dominant neoliberal economic policy models. Health sector challenges to such models must prioritise equity in global pandemic governance via politically assertive and less conciliatory stances towards national governments and multilateral organisations. Mobilisation for health equity should transform the overall health-damaging macroeconomic model, complementing efforts based on specific individual health determinants or medical technologies.
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- 2024
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27. The misplaced embryo: legal parenthood in 'embryo mix-up' cases.
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Simana S, Ravitsky V, and Cohen IG
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Recently in Israel, a woman was mistakenly implanted with an embryo that is genetically related to another couple. Unfortunately, this case is not an isolated occurrence, as other cases of embryo mix-ups have been reported in several countries, including the USA, China, the UK and various other countries within the European Union. Cases of mixed-up embryos are ethically and legally complex: the woman who carried the pregnancy and the woman who is genetically related to the resulting child-both of whom endured emotionally and physically demanding infertility treatments-along with their partners, may be unwilling to relinquish parental rights over the child.This article explores four possible approaches, found in numerous common law jurisdictions, which can be used to address cases involving embryo mix-ups. Our analysis reveals several avenues through which legal parentage can be established. It can be done through gestation and the marital presumption, genetic connections, by adhering to the principle of the best interests of the child, or by recognising multiple individuals as legal parents. We review the advantages and disadvantages of each approach, but we have one clear recommendation: resolving embryo mix-up cases should be done proactively through the establishment of legislation and guidelines, rather than relying on post hoc individual court decisions. Such legislation and guidelines should guarantee the consistency of values throughout diverse reproductive contexts and mandate that fertility clinics and medical professionals provide individuals with comprehensive information regarding the potential risks associated with assisted reproductive treatments., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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28. Generative AI, Specific Moral Values: A Closer Look at ChatGPT's New Ethical Implications for Medical AI.
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Victor G, Bélisle-Pipon JC, and Ravitsky V
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- 2023
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29. Investigating the Influence of Artificial Intelligence on Adolescent Health: An Urgent Call to Action.
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Brisson J, Bélisle-Pipon JC, and Ravitsky V
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- Adolescent, Humans, Adolescent Health, Artificial Intelligence
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- 2023
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30. Ethically cleared to launch?
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Rahimzadeh V, Fogarty J, Caulfield T, Auñón-Chancellor S, Borry P, Candia J, Cohen IG, Covington M, Lynch HF, Greely HT, Hanlon M, Hatt J, Low L, Menikoff J, Meslin EM, Platts S, Ravitsky V, Ruttley T, Seidler RD, Sugarman J, Urquieta E, Williams MA, Wolpe PR, Donoviel D, and McGuire AL
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- Humans, Space Flight ethics, Human Experimentation ethics, Human Experimentation legislation & jurisprudence, Research Subjects
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Rules are needed for human research in commercial spaceflight.
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- 2023
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31. Academic freedom under siege.
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Jecker NS, Verweij M, Ravitsky V, Wangmo T, and Ghaly M
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This paper describes a global pattern of declining academic freedom, often driven by powerful political interference with core functions of academic communities. It argues that countering threats to academic freedom requires doubling down on ethics, specifically standards of justice and fairness in pursuing knowledge and assigning warrant to beliefs. Using the example of the selection of a Qatari university to host the 2024 World Congress of Bioethics, the authors urge fairness towards diverse groups over time and efforts to counter injustices that conferences generate., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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32. Mapping international research output within ethical, legal, and social implications (ELSI) of assisted reproductive technologies.
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Alon I, Chebance Z, Massucci FA, Bounartzi T, and Ravitsky V
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- Humans, Europe, North America, Australia epidemiology, Reproductive Techniques, Assisted
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Purpose: Research about ethical, legal, and social implications (ELSI) of assisted reproductive technologies (ART) is influenced by cultural and value-based perspectives. It impacts regulations, funding, and clinical practice, and shapes the perception of ART in society. We analyze trends in the global literature on ELSI of ART between 1999 and 2019. As most output is produced by North America, Western Europe, and Australia, we focus on international research, i.e., academic articles studying a different country than that of the corresponding author., Methods: The corpus, extracted from PubMed, Web of Science, and Scopus, includes 7714 articles, of which 1260 involved international research. Analysis is based on titles, abstracts and keywords, classification into ART fields and Topic Modeling, the countries of corresponding author, and countries mentioned in abstracts., Results: An absolute increase in the number of international studies, and their relative proportion. Trends of decentralization are apparent, yet geographic centralization remains, which reflects an unequal distribution of research funds across countries and may result in findings that do not reflect global diversity of norms and values. Preference for studying conceptual challenges through philosophical analysis, and for fields that concern only a portion of ART cycles. Less attention was dedicated to economic analysis and barriers to access, or to knowledge of and attitudes. International studies provide an opportunity to expand and diversify the scope of ELSI research., Conclusion: We call on the research community to promote international collaborations, focus on less explored regions, and divert more attention to questions of cost, access, knowledge, and attitudes., (© 2023. The Author(s).)
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- 2023
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33. A Path Forward-and Outward: Repositioning Bioethics to Face Future Challenges.
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Ravitsky V
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- Humans, Bioethics
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This essay explores what the future may hold for bioethics if it continues its evolution toward a field that embraces systemic, collective-level challenges; has a global scale and focus; emphasizes human flourishing; and seeks to have increased societal impact. As The Hastings Center considers strategic priorities for its research, public engagement, and impact, this essay reflects on where we have been and where we are going. It offers an expansive and inclusive vision for the future of bioethics, in order to invite an open and wide-ranging conversation about the future of our field and the role that The Hastings Center can and should play within it., (© 2023 The Hastings Center.)
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- 2023
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34. Mapping ethical, legal, & social implications (ELSI) of assisted reproductive technologies.
- Author
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Alon I, Chebance Z, Massucci FA, Bounartzi T, and Ravitsky V
- Subjects
- Humans, Delivery of Health Care, Europe, North America, Reproductive Techniques, Assisted, Reproduction
- Abstract
Purpose: A significant portion of the research on assisted reproductive technologies explores ethical, legal, and social implications. It has an impact on social perceptions, the evolution of norms of clinical practices, regulations and public funding. This paper reviews and maps the geographical distribution to test the hypothesis of geographical concentration and classifies the output by fields and topics., Methods: We queried PubMed, Scopus and the Web of Science for documents published between 1999 and 2019, excluding clinical trials and medical case reports. Documents were analyzed according to their titles, abstracts and keywords and were classified to assisted reproductive fields and by Topic Modeling. We analyzed geographic distribution., Results: Research output increased nearly tenfold. We show a trend towards decentralization of research, although at a slower rate compared with clinical assisted reproduction research. While the U.S. and the U.K.'s share has dropped, North America and Western Europe are still responsible for more than 70%, while China and Japan had limited participation in the global discussion. Fertility preservation and surrogacy have emerged as the most researched categories, while research about genetics was less prominent., Conclusions: We call to enrich researchers' perspectives by addressing local issues in ways that are tailored to local cultural values, social and economic contexts, and differently structured healthcare systems. Researchers from wealthy centers should conduct international research, focusing on less explored regions and topics. More research on financial issues and access is required, especially regarding regions with limited public funding., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
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35. Individuals and (Synthetic) Data Points: Using Value-Sensitive Design to Foster Ethical Deliberations on Epistemic Transitions.
- Author
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Bélisle-Pipon JC, Ravitsky V, and Bensoussan Y
- Published
- 2023
- Full Text
- View/download PDF
36. The ethics of bioethics conferencing in Qatar.
- Author
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Jecker NS and Ravitsky V
- Subjects
- Humans, Qatar, Ethics, Human Rights, Bioethics
- Abstract
In 2022, the International Association of Bioethics (IAB) announced that the 17th World Congress of Bioethics would be held in Doha, Qatar. In response to ethical concerns expressed about the Qatar selection, the IAB Board of Directors developed and posted to the IAB website a response using a Q&A format. In this Letter, we (the IAB President and Vice President) address concerns about the ethics of bioethics conferencing raised in a 2023 Letter to the Editor of Bioethics by Van der Graaf et al. We do not represent the Board of Directors, and this Letter expresses solely our own views., (© 2023 John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
37. Parent-initiated posthumous-assisted reproduction revisited in light of the interest in genetic origins.
- Author
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Bokek-Cohen Y and Ravitsky V
- Subjects
- Humans, Male, Parents, Prospective Studies, Reproduction, Tissue Donors, Posthumous Conception psychology, Semen
- Abstract
A rich literature in bioethics argues against the use of anonymous gamete donation in the name of the 'interest in knowing one's genetic origins'. This interest stems from medical as well as psychosocial and identity reasons. The term 'genealogical bewilderment' has been coined to express the predicament of those deprived of access to information about their origins. Another rich body of literature in bioethics discusses arguments for and against posthumous-assisted reproduction (PAR), with a recent focus on PAR that is initiated by the parents of a deceased man (rather than his partner). This paper revisits arguments against PAR, in light of arguments regarding the interest in knowing one's genetic origins. Limiting the discussion to the specific context of parent-initiated PAR (PIPAR), we argue that the use of cryopreserved sperm from a deceased identifiable man in the context of PIPAR may be ethically preferable when compared with the use of anonymous donor sperm, since it allows genealogical certainty , that is, giving the prospective child access to information about the identity, life story and ancestry of the genetic progenitor as well as genealogical embeddedness , that is, close relationship with extended family members., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
- Full Text
- View/download PDF
38. Rewriting the genetic bond: Gene editing and our understanding of genetic parenthood.
- Author
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Simana S and Ravitsky V
- Subjects
- Child, Humans, Prospective Studies, Germ Cells, Parent-Child Relations, Gene Editing, Parents
- Abstract
One of the most prominent justifications for the use of germline gene editing (GGE) is that it would allow parents to have a "genetically related child" while preventing the transmission of genetic disorders. However, we argue that since future uses of GGE may involve large-scale genetic modifications, they may affect the genetic relatedness between parents and offspring in a meaningful way: Due to certain genetic modifications, children may inherit much less than 50% of their DNA from each parent. We show that the reduction in genetic relatedness between parents and offspring has three important social and legal implications. First, the desire for a genetically related child may end up not being the strong justification it is currently thought to be for the use of GGE. Second, prospective parents may be reluctant to use GGE because of a potential loss of genetic relatedness. Third, in some jurisdictions, parents who would not pass on "enough" DNA to their child may not be recognized as the child's legal parents. We further argue that the reduction in genetic relatedness challenges current conceptions of genetic parenthood that rely on the quantity of DNA shared with the child or on whether the child was directly derived from the parent's genes. We suggest that genetic parenthood should instead be determined based on the nature of the genetic modifications and whether the child's numerical identity has been preserved after the editing process., (© 2022 John Wiley & Sons Ltd.)
- Published
- 2023
- Full Text
- View/download PDF
39. Going Back to Basics: What is the Target of Prenatal Screening?
- Author
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Laberge AM, Roy MC, Kleiderman E, and Ravitsky V
- Subjects
- Female, Pregnancy, Humans, Prenatal Diagnosis
- Published
- 2023
- Full Text
- View/download PDF
40. Harvey and Gurvir's Law: Ontario Bill for Quality Prenatal Information about Down Syndrome: Terminology, Feasibility, and Ethical Issues.
- Author
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Lemoine ME, Laberge AM, Malo MF, Cloutier S, Roy MC, Birko S, Daigle A, and Ravitsky V
- Subjects
- Pregnancy, Female, Humans, Ontario, Feasibility Studies, Social Stigma, Prenatal Diagnosis, Down Syndrome diagnosis
- Abstract
Harvey and Gurvir's Law is a bill proposed to the Legislative Assembly of Ontario (Canada) to reduce stigma and bias associated with Down syndrome, by developing and disseminating quality information about Down syndrome in the context of prenatal testing.
- Published
- 2023
- Full Text
- View/download PDF
41. Views of Canadian healthcare professionals on the future uses of non-invasive prenatal testing: a mixed method study.
- Author
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Haidar H, Birko S, Laberge AM, Le Clerc-Blain J, and Ravitsky V
- Subjects
- Female, Humans, Pregnancy, Canada, Delivery of Health Care, Prospective Studies, Health Personnel, Prenatal Diagnosis methods
- Abstract
Non-invasive prenatal testing's (NIPT) potential to screen for a wide range of conditions is receiving growing attention. This study explores Canadian healthcare professionals' perceptions towards NIPT's current and possible future uses, including paternity testing, sex determination, and fetal whole genome sequencing. Semi-structured interviews were conducted with ten healthcare professionals, and another 184 participated in a survey. The triangulation of our findings shows that there is considerable agreement among healthcare professionals on expanding NIPT use for medical conditions including fetal aneuploidies and monogenic diseases, but not for non-medical conditions (sex determination for non-medical reasons and paternity testing), nor for risk predisposition information (late onset diseases and Fetal Whole Genome Sequencing). Healthcare professionals raise concerns related to eugenics, the future child's privacy, and psychological and emotional burdens to prospective parents. Professional societies need to take these concerns into account when educating healthcare professionals on the uses of NIPT to ensure prospective parents' reproductive decisions are optimal for them and their families., (© 2022. The Author(s), under exclusive licence to European Society of Human Genetics.)
- Published
- 2022
- Full Text
- View/download PDF
42. Governing the futures of non-invasive prenatal testing: An exploration of social acceptability using the Delphi method.
- Author
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Dupras C, Birko S, Affdal AO, Haidar H, Lemoine ME, and Ravitsky V
- Subjects
- Canada, Delphi Technique, Female, Genetic Testing methods, Humans, Pregnancy, Prospective Studies, Cell-Free Nucleic Acids, Prenatal Diagnosis
- Abstract
Non-invasive prenatal testing (NIPT) using cell-free DNA (cfDNA) offers numerous benefits to pregnant women and their families. It also raises ethical, legal and social concerns regarding, for instance, the possible effects of a routinization of prenatal genetic testing on free and informed decision-making by prospective parents, and the role of the state in governing its use. Technological advances are allowing cfDNA analyses to detect an increasing number of genetic risks and conditions in the fetus, potentially further exacerbating such concerns. From May 2015 to December 2016, we conducted a three-round Policy Delphi study (N
R1 = 61, NR2 = 58, NR3 = 47; overall retention rate = 77.0%) to explore the social acceptability (SA) of current and potential future uses of NIPT in Canada according to participants with relevant professional, research or advocacy expertise. Participants came from four groups: healthcare professionals (NR3 = 14), social sciences and humanities researchers (NR3 = 13), patients/disability rights advocates (NR3 = 14), and cultural/religious communities advocates (NR3 = 6). This paper presents SA criteria and contextual contingencies relevant to the assessment of NIPT's SA according to the group. It also reports what uses (conditions or motives) participants thought should be banned, permitted, publicly funded, or promoted as a public health strategy. According to them, conditions resulting in severe pain or early death, as well as trisomies (13, 18, 21) and sex chromosome abnormalities, should be covered by Canadian public health insurance. However, there was wide agreement that direct-to-consumer NIPT should be legally banned, and that testing for fetal sex for non-medical reasons using NIPT should be either proscribed or discouraged. In addition to identifying areas of consensus, our results point to disagreement regarding, for instance, the required level of governance of whole-genome sequencing and testing for late onset conditions with low penetrance. This study also provides a model for exploring the SA of emerging technologies using the Policy Delphi method., (Copyright © 2020 Elsevier Ltd. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF
43. "Autonomy and solidarity: Bridging the tensions": Celebrating the 15th World Congress of Bioethics.
- Author
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Ravitsky V, Eckenwiler L, and Schmidt H
- Subjects
- Humans, Personal Autonomy, Social Justice, Bioethics
- Published
- 2022
- Full Text
- View/download PDF
44. Colombian adolescents' preferences for independently accessing sexual and reproductive health services: A cross-sectional and bioethics analysis.
- Author
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Brisson J, Ravitsky V, and Williams-Jones B
- Subjects
- Adolescent, Adult, Child, Colombia, Cross-Sectional Studies, Female, Humans, Male, Reproductive Health, Sexual Behavior, Young Adult, Bioethics, Reproductive Health Services
- Abstract
Objective: Our study sought to (1) describe the practices and preferences of Colombian adolescents in accessing sexual and reproductive health services: accompanied versus alone; (2) compare actual practices with stated preferences; and (3) determine age and gender differences regarding the practice and these stated preferences., Methods: 812 participants aged 11-24 years old answered a survey in two Profamilia clinics in the cities of Medellin and Cali in Colombia. A cross-sectional analysis was performed to compare participants' answers based on the variables of gender and age., Results: A quarter of participants visited the clinic alone (25.4%). Females were more likely to go alone in comparison to males (26.3% vs 14.1%; p = 0.031), and older participants went alone more often than younger participants (p < 0.001). Most participants - 72.7% (95 %CI: 69.3-75.9) - expressed a preference in being accompanied to the clinic, and more than 90% had their preferences met. The preferences of older participants were, however, less likely to be met than those of younger participants (p < 0.001), notably, because they predominantly wanted to be accompanied., Conclusion: Contemporary public health and bioethics literature advocates in favor of developing health services that better meet the preferences of adolescents. The present research highlights an apparent blind spot related to the role that others (e.g., parents, friends, partners) can or should play in accompanying adolescent patients when they access sexual and reproductive health services. Respecting adolescents' preferences, and hence their autonomy, is not simply a matter of ensuring freedom from constraints (e.g., their right and ability to go alone). Rather, it should also consider the liberty to choose whether to be accompanied when accessing SHRS and by whom., (Copyright © 2022 Elsevier B.V. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF
45. IAB Presidential Address: Bioethics, justice, and lessons from a global pandemic.
- Author
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Ravitsky V
- Subjects
- Human Rights, Humans, Pandemics, Bioethics, Social Justice
- Published
- 2022
- Full Text
- View/download PDF
46. Expanded Prenatal Testing: Maintaining a Non-Directive Approach to Promote Reproductive Autonomy.
- Author
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Ravitsky V, Roy MC, Richer J, Malo MF, Laforce TM, and Laberge AM
- Subjects
- Female, Humans, Pregnancy, Personal Autonomy, Prenatal Diagnosis
- Published
- 2022
- Full Text
- View/download PDF
47. The Serious Factor in Expanded Prenatal Genetic Testing.
- Author
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Kleiderman E, Rahimzadeh V, Knoppers B, Roy MC, Laberge AM, and Ravitsky V
- Subjects
- Female, Humans, Pregnancy, Genetic Testing, Prenatal Diagnosis
- Published
- 2022
- Full Text
- View/download PDF
48. Mitochondrial Replacement Therapy: In Whose Interests?
- Author
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Noohi F, Ravitsky V, Knoppers BM, and Joly Y
- Subjects
- Humans, Mitochondria genetics, Australia, United Kingdom, Mitochondrial Replacement Therapy, Mitochondrial Diseases genetics, Mitochondrial Diseases prevention & control
- Abstract
Mitochondrial replacement therapy (MRT), also called nuclear genome transfer and mitochondrial donation, is a new technique that can be used to prevent the transmission of mitochondrial DNA diseases. Apart from the United Kingdom, the first country to approve MRT in 2015, Australia became the second country with a clear regulatory path for the clinical applications of this technique in 2021. The rapidly evolving clinical landscape of MRT makes the elaboration and evaluation of the responsible use of this technology a pressing matter. As jurisdictions with less strict or non-existent reproductive laws are continuing to use MRT in the clinical context, the need to address the underlying ethical issues surrounding MRT's clinical translation is fundamental.
- Published
- 2022
- Full Text
- View/download PDF
49. The Emergence and Global Spread of Noninvasive Prenatal Testing.
- Author
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Ravitsky V, Roy MC, Haidar H, Henneman L, Marshall J, Newson AJ, Ngan OMY, and Nov-Klaiman T
- Subjects
- Australia, Canada, China, Female, Humans, Pregnancy, Prenatal Diagnosis, United States, Noninvasive Prenatal Testing
- Abstract
Since its introduction in 2011, noninvasive prenatal testing (NIPT) has spread rapidly around the world. It carries numerous benefits but also raises challenges, often related to sociocultural, legal, and economic contexts. This article describes the implementation of NIPT in nine countries, each with its own unique characteristics: Australia, Canada, China and Hong Kong, India, Israel, Lebanon, the Netherlands, the United Kingdom, and the United States. Themes covered for each country include the structure of the healthcare system, how NIPT is offered, counseling needs and resources, and cultural and legal context regarding disability and pregnancytermination. Some common issues emerge, including cost as a barrier to equitable access, the complexity of decision-making about public funding, and a shortage of appropriate resources that promote informed choice. Conversely, sociocultural values that underlie the use of NIPT vary greatly among countries. The issues described will become even more challenging as NIPT evolves from a second-tier to a first-tier screening test with expanded use.
- Published
- 2021
- Full Text
- View/download PDF
50. "Fostering Autonomy" for Adolescents to Access Health Services: A Need for Clarifications.
- Author
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Brisson J, Ravitsky V, and Williams-Jones B
- Subjects
- Adolescent, Humans, Personal Autonomy, Health Services, Health Services Accessibility
- Published
- 2021
- Full Text
- View/download PDF
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